-
2
-
-
67349108403
-
Oral administration of the GnRH antagonist acyline, in a GIPET-enhanced tablet form, acutely suppresses serum testosterone in normal men: single-dose pharmacokinetics and pharmacodynamics
-
Amory J.K. Leonard T.W. Page S.T. O'Toole E. McKenna M.J. Bremner W.J. (2009) Oral administration of the GnRH antagonist acyline, in a GIPET-enhanced tablet form, acutely suppresses serum testosterone in normal men: single-dose pharmacokinetics and pharmacodynamics. Cancer Chemother Pharmacol 64: 641–645.
-
(2009)
Cancer Chemother Pharmacol
, vol.64
, pp. 641-645
-
-
Amory, J.K.1
Leonard, T.W.2
Page, S.T.3
O'Toole, E.4
McKenna, M.J.5
Bremner, W.J.6
-
3
-
-
58149146747
-
Degarelix compared to leuprolide depot 7.5 mg in a 12-month randomised, open-label, parallel-group phase III study in prostate cancer patients
-
abstract 537
-
Boccon-Gibod L. Klotz L. Schröder H. Andreou C. Persson B.E. Cantor P. (2008) Degarelix compared to leuprolide depot 7.5 mg in a 12-month randomised, open-label, parallel-group phase III study in prostate cancer patients. Eur Urol (Suppl. 7): 205–205. abstract 537.
-
(2008)
Eur Urol
, pp. 205
-
-
Boccon-Gibod, L.1
Klotz, L.2
Schröder, H.3
Andreou, C.4
Persson, B.E.5
Cantor, P.6
-
4
-
-
0036129344
-
Pharmacological profile of a new, potent, and longacting gonadotropin-releasing hormone antagonist: degarelix
-
Broqua P. Riviere P.J. Conn P.M. Rivier J.E. Aubert M.L. Junien J.L. (2002) Pharmacological profile of a new, potent, and longacting gonadotropin-releasing hormone antagonist: degarelix. J Pharmacol Exp Ther 301: 95–102.
-
(2002)
J Pharmacol Exp Ther
, vol.301
, pp. 95-102
-
-
Broqua, P.1
Riviere, P.J.2
Conn, P.M.3
Rivier, J.E.4
Aubert, M.L.5
Junien, J.L.6
-
5
-
-
33646475112
-
Effect of leuprolide and cetrorelix on cell growth, apoptosis, and GnRH receptor expression in primary cell cultures from human prostate carcinoma
-
Castellón E. Clementi M. Hitschfeld C. Sánchez C. Benítez D. Sáenz L. (2006) Effect of leuprolide and cetrorelix on cell growth, apoptosis, and GnRH receptor expression in primary cell cultures from human prostate carcinoma. Cancer Invest 24: 261–268.
-
(2006)
Cancer Invest
, vol.24
, pp. 261-268
-
-
Castellón, E.1
Clementi, M.2
Hitschfeld, C.3
Sánchez, C.4
Benítez, D.5
Sáenz, L.6
-
6
-
-
79956367366
-
Switching from leuprolide to degarelix vs continuous degarelix treatment – effects on long-term prostate-specific antigen control
-
abstract 670
-
Crawford E.D. Moul J.W. Shore N.D. Olesen T.K. Persson B.E. (2010a) Switching from leuprolide to degarelix vs continuous degarelix treatment – effects on long-term prostate-specific antigen control. J Urol 183(4 Suppl): e262–e262. abstract 670.
-
(2010)
J Urol
, vol.183
, Issue.4
, pp. e262-e262
-
-
Crawford, E.D.1
Moul, J.W.2
Shore, N.D.3
Olesen, T.K.4
Persson, B.E.5
-
7
-
-
80051725559
-
Prostate-specific antigen and serum alkaline phosphatase levels in prostate cancer patients receiving degarelix or leuprolide
-
abstract 866
-
Crawford E.D. Moul J.W. Shore N.D. Olesen T.K. Persson B.E. (2010b) Prostate-specific antigen and serum alkaline phosphatase levels in prostate cancer patients receiving degarelix or leuprolide. J Urol 183(4 Suppl): e338–e338. abstract 866.
