메뉴 건너뛰기




Volumn 70, Issue 4, 2010, Pages 580-587

Degarelix, a novel GnRH antagonist, causes minimal histamine release compared with cetrorelix, abarelix and ganirelix in an ex vivo model of human skin samples

Author keywords

abarelix; cetrorelix; degarelix; ganirelix; histamine; human skin

Indexed keywords

ABARELIX; CETRORELIX; COMPOUND 48-80; DEGARELIX; GANIRELIX; GONADORELIN ANTAGONIST; HISTAMINE;

EID: 77956605441     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2010.03730.x     Document Type: Article
Times cited : (23)

References (22)
  • 2
    • 0034033880 scopus 로고    scopus 로고
    • Mechanisms of nonimmunological histamine and tryptase release from human cutaneous mast cells
    • Veien M, Szlam F, Holden JT, Yamaguchi K, Denson DD, Levy JH. Mechanisms of nonimmunological histamine and tryptase release from human cutaneous mast cells. Anesthesiology 2000 92:1074 1081.
    • (2000) Anesthesiology , vol.92 , pp. 1074-1081
    • Veien, M.1    Szlam, F.2    Holden, J.T.3    Yamaguchi, K.4    Denson, D.D.5    Levy, J.H.6
  • 3
    • 0027370304 scopus 로고
    • Single-dose administration of the gonadotropin-releasing hormone antagonist, Nal-Lys (antide) to healthy men
    • Bagatell CJ, Conn PM, Bremner WJ. Single-dose administration of the gonadotropin-releasing hormone antagonist, Nal-Lys (antide) to healthy men. Fertil Steril 1993 60:680 685.
    • (1993) Fertil Steril , vol.60 , pp. 680-685
    • Bagatell, C.J.1    Conn, P.M.2    Bremner, W.J.3
  • 4
    • 0029077953 scopus 로고
    • Dose effects of the gonadotropin-releasing hormone antagonist, Nal-Glu, combined with testosterone enanthate on gonadotropin levels in normal men
    • Bagatell CJ, Rivier JE, Bremner WJ. Dose effects of the gonadotropin-releasing hormone antagonist, Nal-Glu, combined with testosterone enanthate on gonadotropin levels in normal men. Fertil Steril 1995 64:139 145.
    • (1995) Fertil Steril , vol.64 , pp. 139-145
    • Bagatell, C.J.1    Rivier, J.E.2    Bremner, W.J.3
  • 6
    • 77956572589 scopus 로고    scopus 로고
    • FDA-Abarelix prescribing information. Available at. (Ref Type: Internet Communication).
    • FDA-Abarelix prescribing information 2005. Available at http://www.accessdata.fda.gov/drugsatfda-docs/label/2005/021320s002lbl.pdf (Ref Type: Internet Communication).
    • (2005)
  • 9
    • 53249121469 scopus 로고    scopus 로고
    • A 1-year, open label, randomized phase II dose finding study of degarelix for the treatment of prostate cancer in North America
    • Gittelman M, Pommerville PJ, Persson BE, Jensen JK, Olesen TK. A 1-year, open label, randomized phase II dose finding study of degarelix for the treatment of prostate cancer in North America. J Urol 2008 180:1986 1992.
    • (2008) J Urol , vol.180 , pp. 1986-1992
    • Gittelman, M.1    Pommerville, P.J.2    Persson, B.E.3    Jensen, J.K.4    Olesen, T.K.5
  • 10
    • 33847129303 scopus 로고    scopus 로고
    • Rapid suppression of plasma testosterone levels and tumor growth in the Dunning rat model treated with degarelix, a new gonadotropin-releasing hormone antagonist
    • Princivalle M, Broqua P, White R, Meyer J, Mayer G, Elliott L, Bjarnason K, Haigh R, Yea C. Rapid suppression of plasma testosterone levels and tumor growth in the Dunning rat model treated with degarelix, a new gonadotropin-releasing hormone antagonist. J Pharmacol Exp Ther 2007 320:1113 1118.
    • (2007) J Pharmacol Exp Ther , vol.320 , pp. 1113-1118
    • Princivalle, M.1    Broqua, P.2    White, R.3    Meyer, J.4    Mayer, G.5    Elliott, L.6    Bjarnason, K.7    Haigh, R.8    Yea, C.9
  • 11
    • 50849110501 scopus 로고    scopus 로고
    • Degarelix: A novel gonadotropin-releasing hormone (GnRH) receptor blocker - Results from a 1-yr, multicentre, randomised, phase 2 dosage-finding study in the treatment of prostate cancer
    • Van Poppel H, Tombal B, de la Rosette JJ, Persson BE, Jensen JK, Olesen TK. Degarelix: a novel gonadotropin-releasing hormone (GnRH) receptor blocker - results from a 1-yr, multicentre, randomised, phase 2 dosage-finding study in the treatment of prostate cancer. Eur Urol 2008 54:805 813.
    • (2008) Eur Urol , vol.54 , pp. 805-813
