Gender role behaviour in prenatally dexamethasone-treated children at risk for congenital adrenal hyperplasia - A pilot study

Acta Paediatrica, International Journal of Paediatrics

Volumn 100, Issue 9, 2011, Pages

  Hirvikoski, Tatja ^a   Lindholm, Torun ^b   Lajic, Svetlana ^a   Nordenström, Anna ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Congenital adrenal hyperplasia; Dexamethasone; Gender role behaviour; Prenatal treatment; Sex typed behaviour

Indexed keywords

DEXAMETHASONE;

ADOLESCENT; ARTICLE; CHILD; CHILD BEHAVIOR; CLINICAL ARTICLE; CONGENITAL ADRENAL HYPERPLASIA; CONTROLLED STUDY; CORTICOSTEROID THERAPY; FEMALE; HIGH RISK PATIENT; HUMAN; KAROLINSKA INVENTORY OF GENDER ROLE BEHAVIOR; MALE; PILOT STUDY; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; RATING SCALE; SCHOOL CHILD; SEX DIFFERENCE; SEX ROLE; SWEDEN;

ADOLESCENT; ADRENAL HYPERPLASIA, CONGENITAL; ANALYSIS OF VARIANCE; ANTI-INFLAMMATORY AGENTS; CHILD; DEXAMETHASONE; FEMALE; FEMININITY; GENDER IDENTITY; HUMANS; MALE; MASCULINITY; PILOT PROJECTS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PRINCIPAL COMPONENT ANALYSIS; RISK FACTORS; SEX FACTORS; STATISTICS AS TOPIC; SWEDEN; VIRILISM;

EID: 80051879901     PISSN: 08035253     EISSN: 16512227     Source Type: Journal    
DOI: 10.1111/j.1651-2227.2011.02260.x     Document Type: Article

References (33)