-
(2010)
J Urol
, vol.183
, Issue.4
, pp. e338-e338
-
-
Crawford, E.D.1
Moul, J.W.2
Shore, N.D.3
Olesen, T.K.4
Persson, B.E.5
-
8
-
-
33845662144
-
Abarelix for injectable suspension: first-in-class gonadotropin-releasing hormone antagonist for prostate cancer
-
Debruyne F. Bhat G. Garnick M.B. (2006) Abarelix for injectable suspension: first-in-class gonadotropin-releasing hormone antagonist for prostate cancer. Future Oncol 2: 677–696.
-
(2006)
Future Oncol
, vol.2
, pp. 677-696
-
-
Debruyne, F.1
Bhat, G.2
Garnick, M.B.3
-
9
-
-
77956374604
-
Ozarelix, a fourth generation GnRH antagonist, induces apoptosis in hormone refractory androgen receptor negative prostate cancer cells modulating expression and activity of death receptors
-
Festuccia C. Dondi D. Piccolella M. Locatelli A. Gravina G.L. Tombolini V. (2010) Ozarelix, a fourth generation GnRH antagonist, induces apoptosis in hormone refractory androgen receptor negative prostate cancer cells modulating expression and activity of death receptors. Prostate 70: 1340–1349.
-
(2010)
Prostate
, vol.70
, pp. 1340-1349
-
-
Festuccia, C.1
Dondi, D.2
Piccolella, M.3
Locatelli, A.4
Gravina, G.L.5
Tombolini, V.6
-
10
-
-
53249121469
-
A 1-year, open-label, randomized phase II dose-finding study of degarelix, a novel gonadotropin-releasing hormone (GnRH) receptor blocker, in the treatment of prostate cancer in North America
-
Gittelman M. Pommerville P.J. Persson B.E. Jensen J.K. Olesen T.K. (2008) on behalf of the Degarelix Study Group. A 1-year, open-label, randomized phase II dose-finding study of degarelix, a novel gonadotropin-releasing hormone (GnRH) receptor blocker, in the treatment of prostate cancer in North America. J Urol 180: 1986–1992.
-
(2008)
J Urol
, vol.180
, pp. 1986-1992
-
-
Gittelman, M.1
Pommerville, P.J.2
Persson, B.E.3
Jensen, J.K.4
Olesen, T.K.5
-
11
-
-
0029240272
-
Luteinizing hormone-releasing hormone antagonist cetrorelix as primary single therapy in patients with advanced prostatic cancer and paraplegia due to metastatic invasion of spinal cord
-
Gonzalez-Barcena D. Cardenas-Cornejo I. Vadillo-Buenfil M. Comaru-Schally A.M. Cortez-Morales A. Schally A.V. (1995) Luteinizing hormone-releasing hormone antagonist cetrorelix as primary single therapy in patients with advanced prostatic cancer and paraplegia due to metastatic invasion of spinal cord. Urology 45: 275–281.
-
(1995)
Urology
, vol.45
, pp. 275-281
-
-
Gonzalez-Barcena, D.1
Cardenas-Cornejo, I.2
Vadillo-Buenfil, M.3
Comaru-Schally, A.M.4
Cortez-Morales, A.5
Schally, A.V.6
-
12
-
-
0028281076
-
Responses to the antagonistic analog of LH-RH (SB-75, cetrorelix) in patients with benign prostatic hyperplasia and prostatic cancer
-
Gonzalez-Barcena D. Vadillo-Buenfil M. Gomez-Orta F. Fuentes Garcia M. Cardenas-Cornejo I. Graef-Sanchez A. (1994) Responses to the antagonistic analog of LH-RH (SB-75, cetrorelix) in patients with benign prostatic hyperplasia and prostatic cancer. Prostate 24: 84–92.
