Two new doramectin analogs from Streptomyces avermitilis NEAU1069: Fermentation, isolation and structure elucidation

Journal of Antibiotics

Volumn 64, Issue 8, 2011, Pages 591-594

  Wang, Xiang Jing ^a   Wang, Ji Jia ^a   Wang, Ji Dong ^b   Zhang, Ji ^a   Xu, Mei Dong ^b   Xiang, Wen Sheng ^a  

^a NORTHEAST AGRICULTURAL UNIVERSITY   (China)

^b Zhejiang Hisun Pharmaceutical Co Ltd   (China)

Author keywords

new doramectin analogs; Streptomyces avermitilis NEAU1069; structure elucidation

Indexed keywords

ANTINEMATODAL AGENT; DORAMECTIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL STRAIN; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG ISOLATION; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; FERMENTATION; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY; STREPTOMYCES; STREPTOMYCES AVERMITILIS;

ANTHELMINTICS; FERMENTATION; IVERMECTIN; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STREPTOMYCES;

STREPTOMYCES AVERMITILIS;

EID: 80052195437     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.1038/ja.2011.48     Document Type: Article

References (12)

1. Demain, A. L. & Sanchez, S. Microbial drug discovery: 80 years of progress. J. Antibiot. 62, 5-16 (2009).
2. Li, J. W. H. & Vederas, J. C. Drug discovery and natural products: End of an era or an endless frontier? Science 325, 161-165 (2009).
3. Wang, M. et al. New b-class milbemycin compound from Streptomyces avermitilis NEAU1069: Fermentation, isolation and structure elucidation. J. Antibiot. 62, 587-591 (2009).
4. Wang, X. J., Wang, M., Wang, J. D. & Xiang, W. S. Isolation and identification of novel macrocyclic lactones from S. Avermitilis NEAU1069 with acaricidal and nematocidal activity. J. Agric. Food Chem. 58, 2710-2714 (2010).
5. Pacey, M. S., Dutton, C. J., Monday, R. A., Ruddock, J. C. & Smith, G. C. Preparation of 13-epi-selamectin by biotransformation using a blocked mutant of Streptomyces avermitilis. J. Antibiot. 53, 301-305 (2000). (Pubitemid 30199084)
6. Dutton, C. J., Gibson, S. P., Kinns, M., Swanson, A. G. & Bordner, J. Structure of Doramectin. J. Chem. Soc. Perkin Trans. 2, 403-408 (1995).
7. Aoki, A., Fukuda, R. & Nakayabu, T. Antibiotic substances. US. 3,950,360, 13 April (1976).
8. Smith, A. B., Schow, S. R., Bloom, J. D., Thompson, A. S. & Winzenberg, K. N. Total synthesis of milbemycin b3. J. Am. Chem. Soc. 104, 4015-4018 (1982).
9. Schow, S. R., Bloom, J. D., Thompson, A. S., Winzenberg, K. N. & Smith, A. B. Total synthesis of Milbemycin b3 and its C(12) Epimer. J. Am. Chem. Soc. 108, 2662-2674 (1986).
10. Nonaka, K., et al. New milbemycins from Streptomyces hygroscopicus subsp. aureolacrimosus: Fermentation, isolation and structure elucidation. J. Antibiot. 53, 694-704 (2000). (Pubitemid 30612310)
11. Hood, J. D. et al. A novel series of milbemycin antibiotics from Streptomyces strain E225. I. discovery, fermentation and anthelmintic activity. J. Antibiot. 42, 1593-1598 (1989). (Pubitemid 20002653)
12. Xiang, W. S., Wang, J. D., Wang, X. J. & Zhang, J. Two new b-class milbemycins from Streptomyces bingchenggensis: Fermentation, isolation, structure elucidation and biological properties. J. Antibiot. 60, 351-356 (2007).