Occurrence of late gadolinium enhancement is associated with increased left ventricular wall stress and mass in patients with non-ischaemic dilated cardiomyopathy

European Journal of Heart Failure

Volumn 13, Issue 9, 2011, Pages 937-944

  Alter, Peter ^a   Rupp, Heinz ^a   Adams, Philipp ^a   Stoll, Florian ^a   Figiel, Jens H ^a   Klose, Klaus J ^a   Rominger, Marga B ^a   Maisch, Bernhard ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Arrhythmia; Cardiac magnetic resonance imaging; Cardiomyopathy; Cardioverterdefibrillator; Heart failure; Late gadolinium enhancement; Sudden cardiac death; Ventricular wall stress

Indexed keywords

GADOLINIUM;

ADULT; ARTICLE; CARDIOVASCULAR MAGNETIC RESONANCE; CONGESTIVE CARDIOMYOPATHY; CONTRAST ENHANCEMENT; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HEART LEFT VENTRICLE HYPERTROPHY; HEART LEFT VENTRICLE MASS; HEART LEFT VENTRICLE WALL; HEART STRESS; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE SCANNER; PREDICTIVE VALUE; PRIORITY JOURNAL; PROGNOSIS; WALL STRESS;

CARDIOMYOPATHY, DILATED; CONTRAST MEDIA; FEMALE; GADOLINIUM DTPA; HUMANS; HYPERTROPHY, LEFT VENTRICULAR; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; VENTRICULAR DYSFUNCTION, LEFT;

EID: 80051983038     PISSN: 13889842     EISSN: 18790844     Source Type: Journal    
DOI: 10.1093/eurjhf/hfr082     Document Type: Article

References (47)

