Xylitol inhibits carcinogenic acetaldehyde production by Candida species

International Journal of Cancer

Volumn 129, Issue 8, 2011, Pages 2038-2041

  Uittamo, Johanna ^a,b   Nieminen, Mikko T ^a,b   Kaihovaara, Pertti ^a   Bowyer, Paul ^c   Salaspuro, Mikko ^a   Rautemaa, Riina ^a,b,c  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

acetaldehyde; cancer; Candida; xylitol

Indexed keywords

ACETALDEHYDE; ALCOHOL; ALCOHOL DEHYDROGENASE; FRUCTOSE; GLUCOSE; XYLITOL;

ALCOHOL OXIDATION; ARTICLE; CANDIDA; CANDIDA ALBICANS; CANDIDA KRUSEI; CONTROLLED STUDY; ENZYME INHIBITION; FERMENTATION; GAS CHROMATOGRAPHY; NONHUMAN; PRIORITY JOURNAL;

ACETALDEHYDE; CANDIDA; CARCINOGENS; ETHANOL; GLUCOSE; XYLITOL;

EID: 80051997627     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.25844     Document Type: Article

References (22)

1. Secretan B, Straif K, Baan R, Grosse Y, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Guha N, Freeman C, Galichet L, Cogliano V,. A review of human carcinogens. Part E. Tobacco, areca nut, alcohol, coal smoke, and salted fish. Lancet Oncol 2009; 10: 1033-4.
2. Seitz HK, Stickel F,. Acetaldehyde as an underestimated risk factor for cancer development: role of genetics in ethanol metabolism. Genes Nutr 2010; 5: 121-8.
3. Salaspuro MP,. Acetaldehyde, microbes, and cancer of the digestive tract. Crit Rev Clin Lab Sci 2003; 40: 183-8.
4. Homann N, Jousimies-Somer H, Jokelainen K, Heine R, Salaspuro M,. High acetaldehyde levels in saliva after ethanol consumption: methodological aspects and pathogenetic implications. Carcinogenesis 1997; 18: 1739-43. (Pubitemid 28134679)
5. Jones AW,. Distribution of ethanol between saliva and blood in man. Clin Exp Pharmacol Physiol 1979; 6: 53-9. (Pubitemid 9123984)
6. Kurkivuori J, Salaspuro V, Kaihovaara P, Kari K, Rautemaa R, Gronroos L, Meurman JH, Salaspuro M,. Acetaldehyde production from ethanol by oral streptococci. Oral Oncol 2007; 43: 181-6. (Pubitemid 46176706)
7. Muto M, Hitomi Y, Ohtsu A, Shimada H, Kashiwase Y, Sasaki H, Yoshida S, Esumi H,. Acetaldehyde production by non-pathogenic Neisseria in human oral microflora: implications for carcinogenesis in upper aerodigestive tract. Int J Cancer 2000; 88: 342-50.
8. Tillonen J, Homann N, Rautio M, Jousimies-Somer H, Salaspuro M,. Role of yeasts in the salivary acetaldehyde production from ethanol among risk groups for ethanol-associated oral cavity cancer. Alcohol Clin Exp Res 1999; 23: 1409-15. (Pubitemid 29409356)
9. Nieminen MT, Uittamo J, Salaspuro M, Rautemaa R,. Acetaldehyde production from ethanol and glucose by non-Candida albicans yeasts in vitro. Oral Oncol 2009; 45: 245-8.
10. Ghannoum MA, Jurevic RJ, Mukherjee PK, Cui F, Sikaroodi M, Naqvi A, Gillevet PM,. Characterization of the oral fungal microbiome (mycobiome) in healthy individuals. PLoS Pathog 2010; 6: e1000713.
11. Salaspuro M,. Acetaldehyde as a common denominator and cumulative carcinogen in digestive tract cancers. Scand J Gastroenterol 2009; 44: 912-925.
12. Uittamo J, Siikala E, Kaihovaara P, Salaspuro M, Rautemaa R,. Chronic candidosis and oral cancer in APECED-patients: production of carcinogenic acetaldehyde from glucose and ethanol by Candida albicans. Int J Cancer 2009; 124: 754-56.
13. Persson B, Hallborn J, Walfridsson M, Hahn-Hagerdal B, Keranen S, Penttila M, Jörnvall H,. Dual relationships of xylitol and alcohol dehydrogenases in families of two protein types. FEBS Lett 1993; 324: 9-14. (Pubitemid 23165027)
14. Jokelainen K, Roine RP, Vaananen H, Farkkila M, Salaspuro M,. In vitro acetaldehyde formation by human colonic bacteria. Gut 1994; 35: 1271-4. (Pubitemid 24277343)
15. Ly KA, Milgrom P, Rothen M,. Xylitol, sweeteners, and dental caries. Pediatr Dent 2006; 28: 154-63; discussion 192-8.
16. Milgrom P, Ly KA, Rothen M,. Xylitol and its vehicles for public health needs. Adv Dent Res 2009; 21: 44-47.
17. Uhari M, Tapiainen T, Kontiokari T,. Xylitol in preventing acute otitis media. Vaccine 2000; 19 (Suppl 1): S144-7. (Pubitemid 32121736)
18. Tapiainen T, Kontiokari T, Sammalkivi L, Ikaheimo I, Koskela M, Uhari M,. Effect of xylitol on growth of Streptococcus pneumoniae in the presence of fructose and sorbitol. Antimicrob Agents Chemother 2001; 45: 166-9. (Pubitemid 32039109)
19. Lif Holgerson P, Stecksen-Blicks C, Sjostrom I, Oberg M, Twetman S,. Xylitol concentration in saliva and dental plaque after use of various xylitol-containing products. Caries Res 2006; 40: 393-7. (Pubitemid 44329048)
20. Kotter PF, Amore R, Hollenberg CP, Ciriacy M,. Isolation and characterization of the Pichia stipitis xylitol dehydrogenase gene, XYL2, and construction of a xylose-utilizing Saccharomyces cerevisiae transformant. Curr Genet 1990; 18: 493-500.
21. Foster N, Symes C, Barton R, Hobson R,. Rapid identification of Candida glabrata in Candida bloodstream infections. J Med Microbiol 2007; 56: 1639-43. (Pubitemid 350276514)
22. Hazen KC, Howell SA,. Candida, Cryptococcus and other yeasts of Medical Importance. In: Manual of clinical microbiology, Eds:, Murray PR, Baron EJ, Jorqensen JH, Landry ML, Pfaller MA,. 2007, Vol. 2, 1762-88.