Continuing the use of the cockcroft-gault equation for drug dosing in patients with impaired renal function

Clinical Pharmacology and Therapeutics

Volumn 86, Issue 5, 2009, Pages 468-470

  Spruill, W J ^a   Wade, W E ^a   Cobb, H H ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; GENTAMICIN;

BODY SURFACE; BODY WEIGHT; CLINICAL PRACTICE; CREATININE BLOOD LEVEL; DOSE CALCULATION; DRUG CLEARANCE; FOOD AND DRUG ADMINISTRATION; GLOMERULUS FILTRATION RATE; HUMAN; KIDNEY FAILURE; KIDNEY FUNCTION; PRIORITY JOURNAL; SHORT SURVEY;

CLINICAL TRIALS AS TOPIC; CREATININE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DOSAGE CALCULATIONS; GLOMERULAR FILTRATION RATE; HUMANS; KIDNEY DISEASES; KIDNEY FUNCTION TESTS; PHARMACEUTICAL PREPARATIONS; REGRESSION ANALYSIS;

EID: 70350253273     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2009.187     Document Type: Short Survey

References (12)

1. US Food and Drug Administration. Preliminary Concept Paper: Pharmacokinetics in Patients With Impaired Renal Function Study Design, Data Analysis, and Impact on Dosing and Labeling. Presented at the FDA Clinical Pharmacology Advisory Committee meeting on 19 March 2008 http://www.fda.gov/ ohrms/dockets/ac/08/briefing/2008-4351b1-01-FDA.pdf (2008).
2. Levey, A.S., Bosch, J.P., Lewis, J.B., Greene, T., Rogers, N. & Roth, D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann. Intern. Med. 130, 461-470 (1999).
3. US Food and Drug Administration. Guidance for Industry: Pharmacokinetics in Patients with Impaired Renal Function-Study Design, Data Analysis and Impact on Dosing and Labeling (14 May 1998).
4. Myers, G.L. et al. Recommendations for improving serum creatinine measurement: a report from the Laboratory Working Group of the National Kidney Disease Education Program. Clin. Chem. 52, 5-18 (2006).
5. Coresh, J. et al. Calibration and random variation of the serum creatinine assay as critical elements of using equations to estimate glomerular filtration rate. Am. J. Kidney Dis. 39, 920-929 (2002).
6. Spruill, W.J., Wade, W.E. & Cobb, H.H. 3rd. Comparison of estimated glomerular filtration rate with estimated creatinine clearance in the dosing of drugs requiring adjustments in elderly patients with declining renal function. Am. J. Geriatr. Pharmacother. 6, 153-160 (2008).
7. Davies, D.F. & Shock, N.W. Age changes in glomerular filtration rate, effective renal plasma flow, and tubular excretory capacity in adult males. J. Clin. Invest. 29, 496-507 (1950).
8. Wargo, K.A., Eiland, E.H., Hamm, W., English, T.M. & Phillippe, H.M. Comparison of the modification of diet in renal disease and Cockcroft-Gault equations for antimicrobial dosage adjustments. Ann. Pharmacother. 40, 1248-1253 (2006).
9. Moranville, M.P. & Jennings, H.R. Implications of using modification of diet in renal disease versus Cockcroft-Gault equations for renal dosing adjustments. Am. J. Health Syst. Pharm. 66, 154-161 (2009).
10. Stevens, L.A. et al. Comparison of drug dosing recommendations based on measured GFR and kidney function estimating equations. Am. J. Kidney Dis. 54, 33-42 (2009).
11. Levey, A.S. et al. A new equation to estimate glomerular filtration rate. Ann. Intern. Med. 150, 604-612 (2009).
12. Roberts, G. I.P. & Schiøler, C. Modified Diet in Renal Disease method overestimates renal function in selected elderly patients. Age Aging 2009 (in press).