메뉴 건너뛰기




Volumn 6, Issue 9, 2010, Pages 1151-1160

Raltegravir: A review of its pharmacokinetics, pharmacology and clinical studies

Author keywords

AIDS; Antiretroviral agents; HIV integrase; Raltegravir

Indexed keywords

ABACAVIR PLUS LAMIVUDINE; ATAZANAVIR; DARUNAVIR; DARUNAVIR PLUS RITONAVIR; EFAVIRENZ; EFAVIRENZ PLUS EMTRICITABINE PLUS TENOFOVIR DISOPROXIL; ELVITEGRAVIR; EMTRICITABINE PLUS TENOFOVIR DISOPROXIL; ENFUVIRTIDE; ETRAVIRINE; FOSAMPRENAVIR; FOSAMPRENAVIR PLUS RITONAVIR; LAMOTRIGINE; LOPINAVIR; LOPINAVIR PLUS RITONAVIR; MARAVIROC; MIDAZOLAM; NEVIRAPINE; OMEPRAZOLE; PRAVASTATIN; RALTEGRAVIR; RIFABUTIN; RIFAMPICIN; RILPIVIRINE; RITONAVIR; TENOFOVIR; TIPRANAVIR;

EID: 77955790197     PISSN: 17425255     EISSN: None     Source Type: Journal    
DOI: 10.1517/17425255.2010.513383     Document Type: Review
Times cited : (45)

References (62)
  • 1
    • 77955781775 scopus 로고    scopus 로고
    • FDA Available from Version date: 26 March 2010
    • FDA. Isentress; Prescribing Information. Available from: http://www.accessdata.fda.gov/drugsatfda-docs/label/2010/022145s014lbl.pdf. Version date: 26 March 2010
    • Isentress; Prescribing Information
  • 2
    • 65249180642 scopus 로고    scopus 로고
    • Emerging pharmacology: Inhibitors of human immunodeficiency virus integration
    • Hazuda D, Iwamoto M, Wenning L. Emerging pharmacology: inhibitors of human immunodeficiency virus integration. Annu Rev Pharmacol Toxicol 2009;49:377-394
    • (2009) Annu Rev Pharmacol Toxicol , vol.49 , pp. 377-394
    • Hazuda, D.1    Iwamoto, M.2    Wenning, L.3
  • 4
    • 33845366857 scopus 로고    scopus 로고
    • Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-1 integrase, dosed as monotherapy for 10 days in treatment-naive HIV-1-infected individuals
    • Markowitz M, Morales-Ramirez JO, Nguyen BY, et al. Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-1 integrase, dosed as monotherapy for 10 days in treatment-naive HIV-1-infected individuals. J Acquir Immune Defic Syndr 2006;43:509-515
    • (2006) J Acquir Immune Defic Syndr , vol.43 , pp. 509-515
    • Markowitz, M.1    Morales-Ramirez, J.O.2    Nguyen, B.Y.3
  • 5
    • 68449095081 scopus 로고    scopus 로고
    • Effects of Ginkgo biloba extract on the pharmacokinetics of bupropion in healthy volunteers
    • Lei HP, Ji W, Lin J, et al. Effects of Ginkgo biloba extract on the pharmacokinetics of bupropion in healthy volunteers. Br J Clin Pharmacol 2009;68:201-206
    • (2009) Br J Clin Pharmacol , vol.68 , pp. 201-206
    • Lei, H.P.1    Ji, W.2    Lin, J.3
  • 6
    • 38349194563 scopus 로고    scopus 로고
    • Safety, tolerability, and pharmacokinetics of raltegravir after single and multiple doses in healthy subjects
    • Iwamoto M, Wenning LA, Petry AS, et al. Safety, tolerability, and pharmacokinetics of raltegravir after single and multiple doses in healthy subjects. Clin Pharmacol Ther 2008;83:293-299
    • (2008) Clin Pharmacol Ther , vol.83 , pp. 293-299
    • Iwamoto, M.1    Wenning, L.A.2    Petry, A.S.3
  • 7
    • 77955803152 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of once-daily raltegravir (800mg) plus atazanavir (400 mg) in HIV-infected patients [abstract O-13]
    • 15-17 April 2009; Amsterdam, the Netherlands
    • Molto J, Valle M, Mothe B, et al. Pharmacokinetics and safety of once-daily raltegravir (800mg) plus atazanavir (400 mg) in HIV-infected patients [abstract O-13]. 10th International workshop on clinical pharmacology of HIV therapy; 15-17 April 2009; Amsterdam, the Netherlands
    • 10th International Workshop on Clinical Pharmacology of HIV Therapy
    • Molto, J.1    Valle, M.2    Mothe, B.3
  • 8
    • 70149119217 scopus 로고    scopus 로고
    • Raltegravir cerebrospinal fluid concentrations in HIV-1 infection
