Effects of Defatted Safflower Seed Extract and Phenolic Compounds in Diet on Plasma and Liver Lipid in Ovariectomized Rats Fed High-Cholesterol Diets

Journal of Nutritional Science and Vitaminology

Volumn 50, Issue 1, 2004, Pages 32-37

  Cho, Sung Hee ^a   Lee, Hyang Rim ^a   Kim, Tae Hee ^a   Choi, Sang Won ^a   Lee, Won Jung ^b   Choi, Youngsun ^c  

^a Catholic University of Daegu   (South Korea)

^b Kyungpook National University   (South Korea)

^c Daegu University   (South Korea)

Author keywords

Cholesterol; Flavone; Ovariectomy; Safflower lignan; Serotonin

Indexed keywords

ACACETIN; ACETIC ACID ETHYL ESTER; ALANINE AMINOTRANSFERASE; ALCOHOL; ASPARTATE AMINOTRANSFERASE; BILE ACID; CHOLESTEROL; FECES LIPID; FLAVONE DERIVATIVE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIGNAN DERIVATIVE; MATAIRESINOL; PHENOL DERIVATIVE; PLANT EXTRACT; POLYPHENOL DERIVATIVE; SEROTONIN DERIVATIVE; TRIACYLGLYCEROL;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL LEVEL; CELL STRAIN HEPG2; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CHOLESTEROL LIVER LEVEL; CHOLESTEROL SYNTHESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIETARY INTAKE; ESTROGEN DEFICIENCY; EXTRACTION; FECES LEVEL; FEMALE; FOOD COMPOSITION; HUMAN; HUMAN CELL; LIPID BLOOD LEVEL; LIPID LIVER LEVEL; NONHUMAN; OVARIECTOMY; PLANT SEED; RAT; RAT STRAIN; SAFFLOWER; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALIA; CARTHAMUS TINCTORIUS;

EID: 1642421844     PISSN: 03014800     EISSN: 18817742     Source Type: Journal    
DOI: 10.3177/jnsv.50.32     Document Type: Article

References (34)