-
(1994)
Prostate
, vol.24
, pp. 84-92
-
-
Gonzalez-Barcena, D.1
Vadillo-Buenfil, M.2
Gomez-Orta, F.3
Fuentes Garcia, M.4
Cardenas-Cornejo, I.5
Graef-Sanchez, A.6
-
13
-
-
0036316840
-
Acyline: the first study in humans of a potent, new gonadotropin-releasing hormone antagonist
-
Herbst K.L. Anawalt B.D. Amory J.K. Bremner W.J. (2002) Acyline: the first study in humans of a potent, new gonadotropin-releasing hormone antagonist. J Clin Endocrinol Metab 87: 3215–3220.
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 3215-3220
-
-
Herbst, K.L.1
Anawalt, B.D.2
Amory, J.K.3
Bremner, W.J.4
-
14
-
-
10344247116
-
Acyline, a gonadotropin releasing-hormone antagonist suppresses gonadotropins and testosterone for 15 days after a single dose
-
Herbst K.L. Coviello A.D. Page S.T. Amory J.K. Anawalt B.D. Bremner W.J. (2004) Acyline, a gonadotropin releasing-hormone antagonist suppresses gonadotropins and testosterone for 15 days after a single dose. J Clin Endocrinol Metab 89: 5959–5965.
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 5959-5965
-
-
Herbst, K.L.1
Coviello, A.D.2
Page, S.T.3
Amory, J.K.4
Anawalt, B.D.5
Bremner, W.J.6
-
15
-
-
84928580276
-
Studies on prostatic cancer. I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate
-
Huggins C. Hodges C.V. (1941) Studies on prostatic cancer. I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. Cancer Res 1: 293–297.
-
(1941)
Cancer Res
, vol.1
, pp. 293-297
-
-
Huggins, C.1
Hodges, C.V.2
-
17
-
-
0035944837
-
Gonadotropin-releasing-hormone-receptor antagonists
-
Huirne J.A.F. Lambalk C.B. (2001) Gonadotropin-releasing-hormone-receptor antagonists. Lancet 358: 1793–1803.
-
(2001)
Lancet
, vol.358
, pp. 1793-1803
-
-
Huirne, J.A.F.1
Lambalk, C.B.2
-
18
-
-
34250648459
-
Changes of biochemical markers of bone turnover and YKL-40 following hormonal treatment for metastatic prostate cancer are related to survival
-
Johansen J.S. Brasso K. Iversen P. Teisner B. Garnero P. Price P.A. (2007) Changes of biochemical markers of bone turnover and YKL-40 following hormonal treatment for metastatic prostate cancer are related to survival. Clin Cancer Res 13: 3244–3249.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 3244-3249
-
-
Johansen, J.S.1
Brasso, K.2
Iversen, P.3
Teisner, B.4
Garnero, P.5
Price, P.A.6
-
19
-
-
4043064387
-
Comparison of 10 serum bone turnover markers in prostate carcinoma patients with bone metastatic spread: diagnostic and prognostic implications
-
Jung K. Lein M. Stephan C. Von Hösslin K. Semjonow A. Sinha P. (2004) Comparison of 10 serum bone turnover markers in prostate carcinoma patients with bone metastatic spread: diagnostic and prognostic implications. Int J Cancer 111: 783–791.
-
(2004)
Int J Cancer
, vol.111
, pp. 783-791
-
-
Jung, K.1
Lein, M.2
Stephan, C.3
Von Hösslin, K.4
Semjonow, A.5
Sinha, P.6
-
20
-
-
0030751523
-
Luteinizing hormone-releasing hormone antagonist cetrorelix (SB-75) and bombesin antagonist RC-3940-II inhibit the growth of androgen-independent PC-3 prostate cancer in nude mice
-
Jungwirth A. Galvan G. Pinski J. Halmos G. Szepeshazi K. Cai R.Z. (1997) Luteinizing hormone-releasing hormone antagonist cetrorelix (SB-75) and bombesin antagonist RC-3940-II inhibit the growth of androgen-independent PC-3 prostate cancer in nude mice. Prostate 32: 164–172.
