Bactericidal activity and in vitro cytotoxicity assessment of hydroxyapatite containing gold nanoparticles

Journal of Biomedical Nanotechnology

Volumn 7, Issue 3, 2011, Pages 342-350

  Nirmala, R ^a   Park, Hye Min ^a   Kalpana, D ^a   Kang, Hyung Sub ^a   Navamathavan, R ^a   Lee, Yang Soo ^a   Kim, Hak Yong ^a  

^a Chonbuk National University   (South Korea)

Author keywords

Au nanoparticles; Bactericidal; Cell culture; Composite materials; Cytotoxicity; Hydroxyapatite; Wet precipitation

Indexed keywords

AU NANOPARTICLE; AVERAGE SIZE; BACTERICIDAL; BACTERICIDAL ACTIVITY; BIOMEDICAL APPLICATIONS; COMPOSITE NANOPARTICLES; CYTOTOXIC; ENERGY DISPERSIVE X-RAY; FIELD EMISSION SCANNING ELECTRON MICROSCOPY; GOLD NANOPARTICLES; HA POWDERS; IN-VITRO; OSTEOBLASTIC CELLS; STRUCTURE AND THERMAL PROPERTIES; TEM OBSERVATIONS; WET PRECIPITATION; XRD PATTERNS;

ADHESION; APATITE; BACTERICIDES; CELL CULTURE; COMPOSITE MATERIALS; CYTOTOXICITY; FIELD EMISSION MICROSCOPES; HYDROXYAPATITE; INFRARED SPECTROSCOPY; MEDICAL APPLICATIONS; NANOPARTICLES; PRECIPITATION (CHEMICAL); THERMODYNAMIC PROPERTIES; THERMOGRAVIMETRIC ANALYSIS; TRANSMISSION ELECTRON MICROSCOPY; X RAY DIFFRACTION;

GOLD;

ANTIBIOTIC AGENT; GOLD NANOPARTICLE; HYDROXYAPATITE; HYDROXYAPATITE CONTAINING GOLD NANOPARTICLE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; GOLD; METAL NANOPARTICLE;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERICIDAL ACTIVITY; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DISK DIFFUSION; DRUG SYNTHESIS; ENERGY DISPERSIVE X RAY SPECTROSCOPY; ESCHERICHIA COLI; IMMOBILIZATION; IN VITRO STUDY; INFRARED SPECTROSCOPY; NONHUMAN; PARTICLE SIZE; ROENTGEN SPECTROSCOPY; SALMONELLA TYPHIMURIUM; STAPHYLOCOCCUS AUREUS; THERMOGRAVIMETRY; TRANSMISSION ELECTRON MICROSCOPY; X RAY DIFFRACTION; CELL CULTURE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECT; HUMAN; OSTEOBLAST; SCANNING ELECTRON MICROSCOPY;

ANTI-BACTERIAL AGENTS; CELL SURVIVAL; CELLS, CULTURED; DURAPATITE; ESCHERICHIA COLI; GOLD; HUMANS; METAL NANOPARTICLES; MICROSCOPY, ELECTRON, SCANNING; OSTEOBLASTS; SALMONELLA TYPHIMURIUM; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; STAPHYLOCOCCUS AUREUS; X-RAY DIFFRACTION;

EID: 80052307318     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2011.1292     Document Type: Article

References (32)

