Influence of prenatal undernutrition on the effects of clozapine and aripiprazole in the adult male rats: Relevance to a neurodevelopmental origin of schizophrenia?

European Journal of Pharmacology

Volumn 667, Issue 1-3, 2011, Pages 402-409

  Guillemot, Johann ^a   Lukaszewski, Marie Amélie ^a   Montel, Valérie ^a   Delahaye, Fabien ^a   Mayeur, Sylvain ^a   Laborie, Christine ^a   Dickes Coopman, Anne ^a   Dutriez Casteloot, Isabelle ^a   Lesage, Jean ^a   Breton, Christophe ^a   Vieau, Didier ^a  

^a UNIV LILLE   (France)

Author keywords

Atypical neuroleptics; Hypothalamus; Maternal undernutrition; Metabolic syndrome; Schizophrenia

Indexed keywords

ARIPIPRAZOLE; CLOZAPINE; CORTICOSTERONE; GLUCOSE; INSULIN; LEPTIN; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN DERIVED NEUROTROPHIC FACTOR GENE; CHOLECYSTOKININ GENE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DRUG EFFECT; DRUG SENSITIVITY; ENERGY METABOLISM; FEMALE; FOOD INTAKE; GENE; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GLUCOSE BLOOD LEVEL; INSULIN RELEASE; MALE; MALNUTRITION; MATERNAL NUTRITION; METABOLIC REGULATION; METABOLIC SYNDROME X; NERVE CELL DIFFERENTIATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRENATAL EXPOSURE; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHIZOPHRENIA; WEIGHT GAIN;

ANIMALS; ANTIPSYCHOTIC AGENTS; BODY WEIGHT; CLOZAPINE; DISEASE SUSCEPTIBILITY; EATING; FEMALE; GENE EXPRESSION REGULATION; HORMONES; HYPOTHALAMUS; MALE; MALNUTRITION; NERVOUS SYSTEM; OBESITY; PIPERAZINES; PREGNANCY; PRENATAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; QUINOLONES; RATS; RATS, WISTAR; SCHIZOPHRENIA;

EID: 80051986237     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.04.011     Document Type: Article

References (54)

