2-Aminotetraline derivative protects from ischemia/reperfusion brain injury with a broad therapeutic window

Neuropsychopharmacology

Volumn 32, Issue 6, 2007, Pages 1302-1311

  Capone, Carmen ^a   Fabrizi, Cinzia ^b   Piovesan, Paola ^c   Principato, Maria Cristina ^a   Marzorati, Patrizia ^a   Ghirardi, Orlando ^c   Fumagalli, Lorenzo ^b   Carminati, Paolo ^c   De Simoni, Maria Grazia ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c Sigma Tau SpA   (Italy)

Author keywords

5 HT2B; Inflammation; Ischemia; Microglia; Reperfusion; Serotonin

Indexed keywords

2 AMINOTETRALIN; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MESSENGER RNA; NEUROPROTECTIVE AGENT; PROTEIN BAX; PROTEIN BCL 2; SEROTONIN 2B RECEPTOR; SEROTONIN RECEPTOR; ST 1942; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CELL CULTURE; CONTROLLED STUDY; CORPUS STRIATUM; CYTOTOXICITY; DRUG EFFECT; GENE EXPRESSION; HIPPOCAMPUS; MACROPHAGE; MALE; MICROGLIA; MOUSE; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REPERFUSION INJURY; STATISTICAL SIGNIFICANCE;

AMPHETAMINES; ANIMALS; BEHAVIOR, ANIMAL; BRAIN DISEASES; CEREBROVASCULAR CIRCULATION; CHO CELLS; CRICETINAE; CRICETULUS; DNA, COMPLEMENTARY; IMMUNOHISTOCHEMISTRY; INFARCTION, MIDDLE CEREBRAL ARTERY; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C57BL; MICROGLIA; NERVE DEGENERATION; NEUROPROTECTIVE AGENTS; ORGANIC CHEMICALS; RECEPTOR, SEROTONIN, 5-HT2B; REPERFUSION INJURY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; TETRAHYDRONAPHTHALENES;

EID: 34249030993     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1301255     Document Type: Article

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