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1
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70450081001
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Major lipids, apolipoproteins, and risk of vascular disease
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Emerging Risk Factors Collaboration
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Emerging Risk Factors Collaboration, Di Angelantonio E, Sarwar N, et al. Major lipids, apolipoproteins, and risk of vascular disease. JAMA 2009; 302:1993-2000.
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Niacin and fibrates in atherogenic dyslipidemia: Pharmacotherapy to reduce cardiovascular risk
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This article provides a comprehensive and critical review of 25 years of research on the pharmacology, lipid-modifying and antiatherosclerosis effects, and outcomes benefits of niacin and fibrates
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Chapman MJ, Redfern JS, McGovern ME, et al. Niacin and fibrates in atherogenic dyslipidemia: Pharmacotherapy to reduce cardiovascular risk. Pharmacol Ther 2010; 126:314-345. This article provides a comprehensive and critical review of 25 years of research on the pharmacology, lipid-modifying and antiatherosclerosis effects, and outcomes benefits of niacin and fibrates.
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Pharmacol Ther
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Chapman, M.J.1
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Pathogenesis and pathophysiology of the cardiometabolic syndrome
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J Clin Hypertens (Greenwich)
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Kirk, E.P.1
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Insulin resistance and the relationship of a dyslipidemia to coronary heart disease: The Framingham Heart Study
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Robins SJ, Lyass A, Zachariah JP, et al. Insulin resistance and the relationship of a dyslipidemia to coronary heart disease: The Framingham Heart Study. Arterioscler Thromb Vasc Biol 2011; 31:1208-1214.
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Arterioscler Thromb Vasc Biol
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Robins, S.J.1
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Zachariah, J.P.3
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Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): Randomised controlled trial
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Keech A, Simes RJ, Barter P, et al. Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): Randomised controlled trial. Lancet 2005; 366:1849-1861.
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Keech, A.1
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Effects of combination lipid therapy in type 2 diabetes mellitus
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This article presents the results of the most recent outcomes study of fibrate therapy and suggests that routine use of fenofibrate and simvastatin to reduce cardiovascular risk is not warranted for most high-risk patients with type 2 diabetes
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Ginsberg HN, Elam MB, Lovato LC, et al. Effects of combination lipid therapy in type 2 diabetes mellitus. N Engl J Med 2010; 362:1563-1574. This article presents the results of the most recent outcomes study of fibrate therapy and suggests that routine use of fenofibrate and simvastatin to reduce cardiovascular risk is not warranted for most high-risk patients with type 2 diabetes.
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N Engl J Med
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Ginsberg, H.N.1
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Relationships of HDL cholesterol, ApoA-I, and ApoA-II with homocysteine and creatinine in patients with type 2 diabetes treated with fenofibrate
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Taskinen MR, Sullivan DR, Ehnholm C, et al. Relationships of HDL cholesterol, ApoA-I, and ApoA-II with homocysteine and creatinine in patients with type 2 diabetes treated with fenofibrate. Arterioscler Thromb Vasc Biol 2009; 29:950-955.
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Arterioscler Thromb Vasc Biol
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Taskinen, M.R.1
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Cholesteryl ester transfer protein: At the heart of the action of lipid-modulating therapy with statins, fibrates, niacin, and cholesteryl ester transfer protein inhibitors
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Chapman MJ, Le Goff W, Guerin M, et al. Cholesteryl ester transfer protein: At the heart of the action of lipid-modulating therapy with statins, fibrates, niacin, and cholesteryl ester transfer protein inhibitors. EurHeart J 2009; 31:149-164.
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EurHeart J
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Chapman, M.J.1
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The role of fibrates in managing hyperlipidemia: Mechanisms of action and clinical efficacy
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Fazio S, Linton MF. The role of fibrates in managing hyperlipidemia: Mechanisms of action and clinical efficacy. Curr Atheroscler Rep 2004; 6:148-157.
