Therapeutic window of Qingkailing injection for focal cerebral ischemia/reperfusion injury

Neural Regeneration Research

Volumn 6, Issue 21, 2011, Pages 1605-1611

  Cheng, Fafeng ^a   Song, Wenting ^b   Zhong, Xianggen ^a   Lu, Yi ^a   Guo, Shaoying ^a   Wang, Dong ^a   Zhao, Weipeng ^a   Wang, Qingguo ^a  

^a BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b INSTITUTE OF CHINESE MATERIA MEDICA   (China)

Author keywords

Anti oxidation; Focal cerebral ischemia; Infarct volume; Neurological function; Qingkailing injection; Time window

Indexed keywords

CHINESE DRUG; QINGKAILING; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BRAIN CELL; BRAIN FUNCTION; BRAIN INFARCTION SIZE; BRAIN INJURY; BRAIN ISCHEMIA; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG INHIBITION; DRUG MEGADOSE; LOW DRUG DOSE; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEUROPROTECTION; NONHUMAN; REPERFUSION INJURY; TREATMENT RESPONSE;

EID: 80052072288     PISSN: 16735374     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Fisher M, Feuerstein G, Howells DW, et al. Update of the stroke therapy academic industry roundtable preclinical recommendations. Stroke. 2009;40(6):2244-2250.
2. Fisher M, Hanley DF, Howard G, et al. Recommendations from the STAIR V meeting on acute stroke trials, technology and outcomes. Stroke. 2007;38(2):245-248.
3. [3] Beijing University of Chinese Medicine. The study of novel dosage form of An Gong Niu Huang Wan. Xinyiyao Xue Zazhi. 1975(8):12.
4. Cheng FF, Song WT, Guo SY, et al. Meta-analysis of Clearing Heat and Removing Toxicity Therapy on ischemic stroke.Zhongyao Yaoli yu Linchuang. 2011;27(1):106-109.
5. Chen X, Howard OM, Yang X, et al. Effects of Shuanghuanglian and Qingkailing, two multi-components of traditional Chinese medicinal preparations, on human leukocyte function. Life Sci. 2002;70(24):2897-2913.
6. Yue S, Li Q, Liu S, et al. Mechanism of neuroprotective effect induced by QingKaiLing as an adjuvant drug in rabbits with E. coli bacterial meningitis. Acta Neurochir Suppl. 2006;96:413-418.
7. Hua Q, Zhu X, Li P, et al. Refined Qing Kai Ling, traditional Chinese medicinal preparation, reduces ischemic stroke-induced infarct size and neurological deficits and increases expression of endothelial nitric oxide synthase. Biol Pharm Bull. 2008;31(4): 633-637.
8. Lv L, Liu Y, Shi HF, et al. Qingkailing injection attenuates apoptosis and neurologic deficits in a rat model of intracerebral hemorrhage. J Ethnopharmacol. 2009;125(2):269-273.
9. Qi X, Hosoi T, Okuma Y, et al. Sodium 4-phenylbutyrate protects against cerebral ischemic injury. Mol Pharmacol. 2004;66(4): 899-908.
10. Albéri L, Chi Z, Kadam SD, et al. Neonatal stroke in mice causes long-term changes in neuronal Notch-2 expression that may contribute to prolonged injury. Stroke. 2010;41(10 Suppl):S64-71.
11. Cheng FF, Song WT, Guo SY, et al. Comparison of three kinds of neurological function rating systems on focal cerebral ischemia models of rodent animals. Zhongguo Kangfu Yixue Zazhi. 2011; 26(4):337-341.
12. David HN, Haelewyn B, Rouillon C, et al. Neuroprotective effects of xenon: a therapeutic window of opportunity in rats subjected to transient cerebral ischemia. FASEB J. 2008;22(4):1275-1286.
13. Lee EJ, Hung YC, Chen HY, et al. Delayed treatment with carboxy-PTIO permits a 4-h therapeutic window of opportunity and prevents against ischemia-induced energy depletion following permanent focal cerebral ischemia in mice. Neurochem Res. 2009;34(6):1157-1166.
14. Jia J, Zhang X, Hu YS, et al. Protective effect of tetraethyl pyrazine against focal cerebral ischemia/reperfusion injury in rats: therapeutic time window and its mechanism. Thromb Res. 2009; 123(5):727-730.
15. Wang C, Liu JL, Sang HF, et al. Therapeutic time window of flurbiprofen axetil's neuroprotective effect in a rat model of transient focal cerebral ischemia. Chin Med J (Engl). 2008; 121(24):2572-2577.
16. Gao Z, Huang K, Xu H. Protective effects of flavonoids in the roots of Scutellaria baicalensis Georgi against hydrogen peroxide- induced oxidative stress in HS-SY5Y cells. Pharmacol Res. 2001; 43(2):173-178.
17. Liu J, Yin F, Zheng X, et al. Geniposide, a novel agonist for GLP-1 receptor, prevents PC12 cells from oxidative damage via MAP kinase pathway. Neurochem Int. 2007;51(6-7):361-369.
18. Kinouchi H, Kamii H, Mikawa S, et al. Role of superoxide dismutase in ischemic brain injury: a study using SOD-1 transgenic mice. Cell Mol Neurobiol. 1998;18(6):609-620.
