Macrophages induce neuroendocrine differentiation of prostate cancer cells via BMP6-IL6 Loop

Prostate

Volumn 71, Issue 14, 2011, Pages 1525-1537

  Lee, Geun Taek ^a   Kwon, Seok Joo ^a   Lee, Jae Ho ^a   Jeon, Seong Soo ^a,b   Jang, Kee Taek ^b   Choi, Han Yong ^b   Lee, Hyun Moo ^b   Kim, Wun Jae ^c   Lee, Dong Hyeon ^d   Kim, Isaac Yi ^a  

^a ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b Sungkyunkwan University School of Medicine   (South Korea)

^c Chungbuk National University College of Medicine   (South Korea)

^d Ewha Womans University   (South Korea)

Author keywords

bone morphogenetic protein 6; cytokines; IL 6; macrophages; neuroendocrine like prostate cancer cell; transdifferentiation

Indexed keywords

BETA ACTIN; BIOLOGICAL MARKER; BONE MORPHOGENETIC PROTEIN 6; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; NEURON SPECIFIC ENOLASE; NEUTRALIZING ANTIBODY; PARATHYROID HORMONE RELATED PROTEIN; ANDROGEN RECEPTOR; BMP6 PROTEIN, HUMAN; BMP6 PROTEIN, MOUSE; IL6 PROTEIN, HUMAN; INTERLEUKIN-6, MOUSE;

ANIMAL CELL; ARTICLE; CANCER TISSUE; CELL DIFFERENTIATION; CELL INTERACTION; CELL STRAIN LNCAP; CONTROLLED STUDY; FEEDBACK SYSTEM; HUMAN; HUMAN CELL; IN VIVO STUDY; KNOCKOUT MOUSE; MACROPHAGE; MACROPHAGE ACTIVATION; MALE; MOUSE; NEUROSECRETORY CELL; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; ANIMAL; CASTRATION RESISTANT PROSTATE CANCER; COCULTURE; CYTOLOGY; METABOLISM; MONOCYTE; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

ANIMALS; BONE MORPHOGENETIC PROTEIN 6; CELL DIFFERENTIATION; CELL LINE, TUMOR; COCULTURE TECHNIQUES; HUMANS; INTERLEUKIN-6; MACROPHAGES; MALE; MICE, KNOCKOUT; MONOCYTES; NEUROENDOCRINE CELLS; PROSTATIC NEOPLASMS, CASTRATION-RESISTANT; RECEPTORS, ANDROGEN;

EID: 80052080479     PISSN: 02704137     EISSN: 10970045     Source Type: Journal    
DOI: 10.1002/pros.21369     Document Type: Article

