Cytoplasmic hdpr1 is involved in regional lymph node metastasis and tumor development via beta-catenin accumulation in esophageal squamous cell carcinoma

Journal of Histochemistry and Cytochemistry

Volumn 59, Issue 7, 2011, Pages 711-718

  Hou, Jian ^a   Li, En Min ^a   Shen, Jin Hui ^b   Qing Zhao, ^a   Wu, Zhi Yong ^b   Xu, Xiu E ^a   Wu, Jian Yi ^a   Qiao Huang, ^a   Shen, Jian ^a   Guo, Ming Zhou ^c   Xu, Li Yan ^a  

^a SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

^b SHANTOU CENTRAL HOSPITAL   (China)

^c CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Beta catenin; Escc; Hdpr1; Immunohistochemistry; Tissue microarray

Indexed keywords

BETA CATENIN; CELL PROTEIN; PROTEIN HDPR1; UNCLASSIFIED DRUG; DACT1 PROTEIN, HUMAN; NUCLEAR PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ADULT; AGED; ARTICLE; CANCER STAGING; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE MICROARRAY; BIOSYNTHESIS; CYTOPLASM; ESOPHAGUS TUMOR; KAPLAN MEIER METHOD; LYMPH NODE; METABOLISM; MIDDLE AGED; MORTALITY; PATHOLOGY; RETROSPECTIVE STUDY; SQUAMOUS CELL CARCINOMA; SURVIVAL RATE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; AGED; AGED, 80 AND OVER; BETA CATENIN; CARCINOMA, SQUAMOUS CELL; CYTOPLASM; ESOPHAGEAL NEOPLASMS; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NUCLEAR PROTEINS; RETROSPECTIVE STUDIES; SURVIVAL RATE;

EID: 80051775883     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1369/0022155411409941     Document Type: Article

References (27)

