Inflammatory cytokines in paraventricular nucleus modulate sympathetic activity and cardiac sympathetic afferent reflex in rats

Acta Physiologica

Volumn 203, Issue 2, 2011, Pages 289-297

  Shi, Z ^a   Gan, X B ^a   Fan, Z D ^a   Zhang, F ^a   Zhou, Y B ^a   Gao, X Y ^a   De, W ^a   Zhu, G Q ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Angiotensin; Interleukin; Paraventricular nucleus; Sympathetic activity; Tumour necrosis factor

Indexed keywords

ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN II; BRADYKININ; INTERLEUKIN 13; INTERLEUKIN 1BETA; INTERLEUKIN 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DENERVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; KIDNEY NERVE; MALE; MEAN ARTERIAL PRESSURE; NERVE CONDUCTION; NONHUMAN; PARAVENTRICULAR THALAMIC NUCLEUS; PRIORITY JOURNAL; RAT; SENSORY NERVE; SYMPATHETIC FUNCTION; SYMPATHETIC NERVE; SYMPATHETIC REFLEX; VAGOTOMY;

AFFERENT PATHWAYS; ANGIOTENSIN II; ANIMALS; AUTONOMIC PATHWAYS; BLOOD PRESSURE; BRADYKININ; CYTOKINES; HEART; MALE; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; REFLEX; SYMPATHETIC NERVOUS SYSTEM;

EID: 80052260334     PISSN: 17481708     EISSN: 17481716     Source Type: Journal    
DOI: 10.1111/j.1748-1716.2011.02313.x     Document Type: Article

References (42)

