Synthesis of withanolide A depends on carbon source and medium pH in hairy root cultures of Withania somnifera

Industrial Crops and Products

Volumn 35, Issue 1, 2012, Pages 241-243

  Praveen, N ^a,b   Murthy, H N ^a  

^a KARNATAK UNIVERSITY   (India)

^b Konkuk University   (South Korea)

Author keywords

Carbon source; Hairy root culture; Medium pH; Sucrose concentration; Withania somnifera; Withanolide A

Indexed keywords

CARBON SOURCE; HAIRY ROOT CULTURE; MEDIUM PH; SUCROSE CONCENTRATION; WITHANIA SOMNIFERA; WITHANOLIDE-A;

BIOMASS; FRUCTOSE; GLUCOSE; OPTIMIZATION; SUGAR (SUCROSE);

PH EFFECTS;

CARBON; COMMERCIAL SPECIES; DICOTYLEDON; MEDICINAL PLANT; OPTIMIZATION; PH; PHYTOMASS; ROOT SYSTEM; SECONDARY METABOLITE; SUCROSE; TRICHOME;

PANAX GINSENG; WITHANIA SOMNIFERA;

EID: 80051922638     PISSN: 09266690     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.indcrop.2011.07.009     Document Type: Article

References (10)

1. Bhatia P., Ashwath N. Effect of medium pH on shoot regerenration from the cotyledonary explants of tomato. Biotechnology 2005, 4:7-10.
2. Bhattacharaya S.K., Bhattacharya D., Sairam K., Ghosal S. Effect of Withania somnifera glycowithanolides on rat model of tardie dyskinesia. Phytomedicine 2002, 9:167-170.
3. Ganzera M., Choudhary M.I., Khan I.A. Quantitative HPLC analysis of withanolides in Withania somnifera. Fitoterapia 2003, 74:68-76.
4. Mukundan U., Hjortso A.M. Growth and thiophene accumulation by hairy root cultures of Tagetes patula in media of varying initial pH. Plant Cell Rep. 1991, 9:627-630.
5. Murashige T., Skoog F. A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol. Plant 1962, 15:473-497.
6. Murthy H.N., Dijkstra C., Anthony P., White D.A., Davey M.R., Power J.B., Hahn E.J., Paek K.Y. Establishment of Withania somnifera hairy root cultures for the production of withanolide A. J. Int. Plant Biol. 2008, 50:975-981.
7. Sivakumar G., Yu K.W., Hahn E.J., Paek K.Y. Optimization of organic nutrients for ginseng hairy roots production in large-scale bioreactors. Curr. Sci. 2005, 89:641-649.
8. Wang Y., Weathers P.J. Sugars proportionately affect artemisin production. Plant Cell Rep. 2007, 26:1073-1081.
9. Wu C.H., Dewir Y.H., Hahn E.J., Paek K.Y. Optimization of culturing conditions for the production of biomass and phenolics from adventitious roots of Echinacea angustifolia. J. Plant Biol. 2006, 49:193-199.
10. Zhao J., Nakamura N., Hattori M., Kuboyama T., Tohda C., Komatsu K. Withanolide derivatives from roots of Withania somnifera and their neurite outgrowth activities. Chem. Pharm. Bull. 2002, 50:760-765.