High-throughput screening of PLGA thin films utilizing hydrophobic fluorescent dyes for hydrophobic drug compounds

Journal of Pharmaceutical Sciences

Volumn 100, Issue 10, 2011, Pages 4317-4329

  Steele, Terry W J ^a   Huang, Charlotte L ^a   Kumar, Saranya ^a   Widjaja, Effendi ^b   Boey, Freddy Yin Chiang ^a   Loo, Joachim S C ^a   Venkatraman, Subbu S ^a  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b INSTITUTE OF CHEMICAL AND ENGINEERING SCIENCES   (Singapore)

Author keywords

Drug delivery; Fluorescein; High throughput screening; Paclitaxel; PLGA; Polymers; Raman spectroscopy; Scanning electron microscopy; Surface analysis; Thin films

Indexed keywords

COUMARIN 6; FLUORESCEIN DIACETATE; FLUORESCENT DYE; MACROGOL; OCTANOL; PACLITAXEL; POLYGLACTIN; RHODAMINE 6G; UNCLASSIFIED DRUG; WATER; 3',6'-DIACETYLFLUORESCEIN; BIOMATERIAL; CARDIOVASCULAR AGENT; COUMARIN DERIVATIVE; DELAYED RELEASE FORMULATION; DRUG CARRIER; FLUORESCEIN DERIVATIVE; LACTIC ACID; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; RHODAMINE; THIAZOLE DERIVATIVE;

ARTICLE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DISSOLUTION; DRUG STRUCTURE; FILM; FLUOROMETER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; HYDROPHOBICITY; MICROSCOPY; PARTITION COEFFICIENT; PHYSICAL CHEMISTRY; RAMAN MICROSCOPY; SPECTROFLUOROMETER; CHEMICAL PHENOMENA; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; DELAYED RELEASE FORMULATION; KINETICS; MEDICINAL CHEMISTRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHARMACEUTICS; PROCEDURES; RAMAN SPECTROMETRY; SCANNING ELECTRON MICROSCOPY; SOLUBILITY; SPECTROFLUOROMETRY; SURFACE PROPERTY;

CARDIOVASCULAR AGENTS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COATED MATERIALS, BIOCOMPATIBLE; COUMARINS; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; FLUORESCEINS; FLUORESCENT DYES; HIGH-THROUGHPUT SCREENING ASSAYS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; KINETICS; LACTIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; MICROSCOPY; MICROSCOPY, ELECTRON, SCANNING; MOLECULAR STRUCTURE; PACLITAXEL; POLYGLYCOLIC ACID; RHODAMINES; SOLUBILITY; SPECTROMETRY, FLUORESCENCE; SPECTRUM ANALYSIS, RAMAN; SURFACE PROPERTIES; TECHNOLOGY, PHARMACEUTICAL; THIAZOLES;

EID: 80052279147     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22625     Document Type: Article

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