Uptake and antileishmanial activity of meglumine antimoniate-containing liposomes in Leishmania (Leishmania) major-infected macrophages

International Journal of Antimicrobial Agents

Volumn 38, Issue 4, 2011, Pages 341-347

  Treiger Borborema, Samanta Etel ^a   Schwendener, Reto Albert ^b   Osso Junior, João Alberto ^a   De Andrade Junior, Heitor Franco ^c   Do Nascimento, Nanci ^a  

^a INSTITUTO DE PESQUISAS ENERGÉTICAS E NUCLEARES   (Brazil)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Antimony; Glucantime; Leishmaniasis; Liposome; Macrophage

Indexed keywords

LIPOSOME; MEGLUMINE ANTIMONATE; PHOSPHATIDYLSERINE;

AMASTIGOTE; ANIMAL CELL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DETERMINATION; DRUG EFFICACY; DRUG UPTAKE; ENCAPSULATION; FLUORESCENCE MICROSCOPY; IC 50; INCUBATION TIME; LEISHMANIA MAJOR; LIPOSOMAL DELIVERY; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIPROTOZOAL AGENTS; CELL SURVIVAL; CHOLESTEROL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; EXCIPIENTS; FLUORESCENCE; HUMANS; INDICATORS AND REAGENTS; LEISHMANIA MAJOR; LEISHMANIASIS; LIPOSOMES; MACROPHAGES; MALE; MEGLUMINE; MICE; MICE, INBRED C57BL; MICROSCOPY, FLUORESCENCE; ORGANOMETALLIC COMPOUNDS; OXAZINES; PHOSPHATIDYLSERINES; XANTHENES;

EID: 80052270967     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2011.05.012     Document Type: Article

References (37)

