Adenosine diphosphate receptor antagonist clopidogrel sulfate attenuates lps-induced systemic inflammation in a rat model

Shock

Volumn 36, Issue 3, 2011, Pages 317-

  Winning, Johannes ^a   Claus, Ralf A ^a   Pletz, Mathias W ^a   Bauer, Michael ^a   Lösche, Wolfgang ^a  

^a JENA UNIVERSITY HOSPITAL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; CLOPIDOGREL; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; THIENOPYRIDINE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA;

CARDIOVASCULAR DISEASE; CELL INFILTRATION; COMMUNITY ACQUIRED PNEUMONIA; EDEMA; HOSPITALIZATION; HUMAN; INFLAMMATION; LETTER; LIVER; LUNG PARENCHYMA; MORTALITY; NONHUMAN; PROTEIN EXPRESSION; SECONDARY PREVENTION; SEPSIS; STATISTICAL ANALYSIS; VASCULAR DISEASE;

ANIMALS; HUMANS; INFLAMMATION; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; PLATELET AGGREGATION INHIBITORS; PURINERGIC P2Y RECEPTOR ANTAGONISTS; RATS; TICLOPIDINE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 80052016637     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0b013e318224f66a     Document Type: Letter

References (4)

1. Hagiwara S, Iwasaka H, Hasegawa A, Oyama M, Imatomi R, Uchida T, Noguchi T: Adenosine diphosphate receptor antagonist clopidogrel sulfate attenuates LPS-induced systemic inflammation in a rat model. Shock 35(3): 289-292, 2011.
2. Winning J, Reichel J, Eisenhut Y, Hamacher J, Kohl M, Deigner HP, Claus RA, Bauer M, Lösche W: Anti-platelet drugs and outcome in severe infection: clinical impact and underlying mechanisms. Platelets 20(1):50-57, 2009.
3. Seidel M, Winning J, Claus RA, Bauer M, Lösche W: Beneficial effect of clopidogrel in a mouse model of polymicrobial sepsis. J Thromb Haemost 7(6): 1030-1032, 2009.
4. Winning J, Neumann J, Kohl M, Claus RA, Reinhart K, Bauer M, Lösche W: Antiplatelet drugs and outcome in mixed admissions to an intensive care unit. Crit Care Med 38(1):32-37, 2010.