Betahistine in the treatment of Ménière's disease

Neuropsychiatric Disease and Treatment

Volumn 3, Issue 4, 2007, Pages 429-440

  Lacour, Michel ^a   van de Heyning, Paul H ^b   Novotny, Miroslav ^c   Tighilet, Brahim ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

^b ANTWERP UNIVERSITY HOSPITAL   (Belgium)

^c UNIVERSITY HOSPITAL BRNO   (Czech Republic)

Author keywords

Betahistine; M ni re's disease; Vestibular disorders

Indexed keywords

ACETAZOLAMIDE; ALPRAZOLAM; ANTIDEPRESSANT AGENT; ANTIEMETIC AGENT; ANTIHISTAMINIC AGENT; ANTIVERTIGO AGENT; BENZODIAZEPINE DERIVATIVE; BETAHISTINE; CINNARIZINE; CINNARIZINE PLUS DIMENHYDRINATE; CORTICOSTEROID; DIAZEPAM; DIHYDROBENZOPERIDOL; DIMENHYDRINATE; DIURETIC AGENT; DOMPERIDONE; FLUNARIZINE; GLUCOCORTICOID; HALOPERIDOL; HISTAMINE; MECLOZINE; PHENOTHIAZINE; PLACEBO; PROCHLORPERAZINE; SEDATIVE AGENT; SEROTONIN UPTAKE INHIBITOR; SULPIRIDE; THIOPERAMIDE; TRIMETAZIDINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BLURRED VISION; CENTRAL NERVOUS SYSTEM FUNCTION; CLINICAL FEATURE; CLINICAL TRIAL; DEPRESSION; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG MECHANISM; DRUG SAFETY; DRUG TOLERABILITY; EVIDENCE BASED MEDICINE; FLUSHING; GASTROINTESTINAL SYMPTOM; HUMAN; LIFESTYLE MODIFICATION; LONG TERM CARE; LOW DRUG DOSE; MENIERE DISEASE; MORBIDITY; NAUSEA; NAUSEA AND VOMITING; NONHUMAN; PATHOPHYSIOLOGY; PREVALENCE; REHABILITATION CARE; SEDATION; SIDE EFFECT; SKIN MANIFESTATION; VERTIGO; VESTIBULAR DISORDER; VOMITING;

EID: 35648930969     PISSN: 11766328     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (105)

