Synthesis, structure-activity relationship and biological evaluation of anticancer activity for novel N-substituted sophoridinic acid derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 18, 2011, Pages 5251-5254

  Li, Xin ^a   Zhao, Wu Li ^a   Jiang, Jian Dong ^a   Ren, Kai Huan ^a   Du, Na Na ^a   Li, Yang Biao ^a   Wang, Yan Xiang ^a   Bi, Chong Wen ^a   Shao, Rong Guang ^a   Song, Dan Qing ^a  

^a INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

Author keywords

Anticancer activity; Mechanism; N Substituted sophoridinic acid; Structure activity relationship; Topoisomerase I

Indexed keywords

ANTINEOPLASTIC AGENT; BROMOACETYL; DNA TOPOISOMERASE; FUNCTIONAL GROUP; SOPHORIDINIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE; CYTOTOXICITY; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

ALKALOIDS; ANTINEOPLASTIC AGENTS; CELL DEATH; CHEMISTRY TECHNIQUES, SYNTHETIC; DNA TOPOISOMERASES, TYPE I; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR STRUCTURE; NEOPLASMS; QUINOLIZINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80051949850     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.07.038     Document Type: Article

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