    • Yilmaz A, Gisslen M, Spudich S, et al. Raltegravir cerebrospinal fluid concentrations in HIV-1 infection. PLoS One 2009;4:e6877
    • (2009) PLoS One , vol.4
    • Yilmaz, A.1    Gisslen, M.2    Spudich, S.3
  • 9
    • 77949545599 scopus 로고    scopus 로고
    • Raltegravir penetration in the cerebrospinal fluid of HIV-positive patients
    • Calcagno A, Bonora S, Bertucci R, et al. Raltegravir penetration in the cerebrospinal fluid of HIV-positive patients. AIDS 2010;24:931-932
    • (2010) AIDS , vol.24 , pp. 931-932
    • Calcagno, A.1    Bonora, S.2    Bertucci, R.3
  • 10
    • 77955782480 scopus 로고    scopus 로고
    • Steady-state raltegravir penetration in seminal plasma of healthy volunteers [abstract # 609]
    • 16-19 February 2010; San Francisco, CA
    • Bonora S, D'Avolio A, Simele M, et al. Steady-state raltegravir penetration in seminal plasma of healthy volunteers [abstract # 609]. 17th Conference on Retroviruses and Opportunistic Infections; 16-19 February 2010; San Francisco, CA
    • 17th Conference on Retroviruses and Opportunistic Infections
    • Bonora, S.1    D'Avolio, A.2    Simele, M.3
  • 11
    • 77955786151 scopus 로고    scopus 로고
    • Raltegravir concentrations in the cervico-vaginal compartment in HIV-1 infected women treated with raltegravir: DIVA 01 study [abstract # 608]
    • 16-19 February 2010; San Francisco, CA
    • Clavel C, Mandelbrot L, Marcelin AG, et al. Raltegravir concentrations in the cervico-vaginal compartment in HIV-1 infected women treated with raltegravir: DIVA 01 study [abstract # 608]. 17th Conference on Retroviruses and Opportunistic Infections; 16-19 February 2010; San Francisco, CA
    • 17th Conference on Retroviruses and Opportunistic Infections
    • Clavel, C.1    Mandelbrot, L.2    Marcelin, A.G.3
  • 12
    • 77955785472 scopus 로고    scopus 로고
    • Pharmacokinetics of once-daily raltegravir (800 mg) in plasma and PBMCs in HIV-infected patients [abstract #LB-01]
    • 7-9 April 2010; Sorrento, Italy
    • Molto J, Valle M, Back D, et al. Pharmacokinetics of once-daily raltegravir (800 mg) in plasma and PBMCs in HIV-infected patients [abstract #LB-01]. 11th International Workshop on Clinical Pharmacology of HIV Therapy; 7-9 April 2010; Sorrento, Italy
    • 11th International Workshop on Clinical Pharmacology of HIV Therapy
    • Molto, J.1    Valle, M.2    Back, D.3
  • 13
    • 34548065793 scopus 로고    scopus 로고
    • Metabolism and disposition in humans of raltegravir (MK-0518), an anti-AIDS drug targeting the HIV-1 integrase enzyme
    • Kassahun K, McIntosh I, Cui D, et al. Metabolism and disposition in humans of raltegravir (MK-0518), an anti-AIDS drug targeting the HIV-1 integrase enzyme. Drug Metab Dispos 2007;35:1657-1663
    • (2007) Drug Metab Dispos , vol.35 , pp. 1657-1663
    • Kassahun, K.1    McIntosh, I.2    Cui, D.3
  • 14
    • 67349217885 scopus 로고    scopus 로고
    • Pharmacokinetics of raltegravir in individuals with UGT1A1 polymorphisms
    • Wenning LA, Petry AS, Kost JT, et al. Pharmacokinetics of raltegravir in individuals with UGT1A1 polymorphisms. Clin Pharmacol Ther 2009;85:623-627
    • (2009) Clin Pharmacol Ther , vol.85 , pp. 623-627
    • Wenning, L.A.1    Petry, A.S.2    Kost, J.T.3
  • 15
    • 66149137187 scopus 로고    scopus 로고
    • Lack of a clinically important effect of moderate hepatic insufficiency and severe renal insufficiency on raltegravir pharmacokinetics
    • Iwamoto M, Hanley WD, Petry AS, et al. Lack of a clinically important effect of moderate hepatic insufficiency and severe renal insufficiency on raltegravir pharmacokinetics. Antimicrob Agents Chemother 2009;53:1747-1752
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 1747-1752