References (31)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, Thun MJ,. Cancer statistics, 2008. CA Cancer J Clin 2008; 58 (2): 71-96. (Pubitemid 351521864)
2. Pound CR, Partin AW, Eisenberger MA, Chan DW, Pearson JD, Walsh PC,. Natural history of progression after PSA elevation following radical prostatectomy. JAMA 1999; 281: 1591-1597. (Pubitemid 29211767)
3. Yuan TC, Veeramani S, Lin MF,. Neuroendocrine-like prostate cancer cells: Neuroendocrine transdifferentiation of prostate adenocarcinoma cells. Endocr Relat Cancer 2007; 14: 531-547. (Pubitemid 350074046)
4. Abrahamsson PA, di Sant'Agnese PA,. Neuroendocrine cells in the human prostate gland. J Androl 1993; 14: 307-309. (Pubitemid 23320869)
5. Krijnen JL, Janssen PJ, Ruizeveld de Winter JA, van Krimpen H, Schroder FH, van der Kwast TH,. Do neuroendocrine cells in human prostate cancer express androgen receptor? Histochemistry 1993; 100: 393-398. (Pubitemid 23355975)
6. Abrahamsson PA, Wadstrom LB, Alumets J, Falkmer S, Grimelius L,. Peptide-hormone- and serotonin-immunoreactive tumour cells in carcinoma of the prostate. Pathol Res Pract 1987; 182: 298-307. (Pubitemid 17111034)
7. Bostwick DG, Dousa MK, Crawford BG, Wollan PC,. Neuroendocrine differentiation in prostatic intraepithelial neoplasia and adenocarcinoma. Am J Surg Pathol 1994; 18: 1240-1246. (Pubitemid 24362437)
8. Bingle L, Brown NJ, Lewis CE,. The role of tumour-associated macrophages in tumour progression: Implications for new anticancer therapies. J Pathol 2002; 196: 254-265. (Pubitemid 34189413)
9. Murdoch C, Giannoudis A, Lewis CE,. Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood 2004; 104: 2224-2234. (Pubitemid 39331817)
10. Conti P, DiGioacchino M,. MCP-1 and RANTES are mediators of acute and chronic inflammation. Allergy Asthma Proc 2001; 22: 133-137.
11. Leek RD, Lewis CE, Whitehouse R, Greenall M, Clarke J, Harris AL,. Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma. Cancer Res 1996; 56: 4625-4629. (Pubitemid 26338061)
12. Etoh T, Shibuta K, Barnard GF, Kitano S, Mori M,. Angiogenin expression in human colorectal cancer: The role of focal macrophage infiltration. Clin Cancer Res 2000; 6: 3545-3551.
13. Lewis JS, Landers RJ, Underwood JC, Harris AL, Lewis CE,. Expression of vascular endothelial growth factor by macrophages is up-regulated in poorly vascularized areas of breast carcinomas. J Pathol 2000; 192: 150-158.
14. Hildenbrand R, Wolf G, Bohme B, Bleyl U, Steinborn A,. Urokinase plasminogen activator receptor (CD87) expression of tumor-associated macrophages in ductal carcinoma in situ, breast cancer, and resident macrophages of normal breast tissue. J Leukoc Biol 1999; 66: 40-49. (Pubitemid 29321368)
15. Chiao JW, Hsieh TC, Xu W, Sklarew RJ, Kancherla R,. Development of human prostate cancer cells to neuroendocrine-like cells by interleukin-1. Int J Oncol 1999; 15: 1033-1037.
16. Lee SO, Lou W, Johnson CS, Trump DL, Gao AC,. Interleukin-6 protects LNCaP cells from apoptosis induced by androgen deprivation through the Stat3 pathway. Prostate 2004; 60: 178-186. (Pubitemid 38971829)
17. Nakashima J, Tachibana M, Horiguchi Y, Oya M, Ohigashi T, Asakura H, Murai M,. Serum interleukin 6 as a prognostic factor in patients with prostate cancer. Clin Cancer Res 2000; 6 (7): 2702-2706. (Pubitemid 30482107)
18. Drachenberg DE, Elgamal AA, Rowbotham R, Peterson M, Murphy GP,. Circulating levels of interleukin-6 in patients with hormone refractory prostate cancer. Prostate 1999; 41: 127-133. (Pubitemid 29446967)
19. Lou W, Ni Z, Dyer K, Tweardy DJ, Gao AC,. Interleukin-6 induces prostate cancer cell growth accompanied by activation of stat3 signaling pathway. Prostate 2000; 42: 239-242. (Pubitemid 30080423)
20. Duffield JS, Forbes SJ, Constandinou CM, Clay S, Partolina M, Vuthoori S, Wu S, Lang R, Iredale JP,. Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J Clin Invest 2005; 115 (1): 56-65. (Pubitemid 40385505)
21. O'Sullivan C, Lewis CE, Harris AL, McGee JO,. Secretion of epidermal growth factor by macrophages associated with breast carcinoma. Lancet 1993; 342 (8864): 148-149. (Pubitemid 23200443)
22. Sunderkotter C, Steinbrink K, Goebeler M, Bhardwaj R, Sorg C,. Macrophages and angiogenesis. J Leukoc Biol 1994; 55 (3): 410-422. (Pubitemid 24097250)
23. Zhu P, Baek SH, Bourk EM, Ohgi KA, Garcia-Bassets I, Sanjo H, Akira S, Kotol PF, Glass CK, Rosenfeld MG, Rose DW,. Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway. Cell 2006; 124 (3): 615-629. (Pubitemid 43199445)
24. Hong JH, Lee GT, Lee JH, Kwon SJ, Park SH, Kim SJ, Kim IY,. Effect of bone morphogenetic protein-6 on macrophages. Immunology 2009; 128 (1 Suppl): e442-e450.
25. Hoosein NM,. Neuroendocrine and immune mediators in prostate cancer progression. Front Biosci 1998; 3: D1274-D1279.
26. Gordon S,. The macrophage: Past, present and future. Eur J Immunol 2007; 37 (Suppl 1): S9-S17. (Pubitemid 350131264)
27. Hamdy FC, Autzen P, Robinson MC, Horne CH, Neal DE, Robson CN,. Immunolocalization and messenger RNA expression of bone morphogenetic protein-6 in human benign and malignant prostatic tissue. Cancer Res 1997; 57: 4427-4431. (Pubitemid 27413455)
28. Kim IY, Lee DH, Lee DK, Ahn HJ, Kim MM, Kim SJ, Morton RA,. Loss of expression of bone morphogenetic protein receptor type II in human prostate cancer cells. Oncogene 2004; 23 (46): 7651-7659. (Pubitemid 39424923)
29. Apte RN, Voronov E,. Is interleukin-1 a good or bad 'guy' in tumor immunobiology and immunotherapy? Immunol Rev 2008; 222: 222-241. (Pubitemid 351430377)
30. Ahlgren G, Pedersen K, Lundberg S, Aus G, Hugosson J, Abrahamsson PA,. Regressive changes and neuroendocrine differentiation in prostate cancer after neoadjuvant hormonal treatment. Prostate 2000; 42: 274-279. (Pubitemid 30104570)
31. Shimura S, Yang G, Ebara S, Wheeler TM, Frolov A, Thompson TC,. Reduced infiltration of tumor-associated macrophages in human prostate cancer: Association with cancer progression. Cancer Res 2000; 60: 5857-5861.