1. Aantaa E, Skinhoj A. 1976. Controlled clinical trial comparing the effect of betahistine hydrochloride and prochlorperazine maleate on patients with Ménière's disease. Ann Clin Res, 8:284-7.
2. AAO-HNS. Committee on hearing and equilibrium. 1995. Guidelines for the diagnosis and evaluation of therapy in Ménière's disease. Otolaryngol Head Neck Surg, 113:181-5.
3. Airaksinen MS, Panula P. 1988. The histaminergic system in the guinea pig central nervous system: an immunocytochemical mapping study using an antiserum against histamine. J Comp Neurol, 273:163-6.
4. Albera R, Ciuffolotti R, Di Cieco M, et al. 2003. Double-blind, randomized, multicenter study comparing the effect of betahistine and flunarizine on the dizziness handicap in patients with recurrent vestibular vertigo. Acta Otolaryngol, 123:588-93.
5. Allum. JHJ, Keshner EA, Honegger F, et al. 1988. Indicators of the influence a peripheral vestibular deficit has on vestibulo-spinal reflex responses controlling postural stability. Acta Otolaryngol, 106:252-63.
6. Anderson JP, Harris JP. 2001. Impact of Ménière's disease on quality of life. Otol Neurotol, 22:888-94.
7. Andrews JC. 2004. Intralabyrinthine fluid dynamics: Meniere disease. Curr Opin Otolaryngol Head Neck Surg, 12:408-12.
8. Arrang JM, Garbag M, Quatch TT, et al. 1985. Actions of betahistine at histamine receptors in the brain. Eur J Pharmacol, 111:73-84.
9. Arrang JM, Garbag M, Schwartz JC. 1987. Autoregulation of histamine synthesis in brain mediated by presynaptic H3 receptors. Neuroscience, 23:149-57.
10. Arrang JM, Garbarg M, Schwartz JC. 1983. Auto-inhibition of brain histamine release mediated by a novel class H3. of histamine receptor. Nature, 302:832-7.
11. Arrang JM, Garbag M, Schwartz JC. 1992. H3-receptors and control of histamine release. In Schwartz JC, Haas HL eds. The histamine receptors. New York: Wiley-Liss. 145-60.
12. Betts T, Harris D, Gadd E. 1991. The effects of two antivertigo drugs betahistine and prochlorperazine. on driving skills. Br J Clin Pharmacol, 32:455-8.
13. Borel L, Harlay F, Lopez C, et al. 2004. Walking performance of vestibular-defective patients before and after unilateral vestibular neurotomy. Behav Brain Res, 150:191-200.
14. Borel L, Harlay F, Magnan J, et al. 2002. Deficits and recovery of head and trunk orientations and stabilization after unilateral vestibular loss. Brain, 125:880-94.
15. Botta L, Mira E, Valli S, et al. 1998. Effects of betahistine on vestibular receptors of the frog. Acta Otolaryngol, 118:519-23.
16. Brantberg K, Fransson PA, Bergenius J, et al. 1996. Tilt suppression, OKAN, and head-shaking nystagmus at long-term follow-up after unilateral vestibular neurectomy. J Vest Res, 6:23 5-41.
17. Chávez H, Vega R, Soto E. 2005. Histamine (H3) receptors modulate the excitatory amino acid receptor response of the vestibular afferents. Brain Res, 7:1-9.
18. Cirek Z, Schwarz M, Baumann W, et al. 2005. Efficacy and tolerability of a fixed combination of cinnarizine and dimenhydrinate versus betahistine in the treatment of otogenic vertigo: a double-blind, randomised. clinical study. Clin Drug Invest, 26:377-89.
19. Claes J, Van de Heyning PH. 1997. Medical therapy of Ménière's disease: a review of literature. Acta Otolaryngol Suppl, 526:37-42.
20. Claes J, Van de Heyning PH. 2000. A review of medical treatment for Meniere's disease. Acta Otolaryngol Suppl, 544:34-9.
21. Clendaniel RA, Tucci DL. 1997. Vestibular rehabilitation strategies in Meniere's disease. Otolaryngol Clin North Am, 30:1145-58.
22. Cohen H, Ewell LR, Jenkins HA. 1995. Disability in Ménière's disease. Arch Otolaryngol Head Neck Surg, 121:29-33.
23. Constantinescu L, Schneider D, Claussen CF. 1996. The influence of betahistine on the vestibular evoked potentials in patients with peripheral vestibular disorders. In 3rd EUFOS, Bologna: Monduzzi Editore. p. 95-98.
24. Cawthorne T, Hewlett AB. 1954. Ménière's disease. Proc R Soc Med, 47:663-70
25. Curthoys IS, Dai MJ, Halmagyi GM. 1991. Human ocular torsional position before and after unilateral vestibular neurectomy. Exp Brain Res, 85:218-25.
26. Dai MJ, Curthoys IS, Hamlagyi GM. 1989. Linear acceleration perception in the roll plane before and after unilateral vestibular neurectomy. Exp Brain Res, 77:315-28.