    • Iwamoto, M.1    Hanley, W.D.2    Petry, A.S.3
  • 16
    • 79951675492 scopus 로고    scopus 로고
    • Raltegravir and darunavir plasma pharmacokinetic in HIV-1-infeced patients with advanced liver disease [abstract #10]
    • 7-9 April 2010; Sorrento, Italy
    • Tommassi C, Nicastri E, Gallo AL, et al. Raltegravir and darunavir plasma pharmacokinetic in HIV-1-infeced patients with advanced liver disease [abstract #10]. 11th International Workshop on Clinical Pharmacology of HIV Therapy; 7-9 April 2010; Sorrento, Italy
    • 11th International Workshop on Clinical Pharmacology of HIV Therapy
    • Tommassi, C.1    Nicastri, E.2    Gallo, A.L.3
  • 17
    • 77955841022 scopus 로고    scopus 로고
    • Effect of hemodialysis on raltegravir clearance in HIV-infected patients with end stage renal disease [abstract #7]
    • 7-9 April 2010; Sorrento, Italy
    • Molto J, Sanz-Moreno J, Valle M, et al. Effect of hemodialysis on raltegravir clearance in HIV-infected patients with end stage renal disease [abstract #7]. 11th International Workshop on Clinical Pharmacology of HIV Therapy; 7-9 April 2010; Sorrento, Italy
    • 11th International Workshop on Clinical Pharmacology of HIV Therapy
    • Molto, J.1    Sanz-Moreno, J.2    Valle, M.3
  • 18
    • 70449459862 scopus 로고    scopus 로고
    • Safety and efficacy of rlategravir in pediatric HIV infection: Preliminary analysis from the international maternal pediatric adolescent AIDs clinical trial group, P1066 [abstract 881]
    • IMPAACT P1066 8-11 February 2009; Montreal, Canada
    • Wiznia A, Samson P, Acosta E, et al.; IMPAACT P1066. Safety and efficacy of rlategravir in pediatric HIV infection: preliminary analysis from the international maternal pediatric adolescent AIDs clinical trial group, P1066 [abstract 881]. 16th Conference on Retroviruses and Opportunistic Infections; 8-11 February 2009; Montreal, Canada
    • 16th Conference on Retroviruses and Opportunistic Infections
    • Wiznia, A.1    Samson, P.2    Acosta, E.3
  • 19
    • 77955795966 scopus 로고    scopus 로고
    • Interim results from IMPAACT P1066: Raltegravir oral chewable tablet formulation in children 6 to 11 years [abstract # 161LB]
    • The P1066 team 16-19 February 2010; San Francisco, CA
    • Nachman S, Acosta E, Samson P, et al.; the P1066 team. Interim results from IMPAACT P1066: raltegravir oral chewable tablet formulation in children 6 to 11 years [abstract # 161LB]. 17th Conference on Retroviruses and Opportunistic Infections; 16-19 February 2010; San Francisco, CA
    • 17th Conference on Retroviruses and Opportunistic Infections
    • Nachman, S.1    Acosta, E.2    Samson, P.3
  • 20
    • 34249876574 scopus 로고    scopus 로고
    • Updated guideline to perform therapeutic drug monitoring for antiretroviral agents
    • La Porte CJ, Back DJ, Blaschke T, et al. Updated guideline to perform therapeutic drug monitoring for antiretroviral agents. Rev Antivir Ther 2006;3:4-14
    • (2006) Rev Antivir Ther , vol.3 , pp. 4-14
    • La Porte, C.J.1    Back, D.J.2    Blaschke, T.3
  • 21
    • 34147136222 scopus 로고    scopus 로고
    • Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: A phase II randomised controlled trial
    • Grinsztejn B, Nguyen BY, Katlama C, et al. Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: a phase II randomised controlled trial. Lancet 2007;369:1261-1269
    • (2007) Lancet , vol.369 , pp. 1261-1269
    • Grinsztejn, B.1    Nguyen, B.Y.2    Katlama, C.3
  • 22
    • 77955825428 scopus 로고    scopus 로고
    • Pharmacokinetic/pharmacodynamic (PK/PD) analyses for raltegravir (RAL) in phase III studies in treatment experienced HIV-infected patients following 48 weeks of treatment [abstract H-4054]
    • 25-28 October 2008; Washington DC
