Understanding improved dissolution of indomethacin through the use of cohesive poorly water-soluble aluminium hydroxide: Effects of concentration and particle size distribution

Journal of Pharmaceutical Sciences

Volumn 100, Issue 10, 2011, Pages 4269-4280

  Tay, Tracy ^a   Allahham, Ayman ^b   Morton, David A V ^a   Stewart, Peter J ^a  

^a MONASH UNIVERSITY   (Australia)

^b QASSIM UNIVERSITY   (Saudi Arabia)

Author keywords

Aluminium hydroxide; Deagglomeration; Dispersion; Dissolution; Excipients; Indomethacin interactive mixtures; Mathematical models; Oral drug delivery; Particle sizing; Poorly water soluble drugs

Indexed keywords

ALUMINUM HYDROXIDE; INDOMETACIN; INORGANIC SALT; BUFFER; EXCIPIENT; LACTOSE;

ARTICLE; CONCENTRATION RESPONSE; DISPERSION; DRUG SOLUBILITY; LASER DIFFRACTION; PARTICLE SIZE; PH; SURFACE PROPERTY; CHEMICAL MODEL; CHEMISTRY; KINETICS; MEDICINAL CHEMISTRY; PHARMACEUTICS; PROCEDURES; SOLUBILITY;

ALUMINUM HYDROXIDE; BUFFERS; CHEMISTRY, PHARMACEUTICAL; EXCIPIENTS; HYDROGEN-ION CONCENTRATION; INDOMETHACIN; KINETICS; LACTOSE; MODELS, CHEMICAL; PARTICLE SIZE; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL;

EID: 80052270389     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22605     Document Type: Article

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