1. Hundley WG, Bluemke DA, Finn JP, Flamm SD, Fogel MA, Friedrich MG, Ho VB, Jerosch-Herold M, Kramer CM, Manning WJ, Patel M, Pohost GM, Stillman AE, White RD, Woodard PK. ACCF/ACR/AHA/NASCI/SCMR 2010 expert consensus document on cardiovascular magnetic resonance: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents. J Am Coll Cardiol 2010;55:2614-2662.
2. Kim RJ, Fieno DS, Parrish TB, Harris K, Chen EL, Simonetti O, Bundy J, Finn JP, Klocke FJ, Judd RM. Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and contractile function. Circulation 1999;100: 1992-2002. (Pubitemid 29529292)
3. Flett AS, Hayward MP, Ashworth MT, Hansen MS, Taylor AM, Elliott PM, McGregor C, Moon JC. Equilibrium contrast cardiovascular magnetic resonance for the measurement of diffuse myocardial fibrosis: preliminary validation in humans. Circulation 2010;122:138-144.
4. Kim RJ, Wu E, Rafael A, Chen EL, Parker MA, Simonetti O, Klocke FJ, Bonow RO, Judd RM. The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction. N Engl J Med 2000;343:1445-1453.
5. Schelbert EB, Hsu LY, Anderson SA, Mohanty BD, Karim SM, Kellman P, Aletras AH, Arai AE. Late gadolinium enhancement cardiac magnetic resonance identifies post infarction myocardial fibrosis and the border zone at the near cellular level in ex vivo rat heart. Circ Cardiovasc Imaging 2010;3:743-752.
6. Rehwald WG, Fieno DS, Chen EL, Kim RJ, Judd RM. Myocardial magnetic resonance imaging contrast agent concentrations after reversible and irreversible ischemic injury. Circulation 2002;105:224-229. (Pubitemid 34084323)
7. Assomull RG, Pennell DJ, Prasad SK. Cardiovascular magnetic resonance in the evaluation of heart failure. Heart 2007;93:985-992. (Pubitemid 47122058)
8. Alpendurada F, Pennell DJ. Late gadolinium enhancement in cardiomyopathy. Int J Cardiovasc Imaging 2008;24:613-615.
9. O'Hanlon R, Grasso A, Roughton M, Moon JC, Clark S, Wage R, Webb J, Kulkarni M, Dawson D, Sulaibeekh L, Chandrasekaran B, Bucciarelli-Ducci C, Pasquale F, Cowie MR, McKenna WJ, Sheppard MN, Elliott PM, Pennell DJ, Prasad SK. Prognostic significance of myocardial fibrosis in hypertrophic cardiomyopathy. J Am Coll Cardiol 2010;56:867-874.
10. Yilmaz A, Kindermann I, Kindermann M, Mahfoud F, Ukena C, Athanasiadis A, Hill S, Mahrholdt H, Voehringer M, Schieber M, Klingel K, Kandolf R, Bohm M, Sechtem U. Comparative evaluation of left and right ventricular endomyocardial biopsy: differences in complication rate and diagnostic performance. Circulation 2010;122:900-909.
11. Silva C, Moon JC, Elkington AG, John AS, Mohiaddin RH, Pennell DJ. Myocardial late gadolinium enhancement in specific cardiomyopathies by cardiovascular magnetic resonance: a preliminary experience. J Cardiovasc Med (Hagerstown) 2007;8: 1076-1079. (Pubitemid 351339573)
12. Assomull RG, Prasad SK, Lyne J, Smith G, Burman ED, Khan M, Sheppard MN, Poole-Wilson PA, Pennell DJ. Cardiovascular magnetic resonance, fibrosis, and prognosis in dilated cardiomyopathy. J Am Coll Cardiol 2006;48:1977-1985. (Pubitemid 44738448)
13. Wu KC, Weiss RG, Thiemann DR, Kitagawa K, Schmidt A, Dalal D, Lai S, Bluemke DA, Gerstenblith G, Marban E, Tomaselli GF, Lima JA. Late gadolinium enhancement by cardiovascular magnetic resonance heralds an adverse prognosis in nonischemic cardiomyopathy. J Am Coll Cardiol 2008;51:2414-2421. (Pubitemid 351826874)
14. Kwong RY, Chan AK, Brown KA, Chan CW, Reynolds HG, Tsang S, Davis RB. Impact of unrecognized myocardial scar detected by cardiac magnetic resonance imaging on event-free survival in patients presenting with signs or symptoms of coronary artery disease. Circulation 2006;113:2733-2743. (Pubitemid 43947991)
15. Alter P, Rupp H, Rominger MB, Vollrath A, Czerny F, Klose KJ, Maisch B. Relation of B-type natriuretic peptide to left ventricular wall stress as assessed by cardiac magnetic resonance imaging in patients with dilated cardiomyopathy. Can J Physiol Pharmacol 2007;85:790-799. (Pubitemid 350144739)
