Ocular pharmacokinetics of dorzolamide and brinzolamide after single and multiple topical dosing: Implications for effects on ocular blood flow

Drug Metabolism and Disposition

Volumn 39, Issue 9, 2011, Pages 1529-1537

  Kadam, Rajendra S ^a   Jadhav, Gajanan ^a   Ogidigben, Miller ^b   Kompella, Uday B ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRINZOLAMIDE; DORZOLAMIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUEOUS HUMOR; AREA UNDER THE CURVE; ARTICLE; CONJUNCTIVA; CONTROLLED STUDY; CORNEA; DOSAGE SCHEDULE COMPARISON; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG DOSE REGIMEN; DRUG TISSUE LEVEL; EYE BLOOD FLOW; MALE; MAXIMUM PLASMA CONCENTRATION; MULTIPLE DRUG DOSE; NONHUMAN; OPTIC NERVE; PRIORITY JOURNAL; RETINA; SCLERA; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION; TISSUE DISTRIBUTION; VITREOUS BODY;

ADMINISTRATION, TOPICAL; ANIMALS; CARBONIC ANHYDRASE INHIBITORS; CHROMATOGRAPHY, LIQUID; DRUG ADMINISTRATION SCHEDULE; EYE; MALE; OPTIC NERVE; RABBITS; REGIONAL BLOOD FLOW; SULFONAMIDES; TANDEM MASS SPECTROMETRY; THIAZINES; THIOPHENES;

ORYCTOLAGUS CUNICULUS;

EID: 80052015779     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.111.040055     Document Type: Article

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