    • Wenning LA, Hwang E, Nguyen B-Y, et al. Pharmacokinetic/pharmacodynamic (PK/PD) analyses for raltegravir (RAL) in phase III studies in treatment experienced HIV-infected patients following 48 weeks of treatment [abstract H-4054]. 48th Annual ICAAC/46th IDSA Meeting; 25-28 October 2008; Washington DC
    • 48th Annual ICAAC/46th IDSA Meeting
    • Wenning, L.A.1    Hwang, E.2    Nguyen, B.-Y.3
  • 23
    • 84862132912 scopus 로고    scopus 로고
    • Dose range and dose fractionation studies for raltegravir pharmacodynamics in an in vitro hollow fiber infection model system [abstract O-09]
    • 15-17 April 2009; Amsterdam, the Netherlands
    • McSharry J, Weng Q, Kulaway R, Drusano G. Dose range and dose fractionation studies for raltegravir pharmacodynamics in an in vitro hollow fiber infection model system [abstract O-09]. 10th International workshop on clinical pharmacology of HIV therapy; 15-17 April 2009; Amsterdam, the Netherlands
    • 10th International Workshop on Clinical Pharmacology of HIV Therapy
    • McSharry, J.1    Weng, Q.2    Kulaway, R.3    Drusano, G.4
  • 24
    • 84855377735 scopus 로고    scopus 로고
    • AUC0-3h of raltegravir is correlated to AUC0-12h: A novel approach for therapeutic drug monitoring of raltegravir [abstract #41]
    • 7 - 9 April 2010; Sorrento, Italy
    • Burger DM, Colbers EPH, Van Luin M, Koopmans PP. AUC0-3h of raltegravir is correlated to AUC0-12h: a novel approach for therapeutic drug monitoring of raltegravir [abstract #41]. 11th International Workshop on Clinical Pharmacology of HIV Therapy; 7 - 9 April 2010; Sorrento, Italy
    • 11th International Workshop on Clinical Pharmacology of HIV Therapy
    • Burger, D.M.1    Eph, C.2    Van Luin, M.3    Koopmans, P.P.4
  • 25
    • 38349182976 scopus 로고    scopus 로고
    • Lack of a pharmacokinetic effect of raltegravir on midazolam: In vitro/in vivo correlation
    • Iwamoto M, Kassahun K, Troyer MD, et al. Lack of a pharmacokinetic effect of raltegravir on midazolam: in vitro/in vivo correlation. J Clin Pharmacol 2008;48:209-214
    • (2008) J Clin Pharmacol , vol.48 , pp. 209-214
    • Iwamoto, M.1    Kassahun, K.2    Troyer, M.D.3
  • 26
    • 70349496064 scopus 로고    scopus 로고
    • The effect of raltegravir on the glucuronidation of lamotrigine
    • Van Luin M, Colbers A, Verwey-Van Wissen CP, et al. The effect of raltegravir on the glucuronidation of lamotrigine. J Clin Pharmacol 2009;49:1220-1227
    • (2009) J Clin Pharmacol , vol.49 , pp. 1220-1227
    • Van Luin, M.1    Colbers, A.2    Verwey-Van Wissen, C.P.3
  • 28
    • 76149115225 scopus 로고    scopus 로고
    • Raltegravir-based HAART regimen in a patient with large B-cell lymphoma
    • Fulco PP, Hynicka L, Rackley D. Raltegravir-based HAART regimen in a patient with large B-cell lymphoma. Ann Pharmacother 2010;44:377-382
    • (2010) Ann Pharmacother , vol.44 , pp. 377-382
    • Fulco, P.P.1    Hynicka, L.2    Rackley, D.3
  • 30
    • 74249121172 scopus 로고    scopus 로고
    • Pharmacokinetics of double-dose raltegravir in two patients with HIV infection and tuberculosis
    • Burger DM, Magis-Escurra C, van den Berk GE, Gelinck LB. Pharmacokinetics of double-dose raltegravir in two patients with HIV infection and tuberculosis. AIDS 2010;24:328-330
    • (2010) AIDS , vol.24 , pp. 328-330
    • Burger, D.M.1    Magis-Escurra, C.2    Van Den Berk, G.E.3    Gelinck, L.B.4
  • 31
    • 77951817362 scopus 로고    scopus 로고
    • Safe co-administration of raltegravir, pegylated-interferon and, ribavirin in HIV individuals with hepatitis C virus-related liver damage
    • Moreno A, Quereda C, Fortun J, et al. Safe co-administration of raltegravir, pegylated-interferon and, ribavirin in HIV individuals with hepatitis C virus-related liver damage. AIDS 2010;24:1231-1233