1. Cheyette BN, Waxman JS, Miller JR, Takemaru K, Sheldahl LC, Khlebtsova N, Fox EP, Earnest T, Moon RT. 2002. Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation. Dev Cell. 2:449-461.
2. Fisher DA, Kivimae S, Hoshino J, Suriben R, Martin PM, Baxter N, Cheyette BN. 2006. Three Dact gene family members are expressed during embryonic development and in the adult brains of mice. Dev Dyn. 235:2620-2630.
3. Gao X, Wen J, Zhang L, Li X, Ning Y, Meng A, Chen YG. 2008. Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus. J Biol Chem. 283:35679-35688.
4. Gillhouse M, Wagner Nyholm M, Hikasa H, Sokol SY, Grinblat Y. 2004. Two Frodo/Dapper homologs are expressed in the developing brain and mesoderm of zebrafish. Dev Dyn. 230:403-409.
5. Gloy J, Hikasa H, Sokol SY. 2002. Frodo interacts with Dishevelled to transduce Wnt signals. Nat Cell Biol. 4:351-357.
6. Hikasa H, Sokol SY. 2004. The involvement of Frodo in TCFdependent signaling and neural tissue development. Development. 131:4725-4734.
7. Hiscox S, Jiang WG. 1999. Ezrin regulates cell-cell and cellmatrix adhesion, a possible role with E-cadherin/beta-catenin. J Cell Sci. 18:3081-3090.
8. Hu W, McCrea PD, Deavers M, Kavanagh JJ, Kudelka AP, Verschraegen CF. 2000. Increased expression of fascin, motility associated protein, in cell cultures derived from ovarian cancer and in borderline and carcinomatous ovarian tumors. Clin Exp Metastasis. 18(1):83-88.
9. Ilyas M. 2005. Wnt signalling and the mechanistic basis of tumour development. J Pathol. 205:130-144.
10. Katoh M, Katoh M. 2003. Identification and characterization of human DAPPER1 and DAPPER2 genes in silico. Int J Oncol. 22:907-913.
11. Katoh M, Katoh M. 2005. Identification and characterization of rat Dact1 and Dact2 genes in silico. Int J Mol Med. 15:1045-1049.
12. Ke L. 2002. Mortality and incidence trends from esophagus cancer in selected geographic areas of China circa 1970-1990. Int J Cancer. 102:271-274.
13. Lerut T, Coosemans W, De Leyn P, Van Raemdonck D, Deneffe G, Decker G. 1999. Treatment of esophageal carcinoma. Chest. 116:463S-465S.
14. Ligon LA, Karki S, Tokito M, Holzbaur EL. 2001. Dynein binds to beta-catenin and may tether microtubules at adherens junctions. Nat Cell Biol. 3(10):913-917.
15. Nelson WJ, Nusse R. 2004. Convergence of Wnt, beta-catenin, and cadherin pathways. Science. 303:1483-1487.
16. Park JI, Ji H, Jun S, Gu D, Hikasa H, Li L, Sokol SY, McCrea PD. 2006. Frodo links Dishevelled to the p120-catenin/Kaiso pathway: distinct catenin subfamilies promote Wnt signals. Dev Cell. 11:683-695.
17. Parkin DM, Bray F, Ferlay J, Pisani P. 2005. Global cancer statistics, 2002. CA Cancer J Clin. 55:74-108.
18. Shimada H, Nabeya Y, Okazumi S, Matsubara H, Shiratori T, Gunji Y, Kobayashi S, Hayashi H, Ochiai T. 2003. Prediction of survival with squamous cell carcinoma antigen in patients with resectable esophageal squamous cell carcinoma. Surgery. 133:486-494.
19. Tao YS, Edwards RA, Tubb B, Wang S, Bryan J, McCrea PD. 1996. Beta-catenin associates with the actin-bundling protein fascin in a noncadherin complex. J Cell Biol. 134(5):1271-1281.
20. Teran E, Branscomb AD, Seeling JM. 2009. Dpr acts as a molecular switch, inhibiting Wnt signaling when unphosphorylated, but promoting Wnt signaling when phosphorylated by casein kinase Idelta/epsilon. PloS One. 4:e5522.
21. Waxman JS, Hocking AM, Stoick CL, Moon RT. 2004. Zebrafish Dapper1 and Dapper2 play distinct roles in Wnt-mediated developmental processes. Development. 131:5909-5921.
22. Xie JJ, Xu LY, Wu JY, Shen ZY, Zhao Q, Du ZP, Lv Z, Gu W, Pan F, Xu XE, et al. 2010. Involvement of CYR61 and CTGF in the fascin-mediated proliferation and invasiveness of esophageal squamous cell carcinomas cells. Am J Pathol. 176(2):939-951.
23. Xie JJ, Xu LY, Xie YM, Zhang HH, Cai WJ, Zhou F, Shen ZY, Li EM. 2009. Roles of ezrin in the growth and invasiveness of esophageal squamous carcinoma cells. Int J Cancer. 124(11):2549-58.
24. Xie JJ, Xu LY, Zhang HH, Cai WJ, Mai RQ, Xie YM, Yang ZM, Niu YD, Shen ZY, Li EM. 2005. Role of fascin in the proliferation and invasiveness of esophageal carcinoma cells. Biochem Biophys Res Commun. 337(1):355-362.
25. Yang ZQ, Zhao Y, Liu Y, Zhang JY, Zhang S, Jiang GY, Zhang PX, Yang LH, Liu D, Li QC, et al. 2010. Downregulation of HDPR1 is associated with poor prognosis and affects expression levels of p120-catenin and beta-catenin in nonsmall cell lung cancer. Mol Carcinog. 49(5):508-519.
26. Yau TO, Chan CY, Chan KL, Lee MF, Wong CM, Fan ST, Ng IO. 2005. HDPR1, a novel inhibitor of the WNT/beta-catenin signaling, is frequently downregulated in hepatocellular carcinoma: involvement of methylation-mediated gene silencing. Oncogene. 24:1607-1614.
27. Zhang L, Gao X, Wen J, Ning Y, Chen YG. 2006. Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation. J Biol Chem. 281:8607-8612.