Medical management of motility disorders in patients with intestinal failure: A focus on necrotizing enterocolitis, gastroschisis, and intestinal atresia

Journal of Pediatric Surgery

Volumn 46, Issue 8, 2011, Pages 1618-1630

  Dicken, Bryan J ^a,c   Sergi, Consolato ^a   Rescorla, Frederick J ^b   Breckler, Francine ^b   Sigalet, David ^c  

^a UNIVERSITY OF ALBERTA HOSPITAL   (Canada)

^b INDIANA UNIVERSITY   (United States)

^c UNIVERSITY OF CALGARY   (Canada)

Author keywords

Antidiarrheal agents; Dysmotility; Intestinal failure; Promotility agents; Short bowel syndrome

Indexed keywords

ATROPINE; ATROPINE PLUS DIPHENOXYLATE; CISAPRIDE; CODEINE; COLESTYRAMINE; DIPHENOXYLATE; DOMPERIDONE; DOPAMINE RECEPTOR BLOCKING AGENT; ERYTHROMYCIN; LOPERAMIDE; METOCLOPRAMIDE; SEROTONIN 1 RECEPTOR; SEROTONIN 4 AGONIST; SEROTONIN 4 RECEPTOR; SEROTONIN AGONIST; URSODEOXYCHOLIC ACID;

ABDOMINAL PAIN; CLINICAL FEATURE; DIARRHEA; DRUG METABOLISM; DRUG SAFETY; ENTEROPATHY; FEEDING DISORDER; GASTROINTESTINAL MOTILITY DISORDER; GASTROSCHISIS; HEART DISEASE; HUMAN; INTESTINAL FAILURE; INTESTINE ATRESIA; IRRITABILITY; NECROTIZING ENTEROCOLITIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; SHORT BOWEL SYNDROME; STOMACH EMPTYING; VOMITING;

ANTIDIARRHEALS; ENTEROCOLITIS, NECROTIZING; GASTROINTESTINAL AGENTS; GASTROINTESTINAL MOTILITY; GASTROSCHISIS; HUMANS; INTESTINAL ATRESIA; INTESTINAL DISEASES; MALABSORPTION SYNDROMES; SHORT BOWEL SYNDROME;

EID: 80051901955     PISSN: 00223468     EISSN: 15315037     Source Type: Journal    
DOI: 10.1016/j.jpedsurg.2011.04.002     Document Type: Review

References (92)