    • (2010) AIDS , vol.24 , pp. 1231-1233
    • Moreno, A.1    Quereda, C.2    Fortun, J.3
  • 32
    • 77953697687 scopus 로고    scopus 로고
    • Daily dosing of tacrolimus in patients treated with HIV-1 therapy containing a ritonavir-boosted protease inhibitor or raltegravir
    • Bickel M, Anadol E, Vogel M, et al. Daily dosing of tacrolimus in patients treated with HIV-1 therapy containing a ritonavir-boosted protease inhibitor or raltegravir. J Antimicrob Chemother 2010;65:999-1004
    • (2010) J Antimicrob Chemother , vol.65 , pp. 999-1004
    • Bickel, M.1    Anadol, E.2    Vogel, M.3
  • 33
    • 70349456237 scopus 로고    scopus 로고
    • Lack of interaction between raltegravir and cyclosporin in an HIV-infected liver transplant recipient
    • Di BA, Rosso R, Siccardi M, et al. Lack of interaction between raltegravir and cyclosporin in an HIV-infected liver transplant recipient. J Antimicrob Chemother 2009;64:874-875
    • (2009) J Antimicrob Chemother , vol.64 , pp. 874-875
    • Di, B.A.1    Rosso, R.2    Siccardi, M.3
  • 34
    • 67650941473 scopus 로고    scopus 로고
    • Safety and efficacy of raltegravir in HIV-infected transplant patients cotreated with immunosuppressive drugs
    • Tricot L, Teicher E, Peytavin G, et al. Safety and efficacy of raltegravir in HIV-infected transplant patients cotreated with immunosuppressive drugs. Am J Transplant 2009;9:1946-1952
    • (2009) Am J Transplant , vol.9 , pp. 1946-1952
    • Tricot, L.1    Teicher, E.2    Peytavin, G.3
  • 35
    • 69449101785 scopus 로고    scopus 로고
    • Safety and efficacy of raltegravir-based versus efavirenz-based combination therapy in treatment-naive patients with HIV-1 infection: A multicentre, double-blind randomised controlled trial
    • Lennox JL, DeJesus E, Lazzarin A, et al. Safety and efficacy of raltegravir-based versus efavirenz-based combination therapy in treatment-naive patients with HIV-1 infection: a multicentre, double-blind randomised controlled trial. Lancet 2009;374:796-806
    • (2009) Lancet , vol.374 , pp. 796-806
    • Lennox, J.L.1    Dejesus, E.2    Lazzarin, A.3
  • 36
    • 75749107023 scopus 로고    scopus 로고
    • Long-term efficacy and safety of Raltegravir combined with optimized background therapy in treatment-experienced patients with drug-resistant HIV infection: Week 96 results of the BENCHMRK 1 and 2 phase iii trials
    • Steigbigel RT, Cooper DA, Teppler H, et al. Long-term efficacy and safety of Raltegravir combined with optimized background therapy in treatment-experienced patients with drug-resistant HIV infection: week 96 results of the BENCHMRK 1 and 2 phase iii trials. Clin Infect Dis 2010;50:605-612
    • (2010) Clin Infect Dis , vol.50 , pp. 605-612
    • Steigbigel, R.T.1    Cooper, D.A.2    Teppler, H.3
  • 37
    • 75149175071 scopus 로고    scopus 로고
    • Switch to a raltegravir-based regimen versus continuation of a lopinavir-ritonavir-based regimen in stable HIV-infected patients with suppressed viraemia (SWITCHMRK 1 and 2): Two multicentre, double-blind, randomised controlled trials
    • Eron JJ, Young B, Cooper DA, et al. Switch to a raltegravir-based regimen versus continuation of a lopinavir-ritonavir-based regimen in stable HIV-infected patients with suppressed viraemia (SWITCHMRK 1 and 2): two multicentre, double-blind, randomised controlled trials. Lancet 2010;375:396-407
    • (2010) Lancet , vol.375 , pp. 396-407
    • Eron, J.J.1    Young, B.2    Cooper, D.A.3
  • 38
    • 70349902494 scopus 로고    scopus 로고
    • Switch from enfuvirtide to raltegravir in virologically suppressed multidrug-resistant HIV-1-infected patients: A randomized open-label trial
