A rare complication of intrathecal methotrexate in a child with acute lymphoblastic leukemia

Pediatric Hematology and Oncology

Volumn 28, Issue 6, 2011, Pages 517-522

  Tufekci, Ozlem ^a   Yilmaz, Sebnem ^a   Karapinar, Tuba Hilkay ^a   Gozmen, Salih ^a   Cakmakci, Handan ^a   Hiz, Semra ^a   Irken, Gulersu ^a   Oren, Hale ^a  

^a DOKUZ EYLUL UNIVERSITY   (Turkey)

Author keywords

Imaging; intrathecal; methotrexate; neurotoxicity; treatment

Indexed keywords

DEXAMETHASONE; FOLINIC ACID; MERCAPTOPURINE; METHOTREXATE; VINCRISTINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; BLURRED VISION; CASE REPORT; CERVICAL LYMPHADENOPATHY; CHILD; COMPUTER ASSISTED TOMOGRAPHY; DIFFUSION WEIGHTED IMAGING; DYSARTHRIA; FEBRILE NEUTROPENIA; FEMALE; HUMAN; NEUROIMAGING; NEUROTOXICITY; NUCLEAR MAGNETIC RESONANCE IMAGING; PANCYTOPENIA; SCHOOL CHILD; SPLENOMEGALY; TREATMENT RESPONSE;

ANTI-INFLAMMATORY AGENTS; ANTIMETABOLITES, ANTINEOPLASTIC; CHILD; DEXAMETHASONE; FEMALE; HUMANS; INJECTIONS, SPINAL; LEUCOVORIN; MAGNETIC RESONANCE IMAGING; METHOTREXATE; NEUROTOXICITY SYNDROMES; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; TIME FACTORS; VITAMIN B COMPLEX;

EID: 80051983735     PISSN: 08880018     EISSN: 15210669     Source Type: Journal    
DOI: 10.3109/08880018.2011.563773     Document Type: Article

References (24)

1. Schrappe M, Reiter A, Zimmermann M, et al. Long-term results of four consecutive trials in childhood ALL performed by the ALL-BFM study group from 1981 to 1995. Berlin-Frankfurt-Münster. Leukemia. 2000;14:2205-2222. (Pubitemid 32042262)
2. Pui CH. Acute lymphoblastic leukemia in children. Curr Opin Oncol. 2000;12:3-12.
3. Vezmar S, Becker A, Bode U, Jaehde U. Biochemical and clinical aspects of methotrexate neurotoxicity. Chemotherapy. 2003;49:92-104. (Pubitemid 36469805)
4. BleyerWA. Neurologic sequelae of methotrexate and ionizing radiation: a new classification. Cancer Treat Rep. 1981;65(Suppl 1):89-98. (Pubitemid 12160480)
5. Mahoney DH Jr, Shuster JJ, Nitschke R, et al. Acute neurotoxicity in children with B-precursor acute lymphoid leukemia: an association with intermediate-dose intravenous methotrexate and intrathecal triple therapy-a Pediatric Oncology Group study. J Clin Oncol. 1998;16:1712-1722.
6. Walker RW, Allen JC, Rosen G, Caparros B. Transient cerebral dysfunction secondary to high-dose methotrexate. J Clin Oncol. 1986;4:1845-1850. (Pubitemid 17226676)
7. Yim YS, Mahoney DH Jr, Oshman DG. Hemiparesis and ischemic changes of the white matter after intrathecal therapy for children with acute lymphocytic leukemia. Cancer. 1991;67:2058-2061.
8. Haykin M,Gorman M, vanHoff J, et al. Diffusion-weightedMRI correlates of subacutemethotrexaterelated neurotoxicity. J Neurooncol. 2006;76:153-157. (Pubitemid 43125742)
9. Baehring JM, Fulbright RK. Delayed leukoencephalopathy with stroke-like presentation in chemotherapy recipients. J Neurol Neurosurg Psychiatry. 2008;79:535-539. (Pubitemid 351571871)
10. Inaba H, Khan RB, Laningham FH, et al. Clinical and radiological characteristics of methotrexateinduced acute encephalopathy in pediatric patients with cancer. Ann Oncol. 2008;19:178-184.
11. Küker W, Bader P, Herrlinger U, et al. Transient encephalopathy after intrathekal methotrexate chemotherapy: diffusion-weightedMRI. J Neurooncol. 2005;73:47-49. (Pubitemid 40823266)
12. Strunk T, Gottschalk S, Goepel W, et al. Subacute leukencephalopathy after low-dose intrathecal methotrexate in an adolescent heterozygous for the MTHFR C677T polymorphism. Med Pediatr Oncol. 2003;40:48-50. (Pubitemid 35340568)
13. Quinn CT, Griener JC, Bottiglieri T, et al. Effects of intraventricular methotrexate on folate, adenosine, and homocysteine metabolism in cerebrospinal fluid. J Pediatr Hematol Oncol. 2004;26:386-388. (Pubitemid 38747731)
14. Quinn CT, Griener JC, Bottiglieri T, et al. Elevation of homocysteine and excitatory amino acid neurotransmitters in the CSF of children who receive methotrexate for the treatment of cancer. J Clin Oncol. 1997;15:2800-2806. (Pubitemid 27330006)
15. Lai R, Abrey LE, Rosenblum MK, DeAngelis LM. Treatment-induced leukoencephalopathy in primary CNS lymphoma: a clinical and autopsy study. Neurology. 2004;62:451-456. (Pubitemid 38200859)
16. El-Hakam LM, Ramocki MB, Riviello JJ, Illner A. Hyperperfusion onmagnetic resonance imaging in acute chemotherapy-related leukoencephalopathy. J Child Neurol. 2010;25:776-779.
17. Schaefer PW, Copen WA, Lev MH, Gonzalez RG. Diffusion-weighted imaging in acute stroke. Neuroimaging Clin N Am. 2005;15:503-530. (Pubitemid 41796936)
18. Bota DA, Dafer RM. Acute methotrexate neurotoxicity with choreiformmovements and focal neurological deficits: a case report. SouthMed J. 2009;102:1071-1074.
19. Henderson RD, Rajah T, Nicol AJ, Read SJ. Posterior leukoencephalopathy following intrathecal chemotherapy with MRA-documented vasospasm. Neurology. 2003;60:326-328. (Pubitemid 36152032)
20. Drachtman RA, Cole PD, Golden CB, et al. Dextromethorphan is effective in the treatment of subacute methotrexate neurotoxicity. Pediatr Hematol Oncol. 2002;19:319-327. (Pubitemid 34633366)
21. Jaksic W, Veljkovic D, Pozza C, Lewis I. Methotrexate-induced leukoencephalopathy reversed by aminophylline and high-dose folinic acid. Acta Haematol. 2004;111:230-232. (Pubitemid 38716201)
22. Shuper A, Stark B, Kornreich L, et al.Methotrexate treatment protocols and the central nervous system: significant cure with significant neurotoxicity. J Child Neurol. 2000;15:573-580.
23. Bernini JC, Fort DW, Griener JC. et al. Aminophylline for methotrexate-induced neurotoxicity. Lancet. 1995;345:544-547.
24. Packer RJ, Grossman RI, Belasco JB. High dose systemic methotrexate-associated acute neurologic dysfunction. Med Pediatr Oncol. 1983;11:159-161. (Pubitemid 13028993)