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Curr Atheroscler Rep
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Fazio, S.1
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10
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Pharmacoepidemiology safety study of fibrate and statin concomitant therapy
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This retrospective cohort study of claims data from a US managed care plan analyzes the safety profile of fibrate and statin therapy
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Enger C, Gately R, Ming EE, et al. Pharmacoepidemiology safety study of fibrate and statin concomitant therapy. Am J Cardiol 2010; 106:1594-1601. This retrospective cohort study of claims data from a US managed care plan analyzes the safety profile of fibrate and statin therapy.
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Am J Cardiol
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Enger, C.1
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Prevention of cardiovascular disease utilizing fibrates: A pooled meta-analysis
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This meta-analysis of randomized controlled trials examines the effect of fibrates on cardiovascular outcomes
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Loomba RS, Arora R. Prevention of cardiovascular disease utilizing fibrates: A pooled meta-analysis. Am J Ther 2010; 17:e182-e188. This meta-analysis of randomized controlled trials examines the effect of fibrates on cardiovascular outcomes.
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Am J Ther
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Loomba, R.S.1
Arora, R.2
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12
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Effects of fibrates on cardiovascular outcomes: A systematic review and meta-analysis
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This meta-analysis of randomized controlled trials examines the effect of fibrates on cardiovascular outcomes
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Jun M, Foote C, Lv J, et al. Effects of fibrates on cardiovascular outcomes: A systematic review and meta-analysis. Lancet 2010; 375:1875-1884. This meta-analysis of randomized controlled trials examines the effect of fibrates on cardiovascular outcomes.
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Lancet
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Jun, M.1
Foote, C.2
Lv, J.3
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13
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Lipid alterations and decline in the incidence of coronary heart disease in the Helsinki Heart Study
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Manninen V, Elo MO, Frick MH, et al. Lipid alterations and decline in the incidence of coronary heart disease in the Helsinki Heart Study. JAMA 1988; 260:641-651.
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Elo, M.O.2
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14
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Secondary prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease: The Bezafibrate Infarction Prevention (BIP) study
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BIP Study Group
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BIP Study Group. Secondary prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease: The Bezafibrate Infarction Prevention (BIP) study. Circulation 2000; 102:21-27.
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Effects of fenofibrate treatment on cardiovascular disease risk in 9795 individuals with type 2 diabetes and various components of the metabolic syndrome: The Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study
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Scott R, O'Brien R, Fulcher G, et al. Effects of fenofibrate treatment on cardiovascular disease risk in 9795 individuals with type 2 diabetes and various components of the metabolic syndrome: The Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study. Diabetes Care 2009; 32:493-498.
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Is there a role for fibrates in the management of dyslipidemia in the metabolic syndrome?
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Barter PJ, Rye KA. Is there a role for fibrates in the management of dyslipidemia in the metabolic syndrome? Arterioscler Thromb Vasc Biol 2008; 28:39-46.
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Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): A randomised controlled trial
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Keech AC, Mitchell P, Summanen PA, et al. Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): A randomised controlled trial. Lancet 2007; 370:1687-1697.
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Keech, A.C.1
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European Medicines Agency Committee for Medicinal Products for Human Use: Questions and answers on the review of medicines containing fibrates outcome of a procedure under article 31 of directive 2001/83/EC as amended. [Accessed 17 February 2011]
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European Medicines Agency Committee for Medicinal Products for Human Use: Questions and answers on the review of medicines containing fibrates outcome of a procedure under article 31 of directive 2001/83/EC as amended. http://www.ema.europa.eu/docs/en-GB/document-library/Refer rals-document/ Fibrates-31/WC500098373.pdf. [Accessed 17 February 2011]
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19
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Safety considerations with niacin therapy
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Guyton JR, Bays HE. Safety considerations with niacin therapy. Am J Cardiol 2007; 99:22C-31C.