-
(1997)
Prostate
, vol.32
, pp. 164-172
-
-
Jungwirth, A.1
Galvan, G.2
Pinski, J.3
Halmos, G.4
Szepeshazi, K.5
Cai, R.Z.6
-
21
-
-
33749058933
-
Diabetes and cardiovascular disease during androgen deprivation therapy for prostate cancer
-
Keating N.L. O–Malley J. Smith M.R. (2006) Diabetes and cardiovascular disease during androgen deprivation therapy for prostate cancer. J Clin Oncol 24: 4448–4456.
-
(2006)
J Clin Oncol
, vol.24
, pp. 4448-4456
-
-
Keating, N.L.1
O–Malley, J.2
Smith, M.R.3
-
22
-
-
70449334504
-
Abarelix and other gonadotrophin-releasing hormone antagonists in prostate cancer
-
Kirby R.S. Fitzpatrick J.M. Clarke N. (2009) Abarelix and other gonadotrophin-releasing hormone antagonists in prostate cancer. BJU Int 104: 1580–1584.
-
(2009)
BJU Int
, vol.104
, pp. 1580-1584
-
-
Kirby, R.S.1
Fitzpatrick, J.M.2
Clarke, N.3
-
23
-
-
56649116179
-
The efficacy and safety of degarelix: a 12-month, comparative, randomized, open-label, parallel-group phase III study in prostate cancer patients
-
Klotz L. Boccon-Gibod L. Shore N.D. Andreou C. Persson B.E. Cantor P. (2008) The efficacy and safety of degarelix: a 12-month, comparative, randomized, open-label, parallel-group phase III study in prostate cancer patients. BJU Int 102: 1531–1538.
-
(2008)
BJU Int
, vol.102
, pp. 1531-1538
-
-
Klotz, L.1
Boccon-Gibod, L.2
Shore, N.D.3
Andreou, C.4
Persson, B.E.5
Cantor, P.6
-
24
-
-
80051712082
-
Baseline cardiovascular risk factors predict cardiovascular (CV) events during androgen deprivation therapy (ADT) with degarelix
-
Klotz L. Smith M.R. van der Meulen E.A. Tanko L.B. (2010) Baseline cardiovascular risk factors predict cardiovascular (CV) events during androgen deprivation therapy (ADT) with degarelix. Ann Oncol 21(Suppl. 8): viii 276, abstract 883 P–viii 276, abstract 883 P.
-
(2010)
Ann Oncol
, vol.21
-
-
Klotz, L.1
Smith, M.R.2
van der Meulen, E.A.3
Tanko, L.B.4
-
25
-
-
77956605441
-
Degarelix, a novel GnRH antagonist, causes minimal histamine release compared with cetrorelix, abarelix and ganirelix in an ex vivo model of human skin samples
-
Koechling W. Hjortkjaer R. Tankó L.B. (2010) Degarelix, a novel GnRH antagonist, causes minimal histamine release compared with cetrorelix, abarelix and ganirelix in an ex vivo model of human skin samples. Br J Clin Pharmacol 70: 580–587.
-
(2010)
Br J Clin Pharmacol
, vol.70
, pp. 580-587
-
-
Koechling, W.1
Hjortkjaer, R.2
Tankó, L.B.3
-
26
-
-
0032538353
-
Luteinizing hormone-releasing hormone (LH-RH) antagonist cetrorelix inhibits growth of DU-145 human androgen-independent prostate carcinoma in nude mice and suppresses the levels and mRNA expression of IGF-II in tumors
-
Lamharzi N. Schally A.V. Koppan M. (1998) Luteinizing hormone-releasing hormone (LH-RH) antagonist cetrorelix inhibits growth of DU-145 human androgen-independent prostate carcinoma in nude mice and suppresses the levels and mRNA expression of IGF-II in tumors. Regul Pept 77: 185–192.
-
(1998)
Regul Pept
, vol.77
, pp. 185-192
-
-
Lamharzi, N.1
Schally, A.V.2
Koppan, M.3
-
27
-
-
34547663484
-
Serial markers of bone turnover in men with metastatic prostate cancer treated with zoledronic acid for detection of bone metastases progression
-
Lein M. Wirth M. Miller K. Eickenberg H.U. Weissbach L. Schmidt K. (2007) Serial markers of bone turnover in men with metastatic prostate cancer treated with zoledronic acid for detection of bone metastases progression. Eur Urol 52: 1381–1387.
