Direct semi-synthesis of the anticancer lead-drug protoapigenone from apigenin, and synthesis of further new cytotoxic Protoflavone derivatives

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  Hunyadi, Attila ^a,b   Chuang, Da Wei ^b   Danko, Balazs ^a   Chiang, Michael Y ^c   Lee, Chia Lin ^d   Wang, Hui Chun ^b   Wu, Chin Chung ^b   Chang, Fang Rong ^b,e   Wu, Yang Chang ^b,d,f  

^a UNIVERSITY OF SZEGED   (Hungary)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

^e KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^f CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

3 (1 ALLYLOXY 4 OXOCYCLOHEXA 2,5 DIENYL) 1H BENZO[F] CHROMEN 1 ONE; 3 (1 BUTOXY 4 OXOCYCLOHEXA 2,5 DIENYL) 1H BENZO[F] CHROMEN 1 ONE; 3 (1 ETHOXY 4 OXOCYCLOHEXA 2,5 DIENYL) 1H BENZO[F] CHROMEN 1 ONE; 3 (1 ISOPROPOXY 4 OXOCYCLOHEXA 2,5 DIENYL) 1H BENZO[F] CHROMEN 1 ONE; 3 (1 PROPOXY 4 OXOCYCLOHEXA 2,5 DIENYL) 1H BENZO[F] CHROMEN 1 ONE; 3 [1 (PROP 2 YNOXY) 4 OXOCYCLOHEXA 2,5 DIENYL] 1H BENZO[F] CHROMEN 1 ONE; ANTINEOPLASTIC AGENT; APIGENIN DERIVATIVE; PROTOAPIGENONE (8-3'') APIGENIN; PROTOAPIGENONE 1' O ALLYLETHER; PROTOAPIGENONE 1' O BUTYLETHER; PROTOAPIGENONE 1' O ETHYLETHER; PROTOAPIGENONE 1' O ISOPROPYLETHER; PROTOAPIGENONE 1' O METHYLETHER; PROTOAPIGENONE 1' O PROPARGYLETHER; PROTOAPIGENONE 1' O PROPYLETHER; PROTOAPIGENONE DERIVATIVE; PROTOFLAVONE DERIVATIVE; UNCLASSIFIED DRUG; APIGENIN; CYCLOHEXANONE DERIVATIVE; FLAVONE DERIVATIVE; PROTOAPIGENONE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION; CHEMISTRY; DRUG DEVELOPMENT; IC 50; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APIGENIN; CELL LINE, TUMOR; CYCLOHEXANONES; DRUG DISCOVERY; FLAVONES; HUMANS; INHIBITORY CONCENTRATION 50; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80052278356     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0023922     Document Type: Article

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