27. Deering RB, Prescott P, Simmons RL, et al. 1986. A double-blind crossover study comparing betahistine and cinnarizine in the treatment of recurrent vertigo in patients in general practice. Curr Med Res Opin, 10:209-14.
28. Dodson KM, Sismanis A. 2004. Intratympanic perfusion for the treatment of tinnitus. Otolaryngol Clin North Am, 37:991-1000.
29. Dowdal-Osborn M. 2002. Early vestibular rehabilitation in patients with Meniere's disease. Otolaryngol Clin North Am 35:683-90.
30. Doyle KJ, Bauch C, Battista R, et al. 2004. Intratympanic steroid treatment: a review. Otol Neurotol, 25:1034-9.
31. Dunnebier EA, Segenhout JM, Wit HP, et al. 1997. Two-phase endolymphatic hydrops: a new dynamic guinea pig model. Acta Otolaryngol, 117:13-19.
32. Dunnebier EA, Segenhout JM, Dijk F, et al. 2002. Cochlear ultrastructure in two-phase endolymphatic hydrops in the guinea-pig. Eur Arch Otorhinolaryngol, 259:17-23.
33. Elbaz P. 1988. Flunarizine and betahistine. Two different therapeutic approaches in vertigo compared in a double-blind study. Acta Otolaryngol Suppl, 460:143-8.
34. Feijen RA, Segenhout JM, Albers FW, et al. 2004. Cochlear aqueduct flow resistance depends on round window membrane position in guinea pigs. J Assoc Res Otolaryngol, 5:404-10.
35. Filipo R, Barbara M. 1997. Natural history of Méniere's disease: staging the patients or their symptoms? Acta Otolaryngol Suppl, 526:10-13.
36. Fischer AJ. 1991. Histamine in the treatment of vertigo. Acta Otolaryngol Suppl, 479:24-8.
37. Fraysse B, Bebear JP, Dubreuil C, et al. 1991. Betahistine dihydrochloride versus flunarizine. A double-blind study on recurrent vertigo with or without cochlear syndrome typical of Ménière's disease. Acta Otolaryngol Suppl, 490: 1-10.
38. Garbag M, Trung Tuong MD, Gros C, et al. 1989. Effects of histamine H3 receptor ligands on various biochemical indices of histaminergic neuron activity in rat brain. Eur J Pharmacol, 164: 1-11.
39. Gustave dit Duflo S, Gestreau C, Lacour M. 2000. Fos expression in the rat brain after exposure to gravito-inertial force changes. Brain Res, 861:333-44.
40. Gustave dit Duflo S, Gestreau C, Tighilet B, et al. 1999. Fos expression in the cat brainstem after unilateral vestibular neurectomy. Brain Res, 824:1-17.
41. Halmagyi GM, Curthoys IS, Cremer PD, et al. 1990. The human horizontal vestibulo-ocular reflex in response to high-acceleration stimulation before and after unilateral vestibular neurectomy. Exp Brain Res, 81:479-90.
42. Havia M, Kentala E. 2004. Progression of symptoms of dizziness in Ménière's disease. Arch Otolaryngol Head Neck Surg, 130:431-5.
43. Horii A, Takeda N, Matsunaga T, et al. 1993. Effect of unilateral vestibular stimulation on histamine release from the hypothalamus of rats in vivo. J Neurophysiol, 70:1822-6.
44. Horii A, Mitani K, Kitahara T, et al. 2004. Paroxetine, a selective serotonin reuptake inhibitor, reduces depressive symptoms and subjective handicaps in patients with dizziness. Otol Neurotol, 25:536-43.
45. Inverarity DJ, Johnston AR, McQueen DS, et al. 1993. Effects of histamine on rat medial vestibular nucleus neurones in vitro. J Physiol, 459:466.
46. Jaju B, Wang SC. 1971. Effects of diphenhydramine and dimenhydrinate on vestibular neuronal activity of cat: a search for the locus of their antimotion sickness action. J Pharmacol Exp Therap, 176:718-24.
47. Kentala E. 1996. Characteristics of six otologic diseases involving vertigo. Am J Otol, 17:883-92.
48. Kiang NY. 1990. Curious oddments of auditory-nerve studies. Hear Res, 49:1-16.
49. Kingma H, Bonink M, Meulenbroeks, et al. 1997. The dose-dependent effect of betahistine on vestibulo-ocular reflex: a double-blind, placebo controlled study in patients with paroxysmal vertigo. Acta Otolaryngol, 117:1-6.
50. Kinney SE, Sandridge SA, Newman CW. 1997. Long-term effects of Ménière's disease on hearing and quality of life. Am J Otol, 18:67-73.
51. Klockhoff I, Lindblom U. 1967. Ménière's disease and hydrochlorothiazide (Dichlotride) - a critical analysis of symptoms and therapeutic effects. Acta Otolaryngol, 63:347-65.
