Modeling the deagglomeration of micronized benzodiazepines from powder mixtures added to dissolution media

Journal of Pharmaceutical Sciences

Volumn 93, Issue 6, 2004, Pages 1618-1627

  Zhao, Feng Ying ^a,b   Stewart, Peter J ^a  

^a MONASH UNIVERSITY   (Australia)

^b Arrow Pharmaceuticals Ltd   (Australia)

Author keywords

Drug dissolution; Interactive mixtures; Laser diffraction particle sizing; Particle deagglomeration

Indexed keywords

BENZODIAZEPINE DERIVATIVE; DIAZEPAM; DODECYL SULFATE SODIUM; LACTOSE; NITRAZEPAM; OXAZEPAM; POVIDONE; WATER;

ARTICLE; CONCENTRATION (PARAMETERS); DISPERSION; DISSOLUTION; DRUG FORMULATION; DRUG SOLUBILITY; HALF LIFE TIME; KINETICS; LASER DIFFRACTION; MODEL; MOLECULAR INTERACTION; NONLINEAR REGRESSION ANALYSIS; PARTICLE SIZE; POWDER;

EID: 2642536177     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.20083     Document Type: Article

References (17)

1. Stewart PJ, Alway B. 1995. Aggregation during the dissolution of diazepam in interactive mixtures. Particulate Sci Technol 13:213-226.
2. Supabphol R, Stewart PJ. 1996. Aggregation during the dissolution of diazepam in interactive and granulated mixtures. Pharm Sci 2:233-236.
3. Alway B, Sangchantra R, Stewart PJ. 1996. Modelling the dissolution of diazepam in lactose interactive mixtures. Int J Pharm 130:213-224.
4. Westerberg M, Nystrom C. 1993. Physicochemical aspects of drug release. Part 18. Use of a surfactant and a disintegrant for improving drug dissolution rate from ordered mixtures. STP Pharma Sci 3:142-147.
5. Westerberg M, Nystrom C. 1993. Physicochemical aspects of drug release. Part 17. Effect of drug surface area coverage to carrier materials on drug dissolution from ordered mixtures. Int J Pharm 90:1-17.
6. Liu J, Stewart PJ. 1998. Deaggregation during the dissolution of benzodiazepines in interactive mixtures. J Pharm Sci 87:1632-1638.
7. Stewart PJ, Liu J. 2002. The influence of aggregate microenvironment on the dissolution of oxazepam in ternary surfactant interactive mixtures. J Pharm Pharmacol 54:1-6.
8. Zhao F-Y, Stewart PJ. 2003. De-agglomeration of micronizsed benzodiazepines in dissolution media measured by laser diffraction particle sizing. J Pharm Pharmacol 55:749-755.
9. Wagner J. 1969. Interpretation of percent dissolved-time plots derived from in-vitro testing of conventional tablets and capsules. J Pharm Sci 58:1253.
10. Kitazawa S, Johno I, Ito Y, Teramura S, Okada J. 1975. Effect of hardness on the disintegration time and the dissolution rate of uncoated caffeine tablets. J Pharm Pharmacol 27:765-770.
11. Kitazawa S, Johno I, Minouchi T, Okada J. 1977. Interpretation of dissolution rate data from in-vitro testing of compressed tablets. J Pharm Pharmacol 29:453.
12. El-Yazigi A. 1981. Disintegration-dissolution analysis of percent dissolved time data. J Pharm Sci 70:535.
13. Marquardt DW. 1963. An algorithm for least squares estimination of nonlinear parameters. J Soc Indust Appl Math 11:431-444.
14. Carstensen JT. 1996. Modelling and data treatment in pharmaceutical sciences. Lancaster, PA: Technomic Publishing Co.
15. Motulsky HJ, Ransnas LA. 1987. Fitting curves to data using nonlinear regression: A practical and nonmathematical review. FASEB J 1:365-374.
16. Bennett CA, Franklin NC. 1967. Statistical analysis in chemistry and chemical industry. New York: Wiley, pp 663-684.
17. Andreou JG. 1998. The influence of short term storage on drug dissolution of interactive mixtures. M Pharm Thesis, Monash University.