Influence of intramuscular application of autologous conditioned plasma on systemic circulating IGF-1

Journal of Sports Science and Medicine

Volumn 10, Issue 3, 2011, Pages 439-444

  Schippinger, Gert ^a,b   Oettl, Karl ^a   Fankhauser, Florian ^b   Spirk, Stefan ^a,c   Domej, Wolfgang ^a   Hofmann, Peter ^a,c  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b Sportchirurgie Plus Graz ^*  (Austria)

^c UNIVERSITY OF GRAZ   (Austria)

Author keywords

Cancer risk; Doping; IGF 1; Intramuscular application; Platelet rich plasma

Indexed keywords

EID: 80051901104     PISSN: None     EISSN: 13032968     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Anitua, E., Andía, I., Sanchez, M., Azofra, J., del Mar Zalduendo, M., de la Fuente, M., Nurden, P. and Nurden, AT. (2005) Autolo-gous preparations rich in growth factors promote proliferation and induce VEGF and HGF production by human tendon cells in culture. Journal of Orthopaedic Research 23(2), 281-286.
2. Arnoczky, S.P., Anderson, L., Fanelli, G., Ho, S., Mishra, A. and Scgalione, N. (2009) The role of platelet-rich plasma in connective tissue repair. Orthopaedics Today 26, 29.
3. Baltzer, A.W., Moser, C., Jansen, S.A. and Krauspe, R. (2009) Autolo-gous conditioned serum (Orthokine) is an effective treatment for knee osteoarthritis. Osteoarthritis and Cartilage 17, 152-160.
4. Banfi, G., Corsi, M.M. and Volpi, P. (2006) Could platelet rich plasma have effects on systemic circulating growth factors and cyto-kine release in orthopaedic applications? British Journal of Sports Medicine 40, 816.
5. Brabant, G., von zur Mühlen, A., Wüster, C., Ranke, M.B., Kratzsch, J., Kiess, W., Ketelslegers, J.M., Wilhelmsen, L., Hulthén, L., Saller, B., Mattsson, A., Wilde, J., Schemer, R. and Kann, P. (2003) Serum insulin like Growth Factor 1 Reference Values for an Automated Chemiluminescence Immunoassay System: Results from a Multicenter Study. Hormone Research 60, 53-60.
6. Buhr, M. and Siekmann, W. (2009) Intra-articular Injection of Platelet Rich Plasma for cartilage repair. Orthopädische Praxis 45(1), 10-16.
7. Castricini, R., Longo, U.G., De Benedetto, M., Panfoli, N., Pirani, P., Zini, R., Maffulli, N. and Denaro, V. (2011) Platelet-rich plasma augmentation for arthroscopic rotator cuff repair: a randomized controlled trial. The American Journal of Sports Medicine 39, 258-265.
8. Chen, B., Liu, S., Xu, W., Wang, X., Zhao, W. and Wu, J. (2009) IGF-1 and IGFBP-3 and the risk of lung cancer: A meta-analysis based on nested case-control studies. Journal of Experimental & Clinical Cancer Research 28, 89.
9. nd edition. Lawrence Erlbaum Associates.
10. Conway, K., Price, P., Harding, K.G. and Jiang, W.G. (2006) The molecular and clinical impact of hepatocyte growth factor, its receptors, activators, and inhibitors in wound healing. Wound Repair and Regeneration 14, 2-10.
11. Creaney, L. and Hamilton, B. (2008) Growth factor delivery methods in the management of sports injuries: the state of play. British journal of Sports Medicine 42, 314-320.
12. Engebretsen, L., Steffen, K., Alsousou, J., Anitua, E., Bachl, N., Dev-ilee, R., Everts, P., Hamilton, B., Huard, J., Jenoure, P., Kel-berine, F., Kon, E., Maffulli, N., Matheson, G., Mei-Dan, O., Menetrey, J., Philippon, M., Randelli, P., Schamasch, P., Schwellnus, M., Vernec, A. and Verrall, G. (2010) IOC consensus paper on the use of platelet-rich plasma in sports medicine. British journal of Sports Medicine 44, 1072-1081.
13. Eppley, B.L., Woodell, J.E. and Higgins, J. (2004) Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing. Plastic and Reconstructive Surgery 114(6), 1502-1508.
14. Faul, F., Erdfelder, E., Lang, A-G. and Buchner, A. (2007) G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behavior Research Methods 39, 175-191.
15. Foster, T.E., Puskas, B.L., Mandelbaum, B.R., Gerhardt, M.B. and Rodeo, S.A. (2009) Platelet-rich plasma: from basic science to clinical applications. The American Journal of Sports Medicine 37, 2259-2272.
16. Griffin, X.L., Smith, C.M. and Costa, M.L. (2009) The clinical use of platelet rich plasma in the promotion of bone healing: A systematic review. Injury 40, 158-162.
17. Grimberg, A. and Cohen, P. (2000) Role of insulin-like growth factors and their binding proteins in growth control and carcinogene-sis. Journal of Cellular Physiology 183, 1-9.