1. Lajic S, Nordenstrom A, Ritzen EM, Wedell A,. Prenatal treatment of congenital adrenal hyperplasia. Eur J Endocrinol 2004; 151 Suppl 3: U63-9. (Pubitemid 39627057)
2. David M, Forest MG,. Prenatal treatment of congenital adrenal hyperplasia resulting from 21-hydroxylase deficiency. J Pediatr 1984; 105: 799-803. (Pubitemid 15206715)
3. Lajic S, Nordenstrom A, Hirvikoski T,. Long-term outcome of prenatal treatment of congenital adrenal hyperplasia. Endocr Dev 2008; 13: 82-98.
4. Matthews SG,. Antenatal glucocorticoids and the developing brain: mechanisms of action. Semin Neonatol 2001; 6: 309-17. (Pubitemid 34586850)
5. Seckl JR,. Prenatal glucocorticoids and long-term programming. Eur J Endocrinol 2004; 151 Suppl 3: U49-62. (Pubitemid 39627056)
6. Yeh TF, Lin YJ, Lin HC, Huang CC, Hsieh WS, Lin CH, et al., Outcomes at school age after postnatal dexamethasone therapy for lung disease of prematurity. N Engl J Med 2004; 350: 1304-13. (Pubitemid 38375365)
7. LWPES/ESPE. Consensus statement on 21-hydroxylase deficiency from the Lawson Wilkins Pediatric Endocrine Society and the European Society for Paediatric Endocrinology. J Clin Endocrinol Metab 2002; 87: 4048-53.
8. Hirvikoski T, Nordenstrom A, Lindholm T, Lindblad F, Ritzen EM, Lajic S,. Long-term follow-up of prenatally treated children at risk for congenital adrenal hyperplasia: does dexamethasone cause behavioural problems? Eur J Endocrinol 2008; 159: 309-16.
9. Hirvikoski T, Nordenstrom A, Lindholm T, Lindblad F, Ritzen EM, Wedell A, et al., Cognitive functions in children at risk for congenital adrenal hyperplasia treated prenatally with dexamethasone. J Clin Endocrinol Metab 2007; 92: 542-8.
10. Meyer-Bahlburg HF, Dolezal C, Baker SW, Carlson AD, Obeid JS, New MI,. Prenatal androgenization affects gender-related behavior but not gender identity in 5-12-year-old girls with congenital adrenal hyperplasia. Arch Sex Behav 2004; 33: 97-104. (Pubitemid 38987628)
11. Trautman PD, Meyer-Bahlburg HF, Postelnek J, New MI,. Effects of early prenatal dexamethasone on the cognitive and behavioral development of young children: results of a pilot study. Psychoneuroendocrinology 1995; 20: 439-49.
12. Meyer-Bahlburg HF, Dolezal C, Baker SW, Carlson AD, Obeid JS, New MI,. Cognitive and motor development of children with and without congenital adrenal hyperplasia after early-prenatal dexamethasone. J Clin Endocrinol Metab 2004; 89: 610-4. (Pubitemid 38269866)
13. Cohen-Bendahan CC, van de Beek C, Berenbaum SA,. Prenatal sex hormone effects on child and adult sex-typed behavior: methods and findings. Neurosci Biobehav Rev 2005; 29: 353-84. (Pubitemid 40461750)
14. Auyeung B, Baron-Cohen S, Ashwin E, Knickmeyer R, Taylor K, Hackett G, et al., Fetal testosterone predicts sexually differentiated childhood behavior in girls and in boys. Psychol Sci 2009; 20: 144-8.
15. Berenbaum SA,. Cognitive function in congenital adrenal hyperplasia. Endocrinol Metab Clin North Am 2001; 30: 173-92. (Pubitemid 32381720)
16. Dittmann RW, Kappes MH, Kappes ME, Borger D, Meyer-Bahlburg HF, Stegner H, et al., Congenital adrenal hyperplasia. II: gender-related behavior and attitudes in female salt-wasting and simple-virilizing patients. Psychoneuroendocrinology 1990; 15: 421-34.
17. Meyer-Bahlburg HF,. Gender and sexuality in classic congenital adrenal hyperplasia. Endocrinol Metab Clin North Am 2001; 30: 155-71, viii. (Pubitemid 32381719)
18. Nordenstrom A, Servin A, Bohlin G, Larsson A, Wedell A,. Sex-typed toy play behavior correlates with the degree of prenatal androgen exposure assessed by CYP21 genotype in girls with congenital adrenal hyperplasia. J Clin Endocrinol Metab 2002; 87: 5119-24. (Pubitemid 35316354)
19. Berenbaum SA, Duck SC, Bryk K,. Behavioral effects of prenatal versus postnatal androgen excess in children with 21-hydroxylase-deficient congenital adrenal hyperplasia. J Clin Endocrinol Metab 2000; 85: 727-33. (Pubitemid 32273661)
20. Meyer-Bahlburg HF, Sandberg DE, Dolezal CL, Yager TJ,. Gender-related assessment of childhood play. J Abnorm Child Psychol 1994; 22: 643-60. (Pubitemid 24371040)
21. Boldizar JP,. Assessing sex typing and androgyny in children: The Children's Sex Role Inventory. Dev Psychol 1991; 27: 505-15.
22. Meyer-Bahlburg HF, Sandberg DE, Yager TJ, Dolezal CL, Ehrhardt AA,. Questionnaire scales for the assessment of atypical gender development in girls and boys. J Psychol Hum Sex 1994; 6: 19-39.
23. Yu L, Winter S, Xie D,. The child play behavior and activity questionnaire: a parent-report measure of childhood gender-related behavior in China. Arch Sex Behav 2008; 39: 807-15.
24. Lajic S, Wedell A, Bui TH, Ritzen EM, Holst M,. Long-term somatic follow-up of prenatally treated children with congenital adrenal hyperplasia. J Clin Endocrinol Metab 1998; 83: 3872-80. (Pubitemid 28513565)
25. Berenbaum SA,. Effects of early androgens on sex-typed activities and interests in adolescents with congenital adrenal hyperplasia. Horm Behav 1999; 35: 102-10. (Pubitemid 29100814)
26. Connor JM, Serbin LA,. Behaviorally based masculine- and feminine-activity-preference scales for preschoolers: correlates with other classroom behaviors and cognitive tests. Child Dev 1977; 48: 1411-6.
27. Golombok S, Rust J,. The measurement of gender role behaviour in pre-school children: a research note. J Child Psychol Psychiatry 1993; 34: 805-11. (Pubitemid 23204731)
28. Maccoby EE, Jacklin CN,. Gender segregation in children. In:, Reece HW, editor. Advances in child development and behaviour. New York: Academic Press, 1987: 239-87.
29. Sandberg DE, Meyer-Bahlburg HF,. Variability in middle childhood play behavior: effects of gender, age, and family background. Arch Sex Behav 1994; 23: 645-63. (Pubitemid 24378589)
30. Servin A, Nordenstrom A, Larsson A, Bohlin G,. Prenatal androgens and gender-typed behavior: a study of girls with mild and severe forms of congenital adrenal hyperplasia. Dev Psychol 2003; 39: 440-50. (Pubitemid 37189405)
31. Bem SL,. The measurement of psychological androgyny. J Consult Clin Psychol 1974; 42: 155-62.
32. Lalau JD, Aubert ML, Carmignac DF, Gregoire I, Dupouy JP,. Reduction in testicular function in rats. II. Reduction by dexamethasone in fetal and neonatal rats. Neuroendocrinology 1990; 51: 289-93. (Pubitemid 20066595)
33. Hines M,. Prenatal testosterone and gender-related behaviour. Eur J Endocrinol 2006; 155 Suppl 1: S115-21. (Pubitemid 44902269)