메뉴 건너뛰기




Volumn 2, Issue 3, 2011, Pages 113-121

The challenge for gene therapy: Innate immune response to adenoviruses

Author keywords

Adenovirus; Innate immune response; Interferon; Interleukin 1

Indexed keywords

ADENOVIRUS VECTOR; ALPHA INTERFERON; INTERFERON; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR;

EID: 80052057856     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.231     Document Type: Review
Times cited : (71)

References (75)
  • 1
    • 33747182585 scopus 로고    scopus 로고
    • Typing of human adenoviruses in specimens from immunosuppressed patients by PCR-fragment length analysis and real-time quantitative PCR
    • Ebner K, Rauch M, Preuner S, Lion T. Typing of human adenoviruses in specimens from immunosuppressed patients by PCR-fragment length analysis and real-time quantitative PCR. J Clin Microbiol 2006; 44: 2808-15.
    • (2006) J Clin Microbiol , vol.44 , pp. 2808-2815
    • Ebner, K.1    Rauch, M.2    Preuner, S.3    Lion, T.4
  • 2
    • 29744470594 scopus 로고    scopus 로고
    • Phylogenetic analysis of the main neutralization and hemagglutination determinants of all human adenovirus prototypes as a basis for molecular classification and taxonomy
    • Madisch I, Harste G, Pommer H, Heim A. Phylogenetic analysis of the main neutralization and hemagglutination determinants of all human adenovirus prototypes as a basis for molecular classification and taxonomy. J Virol 2005; 79: 15265-76.
    • (2005) J Virol , vol.79 , pp. 15265-15276
    • Madisch, I.1    Harste, G.2    Pommer, H.3    Heim, A.4
  • 4
    • 0142089747 scopus 로고    scopus 로고
    • Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer
    • Raper SE, Chirmule N, Lee FS, Wivel NA, Bagg A, Gao GP, Wilson JM, Batshaw ML. Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer. Mol Genet Metab 2003; 80: 148-58.
    • (2003) Mol Genet Metab , vol.80 , pp. 148-158
    • Raper, S.E.1    Chirmule, N.2    Lee, F.S.3    Wivel, N.A.4    Bagg, A.5    Gao, G.P.6    Wilson, J.M.7    Batshaw, M.L.8
  • 5
    • 59349114095 scopus 로고    scopus 로고
    • Insights into adenovirus host cell interactions from structural studies
    • Nemerow GR, Pache L, Reddy V, Stewart PL. Insights into adenovirus host cell interactions from structural studies. Virology 2009; 384: 380-8.
    • (2009) Virology , vol.384 , pp. 380-388
    • Nemerow, G.R.1    Pache, L.2    Reddy, V.3    Stewart, P.L.4
  • 6
    • 9244257887 scopus 로고    scopus 로고
    • Biology of adenovirus and its use as a vector for gene therapy
    • McConnell MJ, Imperiale MJ. Biology of adenovirus and its use as a vector for gene therapy. Hum Gene Ther 2004; 15: 1022-33.
    • (2004) Hum Gene Ther , vol.15 , pp. 1022-1033
    • McConnell, M.J.1    Imperiale, M.J.2
  • 8
    • 0345708273 scopus 로고    scopus 로고
    • CD46 is a cellular receptor for group B adenoviruses
    • Gaggar A, Shayakhmetov DM, Lieber A. CD46 is a cellular receptor for group B adenoviruses. Nat Med 2003; 9: 1408-12.
    • (2003) Nat Med , vol.9 , pp. 1408-1412
    • Gaggar, A.1    Shayakhmetov, D.M.2    Lieber, A.3
  • 9
    • 0027166647 scopus 로고
    • Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment
    • Wickham TJ, Mathias P, Cheresh DA, Nemerow GR. Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment. Cell 1993; 73: 309-19.