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Am J Cardiol
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Guyton, J.R.1
Bays, H.E.2
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Menon RM, Gonzalez MA, Adams MH, et al. Effect of the rate of niacin administration on the plasma and urine pharmacokinetics of niacin and its metabolites. J Clin Pharmacol 2007; 47:681-688.
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Menon, R.M.1
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Adams, M.H.3
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21
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Efficacy and safety of extendedrelease niacin/laropiprant in patients with type 2 diabetes mellitus
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This clinical trial in patients with type 2 diabetes shows that extended-release niacin plus laropiprant produces marked and durable improvements in lipids/ lipoproteins and is generally well tolerated
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MacLean A, McKenney JM, Scott R, et al. Efficacy and safety of extendedrelease niacin/laropiprant in patients with type 2 diabetes mellitus. Br J Cardiol 2011; 18:37-45. This clinical trial in patients with type 2 diabetes shows that extended-release niacin plus laropiprant produces marked and durable improvements in lipids/ lipoproteins and is generally well tolerated.
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Br J Cardiol
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MacLean, A.1
McKenney, J.M.2
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22
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53149118030
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Maccubbin D, Bays HE, Olsson AG, et al. Lipid-modifying efficacy and tolerability of extended-release niacin/laropiprant in patients with primary hypercholesterolaemia or mixed dyslipidaemia. Int J Clin Pract 2008; 62:1959-1970.
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Int J Clin Pract
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Maccubbin, D.1
Bays, H.E.2
Olsson, A.G.3
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23
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77950641140
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Efficacy and safety of extendedrelease niacin/laropiprant plus statin vs. doubling the dose of statin in patients with primary hypercholesterolaemia or mixed dyslipidaemia
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This clinical trial shows that adding extended-release niacin/laropiprant to ongoing statin therapy produces superior improvements in lipids/lipoproteins compared with doubling the statin dose
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Shah S, Ceska R, Gil-Extremera B, et al. Efficacy and safety of extendedrelease niacin/laropiprant plus statin vs. doubling the dose of statin in patients with primary hypercholesterolaemia or mixed dyslipidaemia. Int J Clin Pract 2010; 64:727-738. This clinical trial shows that adding extended-release niacin/laropiprant to ongoing statin therapy produces superior improvements in lipids/lipoproteins compared with doubling the statin dose.
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Int J Clin Pract
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Shah, S.1
Ceska, R.2
Gil-Extremera, B.3
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24
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Lipoprotein(a) as a cardiovascular risk factor: Current status
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This article, which reviewed the relationship between elevated Lp(a) levels and cardiovascular disease/coronary heart disease, recommends screening for Lp(a) in intermediate or high cardiovascular risk patients and suggests niacin therapy as a possible therapeutic strategy
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Nordestgaard BG, Chapman MJ, Ray K, et al. Lipoprotein(a) as a cardiovascular risk factor: Current status. Eur Heart J 2010; 31:2844-2853. This article, which reviewed the relationship between elevated Lp(a) levels and cardiovascular disease/coronary heart disease, recommends screening for Lp(a) in intermediate or high cardiovascular risk patients and suggests niacin therapy as a possible therapeutic strategy.
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(2010)
Eur Heart J
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, pp. 2844-2853
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Nordestgaard, B.G.1
Chapman, M.J.2
Ray, K.3
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25
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Nicotinic acid: Pharmacological effects and mechanisms of action
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Gille A, Bodor ET, Ahmed K, et al. Nicotinic acid: Pharmacological effects and mechanisms of action. Annu Rev Pharmacol Toxicol 2008; 48:79-106.
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Annu Rev Pharmacol Toxicol
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Gille, A.1
Bodor, E.T.2
Ahmed, K.3
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26
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53249145678
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Effects of a niacin receptor partial agonist, MK-0354, on plasma free fatty acids, lipids, and cutaneous flushing in humans
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Lai E, Waters MG, Tata JR, et al. Effects of a niacin receptor partial agonist, MK-0354, on plasma free fatty acids, lipids, and cutaneous flushing in humans. J Clin Lipidol 2008; 2:375-383.
