Freeze drying of nanosuspensions, 2: The role of the critical formulation temperature on stability of drug nanosuspensions and its practical implication on process design

Journal of Pharmaceutical Sciences

Volumn 100, Issue 10, 2011, Pages 4471-4481

  Beirowski, Jakob ^a   Inghelbrecht, Sabine ^b   Arien, Albertina ^b   Gieseler, Henning ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

Collapse temperature; Compounding; Freeze drying; Glass transition; Lyophilization; Nanosuspensions; Nanotechnology; Stabilization; Vitrification

Indexed keywords

CREMOPHOR; DISACCHARIDE; NANOPARTICLE; POLOXAMER; SUCROSE; TREHALOSE; DRUG; EXCIPIENT;

ARTICLE; CRITICAL FORMULATION TEMPERATURE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG STABILITY; FREEZE DRYING; GLASS TRANSITION TEMPERATURE; NANOPHARMACEUTICS; NANOTECHNOLOGY; PARTICLE SIZE; PROCESS DESIGN; SCANNING ELECTRON MICROSCOPY; TEMPERATURE; THERMAL ANALYSIS; CHEMISTRY; COMPARATIVE STUDY; MEDICINAL CHEMISTRY; PHARMACEUTICS; PROCEDURES;

CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; DRUG STABILITY; EXCIPIENTS; FREEZE DRYING; MICROSCOPY, ELECTRON, SCANNING; NANOPARTICLES; NANOTECHNOLOGY; PHARMACEUTICAL PREPARATIONS; SUCROSE; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; TREHALOSE;

EID: 80052264837     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22634     Document Type: Article

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