Beta-1 and beta-2 adrenergic receptor polymorphism and association with cardiovascular response to orthostatic screening

Autonomic Neuroscience: Basic and Clinical

Volumn 164, Issue 1-2, 2011, Pages 89-95

  Wittwer, E D ^a   Liu, Z ^b   Warner, N D ^a   Schroeder, D R ^a   Nadeau, A M ^a   Allen, A R ^a   Murillo, C J ^a   Elvebak, R L ^a   Aakre, B M ^a   Eisenach, J H ^a  

^a MAYO CLINIC   (United States)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Beta 1 adrenergic receptor; Beta 2 adrenergic receptor; Fainting; Genetic model; Head up tilt; Heart rate

Indexed keywords

ARGININE; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; GLUTAMIC ACID; GLUTAMINE; GLYCINE; ISOLEUCINE; NORADRENALIN; SERINE; THREONINE;

ADULT; ARTERY CATHETERIZATION; ARTICLE; BRACHIAL ARTERY; CARDIOVASCULAR RESPONSE; CAUCASIAN; CLINICAL PROTOCOL; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SCREENING; GENETIC VARIABILITY; HEART INDEX; HEMODYNAMICS; HUMAN; MALE; PRIORITY JOURNAL; STANDING; STATISTICAL MODEL; SUPINE POSITION; SYSTEMIC VASCULAR RESISTANCE;

ADOLESCENT; ADULT; CARDIOVASCULAR DISEASES; FEMALE; GENETIC VARIATION; HEART RATE; HUMANS; MALE; MASS SCREENING; NOREPINEPHRINE; POLYMORPHISM, GENETIC; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; SHY-DRAGER SYNDROME; STROKE; YOUNG ADULT;

EID: 80052268290     PISSN: 15660702     EISSN: 18727484     Source Type: Journal    
DOI: 10.1016/j.autneu.2011.07.004     Document Type: Article

References (29)