    • De Castro N, Braun J, Charreau I, et al. Switch from enfuvirtide to raltegravir in virologically suppressed multidrug-resistant HIV-1-infected patients: a randomized open-label trial. Clin Infect Dis 2009;49:1259-1267
    • (2009) Clin Infect Dis , vol.49 , pp. 1259-1267
    • De Castro, N.1    Braun, J.2    Charreau, I.3
  • 39
    • 64549143423 scopus 로고    scopus 로고
    • Preoperative use of raltegravir-containing regimen as induction therapy: Very rapid decline of HIV-1 viral load
    • Papendorp SG, van den Berk GE. Preoperative use of raltegravir-containing regimen as induction therapy: very rapid decline of HIV-1 viral load. AIDS 2009;23:739
    • (2009) AIDS , vol.23 , pp. 739
    • Papendorp, S.G.1    Van Den Berk, G.E.2
  • 40
    • 33750454570 scopus 로고    scopus 로고
    • Working Group of the office of AIDS Research Advisory Council (OARAC) version December 1, 2010. Available from [Last accessed 7 July 2010]
    • Working Group of the office of AIDS Research Advisory Council (OARAC). Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents, version December 1, 2010. Available from: http://aidsinfo.nih.gov/ contentfiles/AdultandAdolescentGL. pdf. [Last accessed 7 July 2010]
    • Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents
  • 41
    • 72849119170 scopus 로고    scopus 로고
    • High rate of virologic suppression with raltegravir plus etravirine and darunavir/ritonavir among treatment-experienced patients infected with multidrug-resistant HIV: Results of the ANRS 139 TRIO trial
    • Yazdanpanah Y, Fagard C, Descamps D, et al. High rate of virologic suppression with raltegravir plus etravirine and darunavir/ritonavir among treatment-experienced patients infected with multidrug-resistant HIV: results of the ANRS 139 TRIO trial. Clin Infect Dis 2009;49:1441-1449
    • (2009) Clin Infect Dis , vol.49 , pp. 1441-1449
    • Yazdanpanah, Y.1    Fagard, C.2    Descamps, D.3
  • 43
    • 77950232441 scopus 로고    scopus 로고
    • Hepatic safety profile of raltegravir in HIV-infected patients with chronic hepatitis C
    • Vispo E, Mena A, Maida I, et al. Hepatic safety profile of raltegravir in HIV-infected patients with chronic hepatitis C. J Antimicrob Chemother 2010;65:543-547
    • (2010) J Antimicrob Chemother , vol.65 , pp. 543-547
    • Vispo, E.1    Mena, A.2    Maida, I.3
  • 44
    • 77955835206 scopus 로고    scopus 로고
    • Hepatic safety & efficacy of raltegravir in patients co-infected with HIV and hepatitisB and/or C virus [abstract 662]
    • 16-19 February 2010; San Francisco, CA
    • Rockstroh J, Teppler H, Zhao J, et al. Hepatic safety & efficacy of raltegravir in patients co-infected with HIV and hepatitisB and/or C virus [abstract 662]. 17th Conference on Retroviruses and Opportunistic Infections; 16-19 February 2010; San Francisco, CA
    • 17th Conference on Retroviruses and Opportunistic Infections
    • Rockstroh, J.1    Teppler, H.2    Zhao, J.3
  • 46
    • 75649112262 scopus 로고    scopus 로고
    • A case of rhabdomiolysis associated with raltegravir use
    • Dori L, Buonomini AR, Viscione M, et al. A case of rhabdomiolysis associated with raltegravir use. AIDS 2010;24:473-475
    • (2010) AIDS , vol.24 , pp. 473-475
    • Dori, L.1    Buonomini, A.R.2    Viscione, M.3
  • 47
    • 77954348583 scopus 로고    scopus 로고
    • Substitution of raltegravir for ritonavir-boosted protease inhibitors in HIV-infected patients: The SPIRAL study
    • Martinez E, Larrousse M, Llibre JM, et al. Substitution of raltegravir for ritonavir-boosted protease inhibitors in HIV-infected patients: the SPIRAL study. AIDS 2010;24:1697-1707
    • (2010) AIDS , vol.24 , pp. 1697-1707
    • Martinez, E.1    Larrousse, M.2    Llibre, J.M.3
  • 48
    • 50949095712 scopus 로고    scopus 로고