52. Kluyskens P, Lambert P, D'Hooge D. 1990 Trimetazidine versus betahistine in vestibular vertigo. A double blind study. Ann Otolaryngol Chir Cervicofac, 107(Suppl 1):11-9.
53. Kotimaki J, Sorri M, Aantaa E, et al. 1999. Prevalence of Ménière disease in Finland. Laryngoscope, 109:748-53.
54. Lacour M, Borel L. 1993. Vestibular control of posture and gait. Arch Ital Biol, 131:81-104.
55. Lacour M, Sterkers O. 2001. Histamine and betahistine in the treatment of vertigo: elucidation of mechanisms of action. CNS Drugs, 15:853-70.
56. Lacour M, Toupet M, Denise P, et al. 1989. Vestibular compensation. Facts, theories and clinical perspectives. Paris: Elsevier.
57. Laurens-Thalen, EO, Wit HP, Segenhout JM, et al. 2004. Direct measurement of the flow resistance of the aqueduct in the guinea pig. Acta Otolaryngol, 124:1-5.
58. Laurikainen EA, Miller JM, Nuttall AL, et al. 1998. The vascular mechanisms of action of betahistine in the inner ear of the guinea pig. Eur Arch Otorhinolaryngol, 255:119-23.
59. Laurikainen EA, Miller JM, Quirk WS, et al. 1993. Betahistine-induced vascular effects in the rat cochlea. Am J Otol, 14:24-30.
60. Lin JS. 1994. Système histaminergique central et états de vigilance chez le chat. Thèse Doct Sciences, Université Claude Bernard, Lyon.
61. Lopez C, Borel L, Magnan J, et al. 2005. Torsional optokinetic nystagmus after unilateral vestibular loss: asymmetry and compensation. Brain, In press.
62. Luxon LM. 1984. The anatomy and physiology of vestibular system. In Dix MR, Hood J eds. Vertigo. New York: John Wiley and Sons. p 1-36.
63. Martini A, De Domenico F. 1990. Trimetazidine versus betahistine in Ménière's disease. A double blind method. Ann Otolaryngol Chir Cervicofac, 107(Suppl 1):20-7.
64. Mira E. 2001. Betahistine in the treatment of vertigo. History and clinical implications of recent pharmacological researches. Acta Otorhinolaryngol Ital, 21 (Suppl 66):1-7.
65. Mira E, Guidetti G, Ghilardi L, et al. 2003. Betahistine dihydrochloride in the treatment of peripheral vestibular vertigo. Eur Arch Otorhinolaryngol, 260:73-7.
66. Merchant SN, Adams JC, Nadol JB Jr. 2005. Physiopathology of ménière's syndrome: are symptoms caused by endolymphatic hydrops? Otol Neurotol, 26:74-81
67. Meyer JS, Mathew NT, Hartmann A, et al. 1974. Orally administrated betahistine and regional cerebral blood flow in cerebrovascular disease. J Clin Pharmacol, 14:280-5.
68. Novotny M, Kostrica R. 2002. Fixed combination of cinnarizine and dimenhydrinate versus betahistine dimesylate in the treatment of Ménière's disease: a randomized, double-blind, parallel group clinical study. Int Tinnitus J, 8:115-23.
69. Oosterveld Wl. 1984. Betahistine dihydrochloride in the treatment of vertigo of peripheral vestibular origin. A double-blind placebo-controlled study. J Laryngol Otol, 98:37-41.
70. Oosterveld WJ. 1987. Effect of betahistine dihydrochloride on induced vestibular nystagmus: a double blind study. Clin Otolaryngol Allied Sci, 12:131-5.
71. Panula P, Pirvola U, Auvinen S, et al. 1989. Histamine-inummoreactive nerve fibers in the rat brain. Neuroscience, 28:585-610.
72. Phelan KD, Nakamura J, Gallagher JP. 1990. Histamine depolarizes rat medial vestibular nucleus neurons recorded intracellularly in vitro. Neurosci Lett, 109:287-92.
73. Pollard H, Schwartz JC. 1987. Histamine neuronal pathways and their function. Trends Neurosci, 10:86-9.
74. Pondugula SR, Sanneman JD, Wangemann P, et al. 2004. Glucocorticoids stimulate cation absorption by semicircular canal duct epithelium via epithelial sodium channel. Am J Physiol Renal Physiol, 286: F1127-35.
75. Rascol O, Hain TC, Brefel C, et al. 1995. Antivertigo medications and drug-induced vertigo. Drugs, 50:777-91.
76. Scholtz AW, Schwarz M, Baumann W, et al. 2004. Treatment of vertigo due to acute unilateral vestibular loss with a fixed combination of cirmarizine and dimenhydrinate: a double-blind, randomized, parallel-goup clinical study. Clin Ther, 26:866-77.
77. Schwartz JC. 1979. Histamine receptors in brain. Life Sci, 25:895-912.
78. Schwartz JC, Arrang JM, Garbarg M, et al. 1990. A third histaminergic receptor subtype: characterisation, location and functions of the H3-receptor. Agents Actions, 30:13-23.
