Synthesis and antiplasmodial activity of bicyclic dioxanes as simplified dihydroplakortin analogues

Journal of Medicinal Chemistry

Volumn 54, Issue 16, 2011, Pages 5949-5953

  Gemma, Sandra ^a,b,c   Kunjir, Sanil ^a,b,c   Sanna Coccone, Salvatore ^a,b,c   Brindisi, Margherita ^a,b,c   Moretti, Vittoria ^a,b,c   Brogi, Simone ^a,b,c   Novellino, Ettore ^a,d   Basilico, Nicoletta ^a,c,e   Parapini, Silvia ^a,c,e   Taramelli, Donatella ^a,c,e   Campiani, Giuseppe ^a,b,c   Butini, Stefania ^a,b,c  

^a European Research Centre for Drug Discovery and Development (NatSynDrugs)   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

^c UNIVERSITY OF TURIN   (Italy)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^e UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BICYCLO COMPOUND; DIHYDROPLAKORTIN DERIVATIVE; DIOXANE DERIVATIVE; NATURAL PRODUCT; PEROXIDE; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; DRUG CONFORMATION; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; IN VITRO STUDY; NONHUMAN; PLASMODIUM; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIMALARIALS; DIOXANES; DOSE-RESPONSE RELATIONSHIP, DRUG; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PEROXIDES; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80051882075     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200686d     Document Type: Article

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