    • (1993) Cell , vol.73 , pp. 309-319
    • Wickham, T.J.1    Mathias, P.2    Cheresh, D.A.3    Nemerow, G.R.4
  • 10
    • 0035195085 scopus 로고    scopus 로고
    • Import of adenovirus DNA involves the nuclear pore complex receptor CAN/Nup214 and histone H1
    • Trotman LC, Mosberger N, Fornerod M, Stidwill RP, Greber UF. Import of adenovirus DNA involves the nuclear pore complex receptor CAN/Nup214 and histone H1. Nat Cell Biol 2001; 3: 1092-100.
    • (2001) Nat Cell Biol , vol.3 , pp. 1092-1100
    • Trotman, L.C.1    Mosberger, N.2    Fornerod, M.3    Stidwill, R.P.4    Greber, U.F.5
  • 11
    • 0033593811 scopus 로고    scopus 로고
    • Microtubule-dependent plus- and minus end-directed motilities are competing processes for nuclear targeting of adenovirus
    • Suomalainen M, Nakano MY, Keller S, Boucke K, Stidwill RP, Greber UF. Microtubule-dependent plus- and minus end-directed motilities are competing processes for nuclear targeting of adenovirus. J Cell Biol 1999; 144: 657-72.
    • (1999) J Cell Biol , vol.144 , pp. 657-672
    • Suomalainen, M.1    Nakano, M.Y.2    Keller, S.3    Boucke, K.4    Stidwill, R.P.5    Greber, U.F.6
  • 14
    • 18944374760 scopus 로고    scopus 로고
    • Interference with the IL-1-signaling pathway improves the toxicity profile of systemically applied adenovirus vectors
    • Shayakhmetov DM, Li ZY, Ni S, Lieber A. Interference with the IL-1-signaling pathway improves the toxicity profile of systemically applied adenovirus vectors. J Immunol 2005; 174: 7310-9.
    • (2005) J Immunol , vol.174 , pp. 7310-7319
    • Shayakhmetov, D.M.1    Li, Z.Y.2    Ni, S.3    Lieber, A.4
  • 15
    • 78049339834 scopus 로고    scopus 로고
    • MAPK signalling in cellular metabolism: stress or wellness?
    • Gehart H, Kumpf S, Ittner A, Ricci R. MAPK signalling in cellular metabolism: stress or wellness? EMBO Rep; 11: 834-40.
    • EMBO Rep; , vol.11 , pp. 834-840
    • Gehart, H.1    Kumpf, S.2    Ittner, A.3    Ricci, R.4
  • 16
    • 33750682048 scopus 로고    scopus 로고
    • Interaction of adenovirus type 5 fiber with the coxsackievirus and adenovirus receptor activates inflammatory response in human respiratory cells
    • Tamanini A, Nicolis E, Bonizzato A, Bezzerri V, Melotti P, Assael BM, Cabrini G. Interaction of adenovirus type 5 fiber with the coxsackievirus and adenovirus receptor activates inflammatory response in human respiratory cells. J Virol 2006; 80: 11241-54.
    • (2006) J Virol , vol.80 , pp. 11241-11254
    • Tamanini, A.1    Nicolis, E.2    Bonizzato, A.3    Bezzerri, V.4    Melotti, P.5    Assael, B.M.6    Cabrini, G.7
  • 17
    • 77956280280 scopus 로고    scopus 로고
    • The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K
    • Verdino P, Witherden DA, Havran WL, Wilson IA. The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K. Science 2010; 329: 1210-4.
    • (2010) Science , vol.329 , pp. 1210-1214
    • Verdino, P.1    Witherden, D.A.2    Havran, W.L.3    Wilson, I.A.4
  • 18
    • 1942533432 scopus 로고    scopus 로고
    • Adenovirus-induced maturation of dendritic cells through a PI3 kinase-mediated TNF-alpha induction pathway
    • Philpott NJ, Nociari M, Elkon KB, Falck-Pedersen E. Adenovirus-induced maturation of dendritic cells through a PI3 kinase-mediated TNF-alpha induction pathway. Proc Natl Acad Sci U S A 2004; 101: 6200-5.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 6200-6205
    • Philpott, N.J.1    Nociari, M.2    Elkon, K.B.3    Falck-Pedersen, E.4
  • 19
    • 0037790710 scopus 로고    scopus 로고
    • Molecular basis of the inflammatory response to adenovirus vectors
    • Liu Q, Muruve DA. Molecular basis of the inflammatory response to adenovirus vectors. Gene Ther 2003; 10: 935-40.