-
(2007)
Eur Urol
, vol.52
, pp. 1381-1387
-
-
Lein, M.1
Wirth, M.2
Miller, K.3
Eickenberg, H.U.4
Weissbach, L.5
Schmidt, K.6
-
28
-
-
77149172555
-
Androgen-deprivation therapy in prostate cancer and cardiovascular risk: a science advisory from the American Heart Association, American Cancer Society and American Urological Association: endorsed by the American Society for Radiation Oncology
-
Levine G.N. D'Amico A.V. Berger P. Clark P.E. Eckel R.H. Keating N.L. (2010) Androgen-deprivation therapy in prostate cancer and cardiovascular risk: a science advisory from the American Heart Association, American Cancer Society and American Urological Association: endorsed by the American Society for Radiation Oncology. Circulation 121: 833–840.
-
(2010)
Circulation
, vol.121
, pp. 833-840
-
-
Levine, G.N.1
D'Amico, A.V.2
Berger, P.3
Clark, P.E.4
Eckel, R.H.5
Keating, N.L.6
-
29
-
-
0029971482
-
Clinical efficacy of bone alkaline phosphatase and prostate specific antigen in the diagnosis of bone metastasis in prostate cancer
-
Lorente J.A. Morote J. Raventos C. Encabo G. Valenzuela H. (1996) Clinical efficacy of bone alkaline phosphatase and prostate specific antigen in the diagnosis of bone metastasis in prostate cancer. J Urol 155: 1348–1351.
-
(1996)
J Urol
, vol.155
, pp. 1348-1351
-
-
Lorente, J.A.1
Morote, J.2
Raventos, C.3
Encabo, G.4
Valenzuela, H.5
-
30
-
-
0035516095
-
A phase 3, multicenter, open-label, randomized study of abarelix versus leuprolide acetate in men with prostate cancer
-
McLeod D. Zinner N. Tomera K. Gleason D. Fotheringham N. Campion M. (2001) A phase 3, multicenter, open-label, randomized study of abarelix versus leuprolide acetate in men with prostate cancer. Urology 58: 756–761.
-
(2001)
Urology
, vol.58
, pp. 756-761
-
-
McLeod, D.1
Zinner, N.2
Tomera, K.3
Gleason, D.4
Fotheringham, N.5
Campion, M.6
-
31
-
-
6444243321
-
Abarelix: the first gonadotrophin-releasing hormone antagonist for the treatment of prostate cancer
-
Mongiat-Artus P. Teillac P. (2004) Abarelix: the first gonadotrophin-releasing hormone antagonist for the treatment of prostate cancer. Expert Opin Pharmacother 5: 2171–2179.
-
(2004)
Expert Opin Pharmacother
, vol.5
, pp. 2171-2179
-
-
Mongiat-Artus, P.1
Teillac, P.2
-
32
-
-
33646043753
-
Skin reactions to 3-month depot type of luteinizing hormone-releasing hormone agonist therapy
-
Oka D. Shiba M. Arai Y. Nakayama M. Takayama H. Inoue H. (2006) Skin reactions to 3-month depot type of luteinizing hormone-releasing hormone agonist therapy. Jpn Med Assoc J 49: 48–54.
-
(2006)
Jpn Med Assoc J
, vol.49
, pp. 48-54
-
-
Oka, D.1
Shiba, M.2
Arai, Y.3
Nakayama, M.4
Takayama, H.5
Inoue, H.6
-
33
-
-
33751516087
-
Testosterone gel combined with depomedroxyprogesterone acetate (DMPA) is an effective male hormonal contraceptive regimen but is not enhanced by the addition of the GnRH antagonist acyline
-
Page S.T. Amory J.K. Anawalt B.D. Irwig M. Brockenbrough A. Matsumoto A.M. (2006) Testosterone gel combined with depomedroxyprogesterone acetate (DMPA) is an effective male hormonal contraceptive regimen but is not enhanced by the addition of the GnRH antagonist acyline. J Clin Endocrinol Metab 91: 4374–4380.