1. M. Motskin, D. M. Wright, K. Muller, N. Kyle, T. G. Gard, A. E. Porter, and J. N. Skepper, Hydroxyapatite nano and microparticles: Correlation of particle properties with cytotoxicity and biostability. Biomaterials 30, 3307 (2009).
2. Y. Cai, Y. Liu, W. Yan, Q. Hu, J. Tao, M. Zhang, Z. Shi, and R. Tang, Role of hydroxyapatite nanoparticle size in bone cell proliferation. J. Mater. Chem. 17, 3780 (2007).
3. S. Aryal, K. C. R. Bahadur, S. R. Bhattaraj, P. Prabu, and H. Y. Kim, Immobilization of collagen on gold nanoparticle: Preparation, characterization, and hydroxyapatite growth. J. Mater. Chem. 16, 4642 (2006).
4. D. Rautaray, S. Mandal, and M. Sastry, Synthesis of hydroxyapatite crystals using amino acid-capped gold nanoparticles as a scaffold. Langmuir 21, 5185 (2005).
5. C. K. Wang, C. Z. Wang, J. C. Wang, C. C. Hung, W. Y. Li, and W. C. Chen, Preparation and characterization of calcium phosphate deposited on gold nanoparticles. J. Non-Crystalline Solids 356, 927 (2010).
6. S. S. L. Sobhana, J. Sundaraseelan, S. Sekar, T. P. Sastry, and A. B. Mandal, Gelatin-chitosan capped gold nanoparticles: A matrix for the growth of hydroxyapatite. J. Nanopart. Res. 11, 333 (2009).
7. R. A. V. Schnettler, E. Dingeldein, H. J. Pfefferle, O. Kilian, C. Meyer, C. Heiss, and S. Wenisch, Bone ingrowth in bFGF-coated hydroxyapatite ceramic implants. Biomaterials 24, 4603 (2003).
8. J. V. D. Dolder, E. Farber, P. H. M. Spauwen, and J. A. Jansen, Bone tissue reconstruction using titanium fiber mesh combined with rat bone marrow stromal cells. Biomaterials 24, 1745 (2003).
9. H. J. Yen, S. H. Hsu, and C. L. Tsai, Cytotoxicity and immunological response of gold and silver nanoparticles of different sizes. Small 5, 1553 (2009).
10. J. R. Morones, J. L. Elechiguerra, A. Camacho, and J. T. Ramirez, The bactericidal effect of silver nanoparticles. Nanotechnol. 16, 2346 (2005).
11. J. S. Kim, E. Kuk, K. N. Yu, J. S. Kim, S. J. Park, H. J. Lee, S. H. Kim, Y. K. Park, Y. H. Park, G. Y. Hwang, Y. K. Kim, Y. S. Lee, D. H. Jeong, and M. H. Cho, Antimicrobial effects of silver nanoparticles. Nanomed. Nanotechnol. Biol. Med. 3, 95 (2007).
12. 2+) in hydroxyapatite. J. Mater. Sci. Mater. Med. 9, 129 (1998).
13. + solution made using metallic silver. Korean J. Biotechnol. Bioeng. 15, 521 (2000).
14. Q. L. Feng, J. Wu, G. Q. Chen, F. Z. Cui, T. N. Kim, and J. O. Kim, A mechanistic study of the antibacterial effect of silver ions on escherichia coli and staphylococcus aureus. J. Biomed. Mater. Res. 52, 662 (2000).
15. P. S. R. Schabes, G. Canizal, R. B. Herrera, C. Zorrilla, H. B. Liu, and J. A. Ascencio, Biosynthesis and characterization of Ti/Ni bimetallic nanoparticles. Opt. Mater. 29, 95 (2006).
16. H. Gu, P. L. Ho, E. Tong, L. Wang, and B. Xu, Presenting vancomycin on nanoparticles to enhance antimicrobial activities. Nano Lett. 3, 1261 (2003).
17. Z. Ahmad, R. Pandey, S. Sharma, and G. K. Khuller, Alginate nanoparticles as antituberculosis drug carriers: Formulation development, pharmacokinetics and therapeutic potential. Ind. J. Chest Dis. Allied Sci. 48, 171 (2005).
18. 4@Ag nanoparticles. Nanotechnol. 18, 285604 (2007).
19. T. P. Sastry, J. Sundaraseelan, K. Swarnalatha, S. S. L. Sobhana, M. U. Makheswari, S. Sekar, and A. B. Mandal, Growth of hydroxyapatite on physiologically clotted fibrin capped gold nanoparticles. Nanotechnol. 19, 245604 (2008).
20. S. M. Magana, P. Quintana, D. H. Aguilar, J. A. Toledo, C. A. Chavez, M. A. Cortes, L. Leon, Y. F. Pelegrin, T. Lopez, and R. M. T. Sanchez, Antibacterial activity of montmorillonites modified with silver. J. Mol. Catal. A 281, 192 (2008).
21. M. Rai, A. Yadav, and A. Gade, Silver nanoparticles as a new generation of antimicrobials. Biotechnol. Adv. 27, 76 (2009).
22. S. A. Jones, P. G. Bowler, M. Walker, and D. Parsons, Controlling wound bioburden with a novel silver-containing Hydrofiber® dressing. Wound Repair Regen. 12, 288 (2004).
23. 2+]i accompanied by ERK 1/2 activation in humanosteoblast cells. FEBS Lett. 581, 5929 (2007).
24. G. Balasundaram and J. W. Thomas, A perspective on nanophase materials for orthopedic implant applications. J. Mater. Chem. 16, 3737 (2006).
25. K. Duan and R. Wang, Surface modifications of bone implants through wet chemistry. J. Mater. Chem. 16, 2309 (2006).
26. E. S. Thian, J. Huang, M. E. Vickers, S. M. Best, Z. H. Barber, and W. Bonfield, Silicon-substituted hydroxyapatite (Si-HA): A novel calcium phosphate coating for biomedical applications. J. Mater. Sci. 41, 709 (2006).
27. C. Zhang, J. Yang, Z. Quan, P. Yang, C. Li, Z. Hou, and J. Lin, Hydroxyapatite nano- and microcrystal with multiform morphologies: Controllable synthesis and luminescence properties. Cryst. Growth Des. 9, 2725 (2009).
28. S. Koutsopoulos, Synthesis and characterization of hydroxyapatite crystals: A review study on the analytical methods. J. Biomed. Mater. Res. 62, 600 (2002).
29. - content and its influence on the composition of biomimetic apatites. Acta Biomaterialia 2, 181 (2006).
30. M. I. Dominguez, F. R. Sarria, M. A. Centeno, and J. A. Odriozola, Gold/hydroxyapatite catalysts synthesis, characterization and catalytic activity to CO oxidation. Appl. Catalysis B: Environmental 87, 245 (2009).
31. H. Vanessa, E. Katrina, W. Eric, and B. Alison, Siderophores of Marinobacter aquaeolei: Petrobactin and its sulfonated derivatives. Biometals 22, 565 (2009).
32. G. Fotakis and J. A. Timbrell, In vitro cytotoxicity assays: Comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride. Toxicology Lett. 160, 171 (2006).