1. G.L. Carlson, and P. Dark Acute intestinal failure Curr Opin Crit Care 16 4 2010 347 352
2. D. Duro, D. Kamin, and C. Duggan Overview of pediatric short bowel syndrome J Pediatr Gastroenterol Nutr 47 Suppl 1 2008 S33 S36
3. J.J. Wessel, and S.A. Kocoshis Nutritional management of infants with short bowel syndrome Semin Perinatol 31 2 2007 104 111 (Pubitemid 46616963)
4. A.U. Spencer, A. Neaga, and B. West Pediatric short bowel syndrome: redefining predictors of success Ann Surg 242 3 2005 403 409 [discussion 09-12]
5. J.C. Molenaar, D. Tibboel, and A.W. van der Kamp Diagnosis of innervation-related motility disorders of the gut and basic aspects of enteric nervous system development Prog Pediatr Surg 24 1989 173 185
6. G. Karamanolis, and J. Tack Promotility medications-now and in the future Dig Dis 24 3-4 2006 297 307
7. C.E. Nwachukwu, and J.U. Okebe Antimotility agents for chronic diarrhoea in people with HIV/AIDS Cochrane Database Syst Rev 4 2008 CD005644
8. D.T. Beattie, and J.A. Smith Serotonin pharmacology in the gastrointestinal tract: a review Naunyn Schmiedebergs Arch Pharmacol 377 3 2008 181 203
9. G.B. Glavin, and S. Szabo Dopamine in gastrointestinal disease Dig Dis Sci 35 9 1990 1153 1161 (Pubitemid 20289669)
10. P. Holzer Opioid receptors in the gastrointestinal tract Regul Pept 155 1-3 2009 11 17
11. E. Takeshita, B. Matsuura, and M. Dong Molecular characterization and distribution of motilin family receptors in the human gastrointestinal tract J Gastroenterol 41 3 2006 223 230
12. W.M. Sun Small intestinal motility R.N. Ratnaike, Small bowel disorders 1st ed 2000 Oxford University Press New York 190 201
13. S. Feichter, W.A. Meier-Ruge, and E. Bruder The histopathology of gastrointestinal motility disorders in children Semin Pediatr Surg 18 4 2009 206 211
14. E. Husebye The patterns of small bowel motility: physiology and implications in organic disease and functional disorders Neurogastroenterol Motil 11 3 1999 141 161 (Pubitemid 29259606)
15. G. Vantrappen, J. Janssens, and J. Hellemans The interdigestive motor complex of normal subjects and patients with bacterial overgrowth of the small intestine J Clin Invest 59 6 1977 1158 1166 (Pubitemid 8131071)
16. N.W. Read, M.N. Al-Janabi, and C.A. Edwards Relationship between postprandial motor activity in the human small intestine and the gastrointestinal transit of food Gastroenterology 86 4 1984 721 727 (Pubitemid 14164726)
17. S. Cucchiara, O. Borrelli, and G. Salvia A normal gastrointestinal motility excludes chronic intestinal pseudoobstruction in children Dig Dis Sci 45 2 2000 258 264 (Pubitemid 30133883)
18. E. Husebye, P.M. Hellstrom, and T. Midtvedt Intestinal microflora stimulates myoelectric activity of rat small intestine by promoting cyclic initiation and aboral propagation of migrating myoelectric complex Dig Dis Sci 39 5 1994 946 956 (Pubitemid 24188834)
19. E. Husebye, M. Hauer-Jensen, and K. Kjorstad Severe late radiation enteropathy is characterized by impaired motility of proximal small intestine Dig Dis Sci 39 11 1994 2341 2349 (Pubitemid 24350014)
20. E. Husebye, V. Skar, and T. Hoverstad Abnormal intestinal motor patterns explain enteric colonization with gram-negative bacilli in late radiation enteropathy Gastroenterology 109 4 1995 1078 1089
21. K. Nygaard Gastro-intestinal motility after resections and bypass-operations on the small intestine in rats. The effect of different types of anastomosis Acta Chir Scand 133 8 1967 653 663
22. R.A. Cowles, K.A. Ventura, and M. Martinez Reversal of intestinal failure-associated liver disease in infants and children on parenteral nutrition: experience with 93 patients at a referral center for intestinal rehabilitation J Pediatr Surg 45 1 2010 84 87 [discussion 87-8]
23. A.P. Ladd, F.J. Rescorla, and K.W. West Long-term follow-up after bowel resection for necrotizing enterocolitis: factors affecting outcome J Pediatr Surg 33 7 1998 967 972 (Pubitemid 28337303)
24. J.D. Phillips, M.V. Raval, and C. Redden Gastroschisis, atresia, dysmotility: surgical treatment strategies for a distinct clinical entity J Pediatr Surg 43 12 2008 2208 2212