1. Benditt D.G., Ermis C., Padanilam B., Samniah N., Sakaguchi S. Catecholamine response during haemodynamically stable upright posture in individuals with and without tilt-table induced vasovagal syncope. Europace 2003, 5:65-70.
2. Bray M.S., Krushkal J., Li L., Ferrell R., Kardia S., Sing C.F., Turner S.T., Boerwinkle E. Positional genomic analysis identifies the beta(2)-adrenergic receptor gene as a susceptibility locus for human hypertension. Circulation 2000, 101:2877-2882.
3. Brodde O.E. Beta-1 and beta-2 adrenoceptor polymorphisms: functional importance, impact on cardiovascular diseases and drug responses. Pharmacol. Ther. 2008, 117:1-29.
4. Castellano M., Rossi F., Giacche M., Perani C., Rivadossi F., Muiesan M.L., Salvetti M., Beschi M., Rizzoni D., Agabiti-Rosei E. Beta(2)-adrenergic receptor gene polymorphism, age, and cardiovascular phenotypes. Hypertension 2003, 41:361-367.
5. Charkoudian N. Influences of female reproductive hormones on sympathetic control of the circulation in humans. Clin. Auton. Res. 2001, 11:295-301.
6. Eisenach J.H., Wittwer E.D. Beta-adrenoceptor gene variation and intermediate physiological traits: prediction of distant phenotype. Exp. Physiol. 2010, 95:757-764.
7. Eisenach J.H., McGuire A.M., Schwingler R.M., Turner S.T., Joyner M.J. The Arg16/Gly beta2-adrenergic receptor polymorphism is associated with altered cardiovascular responses to isometric exercise. Physiol. Genomics 2004, 16:323-328.
8. Eisenach J.H., Barnes S.A., Pike T.L., Sokolnicki L.A., Masuki S., Dietz N.M., Rehfeldt K.H., Turner S.T., Joyner M.J. The Arg16/Gly {beta}2-adrenergic receptor polymorphism alters the cardiac output response to isometric exercise. J. Appl. Physiol. 2005, 99:1776-1781.
9. Ermis C., Samniah N., Lurie K.G., Sakaguchi S., Benditt D.G. Adrenal/renal contribution to circulating norepinephrine in posturally induced neurally mediated reflex syncope. Am. J. Cardiol. 2003, 91:746-750.
10. Feero W.G., Guttmacher A.E., Collins F.S. Genomic medicine-an updated primer. N. Engl. J. Med. 2010, 362:2001-2011.
11. Garovic V.D., Joyner M.J., Dietz N.M., Boerwinkle E., Turner S.T. Beta(2)-adrenergic receptor polymorphism and nitric oxide-dependent forearm blood flow responses to isoproterenol in humans. J. Physiol. 2003, 546:583-589.
12. Goldstein D.S., Kopin I.J. Adrenomedullary, adrenocortical, and sympathoneural responses to stressors: a meta-analysis. Endocr. Regul. 2008, 42:111-119.
13. Goldstein D.S., McCarty R., Polinsky R.J., Kopin I.J. Relationship between plasma norepinephrine and sympathetic neural activity. Hypertension 1983, 5:552-559.
14. Goldstein D.S., Holmes C., Frank S.M., Naqibuddin M., Dendi R., Snader S., Calkins H. Sympathoadrenal imbalance before neurocardiogenic syncope. Am. J. Cardiol. 2003, 91:53-58.
15. Hesse C., Schroeder D.R., Nicholson W.T., Hart E.C., Curry T.B., Penheiter A.R., Turner S.T., Joyner M.J., Eisenach J.H. Beta2-adrenoceptor gene variation and systemic vasodilatation during ganglionic blockade. J. Physiol. 2010, 588:2669-2678.
16. Jacob G., Garland E.M., Costa F., Stein C.M., Xie H.G., Robertson R.M., Biaggioni I., Robertson D. Beta2-adrenoceptor genotype and function affect hemodynamic profile heterogeneity in postural tachycardia syndrome. Hypertension 2006, 47:421-427.
17. Kannel W.B., Kannel C., Paffenbarger R.S., Cupples L.A. Heart rate and cardiovascular mortality: the Framingham Study. Am. Heart J. 1987, 113:1489-1494.
18. Kristal-Boneh E., Silber H., Harari G., Froom P. The association of resting heart rate with cardiovascular, cancer and all-cause mortality. Eight year follow-up of 3527 male Israeli employees (the CORDIS Study). Eur. Heart J. 2000, 21:116-124.
19. Minson C.T., Halliwill J.R., Young T.M., Joyner M.J. Influence of the menstrual cycle on sympathetic activity, baroreflex sensitivity, and vascular transduction in young women. Circulation 2000, 101:862-868.
20. Nickander K.K., Carlson P.J., Urrutia R.A., Camilleri M., Low P.A. A screen of candidate genes and influence of beta2-adrenergic receptor genotypes in postural tachycardia syndrome. Auton. Neurosci. 2005, 120:97-103.
21. Ramirez-Marrero F.A., Charkoudian N., Hart E.C., Schroeder D., Zhong L., Eisenach J.H., Joyner M.J. Cardiovascular dynamics in healthy subjects with differing heart rate responses to tilt. J. Appl. Physiol. 2008, 105:1448-1453.
22. Ranade K., Jorgenson E., Sheu W.H., Pei D., Hsiung C.A., Chiang F.T., Chen Y.D., Pratt R., Olshen R.A., Curb D., Cox D.R., Botstein D., Risch N. A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate. Am. J. Hum. Genet. 2002, 70:935-942.
23. Snyder E.M., Beck K.C., Dietz N.M., Eisenach J.H., Joyner M.J., Turner S.T., Johnson B.D. Arg16Gly polymorphism of the beta2-adrenergic receptor is associated with differences in cardiovascular function at rest and during exercise in humans. J. Physiol. 2006, 571:121-130.
24. Snyder E.M., Hulsebus M.L., Turner S.T., Joyner M.J., Johnson B.D. Genotype related differences in beta2 adrenergic receptor density and cardiac function. Med. Sci. Sports Exerc. 2006, 38:882-886.
25. Sorrentino S., Forleo C., Iacoviello M., Guida P., D'Andria V., Favale S. Lack of association between genetic polymorphisms affecting sympathetic activity and tilt-induced vasovagal syncope. Auton. Neurosci. 2010, 155:98-103.
26. Takase B., Matsushima Y., Umeda E., Satomura K., Katsushika S., Ohsuzu F., Sato T., Kurita A. Endogenous opioids and epinephrine in nitroglycerin provocation tilt test in patients with neurally mediated syncope. Jpn. Heart J. 2003, 44:493-503.
27. Wilk J.B., Myers R.H., Zhang Y., Lewis C.E., Atwood L., Hopkins P.N., Ellison R.C. Evidence for a gene influencing heart rate on chromosome 4 among hypertensives. Hum. Genet. 2002, 111:207-213.
28. Wilk J.B., Myers R.H., Pankow J.S., Hunt S.C., Leppert M.F., Freedman B.I., Province M.A., Ellison R.C. Adrenergic receptor polymorphisms associated with resting heart rate: the HyperGEN Study. Ann. Hum. Genet. 2006, 70:566-573.
29. Wilton S.B., Anderson T.J., Parboosingh J., Bridge P.J., Exner D.V., Forrest D., Duff H.J. Polymorphisms in multiple genes are associated with resting heart rate in a stepwise allele-dependent manner. Heart Rhythm 2008, 5:694-700.