    • (2003) Gene Ther , vol.10 , pp. 935-940
    • Liu, Q.1    Muruve, D.A.2
  • 20
    • 34447505084 scopus 로고    scopus 로고
    • Toll-like receptors and Type I interferons
    • Uematsu S, Akira S. Toll-like receptors and Type I interferons. J Biol Chem 2007; 282: 15319-23.
    • (2007) J Biol Chem , vol.282 , pp. 15319-15323
    • Uematsu, S.1    Akira, S.2
  • 22
    • 0036671894 scopus 로고    scopus 로고
    • The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
    • Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 2002; 10: 417-26.
    • (2002) Mol Cell , vol.10 , pp. 417-426
    • Martinon, F.1    Burns, K.2    Tschopp, J.3
  • 23
    • 0031739525 scopus 로고    scopus 로고
    • Interleukin-1 beta, interleukin-18, and the interleukin-1 beta converting enzyme
    • Dinarello CA. Interleukin-1 beta, interleukin-18, and the interleukin-1 beta converting enzyme. Ann N Y Acad Sci 1998; 856: 1-11.
    • (1998) Ann N Y Acad Sci , vol.856 , pp. 1-11
    • Dinarello, C.A.1
  • 25
    • 0034163312 scopus 로고    scopus 로고
    • IL-12-independent Th1-type immune responses to respiratory viral infection: requirement of IL-18 for IFN-gamma release in the lung but not for the differentiation of viralreactive Th1-type lymphocytes
    • Xing Z, Zganiacz A, Wang J, Divangahi M, Nawaz F. IL-12-independent Th1-type immune responses to respiratory viral infection: requirement of IL-18 for IFN-gamma release in the lung but not for the differentiation of viralreactive Th1-type lymphocytes. J Immunol 2000; 164: 2575-84.
    • (2000) J Immunol , vol.164 , pp. 2575-2584
    • Xing, Z.1    Zganiacz, A.2    Wang, J.3    Divangahi, M.4    Nawaz, F.5
  • 26
    • 0034988813 scopus 로고    scopus 로고
    • Adenovirus type 7 induces interleukin-8 production via activation of extracellular regulated kinase 1/2
    • Alcorn MJ, Booth JL, Coggeshall KM, Metcalf JP. Adenovirus type 7 induces interleukin-8 production via activation of extracellular regulated kinase 1/2. J Virol 2001; 75: 6450-9.
    • (2001) J Virol , vol.75 , pp. 6450-6459
    • Alcorn, M.J.1    Booth, J.L.2    Coggeshall, K.M.3    Metcalf, J.P.4
  • 27
    • 70349682279 scopus 로고    scopus 로고
    • Chemokine CXCL1/ KC and its receptor CXCR2 are responsible for neutrophil chemotaxis in adenoviral keratitis
    • Chintakuntlawar AV, Chodosh J. Chemokine CXCL1/ KC and its receptor CXCR2 are responsible for neutrophil chemotaxis in adenoviral keratitis. J Interferon Cytokine Res 2009; 29: 657-66.
    • (2009) J Interferon Cytokine Res , vol.29 , pp. 657-666
    • Chintakuntlawar, A.V.1    Chodosh, J.2
  • 28
    • 0033541522 scopus 로고    scopus 로고
    • Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivo
    • Muruve DA, Barnes MJ, Stillman IE, Libermann TA. Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivo. Hum Gene Ther 1999; 10: 965-76.