    • Lack of a significant drug interaction between raltegravir and tenofovir
    • Wenning LA, Friedman EJ, Kost JT, et al. Lack of a significant drug interaction between raltegravir and tenofovir. Antimicrob Agents Chemother 2008;52:3253-3258
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 3253-3258
    • Wenning, L.A.1    Friedman, E.J.2    Kost, J.T.3
  • 49
    • 57049123891 scopus 로고    scopus 로고
    • Minimal effects of ritonavir and efavirenz on the pharmacokinetics of raltegravir
    • Iwamoto M, Wenning LA, Petry AS, et al. Minimal effects of ritonavir and efavirenz on the pharmacokinetics of raltegravir. Antimicrob Agents Chemother 2008;52:4338-4343
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 4338-4343
    • Iwamoto, M.1    Wenning, L.A.2    Petry, A.S.3
  • 50
    • 57049148690 scopus 로고    scopus 로고
    • Minimal pharmacokinetic interaction between the human immunodeficiency virus nonnucleoside reverse transcriptase inhibitor etravirine and the integrase inhibitor raltegravir in healthy subjects
    • Anderson MS, Kakuda TN, Hanley W, et al. Minimal pharmacokinetic interaction between the human immunodeficiency virus nonnucleoside reverse transcriptase inhibitor etravirine and the integrase inhibitor raltegravir in healthy subjects. Antimicrob Agents Chemother 2008;52:4228-4232
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 4228-4232
    • Anderson, M.S.1    Kakuda, T.N.2    Hanley, W.3
  • 51
    • 66949126977 scopus 로고    scopus 로고
    • Effect of tipranavir-ritonavir on pharmacokinetics of raltegravir
    • Hanley WD, Wenning LA, Moreau A, et al. Effect of tipranavir-ritonavir on pharmacokinetics of raltegravir. Antimicrob Agents Chemother 2009;53:2752-2755
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 2752-2755
    • Hanley, W.D.1    Wenning, L.A.2    Moreau, A.3
  • 52
    • 46249087089 scopus 로고    scopus 로고
    • Atazanavir modestly increases plasma levels of raltegravir in healthy subjects
    • Iwamoto M, Wenning LA, Mistry GC, et al. Atazanavir modestly increases plasma levels of raltegravir in healthy subjects. Clin Infect Dis 2008;47:137-140
    • (2008) Clin Infect Dis , vol.47 , pp. 137-140
    • Iwamoto, M.1    Wenning, L.A.2    Mistry, G.C.3
  • 53
    • 70350136060 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of twice daily atazanavir 300 mg and raltegravir 400 mg in healthy subjects [abstract 696]
    • 8-11 February 2009; Montreal, Canada
    • Zhu L, Mahnke L, Butterton J, et al. Pharmacokinetics and safety of twice daily atazanavir 300 mg and raltegravir 400 mg in healthy subjects [abstract 696]. 16th Conference on Retroviruses and Opportunistic Infections; 8-11 February 2009; Montreal, Canada
    • 16th Conference on Retroviruses and Opportunistic Infections
    • Zhu, L.1    Mahnke, L.2    Butterton, J.3
  • 54
    • 84880223641 scopus 로고    scopus 로고
    • Pharmacokinetic evaluation of darunavir/ritonavir and raltegravir in healthy subjects [abstract A-962]
    • 25-28 October 2008; Washington DC
    • Anderson MS, Sekar V, Tomaka F, et al. Pharmacokinetic evaluation of darunavir/ritonavir and raltegravir in healthy subjects [abstract A-962]. 48th Annual ICAAC/46th IDSA Meeting; 25-28 October 2008; Washington DC
    • 48th Annual ICAAC/46th IDSA Meeting
    • Anderson, M.S.1    Sekar, V.2    Tomaka, F.3
  • 55
    • 84255191193 scopus 로고    scopus 로고
    • RAL-KAL: Pharmacokinetics of coadminsitered raltegravir and lopinavir/ritonavir in healthy subjects [abstract TuPe0075]
    • 3-8 August 2008; Mexico City, Mexico
    • Rhame F, Long M, Acosta E. RAL-KAL: pharmacokinetics of coadminsitered raltegravir and lopinavir/ritonavir in healthy subjects [abstract TuPe0075]. 17th International AIDS Conference; 3-8 August 2008; Mexico City, Mexico
