Prevention of pre-eclampsia with low-dose aspirin or vitamins C and e in women at high or low risk: A systematic review with meta-analysis

European Journal of Obstetrics and Gynecology and Reproductive Biology

Volumn 158, Issue 1, 2011, Pages 9-16

  Rossi, A Cristina ^a   Mullin, Patrick M ^b  

^a San Giacomo Hospital   (Italy)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Low dose aspirin; Pre eclampsia; Prevention; Vitamins C E

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA TOCOPHEROL; ASCORBIC ACID; PLACEBO;

CHEMOPROPHYLAXIS; DRUG EFFICACY; DRUG SAFETY; HIGH RISK PREGNANCY; HUMAN; INCIDENCE; LOW DRUG DOSE; META ANALYSIS; NEWBORN MORBIDITY; OBSTETRIC PATIENT; PERINATAL DEATH; PRACTICE GUIDELINE; PREECLAMPSIA; PREGNANCY OUTCOME; PREMATURE LABOR; PRIORITY JOURNAL; REVIEW; RISK REDUCTION; SMALL FOR DATE INFANT; SOLUTIO PLACENTAE; SYSTEMATIC REVIEW;

EID: 80051864729     PISSN: 03012115     EISSN: 18727654     Source Type: Journal    
DOI: 10.1016/j.ejogrb.2011.04.010     Document Type: Review

References (34)