    • Van Poppel, H.1    Tombal, B.2    De La Rosette, J.J.3    Persson, B.E.4    Jensen, J.K.5    Olesen, T.K.6
  • 12
    • 33845662144 scopus 로고    scopus 로고
    • Abarelix for injectable suspension: First-in-class gonadotropin-releasing hormone antagonist for prostate cancer
    • Debruyne F, Bhat G, Garnick MB. Abarelix for injectable suspension: first-in-class gonadotropin-releasing hormone antagonist for prostate cancer. Future Oncol 2006 2:677 696.
    • (2006) Future Oncol , vol.2 , pp. 677-696
    • Debruyne, F.1    Bhat, G.2    Garnick, M.B.3
  • 13
    • 56649116179 scopus 로고    scopus 로고
    • The efficacy and safety of degarelix: A 12-month, comparative, randomized, open-label, parallel-group phase III study in patients with prostate cancer
    • Klotz L, Boccon-Gibod L, Shore ND, Andreou C, Persson BE, Cantor P, Jensen JK, Olesen TK, Schroder FH. The efficacy and safety of degarelix: a 12-month, comparative, randomized, open-label, parallel-group phase III study in patients with prostate cancer. BJU Int 2008 102:1531 1538.
    • (2008) BJU Int , vol.102 , pp. 1531-1538
    • Klotz, L.1    Boccon-Gibod, L.2    Shore, N.D.3    Andreou, C.4    Persson, B.E.5    Cantor, P.6    Jensen, J.K.7    Olesen, T.K.8    Schroder, F.H.9
  • 14
    • 0036129344 scopus 로고    scopus 로고
    • Pharmacological profile of a new, potent, and long-acting gonadotropin-releasing hormone antagonist: Degarelix
    • Broqua P, Riviere PJ, Conn PM, Rivier JE, Aubert ML, Junien JL. Pharmacological profile of a new, potent, and long-acting gonadotropin-releasing hormone antagonist: degarelix. J Pharmacol Exp Ther 2002 301:95 102.
    • (2002) J Pharmacol Exp Ther , vol.301 , pp. 95-102
    • Broqua, P.1    Riviere, P.J.2    Conn, P.M.3    Rivier, J.E.4    Aubert, M.L.5    Junien, J.L.6
  • 15
    • 0025377932 scopus 로고
    • A mast cell secretagogue, compound 48/80, prevents the accumulation of hyaluronan in lung tissue injured by ionizing irradiation
    • Nilsson K, Bjermer L, Hellstrom S, Henriksson R, Hallgren R. A mast cell secretagogue, compound 48/80, prevents the accumulation of hyaluronan in lung tissue injured by ionizing irradiation. Am J Respir Cell Mol Biol 1990 2:199 205.
    • (1990) Am J Respir Cell Mol Biol , vol.2 , pp. 199-205
    • Nilsson, K.1    Bjermer, L.2    Hellstrom, S.3    Henriksson, R.4    Hallgren, R.5
  • 16
    • 0019989774 scopus 로고
    • Histamine release from isolated and intact mast cells of two types of genetically different rat
    • West GB. Histamine release from isolated and intact mast cells of two types of genetically different rat. Agents Actions 1982 12:98 100.
    • (1982) Agents Actions , vol.12 , pp. 98-100
    • West, G.B.1
  • 18
    • 0021955562 scopus 로고
    • Comparison of the histamine-releasing activity of cremophor E1 and some of its derivatives in two experimental models: The in vivo anaesthetized dog and in vitro rat peritoneal mast cells
    • Ennis M, Lorenz W, Kapp B, Luben L, Schmal A. Comparison of the histamine-releasing activity of cremophor E1 and some of its derivatives in two experimental models: the in vivo anaesthetized dog and in vitro rat peritoneal mast cells. Agents Actions 1985 16:265 268.
    • (1985) Agents Actions , vol.16 , pp. 265-268
    • Ennis, M.1    Lorenz, W.2    Kapp, B.3    Luben, L.4    Schmal, A.5
  • 20
    • 0021914102 scopus 로고
    • Histamine release by structural analogs of LHRH
    • Hook WA, Karten M, Siraganian RP. Histamine release by structural analogs of LHRH. Fed Proc 1985 44:1323.
    • (1985) Fed Proc , vol.44 , pp. 1323
    • Hook, W.A.1    Karten, M.2    Siraganian, R.P.3
  • 21
    • 0021246505 scopus 로고
    • Ac-D-NAL(2)1,4FD-Phe2,D-Trp3,D-Arg6-LHRH, a potent antagonist of LHRH, produces transient edema and behavioral changes in rats
    • Schmidt F, Sundaram K, Thau RB, Bardin CW. Ac-D-NAL(2)1,4FD-Phe2,D-Trp3, D-Arg6-LHRH, a potent antagonist of LHRH, produces transient edema and behavioral changes in rats. Contraception 1984 29:283 289.
    • (1984) Contraception , vol.29 , pp. 283-289
    • Schmidt, F.1    Sundaram, K.2    Thau, R.B.3    Bardin, C.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.