Studies on purification and the molecular mechanism of a novel ACE inhibitory peptide from whey protein hydrolysate

Food Chemistry

Volumn 130, Issue 1, 2012, Pages 121-126

  Pan, Daodong ^a,b   Cao, Jinxuan ^a   Guo, Huiqing ^b   Zhao, Bo ^b  

^a NINGBO UNIVERSITY   (China)

^b NANJING NORMAL UNIVERSITY   (China)

Author keywords

ACE inhibitory peptides; Molecule mechanism; Purification and identification; Whey protein hydrolysate

Indexed keywords

ACE-INHIBITORY; ACE-INHIBITORY ACTIVITY; ACTIVE FRACTION; AMINO ACID SEQUENCE; ANGIOTENSIN I-CONVERTING ENZYME; DOCKING TECHNOLOGY; FLEXIBLE MOLECULES; INHIBITORY PEPTIDES; MOLECULAR MECHANISM; REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SEPHADEX; WHEY PROTEIN HYDROLYSATES; WHEY PROTEINS;

AMINO ACIDS; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; ION EXCHANGE; PURIFICATION; SIZE EXCLUSION CHROMATOGRAPHY; ULTRAFILTRATION;

PEPTIDES;

DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; LEUCINE; PROTEIN HYDROLYSATE; TRYPSIN;

AMINO ACID SEQUENCE; ARTICLE; GEL PERMEATION CHROMATOGRAPHY; MOLECULAR DOCKING; MOLECULAR INTERACTION; MOLECULAR WEIGHT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ULTRAFILTRATION; WHEY;

EID: 80051782220     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2011.07.011     Document Type: Article

References (22)

1. S. Arai, T. Osawa, H. Ohigashi, M. Yoshikawa, S. Kaminogawa, and M. Watanabe A mainstay of functional food science in Japan-history present status and future outlook Bioscience Biotechnology and Biochemistry 65 2001 1 13 (Pubitemid 33617434)
2. Y. Ariyoshi Angiotensin converting enzyme inhibitors derived from food proteins Trends in Food Science & Technology 4 1993 139 144
3. H.S. Cheung, F.L. Wang, M.A. Ondetti, E.F. Sabo, and D.W. Cushman Binding of peptide substrates and inhibitors of angiotensin-converting enzyme The Journal of Biological Chemistry 255 2 1980 401 407
4. D.W. Cushman, and H.S. Cheung Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung Biochemical Pharmacology 20 1971 1637 1648
5. W.O. David, and H.N. Norman Principles of modern chemistry 1986 Saunders College Publishing New York
6. R.J. FitzGerald, and H. Meisel Milk protein-derived peptide inhibitors of angiotensin-I-converting enzyme British Journal of Nutrition 84 2000 33 37
7. A. Kawakami, and H. Kayahara Synthesis of Leu-Lys-Tyr derivatives and their interaction with angiotensin converting enzyme Journal of the Japanese Society of Nutrition and Food Science 46 5 1993 425 428
8. M. Mullally, H. Meisel, and R.J. FitzGerald Angiotensin-1-converting enzyme inhibitory activities of gastric and pancreatic proteinase digests of whey proteins International Dairy Journal 7 1997 299 303 (Pubitemid 28042753)
9. M. Mullally, H. Meisel, and R.J. FitzGerald Identification of a novel angiotensin-I-converting enzyme inhibitory peptide corresponding to a tryptic fragment of bovine ß-lactoglobulin FEBS Letters 402 1997 99 101 (Pubitemid 27078237)
10. A. Pihlanto-Leppälä, P. Koskinen, K. Piilola, T. Tupasela, and H. Korhonen Angiotensin I-converting enzyme inhibitory properties of whey protein digest: concentration and characterization of active peptides Journal of Dairy Research 67 2000 53 64 (Pubitemid 30104846)
11. M.S. Rohrbach, E.B. Williams Jr., and R.A. Rolstad Purification and substrate specificity of bovine angiotensin-converting enzyme Journal of Biological Chemistry 256 1 1981 225 230 (Pubitemid 12207109)
12. F.L. Schanbacher, R.S. Talhouk, F.A. Murray, L.I. Gherman, and L.B. Willett Milk-borne bioactive peptides International Dairy Journal 8 1998 393 403 (Pubitemid 28504138)
13. K. Suetsuna, and T. Nakano Identification of an antihypertensive peptide from peptic digest of wakame (Undaria pinnatifida) The Journal of Nutritional Biochemistry 11 9 2000 450 454
14. T. Takano Milk derived peptides and hypertension reduction International Dairy Journal 8 1998 375 381 (Pubitemid 28504136)
15. R. Thomsen, and M.H. Christensen MolDock: A new technique for high accuracy molecular docking Journal of Medicinal Chemistry 49 2006 3315 3321 (Pubitemid 43830529)
16. D. Tome, and H. Debabbi Physiological effects of milk protein components International Dairy Journal 8 1998 383 392 (Pubitemid 28504137)
17. J.P. Wu, R.E. Aluko, and S. Nakai Structural requirements of angiotensin I-converting enzyme. Inhibitory peptides: Quantitative structure-activity. Relationship study of di- and tripeptides Journal of Agricultural Food Chemistry 54 2006 732 738 (Pubitemid 43274109)
18. N. Yamamoto Antihypertensive peptides derived from food proteins Biopolymers 43 1997 129 134 (Pubitemid 27291391)
19. N. Yamamoto, A. Akino, and T. Takano Antihypertensive effect of the peptides derived from casein by an extracellular proteinase from Lactobacillus helveticus CP790 Journal of Dairy Science 77 1994 917 922
20. M. Yoshikawa, H. Fujita, N. Matoba, Y. Tkenaka, T. Ynmamoto, and R. Yamauchi Bioactive peptides derived from food proteins preventing lifestyle-related disease Biofactors 12 2000 143 146 (Pubitemid 32107398)
21. F. Zhang, Z. Wang, and S. Xu Macroporous resin purification of grass carp fish (Ctenopharyngodon idella) scale peptides with in vitro angiotensin-I converting enzyme (ACE) inhibitory ability Food Chemistry 117 2009 387 392
22. Y.H. Zhao, B.F. Li, Z.Y. Liu, S.Y. Dong, X. Zhao, and M.Y. Zeng Antihypertensive effect and purification of an ACE inhibitory peptide from sea cucumber gelatin hydrolysate Process Biochemistry 42 2007 1586 1591 (Pubitemid 350101340)