    • (1999) Hum Gene Ther , vol.10 , pp. 965-976
    • Muruve, D.A.1    Barnes, M.J.2    Stillman, I.E.3    Libermann, T.A.4
  • 29
    • 0036227449 scopus 로고    scopus 로고
    • Differential activation of innate immune responses by adenovirus and adeno-associated virus vectors
    • Zaiss AK, Liu Q, Bowen GP, Wong NC, Bartlett JS, Muruve DA. Differential activation of innate immune responses by adenovirus and adeno-associated virus vectors. J Virol 2002; 76: 4580-90.
    • (2002) J Virol , vol.76 , pp. 4580-4590
    • Zaiss, A.K.1    Liu, Q.2    Bowen, G.P.3    Wong, N.C.4    Bartlett, J.S.5    Muruve, D.A.6
  • 31
    • 33645095181 scopus 로고    scopus 로고
    • Interleukin-23-expressing bone marrow-derived neural stem-like cells exhibit antitumor activity against intracranial glioma
    • Yuan X, Hu J, Belladonna ML, Black KL, Yu JS. Interleukin-23-expressing bone marrow-derived neural stem-like cells exhibit antitumor activity against intracranial glioma. Cancer Res 2006; 66: 2630-8.
    • (2006) Cancer Res , vol.66 , pp. 2630-2638
    • Yuan, X.1    Hu, J.2    Belladonna, M.L.3    Black, K.L.4    Yu, J.S.5
  • 33
  • 35
    • 0030831210 scopus 로고    scopus 로고
    • A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    • Medzhitov R, Preston-Hurlburt P, Janeway CA, Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997; 388: 394-7.
    • (1997) Nature , vol.388 , pp. 394-397
    • Medzhitov, R.1    Preston-Hurlburt, P.2    Janeway Jr, C.A.3
  • 36
    • 12444341944 scopus 로고    scopus 로고
    • Toll-like receptors in innate immunity
    • Takeda K, Akira S. Toll-like receptors in innate immunity. Int Immunol 2005; 17: 1-14.
    • (2005) Int Immunol , vol.17 , pp. 1-14
    • Takeda, K.1    Akira, S.2
  • 37
    • 33947396347 scopus 로고    scopus 로고
    • Innate immune response to adenoviral vectors is mediated by both Toll-like receptordependent and -independent pathways
    • Zhu J, Huang X, Yang Y. Innate immune response to adenoviral vectors is mediated by both Toll-like receptordependent and -independent pathways. J Virol 2007; 81: 3170-80.
    • (2007) J Virol , vol.81 , pp. 3170-3180
    • Zhu, J.1    Huang, X.2    Yang, Y.3
  • 40
    • 77956044074 scopus 로고    scopus 로고
    • Varicella-zoster virus immediate-early protein 62 blocks interferon regulatory factor 3 (IRF3) phosphorylation at key serine residues: a novel mechanism of IRF3 inhibition among herpesviruses
    • Sen N, Sommer M, Che X, White K, Ruyechan WT, Arvin AM. Varicella-zoster virus immediate-early protein 62 blocks interferon regulatory factor 3 (IRF3) phosphorylation at key serine residues: a novel mechanism of IRF3 inhibition among herpesviruses. J Virol 2010; 84: 9240-53.
    • (2010) J Virol , vol.84 , pp. 9240-9253
    • Sen, N.1    Sommer, M.2    Che, X.3    White, K.4    Ruyechan, W.T.5    Arvin, A.M.6
  • 41
    • 46249115827 scopus 로고    scopus 로고
    • Interferon-inducible antiviral effectors
    • Sadler AJ, Williams BR. Interferon-inducible antiviral effectors. Nat Rev Immunol 2008; 8: 559-68.
    • (2008) Nat Rev Immunol , vol.8 , pp. 559-568
    • Sadler, A.J.1    Williams, B.R.2
  • 42
    • 36749029351 scopus 로고    scopus 로고
    • Inhibition of Jak1-dependent signal transduction in airway epithelial cells infected with adenovirus
    • Shi L, Ramaswamy M, Manzel LJ, Look DC. Inhibition of Jak1-dependent signal transduction in airway epithelial cells infected with adenovirus. Am J Respir Cell Mol Biol 2007; 37: 720-8.
