Novel and promising compounds to treat Cryptosporidium parvum infections

Parasitology Research

Volumn 109, Issue 3, 2011, Pages 591-594

  Graczyk, Zofi ^a   Chomicz, Lidia ^b   Kozłowska, Mariola ^c   Kazimierczuk, Zygmunt ^c   Graczyk, Thaddeus K ^d  

^a W STEFA SKI INSTITUTE OF PARASITOLOGY   (Poland)

^b MEDICAL UNIVERSITY OF WARSAW   (Poland)

^c WARSAW UNIVERSITY OF LIFE SCIENCES   (Poland)

^d JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4,6 DICHLORO 2 (4 NITROBENZYLTHIO) 1H BENZIMIDAZOLE; 5 CARBOXY 2 (4 NITROBENZYLTHIO) 1H BENZIMIDAZOLE; 5,6 DICHLORO 2 (4 NITROBENZYLTHIO) 1H BENZIMIDAZOLE; ALKALINE PHOSPHATASE; BENZIMIDAZOLE DERIVATIVE; PAROMOMYCIN; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYPTOSPORIDIOSIS; CRYPTOSPORIDIUM PARVUM; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG RESEARCH; DRUG SCREENING; DRUG STRUCTURE; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; IMMUNOASSAY; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS;

ANIMALS; ANTIPROTOZOAL AGENTS; BENZIMIDAZOLES; CELL LINE; CELL SURVIVAL; CRYPTOSPORIDIUM PARVUM; ENTEROCYTES; HUMANS; INHIBITORY CONCENTRATION 50; PARASITIC SENSITIVITY TESTS;

CRYPTOSPORIDIUM; CRYPTOSPORIDIUM PARVUM; PROTOZOA;

EID: 80052310081     PISSN: 09320113     EISSN: 14321955     Source Type: Journal    
DOI: 10.1007/s00436-011-2290-y     Document Type: Article

References (22)