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Lai, E.1
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29
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Niacin inhibits vascular oxidative stress, redoxsensitive genes, and monocyte adhesion to human aortic endothelial cells
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Ganji SH,Qin S, Zhang L, et al. Niacin inhibits vascular oxidative stress, redoxsensitive genes, and monocyte adhesion to human aortic endothelial cells. Atherosclerosis 2009; 202:68-75.
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30
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The effects of extended-release niacin on carotid intimal media thickness, endothelial function and inflammatory markers in patients with the metabolic syndrome
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Thoenes M, Oguchi A, Nagamia S, et al. The effects of extended-release niacin on carotid intimal media thickness, endothelial function and inflammatory markers in patients with the metabolic syndrome. Int J Clin Pract 2007; 61:1942-1948.
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Thoenes, M.1
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Pleiotropic effects of nicotinic acid: Beyond high density lipoprotein cholesterol elevation
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Epub ahead of print] This article reviews the antithrombotic, anti-inflammatory, and antioxidant effects of niacin and their possible contribution to niacin's observed cardiovascular benefits
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Florentin M, Liberopoulos EN, Kei A, et al. Pleiotropic effects of nicotinic acid: Beyond high density lipoprotein cholesterol elevation. Curr Vasc Pharmacol 2011. [Epub ahead of print] This article reviews the antithrombotic, anti-inflammatory, and antioxidant effects of niacin and their possible contribution to niacin's observed cardiovascular benefits.
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Curr Vasc Pharmacol
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Florentin, M.1
Liberopoulos, E.N.2
Kei, A.3
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32
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Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells
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Lukasova M, Malaval C, Gille A, et al. Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells. J Clin Invest 2011; 121:1163-1173.
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J Clin Invest
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Lukasova, M.1
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Gille, A.3
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Effects of laropiprant on nicotinic acidinduced flushing in patients with dyslipidemia
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Paolini JF, Mitchel YB, Reyes R, et al. Effects of laropiprant on nicotinic acidinduced flushing in patients with dyslipidemia. Am J Cardiol 2008; 101:625-630.
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Paolini, J.F.1
Mitchel, Y.B.2
Reyes, R.3
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34
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Seeing red: Flushing out instigators of niacinassociated skin toxicity
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Dunbar RL, Gelfand JM. Seeing red: Flushing out instigators of niacinassociated skin toxicity. J Clin Invest 2010; 120:2651-2655.
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Hanson J, Gille A, Zwykiel S, et al. Nicotinic acid- and monomethyl fumarateinduced flushing involves GPR109A expressed by keratinocytes and COX-2- dependent prostanoid formation in mice. J Clin Invest 2010; 120:2910-2919.
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Goldberg RB, Jacobson TA. Effects of niacin on glucose control in patients with dyslipidemia. Mayo Clin Proc 2008; 83:470-478.
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Fazio S, Guyton JR, Polis AB, et al. Long-term safety and efficacy of triple combination ezetimibe/simvastatin plus extended-release niacin in patients with hyperlipidemia. Am J Cardiol 2010; 105:487-494.
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Am J Cardiol
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Polis, A.B.3
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Effects of high-dose modified-release nicotinic acid on atherosclerosis and vascular function: A randomized, placebo-controlled, magnetic resonance imaging study
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Lee JM, Robson MD, Yu LM, et al. Effects of high-dose modified-release nicotinic acid on atherosclerosis and vascular function: A randomized, placebo-controlled, magnetic resonance imaging study. J Am Coll Cardiol 2009; 54:1787-1794.
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J Am Coll Cardiol
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Lee, J.M.1
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Yu, L.M.3
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Extended-release niacin or ezetimibe and carotid intima-media thickness
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Taylor AJ, Villines TC, Stanek EJ, et al. Extended-release niacin or ezetimibe and carotid intima-media thickness. N Engl J Med 2009; 361:2113-2122.
