Th1/Th17 cell induction and corresponding reduction in ATP consumption following vaccination with the novel mycobacterium tuberculosis vaccine MVA85A

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  Griffiths, Kristin L ^a   Pathan, Ansar A ^a,b   Minassian, Angela M ^a   Sander, Clare R ^a   Beveridge, Natalie E R ^a   Hill, Adrian V S ^a   Fletcher, Helen A ^a   McShane, Helen ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b BRUNEL UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; BACTERIAL VACCINE; GAMMA INTERFERON; INTERLEUKIN 17; MODIFIED VACCINIA VIRUS ANKARA EXPRESSING ANTIGEN 85A VACCINE; MYCOBACTERIUM TUBERCULOSIS VACCINE; UNCLASSIFIED DRUG; APYRASE; BCG VACCINE; CD39 ANTIGEN; ENZYME INHIBITOR; LEUKOCYTE ANTIGEN; MVA 85A; VIRUS VACCINE;

ADULT; ANTIGEN DETECTION; ARTICLE; BCG VACCINATION; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; DRUG SAFETY; HUMAN; HUMAN EXPERIMENT; IMMUNOREGULATION; LUNG TUBERCULOSIS; NEUTROPHIL; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN METABOLISM; REGULATORY T LYMPHOCYTE; TH1 CELL; TH17 CELL; ADOLESCENT; ANIMAL; CATTLE; CELL COUNT; DRUG ANTAGONISM; DRUG EFFECT; IMMUNOLOGY; METABOLISM; MIDDLE AGED; MONONUCLEAR CELL; MOUSE; MYCOBACTERIUM TUBERCULOSIS; VACCINATION;

BACTERIA (MICROORGANISMS); BOVINAE; MURINAE; MYCOBACTERIUM TUBERCULOSIS; VACCINIA VIRUS ANKARA;

ADENOSINE TRIPHOSPHATE; ADOLESCENT; ADULT; ANIMALS; ANTIGENS, CD; APYRASE; CATTLE; CELL COUNT; ENZYME INHIBITORS; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-17; LEUKOCYTES, MONONUCLEAR; MICE; MIDDLE AGED; MYCOBACTERIUM TUBERCULOSIS; T-LYMPHOCYTES, REGULATORY; TH1 CELLS; TH17 CELLS; TUBERCULOSIS VACCINES; VACCINATION; VIRAL VACCINES; YOUNG ADULT;

EID: 80052059430     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0023463     Document Type: Article

References (35)

