Adenovirus E1A directly targets the E2F/DP-1 complex

Journal of Virology

Volumn 85, Issue 17, 2011, Pages 8841-8851

  Pelka, Peter ^a   Miller, Matthew S ^b   Cecchini, Matthew ^b   Yousef, Ahmed F ^b   Bowdish, Dawn M ^a   Dick, Fred ^b   Whyte, Peter ^a   Mymryk, Joe S ^b  

^a MCMASTER UNIVERSITY   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

E1A PROTEIN; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR DP1; TRANSCRIPTION FACTOR E2F; TRANSCRIPTION FACTOR E2F4; TRANSCRIPTION FACTOR E2F5;

ADENOVIRUS; ADENOVIRUS INFECTION; ARTICLE; BINDING SITE; COMPLEX FORMATION; CONTROLLED STUDY; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE TARGETING; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; REGULATOR GENE; TRANSCRIPTION INITIATION;

ADENOVIRIDAE; ADENOVIRUS E1A PROTEINS; E2F TRANSCRIPTION FACTORS; HELA CELLS; HOST-PATHOGEN INTERACTIONS; HUMANS; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; TRANSCRIPTION FACTOR DP1; VIRUS REPLICATION;

ADENOVIRIDAE;

EID: 80052302753     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00539-11     Document Type: Article

References (35)

1. Avvakumov, N., A. E. Kajon, R. C. Hoeben, and J. S. Mymryk. 2004. Comprehensive sequence analysis of the E1A proteins of human and simian adenoviruses. Virology 329:477-492.
2. Bayley, S. T., and J. S. Mymryk. 1994. Adenovirus E1A proteins and transformation. Int. J. Oncol. 5:425-444.
3. Berk, A. J. 2005. Recent lessons in gene expression, cell cycle control, and cell biology from adenovirus. Oncogene 24:7673-7685.
4. Blais, A., and B. D. Dynlacht. 2004. Hitting their targets: an emerging picture of E2F and cell cycle control. Curr. Opin. Genet. Dev. 14:527-532.
5. Bruton, R. K., et al. 2008. Identification of a second CtBP binding site in adenovirus type 5 E1A conserved region 3. J. Virol. 82:8476-8486.
6. Burkhart, D. L., and J. Sage. 2008. Cellular mechanisms of tumour suppression by the retinoblastoma gene. Nat. Rev. Cancer 8:671-682.
7. Cam, H., et al. 2004. A common set of gene regulatory networks links metabolism and growth inhibition. Mol. Cell 16:399-411.
8. Chen, C., and A. D. Wells. 2007. Comparative analysis of E2F family member oncogenic activity. PLoS One 2:e912.
9. Conboy, C. M., et al. 2007. Cell cycle genes are the evolutionarily conserved targets of the E2F4 transcription factor. PLoS One 2:e1061.
10. Dazard, J. E., et al. 2011. The dynamics of E1A in regulating networks and canonical pathways in quiescent cells. BMC Res. Notes 4:160.
11. Dimova, D. K., and N. J. Dyson. 2005. The E2F transcriptional network: old acquaintances with new faces. Oncogene 24:2810-2826.
12. Ferrari, R., et al. 2008. Epigenetic reprogramming by adenovirus e1a. Science 321:1086-1088.
13. Giacinti, C., and A. Giordano. 2006. RB and cell cycle progression. Oncogene 25:5220-5227.
14. Howe, J. A., J. S. Mymryk, C. Egan, P. E. Branton, and S. T. Bayley. 1990. Retinoblastoma growth suppressor and a 300-kDa protein appear to regulate cellular DNA synthesis. Proc. Natl. Acad. Sci. U. S. A. 87:5883-5887.
15. Huang, H.-J. S., et al. 1988. Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells. Science 242:1563-1566.
16. Jelsma, T. N., et al. 1989. Sequences in E1A proteins of human adenovirus 5 required for cell transformation, repression of a transcriptional enhancer, and induction of proliferating cell nuclear antigen. Virology 171:120-130.
17. Lammens, T., J. Li, G. Leone, and L. De Veylder. 2009. Atypical E2Fs: new players in the E2F transcription factor family. Trends Cell Biol. 19:111-118.
18. Lillie, J. W., M. Green, and M. R. Green. 1986. An adenovirus E1a protein region required for transformation and transcriptional repression. Cell 46:1043-1051.
19. Mannervik, M., S. Fan, A. C. Strom, K. Helin, and G. Akusjarvi. 1999. Adenovirus E4 open reading frame 4-induced dephosphorylation inhibits E1A activation of the E2 promoter and E2F-1-mediated transactivation independently of the retinoblastoma tumor suppressor protein. Virology 256:313-321.
20. McClellan, K. A., and R. S. Slack. 2007. Specific in vivo roles for E2Fs in differentiation and development. Cell Cycle 6:2917-2927.
21. McLaughlin-Drubin, M. E., K. W. Huh, and K. Munger. 2008. Human papillomavirus type 16 E7 oncoprotein associates with E2F6. J. Virol. 82:8695-8705.
22. Mittnacht, S., et al. 1994. Distinct sub-populations of the retinoblastoma protein show a distinct pattern of phosphorylation. EMBO J. 13:118-127.
23. Neill, S. D., C. Hemstrom, A. Virtanen, and J. R. Nevins. 1990. An adenovirus E4 gene product trans-activates E2 transcription and stimulates stable E2F binding through a direct association with E2F. Proc. Natl. Acad. Sci. U. S. A. 87:2008-2012.
24. Pelka, P., J. N. Ablack, G. J. Fonseca, A. F. Yousef, and J. S. Mymryk. 2008. Intrinsic structural disorder in adenovirus E1A: a viral molecular hub linking multiple diverse processes. J. Virol. 82:7252-7263.
25. Pelka, P., et al. 2009. Transcriptional control by adenovirus E1A conserved region 3 via p300/CBP. Nucleic Acids Res. 37:1095-1106.
26. Raychaudhuri, P., R. Rooney, and J. R. Nevins. 1987. Identification of an E1A-inducible cellular factor that interacts with regulatory sequences within the adenovirus E4 promoter. EMBO J. 6:4073-4081.
27. Ren, B., et al. 2002. E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. Genes Dev. 16:245-256.
28. Schaley, J. E., M. Polonskaia, and P. Hearing. 2005. The adenovirus E4-6/7 protein directs nuclear localization of E2F-4 via an arginine-rich motif. J. Virol. 79:2301-2308.
29. Sha, J., M. K. Ghosh, K. Zhang, and M. L. Harter. 2010. E1A interacts with two opposing transcriptional pathways to induce quiescent cells into S phase. J. Virol. 84:4050-4059.
30. Shan, B., and W. H. Lee. 1994. Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis. Mol. Cell. Biol. 14:8166-8173.
31. Trimarchi, J. M., and J. A. Lees. 2002. Sibling rivalry in the E2F family. Nat. Rev. Mol. Cell Biol. 3:11-20.
32. Wang, H.-G., et al. 1993. Identification of specific adenovirus E1A N-termi-nal residues critical to the binding of cellular proteins and to the control of cell growth. J. Virol. 67:476-488.
33. Whyte, P., et al. 1988. Association between an oncogene and an anti-onco-gene: the adenovirus E1A proteins bind to the retinoblastoma gene product. Nature 334:124-129.
34. 1. Mol. Cell. Biol. 16:3698-3706.
35. Wu, X., and A. J. Levine. 1994. p53 and E2F-1 cooperate to mediate apoptosis. Proc. Natl. Acad. Sci. U. S. A. 91:3602-3606.