    • (2007) Am J Respir Cell Mol Biol , vol.37 , pp. 720-728
    • Shi, L.1    Ramaswamy, M.2    Manzel, L.J.3    Look, D.C.4
  • 43
    • 0022447264 scopus 로고
    • Adenovirus VAI RNA antagonizes the antiviral action of interferon by preventing activation of the interferon-induced eIF-2 alpha kinase
    • Kitajewski J, Schneider RJ, Safer B, Munemitsu SM, Samuel CE, Thimmappaya B, Shenk T. Adenovirus VAI RNA antagonizes the antiviral action of interferon by preventing activation of the interferon-induced eIF-2 alpha kinase. Cell 1986; 45: 195-200.
    • (1986) Cell , vol.45 , pp. 195-200
    • Kitajewski, J.1    Schneider, R.J.2    Safer, B.3    Munemitsu, S.M.4    Samuel, C.E.5    Thimmappaya, B.6    Shenk, T.7
  • 44
    • 0033514947 scopus 로고    scopus 로고
    • Interferon-induced human MxA GTPase blocks nuclear import of Thogoto virus nucleocapsids
    • Kochs G, Haller O. Interferon-induced human MxA GTPase blocks nuclear import of Thogoto virus nucleocapsids. Proc Natl Acad Sci U S A 1999; 96: 2082-6.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 2082-2086
    • Kochs, G.1    Haller, O.2
  • 45
    • 66149151694 scopus 로고    scopus 로고
    • Adenovirus induction of IRF3 occurs through a binary trigger targeting Jun N-terminal kinase and TBK1 kinase cascades and type I interferon autocrine signaling
    • Nociari M, Ocheretina O, Murphy M, Falck-Pedersen E. Adenovirus induction of IRF3 occurs through a binary trigger targeting Jun N-terminal kinase and TBK1 kinase cascades and type I interferon autocrine signaling. J Virol 2009; 83: 4081-91.
    • (2009) J Virol , vol.83 , pp. 4081-4091
    • Nociari, M.1    Ocheretina, O.2    Murphy, M.3    Falck-Pedersen, E.4
  • 46
    • 45749110171 scopus 로고    scopus 로고
    • A critical role for type I IFNdependent NK cell activation in innate immune elimination of adenoviral vectors in vivo
    • Zhu J, Huang X, Yang Y. A critical role for type I IFNdependent NK cell activation in innate immune elimination of adenoviral vectors in vivo. Mol Ther 2008; 16: 1300-7.
    • (2008) Mol Ther , vol.16 , pp. 1300-1307
    • Zhu, J.1    Huang, X.2    Yang, Y.3
  • 47
    • 17844402009 scopus 로고    scopus 로고
    • Induction and inhibition of innate inflammatory responses by adenovirus early region proteins
    • Schaack J. Induction and inhibition of innate inflammatory responses by adenovirus early region proteins. Viral Immunol 2005; 18: 79-88.
    • (2005) Viral Immunol , vol.18 , pp. 79-88
    • Schaack, J.1
  • 49
    • 0028246338 scopus 로고
    • Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver
    • Engelhardt JF, Ye X, Doranz B, Wilson JM. Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver. Proc Natl Acad Sci U S A 1994; 91: 6196-200.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 6196-6200
    • Engelhardt, J.F.1    Ye, X.2    Doranz, B.3    Wilson, J.M.4
  • 50
    • 0023106727 scopus 로고
    • Adenovirus early region 1A modulation of interferon antiviral activity
    • Anderson KP, Fennie EH. Adenovirus early region 1A modulation of interferon antiviral activity. J Virol 1987; 61: 787-95.