-
(2006)
J Clin Endocrinol Metab
, vol.91
, pp. 4374-4380
-
-
Page, S.T.1
Amory, J.K.2
Anawalt, B.D.3
Irwig, M.4
Brockenbrough, A.5
Matsumoto, A.M.6
-
34
-
-
70350257619
-
Degarelix: a new approach for the treatment of prostate cancer
-
Persson B.E. Kold Olesen T. Jensen J.K. (2009) Degarelix: a new approach for the treatment of prostate cancer. Neuroendocrinology 90: 235–244.
-
(2009)
Neuroendocrinology
, vol.90
, pp. 235-244
-
-
Persson, B.E.1
Kold Olesen, T.2
Jensen, J.K.3
-
35
-
-
84993773432
-
Effects of switching from leuprolide to degarelix on long-term prostate-specific antigen (PSA) and serum alkaline phosphatase (S-ALP) control
-
abstract 893 P.
-
Persson B.E. Olesen T.K. Jensen J. Mason M. (2010) Effects of switching from leuprolide to degarelix on long-term prostate-specific antigen (PSA) and serum alkaline phosphatase (S-ALP) control. Ann Oncol 21(Suppl. 8): viii 280–viii 280. abstract 893 P.
-
(2010)
Ann Oncol
, vol.21
, pp. viii 280-viii 280
-
-
Persson, B.E.1
Olesen, T.K.2
Jensen, J.3
Mason, M.4
-
36
-
-
0026585139
-
Blockade of the LH response induced by the agonist D-Trp-6-LHRH in rats by a highly potent LH-RH antagonist SB-75
-
Pinski J. Yano T. Miller G. Schally A.V. (1992) Blockade of the LH response induced by the agonist D-Trp-6-LHRH in rats by a highly potent LH-RH antagonist SB-75. Prostate 20: 213–224.
-
(1992)
Prostate
, vol.20
, pp. 213-224
-
-
Pinski, J.1
Yano, T.2
Miller, G.3
Schally, A.V.4
-
37
-
-
84993722719
-
Switching from leuprolide to degarelix vs. continuous degarelix treatment – effects on long-term PSA control
-
abstract N12
-
Plekhanov A. Crawford E.D. Olesen T.K. Van Der Meulen E.A. Persson B.E. (2010) Switching from leuprolide to degarelix vs. continuous degarelix treatment – effects on long-term PSA control. Eur Urol 9(Suppl. 6): 538–538. abstract N12.
-
(2010)
Eur Urol
, vol.9
, pp. 538
-
-
Plekhanov, A.1
Crawford, E.D.2
Olesen, T.K.3
Van Der Meulen, E.A.4
Persson, B.E.5
-
38
-
-
33847129303
-
Rapid suppression of plasma testosterone levels and tumor growth in the Dunning rat model treated with degarelix, a new gonadotropin-releasing hormone antagonist
-
Princivalle M. Broqua P. White R. Meyer J. Mayer G. Elliott L. (2007) Rapid suppression of plasma testosterone levels and tumor growth in the Dunning rat model treated with degarelix, a new gonadotropin-releasing hormone antagonist. J Pharmacol Exp Ther 320: 1113–1118.
-
(2007)
J Pharmacol Exp Ther
, vol.320
, pp. 1113-1118
-
-
Princivalle, M.1
Broqua, P.2
White, R.3
Meyer, J.4
Mayer, G.5
Elliott, L.6
-
39
-
-
33847000174
-
Plasma osteopontin in comparison with bone markers as indicator of bone metastasis and survival outcome in patients with prostate cancer
-
Ramankulov A. Lein M. Kristiansen G. Loening S.A. Jung K. (2007) Plasma osteopontin in comparison with bone markers as indicator of bone metastasis and survival outcome in patients with prostate cancer. Prostate 67: 330–340.