1. V.L. Albaugh, C.R. Henry, N.T. Bello, A. Hajnal, S.L. Lynch, B. Halle, and C.J. Lynch Hormonal and metabolic effects of olanzapine and clozapine related to body weight in rodents Obesity (Silver Spring) 14 2006 36 51 (Pubitemid 46214773)
2. D.B. Allison, K.R. Fontaine, M. Heo, J.L. Mentore, J.C. Cappelleri, L.P. Chandler, P.J. Weiden, and L.J. Cheskin The distribution of body mass index among individuals with and without schizophrenia J. Clin. Psychiatry 60 1999 215 220 (Pubitemid 29193917)
3. F. Angelucci, L. Aloe, A. Iannitelli, S.H. Gruber, and A.A. Mathe Effect of chronic olanzapine treatment on nerve growth factor and brain-derived neurotrophic factor in the rat brain Eur. Neuropsychopharmacol. 15 2005 311 317 (Pubitemid 40487735)
4. A.A. Arjona, S.X. Zhang, B. Adamson, and R.J. Wurtman An animal model of antipsychotic-induced weight gain Behav. Brain Res. 152 2004 121 127 (Pubitemid 38597070)
5. G. Aslanidi, V. Kroutov, G. Philipsberg, K. Lamb, M. Campbell-Thompson, G.A. Walter, S. Kurenov, J. Ignacio Aguirre, P. Keller, K. Hankenson, O.A. Macdougald, and S. Zolotukhin Ectopic expression of Wnt10b decreases adiposity and improves glucose homeostasis in obese rats Am. J. Physiol. Endocrinol. Metab. 293 2007 E726 E736
6. D.T. Balu, and J.T. Coyle Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia Neurosci. Biobehav. Rev. 35 2011 848 870
7. D.T. Balu, B.A. Hoshaw, J.E. Malberg, S. Rosenzweig-Lipson, L.E. Schechter, and I. Lucki Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments Brain Res. 1211 2008 37 43
8. T. Baptista, A. Mata, L. Teneud, M. de Quijada, H.W. Han, and L. Hernandez Effects of long-term administration of clozapine on body weight and food intake in rats Pharmacol. Biochem. Behav. 45 1993 51 54
9. T. Baptista, E.A. de Baptista, J. Lalonde, J. Plamondon, N.M. Kin, S. Beaulieu, R. Joober, and D. Richard Comparative effects of the antipsychotics sulpiride and risperidone in female rats on energy balance, body composition, fat morphology and macronutrient selection Prog. Neuropsychopharmacol. Biol. Psychiatry 28 2004 1305 1311 (Pubitemid 39592928)
10. D.J. Barker The origins of the developmental origins theory J. Intern. Med. 261 2007 412 417 (Pubitemid 46587729)
11. A. Basta-Kaim, B. Budziszewska, M. Leskiewicz, K. Fijal, M. Regulska, M. Kubera, K. Wedzony, and W. Lason Hyperactivity of the hypothalamus-pituitary- adrenal axis in lipopolysaccharide-induced neurodevelopmental model of schizophrenia in rats: effects of antipsychotic drugs Eur. J. Pharmacol. 650 2011 586 595
12. L. Best, A.P. Yates, and G.P. Reynolds Actions of antipsychotic drugs on pancreatic beta-cell function: contrasting effects of clozapine and haloperidol J. Psychopharmacol. 19 2005 597 601 (Pubitemid 41578820)
13. C. Breton, M.A. Lukaszewski, P.Y. Risold, M. Enache, J. Guillemot, G. Riviere, F. Delahaye, J. Lesage, I. Dutriez-Casteloot, C. Laborie, and D. Vieau Maternal prenatal undernutrition alters the response of POMC neurons to energy status variation in adult male rat offspring Am. J. Physiol. Endocrinol. Metab. 296 2009 E462 E472
14. J.O. Brooks III, H.S. Chang, and O. Krasnykh Metabolic risks in older adults receiving second-generation antipsychotic medication Curr. Psychiatry Rep. 11 2009 33 40
15. A.S. Brown, and E.S. Susser Prenatal nutritional deficiency and risk of adult schizophrenia Schizophr. Bull. 34 2008 1054 1063
16. R.C. Casper Nutrients, neurodevelopment, and mood Curr. Psychiatry Rep. 6 2004 425 429 (Pubitemid 41599915)
17. S. Choi, B. DiSilvio, J. Unangst, and J.D. Fernstrom Effect of chronic infusion of olanzapine and clozapine on food intake and body weight gain in male and female rats Life Sci. 81 2007 1024 1030 (Pubitemid 47384786)
18. G.P. Chrousos The role of stress and the hypothalamic-pituitary-adrenal axis in the pathogenesis of the metabolic syndrome: neuro-endocrine and target tissue-related causes Int. J. Obes. Relat. Metab. Disord. 24 Suppl 2 2000 S50 S55
19. G.D. Cooper, J.A. Harrold, J.C. Halford, and A.J. Goudie Chronic clozapine treatment in female rats does not induce weight gain or metabolic abnormalities but enhances adiposity: implications for animal models of antipsychotic-induced weight gain Prog. Neuropsychopharmacol. Biol. Psychiatry 32 2008 428 436 (Pubitemid 351178959)
