Synthesis of 13C-labeled derivatives of cysteine for magnetic resonance imaging studies of drug uptake and conversion to glutathione in rat brain

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 54, Issue 9, 2011, Pages 607-612

  Amoyaw, Prince N A ^a   Springer, James B ^b,e   Gamcsik, Michael P ^c   Mutesi, Rebecca L ^b   D'Alessandro, Michael A ^d   Dempsey, Collin R ^a   Ludeman, Susan M ^a  

^a ACPHS   (United States)

^b DUKE CANCER INSTITUTE   (United States)

^c NORTH CAROLINA STATE UNIVERSITY   (United States)

^d ALBANY COLLEGE OF PHARMACY AND HEALTH SCIENCES   (United States)

^e Eno Research and Consulting LLC   (United States)

Author keywords

2 oxothiazolidine 4 carboxylic acid; ethyl glutamylcysteinate; N acetylcysteine; OTZ; synthesis

Indexed keywords

AMINO ACIDS; BIOCHEMISTRY; CARBOXYLATION; CARBOXYLIC ACIDS; CYTOLOGY; DETOXIFICATION; FREE RADICALS; ISOMERS; NITROGEN COMPOUNDS; PEPTIDES; SODIUM COMPOUNDS;

2-OXOTHIAZOLIDINE-4- CARBOXYLIC ACID; DIASTEREOMERS; DRUG UPTAKE; ETHYL GLUTAMYLCYSTEINATE; GLUTHATHIONE; N-ACETYLCYSTEINE; NEURODEGENERATION; OTZ; PRODRUGS; THIAZOLIDINES;

MAGNETIC RESONANCE IMAGING;

2 OXO 4 THIAZOLIDINECARBOXYLIC ACID; ACETALDEHYDE; ACETIC ACID DERIVATIVE; ACETIC ANHYDRIDE; ACETYLCYSTEINE; BIS(TRIMETHYLSILYL)TRIFLUOROACETAMIDE; CARBON 13; CYSTEINE; CYSTEINE DERIVATIVE; ETHYL GAMMA GLUTAMYL CYSTEINATE; GLUTATHIONE; HYDRAZINE; HYDROGEN SULFIDE; MERCURY (II) ACETATE; N PHTHALOYL GLUTAMIC ANHYDRIDE; PRODRUG; SODIUM ACETATE TRIHYDRATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTINUOUS INFUSION; CYCLIZATION; DRUG DISTRIBUTION; DRUG SYNTHESIS; DRUG UPTAKE; ESTERIFICATION; IN VIVO STUDY; ISOTOPE LABELING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; RAT; SILYLATION;

RATTUS;

EID: 80051912880     PISSN: 03624803     EISSN: 10991344     Source Type: Journal    
DOI: 10.1002/jlcr.1904     Document Type: Article

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