Differential regulation of protein synthesis and mTOR signaling in skeletal muscle and visceral tissues of neonatal pigs after a meal

Pediatric Research

Volumn 70, Issue 3, 2011, Pages 253-260

  Gazzaneo, María C ^a   Orellana, Renán A ^a   Suryawan, Agus ^a   Tuckow, Alexander P ^b   Kimball, Scot R ^b   Wilson, Fiona A ^a   Nguyen, Hanh V ^a   Torrazza, Roberto M ^a   Fiorotto, Marta L ^a   Davis, Teresa A ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INITIATION FACTOR 4E BINDING PROTEIN; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MESSENGER RNA; PROTEIN KINASE B; RAS PROTEIN; RIBOSOME PROTEIN; S6 KINASE; TUBERIN;

ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME SUBSTRATE; GASTROCNEMIUS MUSCLE; GLYCOLYSIS; HEART; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; JEJUNUM; KIDNEY; LIVER; MASSETER MUSCLE; MEAL; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PANCREAS; POLYSOME; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SWINE; VISCERA;

ANIMALS; ANIMALS, NEWBORN; EATING; ENZYME ACTIVATION; MUSCLE, SKELETAL; POLYRIBOSOMES; PROTEIN BIOSYNTHESIS; RANDOM ALLOCATION; RIBOSOMAL PROTEINS; SIGNAL TRANSDUCTION; SWINE; TOR SERINE-THREONINE KINASES; VISCERA;

EID: 80051779574     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1203/PDR.0b013e3182276cfa     Document Type: Article

References (31)

