-
1
-
-
79955413493
-
Neuroprotective effects of a novel water-soluble poly(ADP-ribose) polymerase-1 inhibitor, MP-124, in in vitro and in vivo models of cerebral ischemia
-
Y. Egi, S. Matsuura, T. Maruyama, M. Fujio, S. Yuki, and T. Akira Neuroprotective effects of a novel water-soluble poly(ADP-ribose) polymerase-1 inhibitor, MP-124, in in vitro and in vivo models of cerebral ischemia Brain Res 1389 2011 169 176
-
(2011)
Brain Res
, vol.1389
, pp. 169-176
-
-
Egi, Y.1
Matsuura, S.2
Maruyama, T.3
Fujio, M.4
Yuki, S.5
Akira, T.6
-
2
-
-
0030842946
-
Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia
-
DOI 10.1038/nm1097-1089
-
M.J. Eliasson, K. Sampei, A.S. Mandir, P.D. Hurn, R.J. Traystman, J. Bao, A. Pieper, Z.Q. Wang, T.M. Dawson, S.H. Snyder, and V.L. Dawson Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia Nat Med 3 10 1997 1089 1095 (Pubitemid 27444449)
-
(1997)
Nature Medicine
, vol.3
, Issue.10
, pp. 1089-1095
-
-
Eliasson, M.J.L.1
Sampei, K.2
Mandir, A.S.3
Hurn, P.D.4
Traystman, R.J.5
Bao, J.6
Pieper, A.7
Wang, Z.-Q.8
Dawson, T.M.9
Snyder, S.H.10
Dawson, V.L.11
-
3
-
-
0030832874
-
Ischemic brain injury is mediated by the activation of poly(ADP- ribose)polymerase
-
M. Endres, Z.Q. Wang, S. Namura, C. Waeber, and M.A. Moskowitz Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase J Cereb Blood Flow Metab 17 11 1997 1143 1151 (Pubitemid 27514738)
-
(1997)
Journal of Cerebral Blood Flow and Metabolism
, vol.17
, Issue.11
, pp. 1143-1151
-
-
Endres, M.1
Wang, Z.-Q.2
Namura, S.3
Waeber, C.4
Moskowitz, M.A.5
-
4
-
-
77953764486
-
Evolution of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. from concept to clinic
-
D.V. Ferraris Evolution of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. From concept to clinic J Med Chem 53 12 2010 4561 4584
-
(2010)
J Med Chem
, vol.53
, Issue.12
, pp. 4561-4584
-
-
Ferraris, D.V.1
-
5
-
-
66849097996
-
Update of the stroke therapy academic industry roundtable preclinical recommendations
-
M. Fisher, G. Feuerstein, D.W. Howells, P.D. Hurn, T.A. Kent, S.I. Savitz, and E.H. Lo Update of the stroke therapy academic industry roundtable preclinical recommendations Stroke 40 6 2009 2244 2250
-
(2009)
Stroke
, vol.40
, Issue.6
, pp. 2244-2250
-
-
Fisher, M.1
Feuerstein, G.2
Howells, D.W.3
Hurn, P.D.4
Kent, T.A.5
Savitz, S.I.6
Lo, E.H.7
-
6
-
-
19444362951
-
Clinical perspectives of PARP inhibitors
-
DOI 10.1016/j.phrs.2005.02.013, PII S1043661805000460
-
G. Graziani, and C. Szabo Clinical perspectives of PARP inhibitors Pharmacol. Res. 52 1 2005 109 118 (Pubitemid 40725605)
-
(2005)
Pharmacological Research
, vol.52
, Issue.SPEC. ISS. 1
, pp. 109-118
-
-
Graziani, G.1
Szabo, C.2
-
7
-
-
0035154631
-
NXY-059, a free radical-trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species
-
J.W. Marshall, K.J. Duffin, A.R. Green, and R.M. Ridley NXY-059, a free radical-trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species Stroke 32 1 2001 190 198 (Pubitemid 32063845)
-
(2001)
Stroke
, vol.32
, Issue.1
, pp. 190-198
-
-
Marshall, J.W.B.1
Duffin, K.J.2
Green, A.R.3
Ridley, R.M.4
-
8
-
-
0042919342
-
Functional and histological evidence for the protective effect of NXY-059 in a primate model of stroke when given 4 hours after occlusion
-
DOI 10.1161/01.STR.0000087790.79851.A8
-
J.W. Marshall, R.M. Cummings, L.J. Bowes, R.M. Ridley, and A.R. Green Functional and histological evidence for the protective effect of NXY-059 in a primate model of stroke when given 4 hours after occlusion Stroke 34 9 2003 2228 2233 (Pubitemid 37099841)
-
(2003)
Stroke
, vol.34
, Issue.9
, pp. 2228-2233
-
-
Marshall, J.W.B.1
Cummings, R.M.2
Bowes, L.J.3
Ridley, R.M.4
Green, A.R.5
-
9
-
-
80052034516
-
MP-124, a novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor, ameliorates the ischemic brain damage in non-human primate model
-
Matsuura, S., Egi, Y., Yuki, S., Satoh, H., Akira, T., in press. MP-124, a novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor, ameliorates the ischemic brain damage in non-human primate model. Brain Res.