1. P.J. Meis, R.L. Goldenberg, and B.M. Mercer The preterm prediction study: risk factors for indicated preterm births. Maternal-fetal medicine units network of the national institute of child health and human development Am J Obstet Gynecol 178 3 1998 562 567
2. S.A. Friedman Preeclampsia: a review of the role of prostaglandins Obstet Gynecol 71 1 1988 122 137 (Pubitemid 18025090)
3. S.W. Walsh Preeclampsia: an imbalance in placental prostacyclin and thromboxane production Am J Obstet Gynecol 152 3 1985 335 340 (Pubitemid 15049763)
4. A. Benigni, G. Gregorini, and T. Frusca Effect of low-dose aspirin on fetal and maternal generation of thromboxane by platelets in women at risk for pregnancy-induced hypertension N Engl J Med 321 6 1989 357 362 (Pubitemid 19190440)
5. B.M. Sibai, R. Mirro, C.M. Chesney, and C. Leffler Low-dose aspirin in pregnancy Obstet Gynecol 74 4 1989 551 557 (Pubitemid 19239769)
6. S.T. Davidge Oxidative stress and altered endothelial cell function in preeclampsia Semin Reprod Endocrinol 16 1 1998 65 73 (Pubitemid 28285305)
7. O.D. Saugstad Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production Pediatr Res 23 2 1988 143 150 (Pubitemid 18095054)
8. O.D. Saugstad Update on oxygen radical disease in neonatology Curr Opin Obstet Gynecol 13 2 2001 147 153 (Pubitemid 32673545)
9. N.P. Polyzos, D. Mauri, and M. Tsappi Combined vitamin C and E supplementation during pregnancy for preeclampsia prevention: a systematic review Obstet Gynecol Surv 62 3 2007 202 206 (Pubitemid 46294789)
10. L.M. Askie, L. Duley, D.J. Henderson-Smart, and L.A. Stewart Antiplatelet agents for prevention of pre-eclampsia: a meta-analysis of individual patient data Lancet 369 9575 2007 1791 1798 (Pubitemid 46782996)
11. R. Rahimi, S. Nikfar, A. Rezaie, and M. Abdollahi A meta-analysis on the efficacy and safety of combined vitamin C and E supplementation in preeclamptic women Hypertens Pregnancy 28 4 2009 417 434
12. D.A. Davey, and I. MacGillivray The classification and definition of the hypertensive disorders of pregnancy Am J Obstet Gynecol 158 4 1988 892 898
13. D. Moher, D.J. Cook, S. Eastwood, I. Olkin, D. Rennie, and D.F. Stroup Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement. Quality of reporting of meta-analyses Lancet 354 9193 1999 1896 1900
14. J. Lau, J.P. Ioannidis, N. Terrin, C.H. Schmid, and I. Olkin The case of the misleading funnel plot BMJ 333 7568 2006 597 600 (Pubitemid 44433638)
15. J.P. Higgins, S.G. Thompson, J.J. Deeks, and D.G. Altman Measuring inconsistency in meta-analyses BMJ 327 7414 2003 557 560 (Pubitemid 37088507)
16. CLASP: a randomised trial of low-dose aspirin for the prevention and treatment of pre-eclampsia among 9364 pregnant women. CLASP (Collaborative Low-dose Aspirin Study in Pregnancy) Collaborative Group. Lancet 1994;343(8898):619-29.
17. ECPPA: randomised trial of low dose aspirin for the prevention of maternal and fetal complications in high risk pregnant women. ECPPA (Estudo Colaborativo para Prevencao da Pre-eclampsia com Aspirina) Collaborative Group. Br J Obstet Gynaecol 1996;103(1):39-47.
18. R.N. Byaruhanga, T. Chipato, and S. Rusakaniko A randomized controlled trial of low-dose aspirin in women at risk from pre-eclampsia Int J Gynaecol Obstet 60 2 1998 129 135 (Pubitemid 28059793)
19. C.K. Yu, A.T. Papageorghiou, M. Parra, R. Palma Dias, and K.H. Nicolaides Randomized controlled trial using low-dose aspirin in the prevention of pre-eclampsia in women with abnormal uterine artery Doppler at 23 weeks' gestation Ultrasound Obstet Gynecol 22 3 2003 233 239 (Pubitemid 37088545)
20. M. Vainio, E. Kujansuu, M. Iso-Mustajarvi, and J. Maenpaa Low dose acetylsalicylic acid in prevention of pregnancy-induced hypertension and intrauterine growth retardation in women with bilateral uterine artery notches BJOG 109 2 2002 161 167 (Pubitemid 37338037)
21. A. Ebrashy, M. Ibrahim, A. Marzook, and D. Yousef Usefulness of aspirin therapy in high-risk pregnant women with abnormal uterine artery Doppler ultrasound at 14-16 weeks pregnancy: randomized controlled clinical trial Croat Med J 46 5 2005 826 831 (Pubitemid 41414905)
22. J.M. Morris, R.A. Fay, D.A. Ellwood, C.M. Cook, and K.J. Devonald A randomized controlled trial of aspirin in patients with abnormal uterine artery blood flow Obstet Gynecol 87 1 1996 74 78 (Pubitemid 26015955)
23. Y.E. Rotchell, J.K. Cruickshank, and M.P. Gay Barbados low dose aspirin study in pregnancy (BLASP): a randomised trial for the prevention of pre-eclampsia and its complications Br J Obstet Gynaecol 105 3 1998 286 292 (Pubitemid 28123577)
24. D. Subtil, P. Goeusse, and V. Houfflin-Debarge Randomised comparison of uterine artery Doppler and aspirin (100 mg) with placebo in nulliparous women: the Essai Regional Aspirine Mere-Enfant study (Part 2) BJOG 110 5 2003 485 491 (Pubitemid 36556131)
25. B.M. Sibai, S.N. Caritis, and E. Thom Prevention of preeclampsia with low-dose aspirin in healthy, nulliparous pregnant women. The national institute of child health and human development network of maternal-fetal medicine units N Engl J Med 329 17 1993 1213 1218
26. L. Poston, A.L. Briley, P.T. Seed, F.J. Kelly, and A.H. Shennan Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): randomised placebo-controlled trial Lancet 367 9517 2006 1145 1154
27. D. Beazley, R. Ahokas, J. Livingston, M. Griggs, and B.M. Sibai Vitamin C and E supplementation in women at high risk for preeclampsia: a double-blind, placebo-controlled trial Am J Obstet Gynecol 192 2 2005 520 521 (Pubitemid 40214989)
28. L.C. Chappell, P.T. Seed, and A.L. Briley Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial Lancet 354 9181 1999 810 816 (Pubitemid 29415585)
29. J.A. Spinnato 2nd, S. Freire, and E.S.J.L. Pinto Antioxidant therapy to prevent preeclampsia: a randomized controlled trial Obstet Gynecol 110 6 2007 1311 1318 (Pubitemid 351326075)
30. A.R. Rumbold, C.A. Crowther, R.R. Haslam, G.A. Dekker, and J.S. Robinson Vitamins C and E and the risks of preeclampsia and perinatal complications N Engl J Med 354 17 2006 1796 1806
31. S. Kharb Vitamin E and C in preeclampsia Eur J Obstet Gynecol Reprod Biol 93 1 2000 37 39
32. L.M. Bodnar, G. Tang, R.B. Ness, G. Harger, and J.M. Roberts Periconceptional multivitamin use reduces the risk of preeclampsia Am J Epidemiol 164 5 2006 470 477 (Pubitemid 44576614)
33. S.W. Wen, X.K. Chen, and M. Rodger Folic acid supplementation in early second trimester and the risk of preeclampsia Am J Obstet Gynecol 198 1 2008 45 e1-7
34. E. Bujold, S. Roberge, and Y. Lacasse Prevention of preeclampsia and intrauterine growth restriction with aspirin started in early pregnancy: a meta-analysis Obstet Gynecol 116 2 Pt 1 2010 402 414