Simultaneous extraction of acidic and basic drugs from urine using mixed-mode monolithic silica spin column bonded with octadecyl and cation-exchange group

Journal of Separation Science

Volumn 34, Issue 16-17, 2011, Pages 2232-2239

  Namera, Akira ^a   Yamamoto, Shinobu ^a   Saito, Takeshi ^b   Miyazaki, Shota ^c   Oikawa, Hiroshi ^c   Nakamoto, Akihiro ^d   Nagao, Masataka ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c GL SCIENCES INC   (Japan)

^d Forensic Science Laboratory   (Japan)

Author keywords

Mixed mode; Preconcentration; Silica monolith; SPE

Indexed keywords

ANALYTES; BASIC DRUGS; BENZODIAZEPINES; CATION EXCHANGES; CONVENTIONAL METHODS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; LIMITS OF DETECTION; LINEAR CURVE; LOCAL ANAESTHETIC; MIXED MODE; MODEL DRUGS; MONOLITHIC SILICA; MONOLITHIC SILICA SPIN COLUMN; OCTADECYL; PRE-CONCENTRATION; REVERSED PHASE; SILICA MONOLITHS; SPE; SPIN COLUMN; STRONG CATION EXCHANGES; URINE SAMPLE;

ANESTHETICS; CENTRIFUGATION; COLUMN CHROMATOGRAPHY; GAS CHROMATOGRAPHY; MASS SPECTROMETRY; POSITIVE IONS; SILICA;

BODY FLUIDS;

ALKANE DERIVATIVE; AMITRIPTYLINE; ANTIDEPRESSANT AGENT; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE; CHLORPROMAZINE; CLOTIAZEPAM; DIAZEPAM; IMIPRAMINE; LIDOCAINE; LOCAL ANESTHETIC AGENT; METHANOL; OCTADECYL; PHENACETIN; PHENOBARBITAL; SECOBARBITAL; SILICON DIOXIDE; UNCLASSIFIED DRUG; CATION EXCHANGE RESIN; STREET DRUG;

ADSORPTION; ARTICLE; CATION EXCHANGE; CHEMICAL BOND; CONCENTRATION (PARAMETERS); DRUG ISOLATION; ION EXCHANGE CHROMATOGRAPHY; MASS FRAGMENTOGRAPHY; PH; PRIORITY JOURNAL; URINALYSIS; CHEMISTRY; DEVICES; EVALUATION STUDY; HUMAN; ISOLATION AND PURIFICATION; PROCEDURES; SOLID PHASE EXTRACTION; SUBSTANCE ABUSE; URINE;

CATION EXCHANGE RESINS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; SILICON DIOXIDE; SOLID PHASE EXTRACTION; STREET DRUGS; SUBSTANCE ABUSE DETECTION;

EID: 80052095428     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.201100165     Document Type: Article

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