18. Grimberg, A. (2003) Mechanisms by which IGF-1 may promote cancer. Cancer Biology & Therapy 2, 630-635.
19. Kasemkijwattana, C., Menetrey, J., Bosch, P., Somogyi, G., Moreland, MS., Fu, F.H., Buranapanitkit, B., Watkins, S.S. and Huard, J. (2000) Use of growth factors to improve muscle healing after strain injury. Clinical Orthopaedics and Related Research 370, 272-285.
20. Lann, D. and LeRoith, D. (2008) The role of endocrine insulin-like growth factor-1 and insulin in breast cancer. Journal of Mammary Gland Biology and Neoplasia 13, 371-379.
21. LeRoith, D. and Roberts, C.T. (2003) The Insulin-like growth factor system and cancer. Cancer Letters 195, 127-137.
22. Lopez-Vidriero, E., Goulding, K.A., Simon, D.A., Sanchez, M. and Johnson, D.H. (2010) The use of platelet-rich plasma in arthro-scopy and sports medicine: optimizing the healing environment. Arthroscopy 26, 269-278.
23. Marx, R.E. (2004) Platelet-rich plasma: evidence to support its use. J Oral and Maxillofacial Surgery 62, 489-496.
24. Mishra, A. and Pavelko, T. (2006) Treatment of chronic elbow tendino-sis with buffered platetelet-rich plasma. The American Journal of Sports Medicine 34, 1774-1778.
25. Philippou, A., Maridaki, M., Halapas, A. and Koutsilieris, M. (2007) The role of insulin-like growth factor 1(IGF-1) in skeletal muscle physiology. In Vivo 21, 45-54.
26. Ranly, D.M., Lohmann, C.H., Andreacchio, D., Boyan, BD. and Schwartz, Z. (2007) Platelet rich plasma inhibits demineralized bone matrix-induced bone formation in nude mice. The Journal of Bone And Joint Surgery. American Volume 89, 139-146.
27. Renehan, A.G., Zwahlen, M., Minder, C., O'Dwyer, S.T., Shalet, S.M. and Egger, M. (2004) Insulin-like growth factor (IGF)-1, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis. Lancet 363, 1346-1353.
28. Rowlands, M.A., Gunnell, D., Harris, R., Vatten, L.J., Holly, J.M. and Martin, R.M. (2009) Circulating insulin-like growth factor pep-tides and prostate cancer risk: a systematic review and meta-analysis. International Journal of Cancer 124, 2416-2429.
29. Sánchez, M., Anitua, E., Azofra, J., Andía, I., Padilla, S. and Mujika, I. (2007) Comparison of surgically repaired Achilles tendon tears using platelet-rich fibrin matrices. The American Journal of Sports Medicine 35, 245-251.
30. Sanchez, M., Anitua, E., Cugat, R., Azofra, J., Guadilla, J., Seijas, R. and Andia, I. (2009a) Nonunions treated with autologous preparation rich in growth factors. Journal of Orthopaedic Trauma 23, 52-59.
31. Sánchez, M., Anitua, E., Orive, G., Mujika, I. and Andia, I. (2009b) Platelet-rich therapies in the treatment of orthopaedic sport injuries. Sports medicine 39, 345-354.
32. Saugy, M., Robinson, N., Saudan, C., Baume, N., Avois, L. and Mangin, P. (2006) Human growth hormone doping in sport. British Journal of Sports Medicine 40, 35-39.
33. Sonksen, P.H. (2001) Insulin, growth hormone and sport. The Journal of endocrinology 170, 13-25.
34. Stay, J.J., Terrell, T.R. and Armsey, T.D. (2004) Ergogenic aids: human growth hormone. Current Sports Medicine Reports 3, 229-233.
35. Tentori, L. and Graziani, G. (2007) Doping with growth hormone/IGF-1, anabolic steroids or erythropoietin: is there a risk? Pharmacological Research 55, 359-369.
36. WADA. (2011) The 2011 Prohibited List World Anti-Doping Code. Available from URL http://www.wada-ama.org/Documents/ World_Anti-Doping_Program/WADP-Prohibited-list/To_be_effective/WADA_Prohibited_List_2011_EN.pdf
37. WADA. (2008) World Anti-Doping Agency. Available from URL: http://www.wada-ama.org (accessed 2008 Mar 16).
38. Volpi, P., Quaglia, A., Schoenhuber, H., Melegati, G., Corsi, M.M., Banfi, G. and de Girolamo, L. (2010) Growth factors in the management of sport-induced tendinopathies: results after 24 months from treatment. A pilot study. The Journal of Sports Medicine and Physical Fitness 50, 494-500.
39. Wright-Carpenter, T., Opolon, P., Appell, H.J., Meijer, H., Wehling, P. and Mir, LM. (2004) Treatment of muscle injuries by local administration of autologous conditioned serum: animal experiments using a muscle contusion model. International Journal of Sports Medicine 25, 582-587.
40. Yokota, K., Ishida, O., Sunagawa, T., Suzuki, O., Nakamae, A. and Ochi, M. (2008) Platelet-rich plasma accelerated surgical an-giogenesis in vascular implanted necrotic bone: an experimental study in rabbits. Acta Orthopaedica 79, 106-110.