1. VR Anderson MP Curann 2007 Nitazoxanide: a review of its use in the treatment of gastrointestinal infections Drugs 67 1947 1967 17722965 10.2165/00003495-200767130-00015 1:CAS:528:DC%2BD2sXht1ajt77M (Pubitemid 47347408)
2. M Andrzejewska ML Yepez-Mulia A Tapia R Cedillo-Rivera AE Laudy BJ Starosciak 2004 Synthesis, and antiprotozoal and antibacterial activities of S-substituted 4, 6-dibromo- and 4, 6-dichloro-2-mercaptobenzimidazoles Eur J Pharm Sci 21 323 329 14757505 10.1016/j.ejps.2003.10.024 1:CAS:528: DC%2BD2cXptFWqsA%3D%3D (Pubitemid 38156169)
3. N Bennamane K Zaiona KR AkacemY Y Bantarzi S Bakhata B Nedjar-Kolli L Ouhab 2009 Synthesis of benzimidazole-2-thiones from dimedone: an unexpected cyclisation into a five-membered ring Org Commun 2 49 59 1:CAS:528: DC%2BD1MXmvVCmtr8%3D
4. AS Downey CR Chong TK Graczyk DJ Sullivan 2008 Efficacy of pyrvinium pamoate against Cryptosporidium parvum infection in vitro and in a neonatal mouse model J Antimicrob Agents Chemother 52 3106 3112 10.1128/AAC.00207-08 1:CAS:528:DC%2BD1cXhtF2gtrnE
5. AS Downey CR Chong TK Graczyk DJ Sullivan 2009 In vitro efficacy of pyrvinium pamoate against Entamoeba histolytica and Giardia duodenalis using radiolabeled thymidine incorporation and a SYBR Green I-based fluorescence assay J Antimicrob Chemother 64 751 754 19689977 10.1093/jac/dkp296 1:CAS:528:DC%2BD1MXhtFarsr%2FF
6. EJ Dziuban JL Liang GF Craun V Hill PA Yu J Painter M Moore RL Calderon SL Roy ML Beach 2006 Surveillance for waterborne disease and outbreaks associated with recreational water-United States, 2003-2004 Morb Mort Wkl Rep 55 1 24
7. R Fayer 2004 Cryptosporidium: a water-borne zoonotic parasite Vet Parasitol 126 37 56 15567578 10.1016/j.vetpar.2004.09.004 (Pubitemid 39572936)
8. G Gargala A Delaunay L Favennec P Brasseur JJ Ballet 1999 Enzyme immunoassay detection of Cryptosporidium parvum inhibition by sinefungin in sporozoite infected HCT-8 enterocytic cells Int J Parasitol 29 703 709 10404264 10.1016/S0020-7519(99)00031-4 1:CAS:528:DyaK1MXktlKnsbc%3D (Pubitemid 29319739)
9. TK Graczyk R Fayer MR Cranfield 1997 Zoonotic potential of Cryptosporidium parvum: implications for waterborne cryptosporidiosis Parasitol Today 13 348 351 15275048 10.1016/S0169-4758(97)01076-4 1:STN:280: DC%2BD2cznsFWjug%3D%3D (Pubitemid 27364606)
10. F Hernández-Luis A Hernández-Campos R Castillo G Navarrete-Vázquez O Soria-Arteche M Hernández-Hernández L Yépez-Mulia 2010 Synthesis and biological activity of 2-(trifluoromethyl)-1H-benzimidazole drivatives against some protozoa and Trichinella spiralis Eur J Med Chem 45 3135 41 20430484 10.1016/j.ejmech.2010. 03.050
11. MK Ijaz DB Suchmann JC Pugh TK Graczyk SA Sattar 2000 Evaluation of chloride dioxide as a microbiological water purifier J Chem Specials Manufact Assoc 23 38 43 1:CAS:528:DC%2BD3cXhvVensL0%3D
12. JA Kazimierczuk P Upcroft A Upcroft B Górska A Starosciak A Laudy 2002 Synthesis, antiprotozoal and antibacterial activity of nitro- and halogeno-substituted benzimidazole derivatives Acta Biochim Pol 49 185 195 12136939 1:CAS:528:DC%2BD38XjtFWhurc%3D (Pubitemid 135688019)
13. Z Kazimierczuk M Andrzejewska J Kaustova V Klimesova 2005 Synthesis and antimycobacterial activity of 2-substituted halogenobenzimidazoles Eur J Med Chem 40 203 208 15694655 10.1016/j.ejmech.2004.10.004 1:CAS:528: DC%2BD2MXht1Gjsrs%3D (Pubitemid 40203161)
14. HP Narkhede UB More DS Dalal PP Mahulikar 2007 Solid supported synthesis of 2-derivatives using microwaves J Sci Ind Res 67 374 376
15. MA Pagano M Andrzejewska M Ruzzene S Sarno L Cesaro J Bain M Elliott F Meggio Z Kazimierczuk LA Pinna 2004 Optimization of protein kinase CK2 inhibitors derived from 4, 5, 6, 7-tetrabromobenzimidazole J Med Chem 47 6239 6247 15566294 10.1021/jm049854a 1:CAS:528:DC%2BD2cXpt1Sksbk%3D (Pubitemid 39587248)
16. J Perez-Villaneuva R Santos A Hernández-Campos MA Giulianotti R Castillo JL Medina-Franco 2010 Towards a systematic characterization of the antiprotozoal landscape of benzimidazole derivatives Bioorg Med Chem 18 21 7380 7391 10.1016/j.bmc.2010.09.019
17. JA Reynoldson RCA Thompson RJ Horton 1992 Albendazole as a future antigiardial agent Parasitol Today 8 412 413 15463558 10.1016/0169-4758(92) 90193-6 1:STN:280:DC%2BD2cvpvV2isw%3D%3D
18. L Sharling X Liu DR Gollapalli SK Maurya L Hedstrom B Boris Striepen 2010 A screening pipeline for antiparasitic agents targeting Cryptosporidium inosine monophosphate dehydrogenase PloS Neglected Trop Dis 4 8 e794 10.1371/journal.pntd.0000794
19. D Sunderland TK Graczyk L Tamang PN Breysee 2007 Impact of bathers on levels of Cryptosporidium parvum and Giardia lamblia cysts in recreational beach water Water Res 41 3483 3489 17583766 10.1016/j.watres.2007.05.009 1:CAS:528:DC%2BD2sXns1Kiu7k%3D (Pubitemid 47031277)
20. G Ventura LM Larocca ME Riccioni M Tumbarello MB Lucia 1997 Gastric cryptosporidiosis complicating HIV infection: case report and review of the literature Eur J Gastroenterol Hepatol 9 307 9096436 1:STN:280: DyaK2s3ltVGqug%3D%3D
21. KM Woods MV Nesterenko ST Upton 1995 Development of a microtitre ELISA to quantify development of Cryptosporidium parvum in vitro FEMS Microbiol Lett 128 89 94 7744242 10.1111/j.1574-6968.1995.tb07505.x 1:CAS:528:DyaK2MXkvFGrsrc%3D
22. L Xiao A Singh J Limor TK Graczyk S Gradus AA Lal 2001 Molecular characterization of Cryptosporidium oocysts in samples of raw surface and wastewater Appl Environ Microbiol 67 1097 1101 11229897 10.1128/AEM.67.3.1097- 1101.2001 1:CAS:528:DC%2BD3MXhslSjs74%3D (Pubitemid 33643547)