1. Miksicek RJ. 1994. Interaction of naturally occurring nonsteroidal estrogens with expressed recombinant human estrogen receptor. J Steroid Biochem Mol Biol 49: 153-160.
2. Molteni A, Brizio-Molteni L, Persky V. 1995. In vitro hormonal effects of soybean isoflavones. J Nutr 125: 751S-756S.
3. Kurzer M, Xy X. 1997. Dietary phytoestrogens. Annu Rev Nutr 17: 353-381.
4. Murkies AL, Wilcox G, Davis SR. 1998. Clinical review 92, phytoestrogens. J Clin Endocrinol Metab 83: 297-303.
5. Orcheson LJ, Rickard SE, Seidl MM, Thompson LU. 1998. Flaxseed and its mammalian lignan precursor cause a lengthening or cessation of estrous cycling in rats. Cancer Lett 125: 69-76.
6. Yamashita K, Nohara Y, Katayama K, Namiki, M. 1992. Sesame seed lignans and γ-tocopherol act synergistically to produce vitamin E activity in rats. J Nutr 122: 2440-2446.
7. Jeon SM, Kim JH, An MY, Ku SK, Lee JH, Choi MS, Moon KD. 1998. Effects of diet of Korean safflower (Carthamus tinctorious L.) seed powder on bone tissue in rats during the recovery of rib fracture. J Korean Soc Food Sci Nutr 27: 698-704.
8. USDA: Nutrient Database for Standard References. Release 13. 2001: NDB No. 120218.
9. Palter R, Lundin RE. 1970. A bitter principle of safflower: matairesinol monoglucoside. Phytochem 9: 2407-2409.
10. Palter R, Lundin RE, Haddon WF. 1972. A cathartic lignan glycoside isolated from Carthamus tinctorious. Phytochem 11: 2871-2874.
11. Palter R, Haddon WF, Lundin RE. 1972. Structure of a safflower steroid cellobioside. Phytochem 11; 2327-2328.
12. Zhang HL, Nagatsu A, Watanabe T, Sakakibara J, Okuyama H. 1977. Antioxidative compounds isolated from safflower (Carthamus tinctorious L.) oil cake. Chem Pharm Bull 45: 1910-1914.
13. Kang G-H, Chang E-J, Choi S-W, 1999. Antioxidative activity of phenolic compounds in roasted safflower (Carthamus tinctorious L.) seeds. J Food Sci Nutr 4: 221-225.
14. Jung CG, Ahn KS, Moon JJ. 1989. Study on the effects of Astragali Radix, Cinnamomi Ramulus and Carthami Flos on thrombosis and elevated blood viscosity. Korean J Oriental Med Pathol 4: 74-93.
15. Kim HJ, Bae YC, Park RW, Choi SW, Cho SH, Choi YS, Lee WJ. 2002. Bone-protecting effect of safflower seed in ovariectomized rats. Calcif Tissue Int 71: 88-94.
16. Cho S-H, Choi S-W, Choi Y, Lee W-J. 2001. Effects of defatted safflower and perilla seed powders on lipid metabolism in ovariectomized female rats fed high cholesterol diets. J Korean Soc Food Sci Nutr 30: 112-118.
17. Moon KD, Baek S-S, Kim J-H, Jeon S-M, Lee M-K, Choi M-S. 2001. Safflower seed extract lowers plasma and hepatic lipid in rats red high-cholesterol diets. Nutr Res 21: 895-904.
18. Folch J, Lees M, Sloane-Stanley GH. 1957. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226: 497-509.
19. Sale FO, Marchesini S, Fishman PH, Berra B. 1984. A sensitive enzymatic assay for determination of cholesterol in lipid extracts. Anal Biochem 142: 347-350.
20. Crowell MJ, Macdonald IA. 1980. Enzymatic determination of 3α-, 7α-, and 12-hydroxyl groups of fecal bile salts. Clin Chem 26: 1298-1300.
21. Ramirez ME, McMurry MP, Wiebke GA, Felton KJ, Ren K, Meikle AW, Iverius PH. 1997. Evidence for sex steroid inhibition of lipoprotein lipase in men: comparison of abdominal and femoral adipose tissue. Metabolism 46: 179-185.
22. Valette A, Meignen KM, Mercier L, Liehr JG, Boyer J. 1986. Effects of 2-fluoroestradiol on lipid metabolism in the ovariectomized rat. J Steroid Biochem 25: 575-578.
23. Huxtable RJ. 1992. The pharmacology of extinction. J Enthnopharm 37: 1-11.
24. Prasad K. 1999. Reduction of serum cholesterol and hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed. Circulation 99: 1355-1362.
25. Boker LK, van der Schouw YT, De Kleijn MJJ, Jacques PF, Grobbee DE, Peeters PHM. 2002. Intake of dietary phytoestrogens by Dutch women. J Nutr 132: 1319-1328.
26. Windler EET, Kovanen PT, Chao Y-S, Brown MS, Havel RJ, Goldstein JL. 1980. The estradiol-stimulated lipoprotein receptor of rat liver. J Biol Chem 255: 10464-10471.
27. Landschulz KT, Pathak RK, Rigotti A, Krieger M, Hobbs HH. 1996. Regulation of scavenger receptor class B. type, a high-density lipoprotein receptor, in liver and steroidogenic tissues of the rat. J Clin Invest 98: 984-995.
28. Lamon-Fava S. 2002. High-density lipoproteins: effects of alcohol, estrogen and phytoestrogens. Nutr Rev 60: 1-7.
29. Anthony MS, Clarkson TB, Hughes Jr CL, Morgan TM, Burke GL. 1996. Soybean isoflavones improve cardiovascular risk factors without affecting the reproducing system of peripubertal Rhesus monkeys. J Nutr 126: 43-50,
30. Lamon-Fava S. 2000. Genistein activates apolipoprotein A-1 gene expression in the human hepatoma cell line HepG2. J Nutr 130: 2489-2492.
31. Kozarsky KF, Donahee MH, Rigott A, Iqbal SN, Edelman ER, Krieger M. 1997. Overexpression of the HDL receptor SR-B1 alters plasma HDL and bile cholesterol levels. Nature 387: 414-418.
32. Fluiter K, van derWesthuijzen DR, van Berkel TJ. 1998. In vivo regulation of scavenger receptor B1 and the selective uptake of high-density lipoprotein cholesteryl esters in rat liver parenchmal and Kupffer cells. J Biol Chem 273: 8434-8438.
33. Nogowske L, Mackowiak P, Kandulska K, Sckudelski T, Nowak KW. 1998. Genestien-induced Changes in lipid metabolism of ovariectomized rats. Ann Nutr Metab 42: 360-366.
34. Kirk EA, Sutherland P, Wang SA, Chait A, LeBoeuf RC. 1998. Dietary isoflavones reduce plasma cholesterol and atherosclerosis in C57BL/6 mice but not LDL receptor-deficient mice. J Nutr 128: 954-959.