1. Churchyard GJ, Kleinschmidt I, Corbett EL, Mulder D, De Cock KM, (1999) Mycobacterial disease in South African gold miners in the era of HIV infection. Int J Tuberc Lung Dis 3: 791-798.
2. WHO (2010) Global Tuberculosis Control. World Health Organisation.
3. Dye C, Williams BG, (2010) The population dynamics and control of tuberculosis. Science 328: 856-861.
4. McShane H, Pathan AA, Sander CR, Goonetilleke NP, Fletcher HA, et al. (2005) Boosting BCG with MVA85A: the first candidate subunit vaccine for tuberculosis in clinical trials. Tuberculosis (Edinb) 85: 47-52.
5. McShane H, Pathan AA, Sander CR, Keating SM, Gilbert SC, et al. (2004) Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans. Nat Med 10: 1240-1244.
6. Sander CR, Pathan AA, Beveridge NE, Poulton I, Minassian A, et al. (2009) Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in Mycobacterium tuberculosis-infected individuals. Am J Respir Crit Care Med 179: 724-733.
7. Minassian A, Rowland R, Beveridge NE, Poulton I, Satti I, et al. (Under submission) MVA85A, a candidate TB vaccine, is safe and immunogenic in HIV-infected adults.
8. Brookes RH, Hill PC, Owiafe PK, Ibanga HB, Jeffries DJ, et al. (2008) Safety and immunogenicity of the candidate tuberculosis vaccine MVA85A in West Africa. PLoS One 3: e2921.
9. Fletcher HA, Pathan AA, Berthoud TK, Dunachie SJ, Whelan KT, et al. (2008) Boosting BCG vaccination with MVA85A down-regulates the immunoregulatory cytokine TGF-beta1. Vaccine 26: 5269-5275.
10. De Cassan S, Pathan A, Sander C, Minassian A, Hill AV, et al. (2010) Investigating the induction of vaccine induced Th17 and regulatory T cells in healthy, BCG immunised adults vaccinated with a new tuberculosis vaccine, MVA85A. Clin Vaccine Immunol 17: 1066-1073.
11. Robson SC, Sevigny J, Zimmermann H, (2006) The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance. Purinergic Signal 2: 409-430.
12. Dwyer KM, Hanidziar D, Putheti P, Hill PA, Pommey S, et al. (2010) Expression of CD39 by human peripheral blood CD4+ CD25+ T cells denotes a regulatory memory phenotype. Am J Transplant 10: 2410-2420.
13. Corriden R, Chen Y, Inoue Y, Beldi G, Robson SC, et al. (2008) Ecto-nucleoside triphosphate diphosphohydrolase 1 (E-NTPDase1/CD39) regulates neutrophil chemotaxis by hydrolyzing released ATP to adenosine. J Biol Chem 283: 28480-28486.
14. Pelegrin P, Surprenant A, (2006) Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor. EMBO J 25: 5071-5082.
15. Pelegrin P, Surprenant A, (2009) The P2X(7) receptor-pannexin connection to dye uptake and IL-1beta release. Purinergic Signal 5: 129-137.
16. Petrilli V, Papin S, Dostert C, Mayor A, Martinon F, et al. (2007) Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration. Cell Death Differ 14: 1583-1589.
17. Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F, (2007) Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol 8: 942-949.
18. Borsellino G, Kleinewietfeld M, Di Mitri D, Sternjak A, Diamantini A, et al. (2007) Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression. Blood 110: 1225-1232.
19. Fletcher JM, Lonergan R, Costelloe L, Kinsella K, Moran B, et al. (2009) CD39+Foxp3+ regulatory T Cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis. J Immunol 183: 7602-7610.
20. Altare F, Durandy A, Lammas D, Emile JF, Lamhamedi S, et al. (1998) Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency. Science 280: 1432-1435.
21. Khader SA, Bell GK, Pearl JE, Fountain JJ, Rangel-Moreno J, et al. (2007) IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat Immunol 8: 369-377.
22. Freches D, Romano M, Korf H, Renauld JC, Van Snick J, et al. (2011) Increased pulmonary TNF-{alpha}, IL-6 and IL-17A responses compensate for decreased IFN-{gamma} production in anti-IL-12 auto-vaccine treated, BCG vaccinated mice. Clin Vaccine Immunol 18: 95-104.
23. Babu S, Bhat SQ, Kumar NP, Kumaraswami V, Nutman TB, (2010) Regulatory T cells modulate Th17 responses in patients with positive tuberculin skin test results. J Infect Dis 201: 20-31.
24. Vordermeier HM, Villarreal-Ramos B, Cockle PJ, McAulay M, Rhodes SG, et al. (2009) Viral booster vaccines improve Mycobacterium bovis BCG-induced protection against bovine tuberculosis. Infect Immun 77: 3364-3373.
25. Scriba TJ, Tameris M, Mansoor N, Smit E, van der Merwe L, et al. (2010) Modified vaccinia Ankara-expressing Ag85A, a novel tuberculosis vaccine, is safe in adolescents and children, and induces polyfunctional CD4+ T cells. Eur J Immunol 40: 279-290.
26. Beveridge NE, Fletcher HA, Hughes J, Pathan AA, Scriba TJ, et al. (2008) A comparison of IFNgamma detection methods used in tuberculosis vaccine trials. Tuberculosis (Edinb) 88: 631-640.
27. Rovedatti L, Kudo T, Biancheri P, Sarra M, Knowles CH, et al. (2009) Differential regulation of interleukin 17 and interferon gamma production in inflammatory bowel disease. Gut 58: 1629-1636.
28. Acosta-Rodriguez EV, Rivino L, Geginat J, Jarrossay D, Gattorno M, et al. (2007) Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat Immunol 8: 639-646.
29. Atarashi K, Nishimura J, Shima T, Umesaki Y, Yamamoto M, et al. (2008) ATP drives lamina propria T(H)17 cell differentiation. Nature 455: 808-812.
30. Pelegrin P, Barroso-Gutierrez C, Surprenant A, (2008) P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage. J Immunol 180: 7147-7157.
31. Deaglio S, Dwyer KM, Gao W, Friedman D, Usheva A, et al. (2007) Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med 204: 1257-1265.
32. Delaloye J, Roger T, Steiner-Tardivel QG, Le Roy D, Knaup Reymond M, et al. (2009) Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome. PLoS Pathog 5: e1000480.
33. Okamoto Yoshida Y, Umemura M, Yahagi A, O'Brien RL, Ikuta K, et al. (2010) Essential role of IL-17A in the formation of a mycobacterial infection-induced granuloma in the lung. J Immunol 184: 4414-4422.
34. Cruz A, Fraga AG, Fountain JJ, Rangel-Moreno J, Torrado E, et al. (2010) Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis. J Exp Med 207: 1609-1616.
35. Torrado E, Cooper AM, (2010) IL-17 and Th17 cells in tuberculosis. Cytokine Growth Factor Rev 21: 455-462.