    • 17th International AIDS Conference
    • Rhame, F.1    Long, M.2    Acosta, E.3
  • 56
    • 84877099199 scopus 로고    scopus 로고
    • Steady-state pharmacokinetics (PK) of fosamprenavir (FPV) and raltegravir (RAL) alone and combined with unboosted and ritonavir-boosted FPV [abstract A1-1297]
    • 12-15 September 2009; San Francisco, CA
    • Luber A, Slowinski PD, Acosta E, et al. Steady-state pharmacokinetics (PK) of fosamprenavir (FPV) and raltegravir (RAL) alone and combined with unboosted and ritonavir-boosted FPV [abstract A1-1297]. 49th Interscience Conference on Antimicrobial Agents and Chemotherapy; 12-15 September 2009; San Francisco, CA
    • 49th Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Luber, A.1    Slowinski, P.D.2    Acosta, E.3
  • 57
    • 72949119327 scopus 로고    scopus 로고
    • Assessment of the pharmacokinetics of co-administered maraviroc and raltegravir
    • Andrews E, Glue P, Fang J, et al. Assessment of the pharmacokinetics of co-administered maraviroc and raltegravir. Br J Clin Pharmacol 2010;69:51-57
    • (2010) Br J Clin Pharmacol , vol.69 , pp. 51-57
    • Andrews, E.1    Glue, P.2    Fang, J.3
  • 58
    • 80053221392 scopus 로고    scopus 로고
    • Lack of a clinically important effect of rifabutin (RFB) on raltegravir (RAL) pharmacokinetics [abstract A1-1296]
    • 12-15 September 2009; San Francisco, CA
    • Brainard DM, Petry A, Fang L, et al. Lack of a clinically important effect of rifabutin (RFB) on raltegravir (RAL) pharmacokinetics [abstract A1-1296]. 49th Interscience Conference on Antimicrobial Agents and Chemotherapy; 12-15 September 2009; San Francisco, CA
    • 49th Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Brainard, D.M.1    Petry, A.2    Fang, L.3
  • 59
    • 66949149605 scopus 로고    scopus 로고
    • Effect of rifampin, a potent inducer of drug-metabolizing enzymes, on the pharmacokinetics of raltegravir
    • Wenning LA, Hanley WD, Brainard DM, et al. Effect of rifampin, a potent inducer of drug-metabolizing enzymes, on the pharmacokinetics of raltegravir. Antimicrob Agents Chemother 2009;53:2852-2856
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 2852-2856
    • Wenning, L.A.1    Hanley, W.D.2    Brainard, D.M.3
  • 60
    • 58749102754 scopus 로고    scopus 로고
    • Effects of omeprazole on plasma levels of raltegravir
    • Iwamoto M, Wenning LA, Nguyen BY, et al. Effects of omeprazole on plasma levels of raltegravir. Clin Infect Dis 2009;48:489-492
    • (2009) Clin Infect Dis , vol.48 , pp. 489-492
    • Iwamoto, M.1    Wenning, L.A.2    Nguyen, B.Y.3
  • 61
    • 34748860363 scopus 로고    scopus 로고
    • Rapid and durable antiretroviral effect of the HIV-1 integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: Results of a 48-Week Controlled Study
    • Markowitz M, Nguyen BY, Gotuzzo E, et al. Rapid and durable antiretroviral effect of the HIV-1 integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: results of a 48-Week Controlled Study. J Acquir Immune Defic Syndr 2007;46:125-133
    • (2007) J Acquir Immune Defic Syndr , vol.46 , pp. 125-133
    • Markowitz, M.1    Nguyen, B.Y.2    Gotuzzo, E.3
  • 62
    • 70350558421 scopus 로고    scopus 로고
    • Sustained antiretroviral effect of raltegravir after 96 weeks of combination therapy in treatment-naive patients with HIV-1 infection
    • Markowitz M, Nguyen BY, Gotuzzo E, et al. Sustained antiretroviral effect of raltegravir after 96 weeks of combination therapy in treatment-naive patients with HIV-1 infection. J Acquir Immune Defic Syndr 2009;52:350-356
    • (2009) J Acquir Immune Defic Syndr , vol.52 , pp. 350-356
    • Markowitz, M.1    Nguyen, B.Y.2    Gotuzzo, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.