20. Q. Cordeiro, J. Siqueira-Roberto, and H. Vallada Association between the SLC6A3 A1343G polymorphism and schizophrenia Arq. Neuropsiquiatr. 68 2010 716 719
21. M.J. Fell, K.M. Marshall, J. Williams, and J.C. Neill Effects of the atypical antipsychotic olanzapine on reproductive function and weight gain in female rats J. Psychopharmacol. 18 2004 149 155 (Pubitemid 38954901)
22. J. Ferno, A.O. Vik-Mo, G. Jassim, B. Havik, K. Berge, S. Skrede, O.A. Gudbrandsen, J. Waage, N. Lunder, S. Mork, R.K. Berge, H.A. Jorgensen, and V.M. Steen Acute clozapine exposure in vivo induces lipid accumulation and marked sequential changes in the expression of SREBP, PPAR, and LXR target genes in rat liver Psychopharmacology (Berl.) 203 2009 73 84
23. A.J. Goudie, J.A. Smith, and J.C. Halford Characterization of olanzapine-induced weight gain in rats J. Psychopharmacol. 16 2002 291 296 (Pubitemid 35470572)
24. A. Guijarro, A. Laviano, and M.M. Meguid Hypothalamic integration of immune function and metabolism Prog. Brain Res. 153 2006 367 405 (Pubitemid 44164302)
25. K.A. Helm, P. Rada, and B.G. Hoebel Cholecystokinin combined with serotonin in the hypothalamus limits accumbens dopamine release while increasing acetylcholine: a possible satiation mechanism Brain Res. 963 2003 290 297 (Pubitemid 36126310)
26. C.C. Hung, I.H. Wei, and C.C. Huang Late-onset cholestatic hepatitis induced by olanzapine in a patient with schizophrenia Prog. Neuropsychopharmacol. Biol. Psychiatry 33 2009 1574 1575
27. A. Inoue, M. Seto, S. Sugita, I. Hide, T. Hirose, N. Koga, T. Kikuchi, and Y. Nakata Differential effects on D2 dopamine receptor and prolactin gene expression by haloperidol and aripiprazole in the rat pituitary Brain Res. Mol. Brain Res. 55 1998 285 292 (Pubitemid 28248045)
28. D.E. Johnson, H. Yamazaki, K.M. Ward, A.W. Schmidt, W.S. Lebel, J.L. Treadway, E.M. Gibbs, W.S. Zawalich, and H. Rollema Inhibitory effects of antipsychotics on carbachol-enhanced insulin secretion from perifused rat islets: role of muscarinic antagonism in antipsychotic-induced diabetes and hyperglycemia Diabetes 54 2005 1552 1558 (Pubitemid 40586689)
29. S. Jordan, V. Koprivica, R. Dunn, K. Tottori, T. Kikuchi, and C.A. Altar In vivo effects of aripiprazole on cortical and striatal dopaminergic and serotonergic function Eur. J. Pharmacol. 483 2004 45 53 (Pubitemid 38056603)
30. E. Lauressergues, B. Staels, K. Valeille, Z. Majd, D.W. Hum, P. Duriez, and D. Cussac Antipsychotic drug action on SREBPs-related lipogenesis and cholesterogenesis in primary rat hepatocytes Naunyn Schmiedebergs Arch. Pharmacol. 381 2010 427 439
31. B. Lebrun, B. Bariohay, E. Moyse, and A. Jean Brain-derived neurotrophic factor (BDNF) and food intake regulation: a minireview Auton. Neurosci. 126-127 2006 30 38 (Pubitemid 43833352)
32. M.D. Lee, and P.G. Clifton Meal patterns of free feeding rats treated with clozapine, olanzapine, or haloperidol Pharmacol. Biochem. Behav. 71 2002 147 154 (Pubitemid 34102473)
33. J. Lesage, N. Sebaai, M. Leonhardt, I. Dutriez-Casteloot, C. Breton, S. Deloof, and D. Vieau Perinatal maternal undernutrition programs the offspring hypothalamo-pituitary-adrenal (HPA) axis Stress 9 2006 183 198 (Pubitemid 46005630)
34. J. Minet-Ringuet, P.C. Even, P. Valet, C. Carpene, V. Visentin, D. Prevot, D. Daviaud, A. Quignard-Boulange, D. Tome, and R. de Beaurepaire Alterations of lipid metabolism and gene expression in rat adipocytes during chronic olanzapine treatment Mol. Psychiatry 12 2007 562 571 (Pubitemid 46816768)
35. M. Murashita, I. Kusumi, H. Hosoda, K. Kangawa, and T. Koyama Acute administration of clozapine concurrently increases blood glucose and circulating plasma ghrelin levels in rats Psychoneuroendocrinology 32 2007 777 784 (Pubitemid 47187574)
36. J.W. Newcomer Metabolic syndrome and mental illness Am. J. Manag. Care 13 2007 S170 S177
37. A. Pocai, P.E. Carrington, J.R. Adams, M. Wright, G. Eiermann, L. Zhu, X. Du, A. Petrov, M.E. Lassman, G. Jiang, F. Liu, C. Miller, L.M. Tota, G. Zhou, X. Zhang, M.M. Sountis, A. Santoprete, E. Capito, G.G. Chicchi, N. Thornberry, E. Bianchi, A. Pessi, D.J. Marsh, and R. SinhaRoy Glucagon-like peptide 1/glucagon receptor dual agonism reverses obesity in mice Diabetes 58 2009 2258 2266
