Preparation and characterization of liposomal formulations of neurotensin-degrading enzyme inhibitors

International Journal of Pharmaceutics

Volumn 416, Issue 2, 2011, Pages 448-452

  Van Rooy, Inge ^a   Wu, Shin Ying ^a   Storm, Gert ^a   Hennink, Wim E ^a   Dinter Heidorn, Heike ^b   Schiffelers, Raymond M ^a   Mastrobattista, Enrico ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b ABBOTT GMBH AND CO KG   (Germany)

Author keywords

CNS drugs; Liposomes; Neurotensin; NTDE inhibitors

Indexed keywords

BOVINE SERUM ALBUMIN; ENZYME INHIBITOR; LIPOSOME; NEUROTENSIN DEGRADING ENZYME INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DISPERSION; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; LIPOSOMAL DELIVERY; NONHUMAN; PRIORITY JOURNAL;

ANTIPSYCHOTIC AGENTS; DRUG STABILITY; DRUG STORAGE; ENZYME INHIBITORS; HEPES; LIPOSOMES; METALLOENDOPEPTIDASES; PARTICLE SIZE; SERUM ALBUMIN, BOVINE; SODIUM CHLORIDE; SOLUBILITY; TEMPERATURE;

EID: 80051888033     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.01.017     Document Type: Article

References (30)