25. W.P. Tunell, N.K. Puffinbarger, and D.W. Tuggle Abdominal wall defects in infants. Survival and implications for adult life Ann Surg 221 5 1995 525 528 [discussion 28-30]
26. A. Takahashi, T. Tomomasa, and N. Suzuki The relationship between disturbed transit and dilated bowel, and manometric findings of dilated bowel in patients with duodenal atresia and stenosis J Pediatr Surg 32 8 1997 1157 1160 (Pubitemid 27475890)
27. T.R. Weber, and M.A. Powell Early improvement in intestinal function after isoperistaltic bowel lengthening J Pediatr Surg 31 1 1996 61 63 [discussion 63-4]
28. W.A. Ballance, B.B. Dahms, and N. Shenker Pathology of neonatal necrotizing enterocolitis: a ten-year experience J Pediatr 117 1 Pt 2 1990 S6 13
29. E. Husebye Gastrointestinal motility disorders and bacterial overgrowth J Intern Med 237 4 1995 419 427
30. R.C. Spiller, I.F. Trotman, and B.E. Higgins The ileal brake-inhibition of jejunal motility after ileal fat perfusion in man Gut 25 4 1984 365 374 (Pubitemid 14136456)
31. P. Midrio, M.S. Faussone-Pellegrini, and M.G. Vannucchi Gastroschisis in the rat model is associated with a delayed maturation of intestinal pacemaker cells and smooth muscle cells J Pediatr Surg 39 10 2004 1541 1547 (Pubitemid 39349739)
32. S.K. Srinathan, J.C. Langer, and M.G. Blennerhassett Etiology of intestinal damage in gastroschisis. III: morphometric analysis of the smooth muscle and submucosa J Pediatr Surg 30 3 1995 379 383
33. K. Masumoto, S. Suita, and T. Taguchi The occurrence of unusual smooth muscle bundles expressing alpha-smooth muscle actin in human intestinal atresia J Pediatr Surg 38 2 2003 161 166 (Pubitemid 36160056)
34. I.F. Ozguner, C. Savas, and M. Ozguner Intestinal atresia with segmental musculature and neural defect J Pediatr Surg 40 8 2005 1232 1237 (Pubitemid 41096145)
35. P. Ramachandran, P. Vincent, and S. Ganesh Morphological abnormalities in the innervation of the atretic segment of bowel in neonates with intestinal atresia Pediatr Surg Int 23 12 2007 1183 1186 (Pubitemid 350165321)
36. G. Gabella Hypertrophy of intestinal smooth muscle Cell Tissue Res 163 2 1975 199 214
37. C.B. Bob Phillips, D. Sackett, and B. Haynes Evidence-based medicine 2002
38. J.J. Galligan, and S. Vanner Basic and clinical pharmacology of new motility promoting agents Neurogastroenterol Motil 17 5 2005 643 653 (Pubitemid 41400712)
39. M.M. Costedio, N. Hyman, and G.M. Mawe Serotonin and its role in colonic function and in gastrointestinal disorders Dis Colon Rectum 50 3 2007 376 388 (Pubitemid 46394454)
40. R. Spiller Serotonergic modulating drugs for functional gastrointestinal diseases Br J Clin Pharmacol 54 1 2002 11 20 (Pubitemid 36124749)
41. J.L. Madsen Effects of cisapride on gastrointestinal transit in healthy humans Dig Dis Sci 35 12 1990 1500 1504
42. J.S. Finney, N. Kinnersley, and M. Hughes Meta-analysis of antisecretory and gastrokinetic compounds in functional dyspepsia J Clin Gastroenterol 26 4 1998 312 320 (Pubitemid 28272513)
43. M. Kohl, I. Wuerdemann, and J. Clemen Cisapride may improve feeding tolerance of preterm infants: a randomized placebo-controlled trial Biol Neonate 88 4 2005 270 275 (Pubitemid 41642750)
44. M.F. Chicella, L.A. Batres, and M.S. Heesters Prokinetic drug therapy in children: a review of current options Ann Pharmacother 39 4 2005 706 711 (Pubitemid 40396626)
45. S. Ohwada, Y. Satoh, and S. Kawate Low-dose erythromycin reduces delayed gastric emptying and improves gastric motility after Billroth I pylorus-preserving pancreaticoduodenectomy Ann Surg 234 5 2001 668 674 (Pubitemid 33041770)
46. E. Ng, and V.S. Shah Erythromycin for the prevention and treatment of feeding intolerance in preterm infants Cochrane Database Syst Rev 3 2008 CD001815
47. J.I. Curry, A.D. Lander, and M.D. Stringer A multicenter, randomized, double-blind, placebo-controlled trial of the prokinetic agent erythromycin in the postoperative recovery of infants with gastroschisis J Pediatr Surg 39 4 2004 565 569 (Pubitemid 38500378)