1. Abdulla, M.H., Sattar, M.A., Khan, M.A., Abdullah, N.A. & Johns, E.J. 2009. Influence of sympathetic and AT-receptor blockade on angiotensin II and adrenergic agonist-induced renal vasoconstrictions in spontaneously hypertensive rats. Acta Physiol (Oxf) 195, 397-404.
2. Badoer, E. 2010. The role of the hypothalamic PVN in the regulation of renal sympathetic nerve activity and blood flow during hyperthermia and in heart failure. Am J Physiol Renal Physiol 298, F839-F846.
3. Campese, V.M., Ye, S. & Zhong, H. 2002. Downregulation of neuronal nitric oxide synthase and interleukin-1beta mediates angiotensin II-dependent stimulation of sympathetic nerve activity. Hypertension 39, 519-524.
4. Cassis, P., Conti, S., Remuzzi, G. & Benigni, A. 2010. Angiotensin receptors as determinants of life span. Pflugers Arch 459, 325-332.
5. 1 receptors in paraventricular nucleus contribute to sympathetic activation and enhanced cardiac sympathetic afferent reflex in renovascular hypertensive rats. Exp Physiol 96, 94-103.
6. Cohn, J.N., Levine, T.B., Olivari, M.T., Garberg, V., Lura, D., Francis, G.S., Simon, A.B. & Rector, T. 1984. Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure. N Engl J Med 311, 819-823.
7. Coote, J.H. 2005. A role for the paraventricular nucleus of the hypothalamus in the autonomic control of heart and kidney. Exp Physiol 90, 169-173.
8. Del, C.S., Morello, F., Rabbia, F., Milan, A., Naso, D., Puglisi, E., Mulatero, P. & Veglio, F. 2007. Antihypertensive drugs and the sympathetic nervous system. J Cardiovasc Pharmacol 50, 487-496.
9. Dibbs, Z., Kurrelmeyer, K., Kalra, D., Seta, Y., Wang, F., Bozkurt, B., Baumgarten, G., Sivasubramanian, N. & Mann, D.L. 1999. Cytokines in heart failure: pathogenetic mechanisms and potential treatment. Proc Assoc Am Physicians 111, 423-428.
10. Du, Y.H. & Chen, A.F. 2007. A "love triangle" elicited by electrochemistry: complex interactions among cardiac sympathetic afferent, chemo-, and baroreflexes. J Appl Physiol 102, 9-10.
11. Felder, R.B., Francis, J., Zhang, Z.H., Wei, S.G., Weiss, R.M. & Johnson, A.K. 2003. Heart failure and the brain: new perspectives. Am J Physiol Regul Integr Comp Physiol 284, R259-R276.
12. Felder, R.B., Yu, Y., Zhang, Z.H. & Wei, S.G. 2009. Pharmacological treatment for heart failure: a view from the brain. Clin Pharmacol Ther 86, 216-220.
13. Fisher, J.P. & Fadel, P.J. 2010. Therapeutic strategies for targeting excessive central sympathetic activation in human hypertension. Exp Physiol 95, 572-580.
14. Floras, J.S. 2009. Sympathetic nervous system activation in human heart failure: clinical implications of an updated model. J Am Coll cardiol 54, 375-385.
15. Francis, J., Chu, Y., Johnson, A.K., Weiss, R.M. & Felder, R.B. 2004a. Acute myocardial infarction induces hypothalamic cytokine synthesis. Am J Physiol Heart Circ Physiol 286, H2264-H2271.
16. Francis, J., Zhang, Z.H., Weiss, R.M. & Felder, R.B. 2004b. Neural regulation of the proinflammatory cytokine response to acute myocardial infarction. Am J Physiol Heart Circ Physiol 287, H791-H797.
17. Gekle, M. & Grossmann, C. 2009. Actions of aldosterone in the cardiovascular system: the good, the bad, and the ugly? Pflugers Arch 458, 231-246.
18. Grassi, G., Seravalle, G., Quarti-Trevano, F. & Dell'Oro, R. 2009. Sympathetic activation in congestive heart failure: evidence, consequences and therapeutic implications. Curr Vasc Pharmacol 7, 137-145.
19. Grassi, G., Seravalle, G. & Quarti-Trevano, F. 2010. The 'neuroadrenergic hypothesis' in hypertension: current evidence. Exp Physiol 95, 581-586.
20. Guggilam, A., Patel, K.P., Haque, M., Ebenezer, P.J., Kapusta, D.R. & Francis, J. 2008. Cytokine blockade attenuates sympathoexcitation in heart failure: cross-talk between nNOS, AT-1R and cytokines in the hypothalamic paraventricular nucleus. Eur J Heart Fail 10, 625-634.
21. Han, Y., Shi, Z., Zhang, F., Yu, Y., Zhong, M.K., Gao, X.Y., Wang, W. & Zhu, G.Q. 2007. Reactive oxygen species in the paraventricular nucleus mediate the cardiac sympathetic afferent reflex in chronic heart failure rats. Eur J Heart Fail 9, 967-973.
22. Han, Y., Fan, Z.D., Yuan, N., Xie, G.Q., Gao, J., De, W., Gao, X.Y. & Zhu, G.Q. 2011a. Superoxide anions in paraventricular nucleus mediate the enhanced cardiac sympathetic afferent reflex and sympathetic activity in renovascular hypertensive rats. J Appl Physiol 110, 646-652.