1. E. Afergan, H. Epstein, R. Dahan, N. Koroukhov, K. Rohekar, H.D. Danenberg, and G. Golomb Delivery of serotonin to the brain by monocytes following phagocytosis of liposomes J. Control. Release 132 2008 84 90
2. M. Boules, P. Fredrickson, and E. Richelson Bioactive analogs of neurotensin: focus on CNS effects Peptides 27 2006 2523 2533 (Pubitemid 44402792)
3. R. Caceda, B. Kinkead, and C.B. Nemeroff Neurotensin: role in psychiatric and neurological diseases Peptides 27 2006 2385 2404 (Pubitemid 44402784)
4. P. Dauch, H. Barelli, J.P. Vincent, and F. Checler Fluorimetric assay of the neurotensin-degrading metalloendopeptidase, endopeptidase 24.16 Biochem. J. 280 1991 421 426 Pt 2
5. A.G. de Boer, and P.J. Gaillard Drug targeting to the brain Annu. Rev. Pharmacol. Toxicol. 47 2007 323 355
6. A.G. de Boer, I.C. van der Sandt, and P.J. Gaillard The role of drug transporters at the blood-brain barrier Annu. Rev. Pharmacol. Toxicol. 43 2003 629 656 (Pubitemid 37372656)
7. C. De Mei, M. Ramos, C. Iitaka, and E. Borrelli Getting specialized: presynaptic and postsynaptic dopamine D2 receptors Curr. Opin. Pharmacol. 9 2009 53 58
8. S. Doulut, I. Dubuc, M. Rodriguez, F. Vecchini, H. Fulcrand, H. Barelli, F. Checler, E. Bourdel, A. Aumelas, and J.C. Lallement Synthesis and analgesic effects of N-[3-[(hydroxyamino) carbonyl]-1-oxo-2(R)-benzylpropyl]-l-isoleucyl- l-leucine, a new potent inhibitor of multiple neurotensin/neuromedin N degrading enzymes J. Med. Chem. 36 1993 1369 1379 (Pubitemid 23164493)
9. Feenstra, R.W., Lange, J.H.M., Pras-Raves, M., L., Kruse, C.G., Van Stuivenberg, H.H., Tuinstra, T., Keizer, H.G., 2003. Neurotensin active 2,3-diaryl-pyparazolidine derivatives. WO/2003/078400, September 25.
10. S. Gosk, C. Vermehren, G. Storm, and T. Moos Targeting anti-transferrin receptor antibody (OX26) and OX26-conjugated liposomes to brain capillary endothelial cells using in situ perfusion J. Cereb. Blood Flow Metab. 24 2004 1193 1204 (Pubitemid 39482480)
11. B. Kinkead, and C.B. Nemeroff Neurotensin: an endogenous antipsychotic? Curr. Opin. Pharmacol. 2 2002 99 103
12. P. Kitabgi Inactivation of neurotensin and neuromedin N by Zn metallopeptidases Peptides 27 2006 2515 2522 (Pubitemid 44402791)
13. F. Kratz Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles J. Control. Release 132 2008 171 183
14. L.H. Lindner, and M. Hossann Factors affecting drug release from liposomes Curr. Opin. Drug Discov. Dev. 13 2010 111 123
15. B. McCormack, and G. Gregoriadis Entrapment of cyclodextrin-drug complexes into liposomes: potential advantages in drug delivery J. Drug Target 2 1994 449 454
16. L. Pan, Q. Ho, K. Tsutsui, and L. Takahashi Comparison of chromatographic and spectroscopic methods used to rank compounds for aqueous solubility J. Pharm. Sci. 90 2001 521 529
17. ®: biodistribution, pharmacokinetic features and in vivo antitumor activity J. Control. Release 144 2010 144 150
18. W.M. Pardridge The blood-brain barrier: bottleneck in brain drug development NeuroRx 2 2005 3 14 (Pubitemid 40128022)
19. W.M. Pardridge Blood-brain barrier delivery Drug Discov. Today 12 2007 54 61 (Pubitemid 46014479)
20. R. Peschka, C. Dennehy, and F.C. Szoka Jr. A simple in vitro model to study the release kinetics of liposome encapsulated material J. Control. Release 56 1998 41 51 (Pubitemid 28511125)
21. G. Rouser, S. Fleischer, and A. Yamamoto Two dimensional then layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots Lipids 5 1970 494 496
22. A. Schnyder, S. Krahenbuhl, J. Drewe, and J. Huwyler Targeting of daunomycin using biotinylated immunoliposomes: pharmacokinetics, tissue distribution and in vitro pharmacological effects J. Drug Target 13 2005 325 335 (Pubitemid 41283166)
23. P. Seeman Dopamine D2 receptors as treatment targets in schizophrenia Clin. Schizophr. Relat. Psychoses 4 2010 56 73
24. N. Shi, Y. Zhang, C. Zhu, R.J. Boado, and W.M. Pardridge Brain-specific expression of an exogenous gene after i.v. administration Proc. Natl. Acad. Sci. U. S. A. 98 2001 12754 12759 (Pubitemid 33026054)
25. I. van Rooy, S. Cakir-Tascioglu, W.E. Hennink, G. Storm, R.M. Schiffelers, and E. Mastrobattista In vivo methods to study uptake of nanoparticles into the brain Pharm. Res. 2010
26. I. van Rooy, E. Mastrobattista, G. Storm, W.E. Hennink, and R.M. Schiffelers Comparison of five different targeting ligands to enhance accumulation of liposomes into the brain J. Control. Release 2010
27. B. Vincent, V. Dive, A. Yiotakis, C. Smadja, R. Maldonado, J.P. Vincent, and F. Checler Phosphorus-containing peptides as mixed inhibitors of endopeptidase 3.4.24.15 and 3.4.24.16: effect on neurotensin degradation in vitro and in vivo Br. J. Pharmacol. 115 1995 1053 1063
28. J. Wu, Q. Liu, and R.J. Lee A folate receptor-targeted liposomal formulation for paclitaxel Int. J. Pharm. 316 2006 148 153 (Pubitemid 43786219)
29. Y. Xie, L. Ye, X. Zhang, W. Cui, J. Lou, T. Nagai, and X. Hou Transport of nerve growth factor encapsulated into liposomes across the blood-brain barrier: in vitro and in vivo studies J. Control. Release 105 2005 106 119 (Pubitemid 40805479)
30. X. Zhang, Y. Xie, Y. Jin, X. Hou, L. Ye, and J. Lou The effect of RMP-7 and its derivative on transporting Evans blue liposomes into the brain Drug Deliv. 11 2004 301 309 (Pubitemid 39332001)