Freeze-drying of nanosuspensions, 1: Freezing rate versus formulation design as critical factors to preserve the original particle size distribution

Journal of Pharmaceutical Sciences

Volumn 100, Issue 5, 2011, Pages 1958-1968

  Beirowski, Jakob ^a   Inghelbrecht, Sabine ^b   Arien, Albertina ^b   Gieseler, Henning ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

Excipients; Factorial designNanotechnology; Freeze drying; Lyophilization; Nanoparticles; Nanosuspensions; Particle size; Stabilization

Indexed keywords

EXCIPIENT; ITRACONAZOLE; NANOPARTICLE; STABILIZING AGENT;

ARTICLE; CRYOPROTECTION; DRUG FORMULATION; DRUG STABILITY; DRUG STORAGE; FREEZE DRYING; FREEZE THAWING; PARTICLE SIZE; SUSPENSION;

EID: 79952231337     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22425     Document Type: Article

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