Antibiotics in sepsis: Timing, appropriateness, and (of course) timely recognition of appropriateness

Critical Care Medicine

Volumn 39, Issue 9, 2011, Pages 2184-2186

  Mikkelsen, Mark E ^a   Gaieski, David F ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

appropriate antibiotics; emergency medicine; goal directed resuscitation; septic shock; severe sepsis; time to antibiotics

Indexed keywords

ANTIBIOTIC AGENT;

ANTIBIOTIC SENSITIVITY; ANTIBIOTIC THERAPY; BLOOD CULTURE; CENTRAL VENOUS OXYGEN SATURATION; CLINICAL PROTOCOL; CRITICALLY ILL PATIENT; DISEASE DURATION; DISEASE SEVERITY; DRUG EFFICACY; EDITORIAL; EMERGENCY HEALTH SERVICE; EMERGENCY WARD; EVIDENCE BASED MEDICINE; HEALTH CARE DELIVERY; HEMODYNAMICS; HOSPITALIZATION; HUMAN; HYPOTENSION; INCIDENCE; INTENSIVE CARE UNIT; MORTALITY; NONHUMAN; OXYGEN SATURATION; PHYSICIAN; PRIORITY JOURNAL; RESUSCITATION; RISK FACTOR; SEPSIS; SEPTIC SHOCK; TREATMENT DURATION; TREATMENT INDICATION; TREATMENT OUTCOME; UNITED STATES;

EID: 80051923665     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e3182226ffa     Document Type: Editorial

References (12)

1. Wang HE, Shapiro NI, Angus DC, et al: National estimates of severe sepsis in United States emergency departments. Crit Care Med 2007; 35:1928-1936 (Pubitemid 47220368)
2. Angus DC, Linde-Zwirble WT, Lidicker J, et al: Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001; 29:1303-1310 (Pubitemid 32641789)
3. Martin GS, Mannino DM, Eaton S, et al: The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003; 348:1546-1554 (Pubitemid 36437931)
4. Rivers E, Nguyen B, Havstad S, et al: Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001; 345:1368-1377
5. Kumar A, Roberts D, Wood KE, et al: Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006; 34:1589-1596 (Pubitemid 43810035)
6. Gaieski DF, Mikkelsen ME, Band RA, et al: Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department. Crit Care Med 2010; 38:1045-1053
7. Puskarich MA, Trzeciak S, Shapiro NI, et al: Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol. Crit Care Med 2011; 2066-2071
8. Jones AE, Shapiro NI, Trzeciak S, et al: Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: A randomized clinical trial. JAMA 2010; 303:739-746
9. Kumar A, Haery C, Paladugu B, et al: The duration of hypotension before the initiation of antibiotic treatment is a critical determinant of survival in a murine model of Escherichia coli septic shock: Association with serum lactate and inflammatory cytokine levels. J Infect Dis 2006; 193:251-258 (Pubitemid 43113487)
10. Dellinger RP, Levy MM, Carlet JM, et al: Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008; 36:296-327
11. Localio AR, Berlin JA, Ten Have TR, et al: Adjustments for center in multicenter studies: An overview. Ann Intern Med 2001; 13:112-123 (Pubitemid 32661194)
12. Kumar A, Ellis P, Arabi Y, et al: Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock. Chest 2009; 136: 1237-1248