-
Brain Res
-
-
Matsuura, S.1
Egi, Y.2
Yuki, S.3
Satoh, H.4
Akira, T.5
-
10
-
-
17044430692
-
Ischemic nitric oxide and poly(ADP-ribose) polymerase-1 in cerebral ischemia: Male toxicity, female protection
-
L.D. McCullough, Z. Zeng, K.K. Blizzard, I. Debchoudhury, and P.D. Hurn Ischemic nitric oxide and poly(ADP-ribose) polymerase-1 in cerebral ischemia: male toxicity, female protection J Cereb Blood Flow Metab 25 4 2005 502 512
-
(2005)
J Cereb Blood Flow Metab
, vol.25
, Issue.4
, pp. 502-512
-
-
McCullough, L.D.1
Zeng, Z.2
Blizzard, K.K.3
Debchoudhury, I.4
Hurn, P.D.5
-
11
-
-
46749118458
-
Role of the peroxynitrite-poly(ADP-ribose) polymerase pathway in human disease
-
DOI 10.2353/ajpath.2008.080019
-
P. Pacher, and C. Szabo Role of the peroxynitrite-poly(ADP-ribose) polymerase pathway in human disease Am. J. Pathol. 173 1 2008 2 13 (Pubitemid 351947950)
-
(2008)
American Journal of Pathology
, vol.173
, Issue.1
, pp. 2-13
-
-
Pacher, P.1
Szabo, C.2
-
12
-
-
34247263212
-
A critical appraisal of the NXY-059 neuroprotection studies for acute stroke: A need for more rigorous testing of neuroprotective agents in animal models of stroke
-
DOI 10.1016/j.expneurol.2007.03.003, PII S0014488607000970
-
S.I. Savitz A critical appraisal of the NXY-059 neuroprotection studies for acute stroke: a need for more rigorous testing of neuroprotective agents in animal models of stroke Exp. Neurol. 205 1 2007 20 25 (Pubitemid 46621180)
-
(2007)
Experimental Neurology
, vol.205
, Issue.1
, pp. 20-25
-
-
Savitz, S.I.1
-
13
-
-
34547795720
-
NXY-059 for the treatment of acute ischemic stroke
-
DOI 10.1056/NEJMoa070240
-
A. Shuaib, K.R. Lees, P. Lyden, J. Grotta, A. Davalos, S.M. Davis, H.C. Diener, T. Ashwood, W.W. Wasiewski, and U. Emeribe NXY-059 for the treatment of acute ischemic stroke N Engl J Med 357 6 2007 562 571 (Pubitemid 47236281)
-
(2007)
New England Journal of Medicine
, vol.357
, Issue.6
, pp. 562-571
-
-
Shuaib, A.1
Lees, K.R.2
Lyden, P.3
Grotta, J.4
Davalos, A.5
Davis, S.M.6
Diener, H.-C.7
Ashwood, T.8
Wasiewski, W.W.9
Emeribe, U.10
-
14
-
-
0344065373
-
Recommendations for standards regarding preclinical neuroprotective and restorative drug development
-
Stroke Therapy Academic Industry Roundtable
-
Stroke Therapy Academic Industry Roundtable Recommendations for standards regarding preclinical neuroprotective and restorative drug development Stroke 30 12 1999 2752 2758
-
(1999)
Stroke
, vol.30
, Issue.12
, pp. 2752-2758
-
-
-
15
-
-
0034943173
-
Recommendations for clinical trial evaluation of acute stroke therapies
-
Stroke Therapy Academic Industry Roundtable
-
Stroke Therapy Academic Industry Roundtable Recommendations for clinical trial evaluation of acute stroke therapies Stroke 32 7 2001 1598 1606
-
(2001)
Stroke
, vol.32
, Issue.7
, pp. 1598-1606
-
-
-
16
-
-
0032127666
-
Role of poly(ADP-ribose) synthetase in inflammation and ischaemia- reperfusion
-
DOI 10.1016/S0165-6147(98)01193-6
-
C. Szabo, and V.L. Dawson Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion Trends Pharmacol Sci 19 7 1998 287 298 (Pubitemid 28358088)
-
(1998)
Trends in Pharmacological Sciences
, vol.19
, Issue.7
, pp. 287-298
-
-
Szabo, C.1
Dawson, V.L.2
-
17
-
-
0030870278
-
Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts antiinflammatory effects
-
DOI 10.1084/jem.186.7.1041
-
C. Szabo, L.H. Lim, S. Cuzzocrea, S.J. Getting, B. Zingarelli, R.J. Flower, A.L. Salzman, and M. Perretti Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts antiinflammatory effects J Exp Med 186 7 1997 1041 1049 (Pubitemid 27441148)
-
(1997)
Journal of Experimental Medicine
, vol.186
, Issue.7
, pp. 1041-1049
-
-
Szabo, C.1
Lim, L.H.K.2
Cuzzocrea, S.3
Getting, S.J.4
Zingarelli, B.5
Flower, R.J.6
Salzman, A.L.7
Perretti, M.8
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