23. Han, Y., Yuan, N., Zhang, S.J., Gao, J., Shi, Z., Zhou, Y.B., Gao, X.Y. & Zhu, G.Q. 2011b. c-Src in paraventricular nucleus modulates sympathetic activity and cardiac sympathetic afferent reflex in renovascular hypertensive rats. Pflugers Arch 461, 437-446.
24. Kang, Y.M., Zhang, Z.H., Xue, B.J., Weiss, R.M., Johnson, A.K. & Felder, R.B. 2007. Brain pro-inflammatory cytokines contribute to sympathetic drive in heart failure. FASEB J 21, A1266.
25. Kang, Y.M., Ma, Y., Elks, C., Zheng, J.P., Yang, Z.M. & Francis, J. 2008a. Cross-talk between cytokines and renin-angiotensin in hypothalamic paraventricular nucleus in heart failure: role of nuclear factor-kappaB. Cardiovasc Res 79, 671-678.
26. Kang, Y.M., Zhang, Z.H., Xue, B., Weiss, R.M. & Felder, R.B. 2008b. Inhibition of brain proinflammatory cytokine synthesis reduces hypothalamic excitation in rats with ischemia-induced heart failure. Am J Physiol Heart Circ Physiol 295, H227-H236.
27. Kenney, M.J., Weiss, M.L. & Haywood, J.R. 2003. The paraventricular nucleus: an important component of the central neurocircuitry regulating sympathetic nerve outflow. Acta Physiol Scand 177, 7-15.
28. Malliani, A. & Montano, N. 2002. Emerging excitatory role of cardiovascular sympathetic afferents in pathophysiological conditions. Hypertension 39, 63-68.
29. Mancia, G., Grassi, G., Giannattasio, C. & Seravalle, G. 1999. Sympathetic activation in the pathogenesis of hypertension and progression of organ damage. Hypertension 34, 724-728.
30. Nishimura, M., Takahashi, H. & Yoshimura, M. 2007. Upregulation of the brain renin-angiotensin system in rats with chronic renal failure. Acta Physiol (Oxf) 189, 369-377.
31. Paxinos, G. & Watson, C. (2005) The rat brain in stereotaxic coordinates. 5th edn, pp 76-90. Elsevier Academic Press, San Diego.
32. Schulz, R., Aker, S., Belosjorow, S. & Heusch, G. 2004. TNFalpha in ischemia/reperfusion injury and heart failure. Basic Res Cardiol 99, 8-11.
33. Shi, Z., Chen, A.D., Xu, Y., Chen, Q., Gao, X.Y., Wang, W. & Zhu, G.Q. 2009. Long-term administration of tempol attenuates postinfarct ventricular dysfunction and sympathetic activity in rats. Pflugers Arch 458, 247-257.
34. Sriramula, S., Haque, M., Majid, D.S. & Francis, J. 2008. Involvement of tumor necrosis factor-alpha in angiotensin II-mediated effects on salt appetite, hypertension, and cardiac hypertrophy. Hypertension 51, 1345-1351.
35. Su, K.H., Tsai, J.Y., Kou, Y.R., Chiang, A.N., Hsiao, S.H., Wu, Y.L., Hou, H.H., Pan, C.C., Shyue, S.K. & Lee, T.S. 2009. Valsartan regulates the interaction of angiotensin II type 1 receptor and endothelial nitric oxide synthase via Src/PI3K/Akt signalling. Cardiovasc Res 82, 468-475.
36. 1 receptor in paraventricular nucleus mediates the enhanced cardiac sympathetic afferent reflex in rats with chronic heart failure. Auton Neurosci 121, 56-63.
37. Zhang, Z.H., Wei, S.G., Francis, J. & Felder, R.B. 2003. Cardiovascular and renal sympathetic activation by blood-borne TNF-alpha in rat: the role of central prostaglandins. Am J Physiol Regul Integr Comp Physiol 284, R916-R927.
38. Zhong, M.K., Duan, Y.C., Chen, A.D., Xu, B., Gao, X.Y., De, W. & Zhu, G.Q. 2008. Paraventricular nucleus is involved in the central pathway of cardiac sympathetic afferent reflex in rats. Exp Physiol 93, 746-753.
39. Zhong, M.K., Gao, J., Zhang, F., Xu, B., Fan, Z.D., Wang, W. & Zhu, G.Q. 2009. Reactive oxygen species in rostral ventrolateral medulla modulate cardiac sympathetic afferent reflex in rats. Acta Physiol (Oxf) 197, 297-304.
40. Zhou, L.M., Shi, Z., Gao, J., Han, Y., Yuan, N., Gao, X.Y. & Zhu, G.Q. 2010. Angiotensin-(1-7) and angiotension II in the rostral ventrolateral medulla modulate the cardiac sympathetic afferent reflex and sympathetic activity in rats. Pflugers Arch 459, 681-688.
41. Zhu, G.Q., Gao, L., Li, Y., Patel, K.P., Zucker, I.H. & Wang, W. 2004. AT1 receptor mRNA antisense normalizes enhanced cardiac sympathetic afferent reflex in rats with chronic heart failure. Am J Physiol Heart Circ Physiol 287, H1828-H1835.
42. Zhu, G.Q., Xu, Y., Zhou, L.M., Li, Y.H., Fan, L.M., Wang, W., Gao, X.Y. & Chen, Q. 2009. Enhanced cardiac sympathetic afferent reflex involved in sympathetic overactivity in renovascular hypertensive rats. Exp Physiol 94, 785-794.