16. Alter P, Rupp H, Rominger MB, Vollrath A, Czerny F, Figiel JH, Adams P, Stoll F, Klose KJ, Maisch B. B-type natriuretic peptide and wall stress in dilated human heart. Mol Cell Biochem 2008;314:179-191.
17. Alter P, Rupp H, Rominger MB, Klose KJ, Maisch B. A new methodological approach to assess cardiac work by pressure-volume and stress-length relations in patients with aortic valve stenosis and dilated cardiomyopathy. Pflugers Arch 2008;455:627-636. (Pubitemid 350160477)
18. Mirsky I. Left ventricular stresses in the intact human heart. Biophys J 1969;9: 189-208.
19. Vohringer M, Mahrholdt H, Yilmaz A, Sechtem U. Significance of late gadolinium enhancement in cardiovascular magnetic resonance imaging (CMR). Herz 2007; 32:129-137. (Pubitemid 46980389)
20. Alter P, Rupp H, Rominger MB, Czerny F, Vollrath A, Klose KJ, Maisch B. A new method to assess ventricular wall stress in patients with heart failure and its relation to heart rate variability. Int J Cardiol 2010;139:301-303.
21. Alter P, Rupp H, Maisch B. Assessment and relevance of ventricular wall stress in heart failure. Eur Heart J 2008;29:2316.
22. Swanson SD, Dou C, Miller DL. Magnetic resonance imaging of microvascular leakage induced by myocardial contrast echocardiography in rats. Magn Reson Imaging 2006;24:603-609. (Pubitemid 43776560)
23. Nassenstein K, Breuckmann F, Bucher C, Kaiser G, Konorza T, Schafer L, Konietzka I, de Greiff A, Heusch G, Erbel R, Barkhausen J. How much myocardial damage is necessary to enable detection of focal late gadolinium enhancement at cardiac MR imaging? Radiology 2008;249:829-835.
24. Melacini P, Corbetti F, Calore C, Pescatore V, Smaniotto G, Pavei A, Bobbo F, Cacciavillani L, Iliceto S. Cardiovascular magnetic resonance signs of ischemia in hypertrophic cardiomyopathy. Int J Cardiol 2008;128:364-373.
25. Moon JC, McKenna WJ, McCrohon JA, Elliott PM, Smith GC, Pennell DJ. Toward clinical risk assessment in hypertrophic cardiomyopathy with gadolinium cardiovascular magnetic resonance. J Am Coll Cardiol 2003;41:1561-1567. (Pubitemid 36543376)
26. Moon JC, Reed E, Sheppard MN, Elkington AG, Ho SY, Burke M, Petrou M, Pennell DJ. The histologic basis of late gadolinium enhancement cardiovascular magnetic resonance in hypertrophic cardiomyopathy. J Am Coll Cardiol 2004;43: 2260-2264. (Pubitemid 38757595)
27. Bruder O, Wagner A, Jensen CJ, Schneider S, Ong P, Kispert EM, Nassenstein K, Schlosser T, Sabin GV, Sechtem U, Mahrholdt H. Myocardial scar visualized by cardiovascular magnetic resonance imaging predicts major adverse events in patients with hypertrophic cardiomyopathy. J Am Coll Cardiol 2010;56:875-887.
28. Alter P, Rupp H, Stoll F, Adams P, Wagner J, Rominger MB, Maisch B. Left ventricular hypertrophy follows increased enddiastolic wall stress in patients with dilative heart failure. Clin Res Cardiol 2010;99(Suppl 2): DOI: 10.1007/s00392-010-1200-0.
29. Barclay JL, Egred M, Kruszewski K, Nandakumar R, Norton MY, Stirrat C, Redpath TW, Walton S, Hillis GS. The relationship between transmural extent of infarction on contrast enhanced magnetic resonance imaging and recovery of contractile function in patients with first myocardial infarction treated with thrombolysis. Cardiology 2007;108:217-222. (Pubitemid 350126462)
30. Ichikawa Y, Sakuma H, Suzawa N, Kitagawa K, Makino K, Hirano T, Takeda K. Late gadolinium-enhanced magnetic resonance imaging in acute and chronic myocardial infarction. Improved prediction of regional myocardial contraction in the chronic state by measuring thickness of nonenhanced myocardium. J Am Coll Cardiol 2005;45:901-909. (Pubitemid 40342817)