-
(2007)
Prostate
, vol.67
, pp. 330-340
-
-
Ramankulov, A.1
Lein, M.2
Kristiansen, G.3
Loening, S.A.4
Jung, K.5
-
41
-
-
36749096941
-
Prediction of survival of metastatic prostate cancer based on early serial measurements of prostate specific antigen and alkaline phosphatase
-
Robinson D. Sandblom G. Johansson R. Garmo H. Stattin P. Mommsen S. (2008) Prediction of survival of metastatic prostate cancer based on early serial measurements of prostate specific antigen and alkaline phosphatase. J Urol 179: 117–122.
-
(2008)
J Urol
, vol.179
, pp. 117-122
-
-
Robinson, D.1
Sandblom, G.2
Johansson, R.3
Garmo, H.4
Stattin, P.5
Mommsen, S.6
-
42
-
-
77953849770
-
Alkaline phosphatase changes in prostate cancer patients receiving degarelix or leuprolide: results from a 12-month, comparative, phase III study (CS21)
-
Schröder F.H. Tombal B. Miller K. Boccon-Gibod L. Shore N.D. Crawford E.D. (2010) Alkaline phosphatase changes in prostate cancer patients receiving degarelix or leuprolide: results from a 12-month, comparative, phase III study (CS21). BJU Int 106: 182–187.
-
(2010)
BJU Int
, vol.106
, pp. 182-187
-
-
Schröder, F.H.1
Tombal, B.2
Miller, K.3
Boccon-Gibod, L.4
Shore, N.D.5
Crawford, E.D.6
-
43
-
-
0001887220
-
Comparison of abarelix depot (A-D) and goserelin (G) plus bicalutamide (B) in advanced prostate cancer: results of a multicentre, open-label, randomised, phase III study
-
Selvaggi F. Khoe G.S.S. Van Cangh P. Jung J.-L. Schulman C.C. Vallancien G. (2001) Comparison of abarelix depot (A-D) and goserelin (G) plus bicalutamide (B) in advanced prostate cancer: results of a multicentre, open-label, randomised, phase III study. Eur Urol 39(Suppl. 5): 78–78.
-
(2001)
Eur Urol
, vol.39
, pp. 78
-
-
Selvaggi, F.1
Khoe, G.S.S.2
Van Cangh, P.3
Jung, J.-L.4
Schulman, C.C.5
Vallancien, G.6
-
44
-
-
0026648459
-
The gonadotropin-releasing hormone (GnRH) agonist-induced initial rise of bioactive LH and testosterone can be blunted in a dose-dependent manner by GnRH antagonist in the non-human primate
-
Sharma O.P. Weinbauer G.F. Behre H.M. Nieschlag E. (1992) The gonadotropin-releasing hormone (GnRH) agonist-induced initial rise of bioactive LH and testosterone can be blunted in a dose-dependent manner by GnRH antagonist in the non-human primate. Urol Res 20: 317–321.
-
(1992)
Urol Res
, vol.20
, pp. 317-321
-
-
Sharma, O.P.1
Weinbauer, G.F.2
Behre, H.M.3
Nieschlag, E.4
-
45
-
-
78349311655
-
Cardiovascular safety of degarelix: results from a 12-month, comparative, randomized, open label, parallel-group phase III trial in patients with prostate cancer
-
Smith M.R. Klotz L. Persson B.E. Olesen T.K. Wilde A.A. (2010) Cardiovascular safety of degarelix: results from a 12-month, comparative, randomized, open label, parallel-group phase III trial in patients with prostate cancer. J Urol 184: 2313–2319.
-
(2010)
J Urol
, vol.184
, pp. 2313-2319
-
-
Smith, M.R.1
Klotz, L.2
Persson, B.E.3
Olesen, T.K.4
Wilde, A.A.5
-
46
-
-
74749105209
-
Degarelix: a gonadotropin-releasing hormone antagonist for the management of prostate cancer
-
Steinberg M. (2009) Degarelix: a gonadotropin-releasing hormone antagonist for the management of prostate cancer. Clin Ther 31: 2312–2331.