    • (1987) J Virol , vol.61 , pp. 787-795
    • Anderson, K.P.1    Fennie, E.H.2
  • 51
    • 0025874550 scopus 로고
    • Inhibition of interferon-inducible gene expression by adenovirus E1A proteins: block in transcriptional complex formation
    • Kalvakolanu DV, Bandyopadhyay SK, Harter ML, Sen GC. Inhibition of interferon-inducible gene expression by adenovirus E1A proteins: block in transcriptional complex formation. Proc Natl Acad Sci U S A 1991; 88: 7459-63.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 7459-7463
    • Kalvakolanu, D.V.1    Bandyopadhyay, S.K.2    Harter, M.L.3    Sen, G.C.4
  • 52
    • 27944462290 scopus 로고    scopus 로고
    • Inactivating intracellular antiviral responses during adenovirus infection
    • Weitzman MD, Ornelles DA. Inactivating intracellular antiviral responses during adenovirus infection. Oncogene 2005; 24: 7686-96.
    • (2005) Oncogene , vol.24 , pp. 7686-7696
    • Weitzman, M.D.1    Ornelles, D.A.2
  • 53
    • 0030988482 scopus 로고    scopus 로고
    • Insertion of the adenoviral E3 region into a recombinant viral vector prevents antiviral humoral and cellular immune responses and permits long-term gene expression
    • Ilan Y, Droguett G, Chowdhury NR, Li Y, Sengupta K, Thummala NR, Davidson A, Chowdhury JR, Horwitz MS. Insertion of the adenoviral E3 region into a recombinant viral vector prevents antiviral humoral and cellular immune responses and permits long-term gene expression. Proc Natl Acad Sci U S A 1997; 94: 2587-92.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 2587-2592
    • Ilan, Y.1    Droguett, G.2    Chowdhury, N.R.3    Li, Y.4    Sengupta, K.5    Thummala, N.R.6    Davidson, A.7    Chowdhury, J.R.8    Horwitz, M.S.9
  • 54
    • 33645060190 scopus 로고    scopus 로고
    • A novel mechanism of nuclear factor-kappaB regulation by adenoviral protein 14
    • Carmody RJ, Maguschak K, Chen YH. A novel mechanism of nuclear factor-kappaB regulation by adenoviral protein 14.7K. Immunology 2006; 117: 188-95.
    • (2006) 7K. Immunology , vol.117 , pp. 188-195
    • Carmody, R.J.1    Maguschak, K.2    Chen, Y.H.3
  • 56
    • 0027538121 scopus 로고
    • Retrieval of transmembrane proteins to the endoplasmic reticulum
    • Jackson MR, Nilsson T, Peterson PA. Retrieval of transmembrane proteins to the endoplasmic reticulum. J Cell Biol 1993; 121: 317-33.
    • (1993) J Cell Biol , vol.121 , pp. 317-333
    • Jackson, M.R.1    Nilsson, T.2    Peterson, P.A.3
  • 57
    • 0024331809 scopus 로고
    • The adenovirus E1B 19-kilodalton protein stimulates gene expression by increasing DNA levels
    • Herrmann CH, Mathews MB. The adenovirus E1B 19-kilodalton protein stimulates gene expression by increasing DNA levels. Mol Cell Biol 1989; 9: 5412-23.
    • (1989) Mol Cell Biol , vol.9 , pp. 5412-5423
    • Herrmann, C.H.1    Mathews, M.B.2
  • 58
    • 54749109597 scopus 로고    scopus 로고
    • Immunosuppression enhances oncolytic adenovirus replication and antitumor efficacy in the Syrian hamster model
    • Thomas MA, Spencer JF, Toth K, Sagartz JE, Phillips NJ, Wold WS. Immunosuppression enhances oncolytic adenovirus replication and antitumor efficacy in the Syrian hamster model. Mol Ther 2008; 16: 1665-73.