19. Wakade C, Khan MM, De Sevilla LM, et al. Tamoxifen neuroprotection in cerebral ischemia involves attenuation of kinase activation and superoxide production and potentiation of mitochondrial superoxide dismutase. Endocrinology. 2008;149(1): 367-379.
20. Brenman JE, Chao DS, Gee SH, et al. Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains. Cell. 1996;84(5): 757-767.
21. Aarts M, Liu Y, Liu L, et al. Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions. Science. 2002;298(5594):846-850.
22. Fabian RH, Perez-Polo JR, Kent TA. Perivascular nitric oxide and superoxide in neonatal cerebral hypoxia-ischemia. Am J Physiol Heart Circ Physiol. 2008;295(4):H1809-1814.
23. Brennan AM, Suh SW, Won SJ, et al. NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation. Nat Neurosci. 2009;12(7):857-863.
24. Zhu XL, Xiong LZ, Wang Q, et al. Therapeutic time window and mechanism of tetramethylpyrazine on transient focal cerebral ischemia/reperfusion injury in rats. Neurosci Lett. 2009;449(1) 24-27.
25. Gao YF, Yuan ZZ, Niu FL, et al. Influence of hyocholic acid on ICAM-1 of brain microvascular endothelial cell in rats after ischemia and reperfusion injury in vitro. Beijing Zhongyiyao Daxue Xuebao. 2007;30(10):670-673.
26. Zhu XL, Zhang N, Li PT, et al. Effects of cholic acid and jasminoidin on the levels of cerebral TNF-α, IL-1 β and ICAM-1 in the rats undergone cerebral ischemia. Beijing Zhongyiyao Daxue Xuebao. 2004;27(6):26-29.
27. Zhang ZJ, Li P, Wang Z, et al. A comparative study on the individual and combined effects of baicalin and jasminoidin on focal cerebral ischemia-reperfusion injury. Brain Res. 2006; 1123(1):188-195.
28. China Pharmacopoeia Committee. Pharmacopoeia of the People's Republic of China. 2005 ed. Beijing: Chemical Industry Press. 2005.
29. Capone C, Fabrizi C, Piovesan P, et al. 2-Aminotetraline derivative protects from ischemia/reperfusion brain injury with a broad therapeutic window. Neuropsychopharmacology. 2007; 32(6):1302-1311.
30. De Simoni MG, Storini C, Barba M, et al. Neuroprotection by complement (C1) inhibitor in mouse transient brain ischemia. J Cereb Blood Flow Metab. 2003;23(2):232-239.
31. Menzies SA, Hoff JT, Betz AL. Middle cerebral artery occlusion in rats: a neurological and pathological evaluation of a reproducible model. Neurosurgery. 1992;31(1):100-107.
32. Clark WM, Lessov NS, Dixon MP, et al. Monofilament intraluminal middle cerebral artery occlusion in the mouse. Neurol Res. 1997; 19(6):641-648.
33. Pillet S, von Messling V. Canine distemper virus selectively inhibits apoptosis progression in infected immune cells. J Virol. 2009;83(12):6279-6287.
34. Bindokas VP, Jordán J, Lee CC, et al. Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine. J Neurosci. 1996;16(4):1324-1336.
35. Girouard H, Park L, Anrather J, et al. Cerebrovascular nitrosative stress mediates neurovascular and endothelial dysfunction induced by angiotensin II. Arterioscler Thromb Vasc Biol. 2007; 27(2):303-309.
36. Robinson KM, Janes MS, Pehar M, et al. Selective fluorescent imaging of superoxide in vivo using ethidium-based probes. Proc Natl Acad Sci U S A. 2006;103(41):15038-15043.
37. Girouard H, Wang G, Gallo EF, et al. NMDA receptor activation increases free radical production through nitric oxide and NOX2. J Neurosci. 2009;29(8):2545-2552.
38. Wang Q, Sun AY, Simonyi A, et al. Ethanol preconditioning protects against ischemia/reperfusion-induced brain damage: role of NADPH oxidase-derived ROS. Free Radic Biol Med. 2007; 43(7):1048-1060.
39. Gümüştaş K, Meta Güzeyli FM, Atükeren P, et al. The effects of vitamin E on lipid peroxidation, nitric oxide production and superoxide dismutase expression in hyperglycemic rats with cerebral ischemia-reperfusion injury. Turk Neurosurg. 2007;17(2): 78-82.
40. Lazzarino G, Tavazzi B, Di Pierro D, et al. The relevance of malondialdehyde as a biochemical index of lipid peroxidation of postischemic tissues in the rat and human beings. Biol Trace Elem Res. 1995;47(1-3):165-170.
41. Wei Y, Sowers JR, Nistala R, et al. Angiotensin II-induced NADPH oxidase activation impairs insulin signaling in skeletal muscle cells. J Biol Chem. 2006;281(46):35137-35146.
42. Whaley-Connell AT, Morris EM, Rehmer N, et al. Albumin activation of NAD(P)H oxidase activity is mediated via Rac1 in proximal tubule cells. Am J Nephrol. 2007;27(1):15-23.