A novel binding assay identifies high affinity ligands to the rosiglitazone binding site of mitoNEET

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 18, 2011, Pages 5498-5501

  Geldenhuys, Werner J ^a   Funk, Max O ^b   Awale, Prabha S ^a   Lin, Li ^a   Carroll, Richard T ^a  

^a NORTHEAST OHIO MEDICAL UNIVERSITY   (United States)

^b UNIVERSITY OF TOLEDO   (United States)

Author keywords

Copper chelating beads; His tagged protein; Mitochondria; mitoNEET; PPAR gamma; Scintillation proximity assay beads

Indexed keywords

2 IMINOTHIAZOLIDIN 4 ONE; 2 THIOXOTHIAZOLIDIN 4 ONE; ROSIGLITAZONE; THIAZOLIDINE 2,4 DIONE; THIAZOLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; DRUG DETERMINATION; DRUG STRUCTURE;

BINDING SITES; DOSE-RESPONSE RELATIONSHIP, DRUG; LIGANDS; MITOCHONDRIAL PROTEINS; MOLECULAR STRUCTURE; RECOMBINANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINEDIONES;

EID: 80051950269     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.06.111     Document Type: Article

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