    • (2008) Mol Ther , vol.16 , pp. 1665-1673
    • Thomas, M.A.1    Spencer, J.F.2    Toth, K.3    Sagartz, J.E.4    Phillips, N.J.5    Wold, W.S.6
  • 59
    • 6544263753 scopus 로고    scopus 로고
    • Transient cyclophosphamide treatment before intraportal readministration of an adenoviral vector can induce re-expression of the original gene construct in rat liver
    • Kuriyama S, Tominaga K, Kikukawa M, Tsujimoto T, Nakatani T, Tsujinoue H, Okuda H, Nagao S, Mitoro A, Yoshiji H, Fukui H. Transient cyclophosphamide treatment before intraportal readministration of an adenoviral vector can induce re-expression of the original gene construct in rat liver. Gene Ther 1999; 6: 749-57.
    • (1999) Gene Ther , vol.6 , pp. 749-757
    • Kuriyama, S.1    Tominaga, K.2    Kikukawa, M.3    Tsujimoto, T.4    Nakatani, T.5    Tsujinoue, H.6    Okuda, H.7    Nagao, S.8    Mitoro, A.9    Yoshiji, H.10    Fukui, H.11
  • 60
    • 0034830243 scopus 로고    scopus 로고
    • CAR-binding ablation does not change biodistribution and toxicity of adenoviral vectors
    • Alemany R, Curiel DT. CAR-binding ablation does not change biodistribution and toxicity of adenoviral vectors. Gene Ther 2001; 8: 1347-53.
    • (2001) Gene Ther , vol.8 , pp. 1347-1353
    • Alemany, R.1    Curiel, D.T.2
  • 61
    • 18944396179 scopus 로고    scopus 로고
    • Adenovirus binding to blood factors results in liver cell infection and hepatotoxicity
    • Shayakhmetov DM, Gaggar A, Ni S, Li ZY, Lieber A. Adenovirus binding to blood factors results in liver cell infection and hepatotoxicity. J Virol 2005; 79: 7478-91.
    • (2005) J Virol , vol.79 , pp. 7478-7491
    • Shayakhmetov, D.M.1    Gaggar, A.2    Ni, S.3    Li, Z.Y.4    Lieber, A.5
  • 64
    • 73849140058 scopus 로고    scopus 로고
    • Expanded anticancer therapeutic window of hexon-modified oncolytic adenovirus
    • Shashkova EV, May SM, Doronin K, Barry MA. Expanded anticancer therapeutic window of hexon-modified oncolytic adenovirus. Mol Ther 2009; 17: 2121-30.
    • (2009) Mol Ther , vol.17 , pp. 2121-2130
    • Shashkova, E.V.1    May, S.M.2    Doronin, K.3    Barry, M.A.4
  • 65
    • 77956585904 scopus 로고    scopus 로고
    • Substitution of adenovirus serotype 3 hexon onto a serotype 5 oncolytic adenovirus reduces factor X binding, decreases liver tropism, and improves antitumor efficacy
    • Short JJ, Rivera AA, Wu H, Walter MR, Yamamoto M, Mathis JM, Curiel DT. Substitution of adenovirus serotype 3 hexon onto a serotype 5 oncolytic adenovirus reduces factor X binding, decreases liver tropism, and improves antitumor efficacy. Mol Cancer Ther 2010; 9: 2536-44.
    • (2010) Mol Cancer Ther , vol.9 , pp. 2536-2544
    • Short, J.J.1    Rivera, A.A.2    Wu, H.3    Walter, M.R.4    Yamamoto, M.5    Mathis, J.M.6    Curiel, D.T.7
  • 66
    • 68949215573 scopus 로고    scopus 로고
    • Adenovirus type 5 with modified hexons induces robust transgene-specific immune responses in mice with pre-existing immunity against adenovirus type 5
    • Abe S, Okuda K, Ura T, Kondo A, Yoshida A, Yoshizaki S, Mizuguchi H, Klinman D, Shimada M. Adenovirus type 5 with modified hexons induces robust transgene-specific immune responses in mice with pre-existing immunity against adenovirus type 5. J Gene Med 2009; 11: 570-9.