79. Selmani Z, Marttila T, Pyykkö I. 2005. Incidence of virus infection as a cause of Ménière's disease or endolymphatic hydrops assessed by electrocochleography. Eur Arch Otorhinolaryngol, 262:331-4
80. Serafin M, Khateb A, Vibert N, et al. 1993. Medial vestibular nucleus in the guinea-pig: histaminergic receptors. I. An in vitro study. Exp Brain Res, 93:242-8.
81. Shojaku H, Watanabe Y. 1997. The prevalence of definite cases of Méniere's disease. Acta Otolaryngol, 528:94-6.
82. Smith PF, Curthoys IS. 1989. Mechanisms of recovery following unilateral labyrinthectomy: a review. Brain Res Brain Res Rev, 14:155-80.
83. Smith WK, Sankar V, Pfleiderer AG. 2005. A national survey amongst UK otolaryngologists regarding the treatment of Ménière's disease. J Laryngol Otol, 119:102-5.
84. Stahle J, Stahle C, Arenberg IK. 1978. Incidence of Ménière's disease. Arch Otolaryngol, 104:99-102.
85. Stephens SD, Lewis PA, Charny MC, et al. 1990. Characteristics of self-reported hearing problems in a community survey. Audiology, 29:93-100.
86. Stephens SD, Hogan S, Meredith R. 1991. The desynchrony between complaints and signs of vestibular disorders. Acta Otolaryngol, 111:188-92.
87. Takeda N, Morita M, Kubo T, et al. 1987. Histaminergic projection from the posterior hypothalamus to the medial vestibular nucleus of rats and its relation to motion sickness. In Graham MD, Kemink JL eds. The vestibular system: Neurophysiologic and clinical research. New York: Raven Press. p. 601-17.
88. Tighilet B, Lacour M. 1996. Distribution of histaminergic axonal fibres in the vestibular nuclei of the cat. Neuroreport, 7:873-8.
89. Tighilet B, Lacour A 1997. Histamine immunoreactivity changes in vestibular-lesioned and histammergic-treated cats. Eur J Phannacol, 330:65-77.
90. Tighilet B, Leonard J, Lacour M. 1995. Betahistine dihydrochloride treatment facilitates vestibular compensation in the cat. J Vest Res, 5:53-66.
91. Tighilet B, Trottier S, Lacour M. 2005. Dose and duration-dependent effects of betahistine dihydrochloride treatment on histamine turnover in the cat. Eur J Pharmacol, 523:54-63.
92. Tighilet B, Trottier S, Mourre C, et al. 2002. Betahistine dihydrochloride interaction with the histaminergic system in the cat: neurochemical and molecular mechanisms. Eur J Pharmacol, 446:63-73.
93. Tighilet B, Trottier S, Mourre C, et al. 2006. Changes in histaminergic system during vestibular compensation in the cat. J Physiol Lond, In press.
94. Timmerman H. 1991. Histamine agonists and antagonists. Acta Otolaryngol Suppl, 479:5-11.
95. Tumarkin, A. 1936. The otolythic catastrophe: a new syndrome. BMJ, 2:175-7.
96. Van de Heyning PH, Boudewyns A, Wuyts F. 2005. Surgical treatment of Ménière's disease. Curr Opn Neurol, 18:23-28.
97. van Deelen GW, Huizing EH. 1986. Use of a diuretic (Dyazide) in the treatment of Ménière's disease. A double-blind cross-over placebo-controlled study. ORL J Otorhinolaryngol Relat Spec, 48:287-92.
98. Vibert D, Häusler R. 2000. Long-term evolution of subjective visual vertical after vestibular neurectomy and labyrinthectomy. Acta Otolaryngol, 120:620-2.
99. Watanabe Y, Mizokoshi K, Shojaku H, et al. 1995. Epidemiological and clinical characteristics of Ménière's disease in Japan. Acta Otolaryngol Suppl, 519:206-10.
100. Wang JJ, Dutia MB. 1995. Effects of histamine and betahistine on rat medial vestibular nucleus neurones: possible mechanism of action of anti-histaminergic drugs in vertigo and motion sickness. Exp Brain Res, 105:18-24.
101. Wilson VJ, Melvill Jones G. 1979. Mammalian vestibular physiology. New York: Plenum Press.
102. Warmerdam T J, Schroder FH, Wit HP, et al. 2003. Perilymphatic and endolymphatic pressure during endolymphatic hydrops. Eur Arch Otorhinolaryngol, 260:9-11.
103. Wladislavosky-Waserman P, Facer G, et al. 1984. Ménière's disease: a 30year epidemiologic and clinical study in Rochester, MN, 1951-1980. Laryngoscope, 94:1098-02.
104. Xerri C, Lacour M, 1980. Compensation des déficits posturaux et cinétiques après neurectomie vestibulaire unilatérale chez le chat. Rôle de l'activité sensorimotrice. Acta Otolaryngol, 90:414-20.
105. Yabe T, de Waele C, Serafin M, et al. 1993. Medial vestibular nucleus in the guinea-pig: histaminergic receptors. II. An in vivo study. Exp Brain Res, 93:249-58.