48. P.C. Ng Use of oral erythromycin for the treatment of gastrointestinal dysmotility in preterm infants Neonatology 95 2 2009 97 104
49. F. Caron, P. Ducrotte, and E. Lerebours Effects of amoxicillin- clavulanate combination on the motility of the small intestine in human beings Antimicrob Agents Chemother 35 6 1991 1085 1088
50. J. Wood Physiology of the enteric nervous system L. Johnson, Physiology of the Gastrointestinal tract 2nd ed. 1987 Raven Press New York 67 105
51. M. Horowitz, P.E. Harding, and B.E. Chatterton Acute and chronic effects of domperidone on gastric emptying in diabetic autonomic neuropathy Dig Dis Sci 30 1 1985 1 9 (Pubitemid 15151506)
52. D. Patterson, T. Abell, and R. Rothstein A double-blind multicenter comparison of domperidone and metoclopramide in the treatment of diabetic patients with symptoms of gastroparesis Am J Gastroenterol 94 5 1999 1230 1234 (Pubitemid 29214634)
53. S.J. Veldhuyzen van Zanten, M.J. Jones, and M. Verlinden Efficacy of cisapride and domperidone in functional (nonulcer) dyspepsia: a meta-analysis Am J Gastroenterol 96 3 2001 689 696 (Pubitemid 32240716)
54. J. Wiley, and C. Owyang Dopaminergic modulation of rectosigmoid motility: action of domperidone J Pharmacol Exp Ther 242 2 1987 548 551 (Pubitemid 17143487)
55. C.E. Gariepy, and H. Mousa Clinical management of motility disorders in children Semin Pediatr Surg 18 4 2009 224 238
56. G.L. Kearns, H.L. Butler, and J.K. Lane Metoclopramide pharmacokinetics and pharmacodynamics in infants with gastroesophageal reflux J Pediatr Gastroenterol Nutr 7 6 1988 823 829
57. H.M. Machida, D.A. Forbes, and D.G. Gall Metoclopramide in gastroesophageal reflux of infancy J Pediatr 112 3 1988 483 487 (Pubitemid 18079844)
58. V. Tolia, J. Calhoun, and L. Kuhns Randomized, prospective double-blind trial of metoclopramide and placebo for gastroesophageal reflux in infants J Pediatr 115 1 1989 141 145 (Pubitemid 19177986)
59. D. Sigalet, D. Boctor, and M. Robertson Improved outcomes in paediatric intestinal failure with aggressive prevention of liver disease Eur J Pediatr Surg 19 6 2009 348 353
60. D.L. Sigalet, and G.R. Martin Hormonal therapy for short bowel syndrome J Pediatr Surg 35 2 2000 360 363 [discussion 64]
61. M. Tonini, R. De Giorgio, and V. Spelta 5-HT4 receptors contribute to the motor stimulating effect of levosulpiride in the guinea-pig gastrointestinal tract Dig Liver Dis 35 4 2003 244 250 (Pubitemid 41070479)
62. F. Mearin, L. Rodrigo, and A. Perez-Mota Levosulpiride and cisapride in the treatment of dysmotility-like functional dyspepsia: a randomized, double-masked trial Clin Gastroenterol Hepatol 2 4 2004 301 308 (Pubitemid 38447194)
63. L.R. Schiller, G.R. Davis, and C.A. Santa Ana Studies of the mechanism of the antidiarrheal effect of codeine J Clin Invest 70 5 1982 999 1008 (Pubitemid 13254923)
64. M.J. Lentze Intestinal adaptation in short-bowel syndrome Eur J Pediatr 148 4 1989 294 299 (Pubitemid 19031031)
65. J. Jailwala, T.F. Imperiale, and K. Kroenke Pharmacologic treatment of the irritable bowel syndrome: a systematic review of randomized, controlled trials Ann Intern Med 133 2 2000 136 147 (Pubitemid 30490414)
66. A. Carr, and D.A. Cooper Adverse effects of antiretroviral therapy Lancet 356 9239 2000 1423 1430
67. D.E. Baker Loperamide: a pharmacological review Rev Gastroenterol Disord 7 Suppl 3 2007 S11 18
68. F. Musial, P. Enck, and K.T. Kalveram The effect of loperamide on anorectal function in normal healthy men J Clin Gastroenterol 15 4 1992 321 324 (Pubitemid 23011451)
69. K.R. Palmer, C.L. Corbett, and C.D. Holdsworth Double-blind cross-over study comparing loperamide, codeine and diphenoxylate in the treatment of chronic diarrhea Gastroenterology 79 6 1980 1272 1275 (Pubitemid 11250471)
70. R.F. King, T. Norton, and G.L. Hill A double-blind crossover study of the effect of loperamide hydrochloride and codeine phosphate on ileostomy output Aust N Z J Surg 52 2 1982 121 124 (Pubitemid 12124660)