    • (2009) J Gene Med , vol.11 , pp. 570-579
    • Abe, S.1    Okuda, K.2    Ura, T.3    Kondo, A.4    Yoshida, A.5    Yoshizaki, S.6    Mizuguchi, H.7    Klinman, D.8    Shimada, M.9
  • 67
    • 37549008707 scopus 로고    scopus 로고
    • Modification of adenovirus gene transfer vectors with synthetic polymers: a scientific review and technical guide
    • Kreppel F, Kochanek S. Modification of adenovirus gene transfer vectors with synthetic polymers: a scientific review and technical guide. Mol Ther 2008; 16: 16-29.
    • (2008) Mol Ther , vol.16 , pp. 16-29
    • Kreppel, F.1    Kochanek, S.2
  • 68
    • 68649104639 scopus 로고    scopus 로고
    • Chemical modification with high molecular weight polyethylene glycol reduces transduction of hepatocytes and increases efficacy of intravenously delivered oncolytic adenovirus
    • Doronin K, Shashkova EV, May SM, Hofherr SE, Barry MA. Chemical modification with high molecular weight polyethylene glycol reduces transduction of hepatocytes and increases efficacy of intravenously delivered oncolytic adenovirus. Hum Gene Ther 2009; 20: 975-88.
    • (2009) Hum Gene Ther , vol.20 , pp. 975-988
    • Doronin, K.1    Shashkova, E.V.2    May, S.M.3    Hofherr, S.E.4    Barry, M.A.5
  • 69
    • 73849099821 scopus 로고    scopus 로고
    • Systemic administration of a PEGylated adenovirus vector with a cancer-specific promoter is effective in a mouse model of metastasis
    • Yao X, Yoshioka Y, Morishige T, Eto Y, Watanabe H, Okada Y, Mizuguchi H, Mukai Y, Okada N, Nakagawa S. Systemic administration of a PEGylated adenovirus vector with a cancer-specific promoter is effective in a mouse model of metastasis. Gene Ther 2009; 16: 1395-404.
    • (2009) Gene Ther , vol.16 , pp. 1395-1404
    • Yao, X.1    Yoshioka, Y.2    Morishige, T.3    Eto, Y.4    Watanabe, H.5    Okada, Y.6    Mizuguchi, H.7    Mukai, Y.8    Okada, N.9    Nakagawa, S.10
  • 70
    • 77957608988 scopus 로고    scopus 로고
    • Optimized PEGylated adenovirus vector reduces the anti-vector humoral immune response against adenovirus and induces a therapeutic effect against metastatic lung cancer
    • Eto Y, Yoshioka Y, Ishida T, Yao X, Morishige T, Narimatsu S, Mizuguchi H, Mukai Y, Okada N, Kiwada H, Nakagawa S. Optimized PEGylated adenovirus vector reduces the anti-vector humoral immune response against adenovirus and induces a therapeutic effect against metastatic lung cancer. Biol Pharm Bull 2010; 33: 1540-4.
    • (2010) Biol Pharm Bull , vol.33 , pp. 1540-1544
    • Eto, Y.1    Yoshioka, Y.2    Ishida, T.3    Yao, X.4    Morishige, T.5    Narimatsu, S.6    Mizuguchi, H.7    Mukai, Y.8    Okada, N.9    Kiwada, H.10    Nakagawa, S.11
  • 71
    • 10944247251 scopus 로고    scopus 로고
    • Evaluation of polyethylene glycol modification of first-generation and helper-dependent adenoviral vectors to reduce innate immune responses
    • Mok H, Palmer DJ, Ng P, Barry MA. Evaluation of polyethylene glycol modification of first-generation and helper-dependent adenoviral vectors to reduce innate immune responses. Mol Ther 2005; 11: 66-79.
    • (2005) Mol Ther , vol.11 , pp. 66-79
    • Mok, H.1    Palmer, D.J.2    Ng, P.3    Barry, M.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.