38. B. Pouzet, T. Mow, M. Kreilgaard, and S. Velschow Chronic treatment with antipsychotics in rats as a model for antipsychotic-induced weight gain in human Pharmacol. Biochem. Behav. 75 2003 133 140 (Pubitemid 36577588)
39. G.P. Reynolds, and S.L. Kirk Metabolic side effects of antipsychotic drug treatment-pharmacological mechanisms Pharmacol. Ther. 125 2010 169 179
40. G. Riviere, A. Michaud, C. Breton, G. VanCamp, C. Laborie, M. Enache, J. Lesage, S. Deloof, P. Corvol, and D. Vieau Angiotensin-converting enzyme 2 (ACE2) and ACE activities display tissue-specific sensitivity to undernutrition-programmed hypertension in the adult rat Hypertension 46 2005 1169 1174 (Pubitemid 41533021)
41. M.C. Ryan, P. Collins, and J.H. Thakore Impaired fasting glucose tolerance in first-episode, drug-naive patients with schizophrenia Am. J. Psychiatry 160 2003 284 289 (Pubitemid 41110453)
42. P.A. Saiz, M.P. Garcia-Portilla, C. Arango, B. Morales, B. Arias, P. Corcoran, J.M. Fernandez, V. Alvarez, E. Coto, M.T. Bascaran, M. Bousono, L. Fananas, and J. Bobes Genetic polymorphisms in the dopamine-2 receptor (DRD2), dopamine-3 receptor (DRD3), and dopamine transporter (SLC6A3) genes in schizophrenia: data from an association study Prog. Neuropsychopharmacol. Biol. Psychiatry 34 2010 26 31
43. Y.E. Savoy, M.A. Ashton, M.W. Miller, F.M. Nedza, D.K. Spracklin, M.H. Hawthorn, H. Rollema, F.F. Matos, and E. Hajos-Korcsok Differential effects of various typical and atypical antipsychotics on plasma glucose and insulin levels in the mouse: evidence for the involvement of sympathetic regulation Schizophr. Bull. 36 2010 410 418
44. N. Sebaai, J. Lesage, C. Breton, D. Vieau, and S. Deloof Perinatal food deprivation induces marked alterations of the hypothalamo-pituitary-adrenal axis in 8-month-old male rats both under basal conditions and after a dehydration period Neuroendocrinology 79 2004 163 173 (Pubitemid 38698119)
45. E. Susser, D. St Clair, and L. He Latent effects of prenatal malnutrition on adult health: the example of schizophrenia Ann. N.Y. Acad. Sci. 1136 2008 185 192 (Pubitemid 351862175)
46. M.E. Talkowski, G. Kirov, M. Bamne, L. Georgieva, G. Torres, H. Mansour, K.V. Chowdari, V. Milanova, J. Wood, L. McClain, K. Prasad, B. Shirts, J. Zhang, M.C. O'Donovan, M.J. Owen, B. Devlin, and V.L. Nimgaonkar A network of dopaminergic gene variations implicated as risk factors for schizophrenia Hum. Mol. Genet. 17 2008 747 758 (Pubitemid 351292263)
47. J.H. Thakore, J.N. Mann, I. Vlahos, A. Martin, and R. Reznek Increased visceral fat distribution in drug-naive and drug-free patients with schizophrenia Int. J. Obes. Relat. Metab. Disord. 26 2002 137 141 (Pubitemid 34098681)
48. Z. Thornton-Jones, J.C. Neill, and G.P. Reynolds The atypical antipsychotic olanzapine enhances ingestive behaviour in the rat: a preliminary study J. Psychopharmacol. 16 2002 35 37 (Pubitemid 34273071)
49. G. Tulipano, C. Rizzetti, I. Bianchi, A. Fanzani, P. Spano, and D. Cocchi Clozapine-induced alteration of glucose homeostasis in the rat: the contribution of hypothalamic-pituitary-adrenal axis activation Neuroendocrinology 85 2007 61 70 (Pubitemid 46725692)
50. K. Wahlbeck, T. Forsen, C. Osmond, D.J. Barker, and J.G. Eriksson Association of schizophrenia with low maternal body mass index, small size at birth, and thinness during childhood Arch. Gen. Psychiatry 58 2001 48 52 (Pubitemid 32057764)
51. E. Walker, V. Mittal, and K. Tessner Stress and the hypothalamic pituitary adrenal axis in the developmental course of schizophrenia Annu. Rev. Clin. Psychol. 4 2008 189 216 (Pubitemid 351668616)
52. M.Q. Xu, W.S. Sun, B.X. Liu, G.Y. Feng, L. Yu, L. Yang, G. He, P. Sham, E. Susser, D. St Clair, and L. He Prenatal malnutrition and adult schizophrenia: further evidence from the 1959-1961 Chinese famine Schizophr. Bull. 35 2009 568 576
53. T. Yamauchi, K. Tatsumi, M. Makinodan, S. Kimoto, M. Toritsuka, H. Okuda, T. Kishimoto, and A. Wanaka Olanzapine increases cell mitotic activity and oligodendrocyte-lineage cells in the hypothalamus Neurochem. Int. 57 2010 565 571
54. L.H. Yang, T.M. Chen, S.T. Yu, and Y.H. Chen Olanzapine induces SREBP-1-related adipogenesis in 3T3-L1 cells Pharmacol. Res. 56 2007 202 208