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N Engl J Med
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Taylor, A.J.1
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40
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77953121328
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The ARBITER 6-HALTS Trial (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6-HDL and LDL Treatment Strategies in Atherosclerosis): Final results and the impact of medication adherence, dose, and treatment duration
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This article presents the final results of ARBITER 6-HALTS trial and shows that niacin is superior to ezetimibe in regressing carotid intima-media thickness in patients receiving statins
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Villines TC, Stanek EJ, Devine PJ, et al. The ARBITER 6-HALTS Trial (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6-HDL and LDL Treatment Strategies in Atherosclerosis): Final results and the impact of medication adherence, dose, and treatment duration. J Am Coll Cardiol 2010; 55:2721-2726. This article presents the final results of ARBITER 6-HALTS trial and shows that niacin is superior to ezetimibe in regressing carotid intima-media thickness in patients receiving statins.
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J Am Coll Cardiol
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Villines, T.C.1
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41
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72049123762
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The HALTS trial-halting atherosclerosis or halted too early?
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Blumenthal RS, Michos ED. The HALTS trial-halting atherosclerosis or halted too early? N Engl J Med 2009; 361:2178-2180.
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N Engl J Med
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Kastelein JJ, Bots ML. Statin therapy with ezetimibe or niacin in high-risk patients. N Engl J Med 2009; 361:2180-2183.
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N Engl J Med
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Abstract 685: Comparative effect of statins vs niacin on MRI measured regression of carotid atherosclerosis in a randomized clinical trial: The NIA Plaque Study
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Sibley CT, Gottlieb I, Cox C, et al. Abstract 685: Comparative effect of statins vs niacin on MRI measured regression of carotid atherosclerosis in a randomized clinical trial: The NIA Plaque Study. Circulation 2009; 120:S376.
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Circulation
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Sibley, C.T.1
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77952397461
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Meta-analysis of the effect of nicotinic acid alone or in combination on cardiovascular events and atherosclerosis
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This meta-analysis of randomized controlled trials reveals benefits of niacin (alone or in combination) on all cardiovascular events and atherosclerosis progression
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Bruckert E, Labreuche J, Amarenco P. Meta-analysis of the effect of nicotinic acid alone or in combination on cardiovascular events and atherosclerosis. Atherosclerosis 2010; 210:353-361. This meta-analysis of randomized controlled trials reveals benefits of niacin (alone or in combination) on all cardiovascular events and atherosclerosis progression.
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Bruckert, E.1
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Should both HDL-C and LDL-C be targets for lipid therapy? A review of current evidence
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Brown BG, Zhao XQ, Cheung MC. Should both HDL-C and LDL-C be targets for lipid therapy? A review of current evidence. J Clin Lipidol 2007; 1:88-94.
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46
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Brown BG, Zhao XQ. Nicotinic acid, alone and in combinations, for reduction of cardiovascular risk. Am J Cardiol 2008; 101:58B-62B.
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AIM-HIGH Investigators This article describes the baseline characteristics of patients enrolled in the AIMHIGH trial, a key ongoing study designed to assess whether niacin superimposed on statin therapy reduces residual CV risk beyond statin alone
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AIM-HIGH Investigators. The role of niacin in raising high-density lipoprotein cholesterol to reduce cardiovascular events in patients with atherosclerotic cardiovascular disease and optimally treated low-density lipoprotein cholesterol: Baseline characteristics of study participants. The atherothrombosis intervention in metabolic syndrome with low HDL/high triglycerides: Impact on global health outcomes (AIM-HIGH) trial. Am Heart J 2011; 161:538-543. This article describes the baseline characteristics of patients enrolled in the AIMHIGH trial, a key ongoing study designed to assess whether niacin superimposed on statin therapy reduces residual CV risk beyond statin alone.
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