Betahistine in the treatment of tinnitus in patients with vestibular disorders

Brazilian Journal of Otorhinolaryngology

Volumn 77, Issue 4, 2011, Pages 499-503

  Ganança, Maurício Malavasi ^a   Caovilla, Heloisa Helena ^a   Gazzola, Juliana Maria ^a   Ganança, Cristina Freitas ^a   Ganança, Fernando Freitas ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Dizziness; Medication therapy management; Tinnitus; Vertigo

Indexed keywords

EID: 80052074733     PISSN: 18088694     EISSN: 18088686     Source Type: Journal    
DOI: 10.1590/S1808-86942011000400014     Document Type: Article

References (31)

1. Henry JA, Dennis KC, Schechter MA. General review of tinnitus: prevalence, mechanisms, effects, and management. J Speech Lang Hear Res. 2005;48:1204-3.
2. Nondahl DM, Cruickshanks KJ, Dalton DS, Klein BE, Klein R, Schubert CR, et al. The impact of tinnitus on quality of life in older adults. J Am Acad Audiol. 2007;18:257-66.
3. Pinto PCL, Sanchez TG, Tomita S. Avaliação da relação entre severidade do zumbido e perda auditiva, sexo e idade do paciente. Braz J Otorhinolaryngol. 2010;76(1):18-24.
4. Fornaro M, Martino M. Tinnitus psychopharmacology: A comprehensive review of its pathomechanisms and management. Neuropsychiatr Dis Treat. 2010;6:209-18.
5. Axelsson A. Tinnitus epidemiology. In: Reich GF, Vernon JA, eds. Fifth international tinnitus seminar; 1995; Portland, Oregon. Proceedings. Portland, Oregon: American Tinnitus Association. 1995;12-15.p.249-53.
6. Crummer RW, Hassan GA. Diagnostic Approach to Tinnitus. Am Fam Physician. 2004;69:120-6,127-8.
7. Sanchez TG, Medeiros ÍRT, Levy CP, Ramalho JRO, Bento F. Zumbido em pacientes com audiometria normal: caracterização clínica e repercussões. Braz J Otorhinolaryngol. 2005;71(4):427-31.
8. Ferreira LMBM, Ramos Júnior AN, Mendes EP. Caracterização do zumbido em idosos e de possíveis transtornos relacionados. Braz J Otorhinolaryngol. 2009;75(2):249-55.
9. Lacour M, van de Heyning PH, Novotny M, Tighilet B. Betahistine in the treatment of Ménières disease. Neuropsych Dis Treat. 2007;3:1-12.
10. Patterson MB, Balough BJ. Review of pharmacological therapy for tinnitus. Int Tinnitus J. 2006;12(2):149-59.
11. Elgoyhen AB, Langguth B. Pharmacological approaches to the treatment of tinnitus. Drug Discov Today. 2010;15(7-8):300-5.
12. Seidman MD, Standring RT, Dornhoffer JL. Tinnitus: current understanding and contemporary management. Curr Opin Otolaryngol Head Neck Surg. 2010;18(5):363-8.
13. Møller AR. Tinnitus: presence and future. Prog Brain Res. 2007;166:3-16.
14. Onishi E, Kasse C, Rodrigues C, Oliveira MHP, Aprile MR, Bataglia PUR, Karsch UM. Como diagnosticar e tratar zumbido. Rev Bras Med. 2008;65:32-7.
15. James AL, Burton MJ. Betahistine for Ménières disease or syndrome. Cochrane Database Syst Rev. 2001;(1):CD001873.
16. Ma FR, Xin Y, Zhao YM, Lü JQ. Efficacy of Betahistine Mesilate combined with Flunarizine Hydrochloride for treating tinnitus. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2006;41:269-73.
17. Gryczyńska D, Drobik-Wasiewicz K, Malicka M, Kotecki M. Therapy of tinnitus in children. Otolaryngol Pol. 2007;61:784-8.
18. Frew IJC, Menon GN. Betahistine hydrochloride in Ménières disease. Postgrad Med J. 1976;52:501-3.
19. Dziadziola JK, Laurikainen EL, Rachel JD, Quirk WS. Betahistine increases vestibular blood flow. Otolaryngol Head Neck Surg. 1999;120:400-5.
20. Dutia MB. Betahistine, vestibular function and compensation: in vitro studies of vestibular function and plasticity. Acta Otolaryngol Suppl. 2000;544:11-4.
21. Lacour M, Tighilet B. Vestibular compensation in the cat: the role of the histaminergic system. Acta Otolaryngol Suppl. 2000;544:15-8.
22. Lacour M, Sterkers O. Histamine and betahistine in the treatment of vertigo: elucidadtion of mechanisms of action. CNS Drugs. 2001;15:853-70.
23. Ganança MM, Munhoz MSL, Caovilla HH, Silva MLG. Managing vertigo. Hannover: Solvay; 2006. p.112.
24. Ganança MM, Caovilla HH, Munhoz MSL, Ganança CF, Silva MLG, Serafini F, et al. Optimizing the pharmacological component of integrated balance therapy. Braz J Otorhinolaringol. 2007;73:12-8.
25. Strupp M, Hupert D, Frenzel C, Wagner J, Hahn A, Jahn K, et al. Long-term prophylactic treatment of attacks of vertigo in Ménière's disease: comparison of a high with a low dosage of betahistine in an open trial. Acta Otolaryngol. 2008;128(5):520-4.
26. Ganança MM, Caovilla HH, Ganança FF. Comparable efficacy and tolerability between twice daily and three times daily betahistine for Ménières disease. Acta Otolaryngol. 2009;129(5):487-92.
27. Novotný M, Kostrica R. Fixed combination of cinnarizine and dimenhydrinate versus betahistine dimesylate in the treatment of Ménières disease: a randomized, double-blind, parallel group clinical study. Int Tinnitus J. 2002;8:115-23.
28. Ohsaki K, Ueno M, Zheng HX, Wang QC, Nishizaki K, Nobuto Y, et al. Evaluation of tinnitus patients by peroral multi-drug treatment. Auris Nasus Larynx. 1998;25:149-54.
29. Robinson SK, Viirre ES, Bailey KA, Gerke MA, Harris JP, Stein MB. Randomized placebo-controlled trial of a selective serotonin reuptake inhibitor in the treatment of nondepressed tinnitus subjects. Psychosom Med. 2005;67:981-8.
30. Robinson S. Antidepressants for treatment of tinnitus. Prog Brain Res. 2007;166:263-71.
31. Robinson SK, Viirre ES, Stein MB. Antidepressant therapy in tinnitus. Hear Res. 2007;226:221-31.