Synthesis and activity evaluation of benzoylurea derivatives as potential antiproliferative agents

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 3, 2009, Pages 755-758

  Song, Dan Qing ^a   Wang, Yue Ming ^a   Du, Na Na ^a   He, Wei Ying ^a   Chen, Ke Liang ^a   Wang, Gui Fang ^a   Yang, Peng ^a   Wu, Lian Zong ^a   Zhang, Xue Bo ^a   Jiang, Jian Dong ^a  

^a INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

Author keywords

Anticancer; Benzoylurea; Mechanism; p Conjugation; Structure activity relationship

Indexed keywords

AROMATIC COMPOUND; BENZYL DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PYRIDINE DERIVATIVE; TUBULIN; UREA DERIVATIVE; VINCRISTINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL KILLING; CELL PROLIFERATION; CONJUGATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HEPATOMA CELL; HUMAN; HUMAN CELL; IC 50; MITOSIS INHIBITION; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CARBOXYLIC ACIDS; CELL PROLIFERATION; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HUMANS; INHIBITORY CONCENTRATION 50; MITOSIS; MODELS, CHEMICAL; MOLECULAR CONFORMATION; NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 58549095420     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.12.020     Document Type: Article

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