31. McCrohon JA, Moon JC, Prasad SK, McKenna WJ, Lorenz CH, Coats AJ, Pennell DJ. Differentiation of heart failure related to dilated cardiomyopathy and coronary artery disease using gadolinium-enhanced cardiovascular magnetic resonance. Circulation 2003;108:54-59. (Pubitemid 36859020)
32. Brilla CG, Funck RC, Rupp H. Lisinopril-mediated regression of myocardial fibrosis in patients with hypertensive heart disease. Circulation 2000;102:1388-1393.
33. Unverferth DV, Baker PB, Swift SE, Chaffee R, Fetters JK, Uretsky BF, Thompson ME, Leier CV. Extent of myocardial fibrosis and cellular hypertrophy in dilated cardiomyopathy. Am J Cardiol 1986;57:816-820. (Pubitemid 16054340)
34. Schalla S, Bekkers SC, Dennert R, van Suylen RJ, Waltenberger J, Leiner T, Wildberger J, Crijns HJ, Heymans S. Replacement and reactive myocardial fibrosis in idiopathic dilated cardiomyopathy: comparison of magnetic resonance imaging with right ventricular biopsy. Eur J Heart Fail 2010;12:227-231.
35. Maisch B, Alter P, Pankuweit S. Diabetic cardiomyopathy-fact or fiction? Herz 2011;36:102-115.
36. Mahrholdt H, Goedecke C, Wagner A, Meinhardt G, Athanasiadis A, Vogelsberg H, Fritz P, Klingel K, Kandolf R, Sechtem U. Cardiovascular magnetic resonance assessment of human myocarditis: a comparison to histology and molecular pathology. Circulation 2004;109:1250-1258. (Pubitemid 38379570)
37. Syed IS, Glockner JF, Feng D, Araoz PA, Martinez MW, Edwards WD, Gertz MA, Dispenzieri A, Oh JK, Bellavia D, Tajik AJ, Grogan M. Role of cardiac magnetic resonance imaging in the detection of cardiac amyloidosis. JACC Cardiovasc Imaging 2010;3:155-164.
38. Alter P, Rupp H. Myocardial fibrosis in left ventricular non-compaction: is late gadolinium enhancement indeed indicative of fibrosis? Eur J Heart Fail 2011;13: 577-578.
39. Hombach V, Merkle N, Torzewski J, Kraus JM, Kunze M, Zimmermann O, Kestler HA, Wohrle J. Electrocardiographic and cardiac magnetic resonance imaging parameters as predictors of a worse outcome in patients with idiopathic dilated cardiomyopathy. Eur Heart J 2009;30:2011-2018.
40. van den Heuvel AF, van Veldhuisen DJ, van der Wall EE, Blanksma PK, Siebelink HM, Vaalburg WM, van Gilst WH, Crijns HJ. Regional myocardial blood flow reserve impairment and metabolic changes suggesting myocardial ischemia in patients with idiopathic dilated cardiomyopathy. J Am Coll Cardiol 2000;35:19-28. (Pubitemid 30061254)
41. de Simone G, Gottdiener JS, Chinali M, Maurer MS. Left ventricular mass predicts heart failure not related to previous myocardial infarction: the Cardiovascular Health Study. Eur Heart J 2008;29:741-747. (Pubitemid 351431013)
42. Wang Z, Taylor LK, Denney WD, Hansen DE. Initiation of ventricular extrasystoles by myocardial stretch in chronically dilated and failing canine left ventricle. Circulation 1994;90:2022-2031. (Pubitemid 24320955)
43. Franz MR, Cima R, Wang D, Profitt D, Kurz R. Electrophysiological effects of myocardial stretch and mechanical determinants of stretch-activated arrhythmias. Circulation 1992;86:968-978.
44. Watanabe H, Murakami M, Ohba T, Takahashi Y, Ito H. TRP channel and cardiovascular disease. Pharmacol Ther 2008;118:337-351.
45. Kuijpers NH, ten Eikelder HM, Bovendeerd PH, Verheule S, Arts T, Hilbers PA. Mechanoelectric feedback leads to conduction slowing and block in acutely dilated atria: a modeling study of cardiac electromechanics. Am J Physiol Heart Circ Physiol 2007;292:H2832-H2853. (Pubitemid 47084533)
46. Kelly D, Mackenzie L, Hunter P, Smaill B, Saint DA. Gene expression of stretchactivated channels and mechanoelectric feedback in the heart. Clin Exp Pharmacol Physiol 2006;33:642-648. (Pubitemid 43894028)
47. Young AA, Dokos S, Powell KA, Sturm B, McCulloch AD, Starling RC, McCarthy PM, White RD. Regional heterogeneity of function in nonischemic dilated cardiomyopathy. Cardiovasc Res 2001;49:308-318. (Pubitemid 32119548)