-
(2009)
Clin Ther
, vol.31
, pp. 2312-2331
-
-
Steinberg, M.1
-
47
-
-
26544456233
-
Flare associated with LHRH-agonist therapy
-
Thompson I.M. (2001) Flare associated with LHRH-agonist therapy. Rev Urol 3(Suppl. 3): S10–S14.
-
(2001)
Rev Urol
, vol.3
, pp. S10-S14
-
-
Thompson, I.M.1
-
48
-
-
77949653652
-
Additional analysis of the secondary end point of biochemical recurrence rate in a phase 3 trial (CS21) comparing degarelix 80 mg versus leuprolide in prostate cancer patients segmented by baseline characteristics
-
Tombal B. Miller K. Boccon-Gibod L. Schröder F. Shore N. Crawford E.D. (2010) Additional analysis of the secondary end point of biochemical recurrence rate in a phase 3 trial (CS21) comparing degarelix 80 mg versus leuprolide in prostate cancer patients segmented by baseline characteristics. Eur Urol 57: 836–842.
-
(2010)
Eur Urol
, vol.57
, pp. 836-842
-
-
Tombal, B.1
Miller, K.2
Boccon-Gibod, L.3
Schröder, F.4
Shore, N.5
Crawford, E.D.6
-
49
-
-
0035046991
-
The gonadotropin-releasing hormone antagonist abarelix depot versus luteinizing hormone releasing hormone agonists leuprolide or goserelin: initial results of endocrinological and biochemical efficacies in patients with prostate cancer
-
Tomera K. Gleason D. Gittelman M. Moseley W. Zinner N. Murdoch M. (2001) The gonadotropin-releasing hormone antagonist abarelix depot versus luteinizing hormone releasing hormone agonists leuprolide or goserelin: initial results of endocrinological and biochemical efficacies in patients with prostate cancer. J Urol 165: 1585–1589.
-
(2001)
J Urol
, vol.165
, pp. 1585-1589
-
-
Tomera, K.1
Gleason, D.2
Gittelman, M.3
Moseley, W.4
Zinner, N.5
Murdoch, M.6
-
50
-
-
0036128522
-
A phase 3, multicenter, open label, randomized study of abarelix versus leuprolide plus daily antiandrogen in men with prostate cancer
-
Trachtenberg J. Gittleman M. Steidle C. Barzell W. Friedel W. Pessis D. (2002) A phase 3, multicenter, open label, randomized study of abarelix versus leuprolide plus daily antiandrogen in men with prostate cancer. J Urol 167: 1670–1674.
-
(2002)
J Urol
, vol.167
, pp. 1670-1674
-
-
Trachtenberg, J.1
Gittleman, M.2
Steidle, C.3
Barzell, W.4
Friedel, W.5
Pessis, D.6
-
51
-
-
44649169622
-
Testosterone surge: rationale for gonadotropin-releasing hormone blockers?
-
Van Poppel H. Nilsson S. (2008) Testosterone surge: rationale for gonadotropin-releasing hormone blockers? Urology 71: 1001–1006.
-
(2008)
Urology
, vol.71
, pp. 1001-1006
-
-
Van Poppel, H.1
Nilsson, S.2
-
52
-
-
50849110501
-
Degarelix: a novel gonadotropin-releasing hormone (GnRH) receptor blocker – results from a 1-yr, multicentre, randomised, phase II dose-finding study in the treatment of prostate cancer
-
Van Poppel H. Tombal B. de la Rosette J.J. Persson B.E. Jensen J.K. Olesen T.K. (2008) on behalf of the Degarelix Study Group. Degarelix: a novel gonadotropin-releasing hormone (GnRH) receptor blocker – results from a 1-yr, multicentre, randomised, phase II dose-finding study in the treatment of prostate cancer. Eur Urol 54: 805–815.
-
(2008)
Eur Urol
, vol.54
, pp. 805-815
-
-
Van Poppel, H.1
Tombal, B.2
de la Rosette, J.J.3
Persson, B.E.4
Jensen, J.K.5
Olesen, T.K.6
|