71. N.H. Alam, R. Meier, and H. Schneider Partially hydrolyzed guar gum-supplemented oral rehydration solution in the treatment of acute diarrhea in children J Pediatr Gastroenterol Nutr 31 5 2000 503 507
72. H.R. Chowdhury, M. Yunus, and K. Zaman The efficacy of bismuth subsalicylate in the treatment of acute diarrhoea and the prevention of persistent diarrhoea Acta Paediatr 90 6 2001 605 610 (Pubitemid 32595861)
73. W.E. Roediger, and A. Moore Effect of short-chain fatty acid on sodium absorption in isolated human colon perfused through the vascular bed Dig Dis Sci 26 2 1981 100 106 (Pubitemid 11184318)
74. T. Sakata Effects of indigestible dietary bulk and short chain fatty acids on the tissue weight and epithelial cell proliferation rate of the digestive tract in rats J Nutr Sci Vitaminol (Tokyo) 32 4 1986 355 362
75. W.E. Roediger Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man Gut 21 9 1980 793 798 (Pubitemid 11209227)
76. J.A. Roth, W.L. Frankel, and W. Zhang Pectin improves colonic function in rat short bowel syndrome J Surg Res 58 2 1995 240 246
77. G.H. Rabbani, G.J. Fuchs, and Teka T. Beneficial effects of pectin and raw banana in the dietary management of persistent diarrhea in children [abstract] Gastroenterology 114 1998 A407
78. Y. Finkel, G. Brown, and H.L. Smith The effects of a pectin-supplemented elemental diet in a boy with short gut syndrome Acta Paediatr Scand 79 10 1990 983 986 (Pubitemid 20333517)
79. M. Puwanant, L. Mo-Suwan, and S. Patrapinyokul Recurrent D-lactic acidosis in a child with short bowel syndrome Asia Pac J Clin Nutr 14 2 2005 195 198 (Pubitemid 40769792)
80. K.V. Kowdley Ursodeoxycholic acid therapy in hepatobiliary disease Am J Med 108 6 2000 481 486 (Pubitemid 30214200)
81. M. Trauner, and I.W. Graziadei Review article: mechanisms of action and therapeutic applications of ursodeoxycholic acid in chronic liver diseases Aliment Pharmacol Ther 13 8 1999 979 996
82. K.D. Setchell, C.M. Rodrigues, and C. Clerici Bile acid concentrations in human and rat liver tissue and in hepatocyte nuclei Gastroenterology 112 1 1997 226 235 (Pubitemid 27009006)
83. A. Radominska, S. Treat, and J. Little Bile acid metabolism and the pathophysiology of cholestasis Semin Liver Dis 13 3 1993 219 234 (Pubitemid 23294210)
84. R. Olsson, K.M. Boberg, and O.S. de Muckadell High-dose ursodeoxycholic acid in primary sclerosing cholangitis: a 5-year multicenter, randomized, controlled study Gastroenterology 129 5 2005 1464 1472 (Pubitemid 41597389)
85. K.D. Lindor, K.V. Kowdley, and V.A. Luketic High-dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis Hepatology 50 3 2009 808 814
86. P. Beau, J. Labat-Labourdette, and P. Ingrand Is ursodeoxycholic acid an effective therapy for total parenteral nutrition-related liver disease? J Hepatol 20 2 1994 240 244 (Pubitemid 24086839)
87. M.I. Spagnuolo, R. Iorio, and A. Vegnente Ursodeoxycholic acid for treatment of cholestasis in children on long-term total parenteral nutrition: a pilot study Gastroenterology 111 3 1996 716 719 (Pubitemid 26293237)
88. M. Merli, S. Bertasi, and R. Servi Effect of a medium dose of ursodeoxycholic acid with or without taurine supplementation on the nutritional status of patients with cystic fibrosis: a randomized, placebo-controlled, crossover trial J Pediatr Gastroenterol Nutr 19 2 1994 198 203 (Pubitemid 24299630)
89. G. De Marco, D. Sordino, and E. Bruzzese Early treatment with ursodeoxycholic acid for cholestasis in children on parenteral nutrition because of primary intestinal failure Aliment Pharmacol Ther 24 2 2006 387 394 (Pubitemid 43972907)
90. L. Sinha, R. Liston, and H.J. Testa Idiopathic bile acid malabsorption: qualitative and quantitative clinical features and response to cholestyramine Aliment Pharmacol Ther 12 9 1998 839 844 (Pubitemid 28428947)
91. J.T. Garbutt, and T.J. Kenney Effect of cholestyramine on bile acid metabolism in normal man J Clin Invest 51 11 1972 2781 2789
92. A.J. Williams, M.V. Merrick, and M.A. Eastwood Idiopathic bile acid malabsorption-a review of clinical presentation, diagnosis, and response to treatment Gut 32 9 1991 1004 1006