1. World Health Organization. Leishmaniasis. Geneva, Switzerland: WHO. http://apps.who.int/tdr/svc/diseases/leishmaniasis [accessed 22 December 2010].
2. R. Reithinger, J. Dujardin, H. Louzir, C. Pirmez, B. Alexander, and S. Brooker Cutaneous leishmaniasis Lancet Infect Dis 7 2007 581 596 (Pubitemid 47277438)
3. W.L. Roberts, W.J. McMurray, and P.M. Rainey Characterization of the antimonial antileishmanial agent meglumine antimoniate (Glucantime) Antimicrob Agents Chemother 42 1998 1076 1082 (Pubitemid 28227900)
4. S. Noazin, A. Khamesipour, L.H. Moulton, M. Tanner, K. Nasseri, and F. Modabber Efficacy of killed whole-parasite vaccines in the prevention of leishmaniasis: a meta-analysis Vaccine 27 2009 4747 4753
5. D.O. Santos, C.E.R. Coutinho, M.F. Madeira, C.G. Bottino, R.T. Vieira, and S.B. Nascimento Leishmaniasis treatment - a challenge that remains: a review Parasitol Res 103 2008 1 10
6. F. Frézard, C. Demicheli, and R.R. Ribeiro Pentavalent antimonials: new perspectives for old drugs Molecules 14 2009 2317 2336
7. V.P. Torchilin Recent advances with liposomes as pharmaceutical carriers Nat Rev Drug Discov 4 2005 145 160 (Pubitemid 40282557)
8. M. Owais, and C.M. Gupta Targeted drug delivery to macrophages in parasitic infections Curr Drug Deliv 2 2005 311 318 (Pubitemid 41277764)
9. R.A. Schwendener Liposomes in biology and medicine Adv Exp Med Biol 620 2007 117 128
10. A.G. Tempone, D. Perez, S. Rath, A.L. Vilarinho, R.A. Mortara, and H.F. de Andrade Jr. Targeting Leishmania (L.) chagasi amastigotes through macrophage scavenger receptors: the use of drugs entrapped in liposomes containing phosphatidylserine J Antimicrob Chemother 54 2004 60 68 (Pubitemid 39028968)
11. D.A. Schettini, R.R. Ribeiro, C. Demicheli, O.G.F. Rocha, M.N. Melo, and M.S.M. Michalick Improved targeting of antimony to the bone marrow of dogs using liposomes of reduced size Int J Pharm 315 2006 140 147 (Pubitemid 44275230)
12. A.G. Tempone, and H.F. de Andrade Jr. Nanoformulations of pentavalent antimony entrapped in phosphatidylserine-liposomes demonstrate highest efficacy against experimental visceral leishmaniasis Rev Inst Adolfo Lutz 67 2008 131 136
13. F. Frézard, and C. Demicheli New delivery strategies for the old pentavalent antimonial drugs Expert Opin Drug Deliv 7 2010 1343 1358
14. A.G. Tempone, A.C.M.P. da Silva, C.A. Brandt, F.S. Martinez, S.E.T. Borborema, and M.A.B. da Silveira Synthesis and antileishmanial activities of novel 3-substituted quinolines Antimicrob Agents Chemother 49 2005 1076 1080 (Pubitemid 40327726)
15. G. Iezzi, A. Fröhlich, B. Ernst, F. Ampenberger, S. Saeland, and N. Glaichenhaus Lymph node resident rather than skin-derived dendritic cells initiate specific T cell responses after Leishmania major infection J Immunol 177 2006 1250 1256 (Pubitemid 44036630)
16. S.M. Zeisberger, B. Odermatt, C. Marty, A.H.M. Zehnder-Fjällman, K. Ballmer-Hofer, and R.A. Schwendener Clodronate-liposome-mediated depletion of tumour-associated macrophages: a new and highly effective antiangiogenic therapy approach Br J Cancer 95 2006 272 281 (Pubitemid 44187587)
17. J.A. Osso Jr., K.N. Suzuki, R.F. Costa, G. Barrio, T.P. Brambilla, and P.C. Lopes Radioisotope production for nuclear medicine using the IEA-R1m reactor at IPEN-CNEN/SP-Brazil Transactions of the Research Reactor Fuel Management (RRFM) Conference 22-25 March, Vienna, Austria 2009 247 251
18. C. Chen, D. Han, C. Cai, and X. Tang An overview of liposome lyophilization and its future potential J Control Release 142 2010 299 311
19. B. Stark, G. Pabst, and R. Prassl Long-term stability of sterically stabilized liposomes by freezing and freeze-drying: effects of cryoprotectants on structure Eur J Pharm Sci 41 2010 546 555
20. H. Hillaireau, and P. Couvreur Nanocarriers' entry into the cell: relevance to drug delivery Cell Mol Life Sci 66 2009 2873 2896
21. W.L. Roberts, J.D. Berman, and P.M. Rainey In vitro antileishmanial properties of tri- and pentavalent antimonial preparations Antimicrob Agents Chemother 39 1995 1234 1239
22. M. Ephros, A. Bitnun, P. Shaked, E. Waldman, and D. Zilberstein Stage-specific activity of pentavalent antimony against Leishmania donovani axenic amastigotes Antimicrob Agents Chemother 43 1999 278 282 (Pubitemid 29079158)
23. S. Yan, F. Li, K. Ding, and H. Sun Reduction of pentavalent antimony by trypanothione and formation of a binary and ternary complex of antimony(III) and trypanothione J Biol Inorg Chem 8 2003 689 697 (Pubitemid 36960817)
24. F. Frézard, C. Demicheli, C.S. Ferreira, and M.A.P. Costa Glutathione-induced conversion of pentavalent antimony to trivalent antimony in meglumine antimoniate Antimicrob Agents Chemother 45 2001 913 916 (Pubitemid 32182044)
25. C. Brochu, J. Wang, G. Roy, N. Messier, X.Y. Wang, and N.G. Saravia Antimony uptake systems in the protozoan parasite Leishmania and accumulation differences in antimony-resistant parasites Antimicrob Agents Chemother 47 2003 3073 3079 (Pubitemid 37229559)
26. M.R. Jaafari, N. Bavarsad, B.S.F. Bazzaz, A. Samiei, D. Soroush, and S. Ghorbani Effect of topical liposomes containing paromomycin sulfate in the course of Leishmania major infection in susceptible BALB/c mice Antimicrob Agents Chemother 53 2009 2259 2265
27. A. Papagiannaros, C. Bories, C. Demetzos, and P.M. Loiseau Antileishmanial and trypanocidal activities of new miltefosine liposomal formulations Biomed Pharmacother 59 2005 545 550 (Pubitemid 41820384)
28. I.N. Gomes, L.C. Palma, G.O. Campos, J.G.B. Lima, T.F. de Almeida, and J.P.B. Menezes The scavenger receptor MARCO is involved in Leishmania major infection by CBA/J macrophages Parasite Immunol 31 2009 188 198
29. F. Ahsana, I.P. Rivasb, M.A. Khana, and A.I.T. Suarez Targeting to macrophages: role of physicochemical properties of particulate carriers - liposomes and microspheres - on the phagocytosis by macrophages J Control Release 79 2002 29 40
30. R.A. Schwendener, P.A. Lagocki, and Y.E. Rahman The effects of charge and size on the interaction of unilamellar liposomes with macrophages Biochim Biophys Acta 772 1984 93 101 (Pubitemid 14136820)
31. A.J. Schroit, J. Madsen, and R. Nayar Liposome-cell interactions: in vitro discrimination of uptake mechanism and in vivo targeting strategies to mononuclear phagocytes Chem Phys Lipids 40 1986 373 393 (Pubitemid 16040788)
32. I.J. Fidler Targeting of immunomodulators to mononuclear phagocytes for therapy of cancer Adv Drug Deliv Rev 2 1988 69 106
33. T. Dey, K. Anam, F. Afrin, and N. Ali Antileishmanial activities of stearylamine-bearing liposomes Antimicrob Agents Chemother 44 2000 1739 1742 (Pubitemid 30340831)
34. S. Pal, R. Ravindran, and N. Ali Combination therapy using sodium antimony gluconate in stearylamine-bearing liposomes against established and chronic Leishmania donovani infection in BALB/c mice Antimicrob Agents Chemother 38 2004 3591 3593 (Pubitemid 39129369)
35. J. Roychoudhury, R. Sinha, and N. Ali Therapy with sodium stibogluconate in stearylamine-bearing liposomes confers cure against SSG-resistant Leishmania donovani in BALB/c mice PLoS One 6 2011 e17376
36. R.R. Ribeiro, E.P. Moura, V.M. Pimentel, W.M. Sampaio, S.M. Silva, and D.A. Schettini Reduced tissue parasitic load and infectivity to sand flies in dogs naturally infected by Leishmania (Leishmania) chagasi following treatment with a liposome formulation of meglumine antimoniate Antimicrob Agents Chemother 52 2008 2564 2572 (Pubitemid 351915689)
37. K.C. Carter, T.F. Dolan, J. Alexander, A.J. Baillie, and C. McColgan Visceral leishmaniasis: drug carrier characteristics and the ability to clear parasites from the liver, spleen and bone marrow in Leishmania donovani infected BALB/c mice J Pharm Pharmacol 41 1989 87 91 (Pubitemid 19109540)