Metabolic study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone to the enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in vitro in human bronchial epithelial cells using chiral capillary electrophoresis

Journal of Chromatography A

Volumn 1218, Issue 37, 2011, Pages 6505-6510

  Yang, Youyou ^a   Yu, Cong ^a   Zhou, Meng ^b   Pang, Nannan ^a   Li, Ning ^b   Nie, Honggang ^a   Liao, Jie ^b   Bai, Yu ^a   Liu, Huwei ^a  

^a PEKING UNIVERSITY   (China)

^b CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

4 (Methylnitrosamino) 1 (3 pyridyl) 1 butanol; 4 (Methylnitrosamino) 1 (3 pyridyl) 1 butanone; Chiral CE; Cytotoxicity; Stereoselectively metabolic transformation; Sulfated cyclodextrin; Tobacco specific N nitrosamines

Indexed keywords

4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANOL; 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE; CARBONYL REDUCTION; CELL COUNTING; CHIRAL CAPILLARY ELECTROPHORESIS; CHIRAL CE; CHIRAL CENTERS; HUMAN BRONCHIAL EPITHELIAL CELLS; IN-VITRO; INCUBATION TIME; LOW LIMITS OF DETECTIONS; METABOLIC TRANSFORMATIONS; N-NITROSAMINES; SOLID-PHASE EXTRACTION; STEREOSELECTIVE FORMATION;

CAPILLARY ELECTROPHORESIS; CHIRALITY; ENANTIOMERS; EXTRACTION; KETONES; METABOLISM; METHANOL; TOBACCO;

CELLS;

2 HYDROXYPROPYL BETA CYCLODEXTRIN; 4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANOL; 4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; BETA CYCLODEXTRIN; CARBOXYMETHYL BETA CYCLODEXTRIN; HIGHLY SULFATED BETA CYCLODEXTRIN; UNCLASSIFIED DRUG;

ARTICLE; BRONCHUS MUCOSA; CAPILLARY ELECTROPHORESIS; CELL ASSAY; CELL COUNT; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHIRALITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ENANTIOMER; EPITHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; LIMIT OF DETECTION; LIMIT OF QUANTITATION; METABOLISM; PH; PRIORITY JOURNAL; REPRODUCIBILITY; SOLID PHASE EXTRACTION; STEREOCHEMISTRY; TEMPERATURE SENSITIVITY;

BRONCHI; CELLS, CULTURED; ELECTROPHORESIS, CAPILLARY; EPITHELIAL CELLS; HUMANS; NITROSAMINES; PYRIDINES; REPRODUCIBILITY OF RESULTS; RESPIRATORY MUCOSA; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; STEREOISOMERISM;

NICOTIANA TABACUM;

EID: 80051870712     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2011.07.009     Document Type: Article

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