1. Denne SC, Kalhan SC 1987 Leucine metabolism in human newborns. Am J Physiol 253:E608-E615
2. Denne SC, Rossi EM, Kalhan SC 1991 Leucine kinetics during feeding in normal newborns. Pediatr Res 30:23-27
3. Ehrenkranz RA 2007 Early, aggressive nutritional management for very low birth weight infants: what is the evidence? Semin Perinatol 31:48-55 (Pubitemid 46616955)
4. Saigal S, Stoskopf BL, Streiner DL, Burrows E 2001 Physical growth and current health status of infants who were of extremely low birth weight and controls at adolescence. Pediatrics 108:407-415
5. Stephens BE, Vohr BR 2009 Neurodevelopmental outcome of the premature infant. Pediatr Clin North Am 56:631-646
6. Neubauer AP, Voss W, Kattner E 2008 Outcome of extremely low birth weight survivors at school age: the influence of perinatal parameters on neurodevelopment. Eur J Pediatr 167:87-95 (Pubitemid 350159825)
7. Davis TA, Burrin DG, Fiorotto ML, Nguyen HV 1996 Protein synthesis in skeletal muscle and jejunum is more responsive to feeding in 7-than in 26-day-old pigs. Am J Physiol 270:E802-E809
8. Davis TA, Fiorotto ML, Nguyen HV, Reeds PJ 1993 Enhanced response of muscle protein synthesis and plasma insulin to food intake in suckled rats. Am J Physiol 265:R334-R340 (Pubitemid 23275073)
9. Davis TA, Fiorotto ML 2009 Regulation of muscle growth in neonates. Curr Opin Clin Nutr Metab Care 12:78-85
10. Suryawan A, O'Connor PM, Bush JA, Nguyen HV, Davis TA 2009 Differential regulation of protein synthesis by amino acids and insulin in peripheral and visceral tissues of neonatal pigs. Amino Acids 37:97-104
11. O'Connor PM, Bush JA, Suryawan A, Nguyen HV, Davis TA 2003 Insulin and amino acids independently stimulate skeletal muscle protein synthesis in neonatal pigs. Am J Physiol Endocrinol Metab 284:E110-E119 (Pubitemid 36076229)
12. Suryawan A, O'Connor PM, Kimball SR, Bush JA, Nguyen HV, Jefferson LS, Davis TA 2004 Amino acids do not alter the insulin-induced activation of the insulin signaling pathway in neonatal pigs. J Nutr 134:24-30 (Pubitemid 38057418)
13. O'Connor PM, Kimball SR, Suryawan A, Bush JA, Nguyen HV, Jefferson LS, Davis TA 2003 Regulation of translation initiation by insulin and amino acids in skeletal muscle of neonatal pigs. Am J Physiol Endocrinol Metab 285:E40-E53 (Pubitemid 36736360)
14. Suryawan A, Orellana RA, Nguyen HV, Jeyapalan AS, Fleming JR, Davis TA 2007 Activation by insulin and amino acids of signaling components leading to translation initiation in skeletal muscle of neonatal pigs is developmentally regulated. Am J Physiol Endocrinol Metab 293:E1597-E1605 (Pubitemid 350255109)
15. Wang L, Harris TE, Roth RA, Lawrence JC Jr 2007 PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding. J Biol Chem 282:20036-20044 (Pubitemid 47100127)
16. Kim E, Goraksha-Hicks P, Li L, Neufeld TP, Guan KL 2008 Regulation of TORC1 by Rag GTPases in nutrient response. Nat Cell Biol 10:935-945
17. Davis TA 2008 Insulin and amino acids are critical regulators of neonatal muscle growth. Nutr Today 43:143-149
18. O'Connor PM, Kimball SR, Suryawan A, Bush JA, Nguyen HV, Jefferson LS, Davis TA 2004 Regulation of neonatal liver protein synthesis by insulin and amino acids in pigs. Am J Physiol Endocrinol Metab 286:E994-E1003 (Pubitemid 38668824)
19. Wilson FA, Suryawan A, Orellana RA, Kimball SR, Gazzaneo MC, Nguyen HV, Fiorotto ML, Davis TA 2009 Feeding rapidly stimulates protein synthesis in skeletal muscle of neonatal pigs by enhancing translation initiation. J Nutr 139:1873-1880
20. Escobar J, Frank JW, Suryawan A, Nguyen HV, Kimball SR, Jefferson LS, Davis TA 2005 Physiological rise in plasma leucine stimulates muscle protein synthesis in neonatal pigs by enhancing translation initiation factor activation. Am J Physiol Endocrinol Metab 288:E914-E921 (Pubitemid 40547885)
21. Davis TA, Fiorotto ML, Beckett PR, Burrin DG, Reeds PJ, Wray-Cahen D, Nguyen HV 2001 Differential effects of insulin on peripheral and visceral tissue protein synthesis in neonatal pigs. Am J Physiol Endocrinol Metab 280:E770-E779
22. Suryawan A, Davis TA 2010 The abundance and activation of mTORC1 regulators in skeletal muscle of neonatal pigs are modulated by insulin, amino acids and, age. J Appl Physiol 109:1448-1454
23. Wilson FA, Suryawan A, Gazzaneo MC, Orellana RA, Nguyen HV, Davis TA 2010 Stimulation of muscle protein synthesis by prolonged parenteral infusion of leucine is dependent on amino acid availability in neonatal pigs. J Nutr 140:264-270
24. Burrin DG, Davis TA, Ebner S, Schoknecht PA, Fiorotto ML, Reeds PJ, McAvoy S 1995 Nutrient-independent and nutrient-dependent factors stimulate protein synthesis in colostrum-fed newborn pigs. Pediatr Res 37:593-599
25. Davis TA, Fiorotto ML, Burrin DG, Reeds PJ, Nguyen HV, Beckett PR, Vann RC, O'Connor PM 2002 Stimulation of protein synthesis by both insulin and amino acids is unique to skeletal muscle in neonatal pigs. Am J Physiol Endocrinol Metab 282:E880-E890 (Pubitemid 34654750)
26. Suryawan A, Escobar J, Frank JW, Nguyen HV, Davis TA 2006 Developmental regulation of the activation of signaling components leading to translation initiation in skeletal muscle of neonatal pigs. Am J Physiol Endocrinol Metab 291:E849-E859 (Pubitemid 44484929)
27. Vary TC, Lynch CJ 2006 Meal feeding stimulates phosphorylation of multiple effector proteins regulating protein synthetic processes in rat hearts. J Nutr 136:2284-2290 (Pubitemid 44329983)
28. Reiter AK, Anthony TJ, Anthony JC, Jefferson LS, Kimball SR 2004 The mTOR signaling pathway mediates control of ribosomal protein mRNA translation in rat liver. Int J Biochem Cell Biol 36:2169-2179 (Pubitemid 39094440)
29. Stoll B, Burrin DG, Henry JF, Jahoor F, Reeds PJ 1999 Dietary and systemic phenylalanine utilization for mucosal and hepatic constitutive protein synthesis in pigs. Am J Physiol 276:G49-G57 (Pubitemid 29063599)
30. Elango R, Pencharz PB, Ball RO 2002 The branched-chain amino acid requirement of parenterally fed neonatal piglets is less than the enteral requirement. J Nutr 132:3123-3129
31. Perry RP, Meyuhas O 1990 Translational control of ribosomal protein production in mammalian cells. Enzyme 44:83-92